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The map label for this gene is Hgd [H]

Identifier: 51892076

GI number: 51892076

Start: 1053749

End: 1054633

Strand: Reverse

Name: Hgd [H]

Synonym: STH938

Alternate gene names: 51892076

Gene position: 1054633-1053749 (Counterclockwise)

Preceding gene: 51892080

Following gene: 51892070

Centisome position: 29.57

GC content: 70.85

Gene sequence:

>885_bases
GTGATGGCCAACCTCGGATTCATCGGACTCGGACGCATGGGCCGGCACATGGCGCGCAACCTGATCAGGGCCGGACACAC
CGTCACCCTCTACAACCGCAGCCAGGCGGTCGTCGATGAACTCGTGGCCGAAGGCGGCCGGCGGGCGGCGGGCCCCGCGG
AGGTGGCGCGGGACGCCCGCGTGCTCTTCACCTGCCTCACCACGCCCGACGTGGTCGAGAGCATCCTGCGTCAGGCGCTG
GAGGGCGCGCAGCCCGGCGACATCTTCGTCGACCACTCGACCATCGGCGTGCGGGACGCCAAGCGCATCGCCGCGATGTG
CGCGGAGAAGGGCGTCCAGTTCATCGACGCCCCGGTCTCGGGCGGCCCCTGGGGCGCGGAGGCCGGGACGCTCACCATCA
TGTGCGGCGGCGACCGGGCGGCCTTCGAGGCGGTGCTCCCCTACCTTCAGGTCGAGGGCAAGGCAATCCACCACCTGGGA
CCGGTGGGCGCGGGCTCCGTGGCCAAGCTCTGCAACAACCTCCTGGTGGGCATCCACACGGCGGCCATGGCCGAGGCCTT
CGTGCTGGGCACCAAGGCCGGTGTCGACCCCAAGGCGCTCTACGAGATCATCTCCAACGCGACCGGCCACTCGGCGCAGA
TCGCCCGCAACATCCCCCAGTTCGTCTTCCCGGGCAAGTTCGACGCCGCCTTCTCCATCGACCACCTGCACAAGGACGTC
GCCCTCGCGGTGGAACTGGGGAAGGACGAGAACGTGCGGATGGTGCTCGGGGCCGTCACGCAGCAGCTCCTGGCCGAGGC
CCGGGCGCTGGGCTACGGCGGCTCGGACCAGGCCGCGCTGATCCGGCCGCTGGAGGAGTTGGCCGGCGTGAAGGTGCGGG
CCTGA

Upstream 100 bases:

>100_bases
CCCTGCGTCGCCCTGCATGTCTGGAACGTGCCGGATCCGCCGCCCGGCATCGCCCCGGATATGGTAGGATGGACTTGCAA
TCCTGGCAGAGGAGGATGCC

Downstream 100 bases:

>100_bases
CCCCCGCGCACGCGAACCGGCACCCCCGGGCGTTCCGAGCCCGGGGGTGCTCCGCGCTCCGGATCAGTGAACGGGATCGG
GCCGGGCCTCCGCCCAATCC

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MMANLGFIGLGRMGRHMARNLIRAGHTVTLYNRSQAVVDELVAEGGRRAAGPAEVARDARVLFTCLTTPDVVESILRQAL
EGAQPGDIFVDHSTIGVRDAKRIAAMCAEKGVQFIDAPVSGGPWGAEAGTLTIMCGGDRAAFEAVLPYLQVEGKAIHHLG
PVGAGSVAKLCNNLLVGIHTAAMAEAFVLGTKAGVDPKALYEIISNATGHSAQIARNIPQFVFPGKFDAAFSIDHLHKDV
ALAVELGKDENVRMVLGAVTQQLLAEARALGYGGSDQAALIRPLEELAGVKVRA

Sequences:

>Translated_294_residues
MMANLGFIGLGRMGRHMARNLIRAGHTVTLYNRSQAVVDELVAEGGRRAAGPAEVARDARVLFTCLTTPDVVESILRQAL
EGAQPGDIFVDHSTIGVRDAKRIAAMCAEKGVQFIDAPVSGGPWGAEAGTLTIMCGGDRAAFEAVLPYLQVEGKAIHHLG
PVGAGSVAKLCNNLLVGIHTAAMAEAFVLGTKAGVDPKALYEIISNATGHSAQIARNIPQFVFPGKFDAAFSIDHLHKDV
ALAVELGKDENVRMVLGAVTQQLLAEARALGYGGSDQAALIRPLEELAGVKVRA
>Mature_294_residues
MMANLGFIGLGRMGRHMARNLIRAGHTVTLYNRSQAVVDELVAEGGRRAAGPAEVARDARVLFTCLTTPDVVESILRQAL
EGAQPGDIFVDHSTIGVRDAKRIAAMCAEKGVQFIDAPVSGGPWGAEAGTLTIMCGGDRAAFEAVLPYLQVEGKAIHHLG
PVGAGSVAKLCNNLLVGIHTAAMAEAFVLGTKAGVDPKALYEIISNATGHSAQIARNIPQFVFPGKFDAAFSIDHLHKDV
ALAVELGKDENVRMVLGAVTQQLLAEARALGYGGSDQAALIRPLEELAGVKVRA

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=30.4964539007092, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=31.9587628865979, Blast_Score=138, Evalue=5e-33,
Organism=Escherichia coli, GI145693186, Length=292, Percent_Identity=34.9315068493151, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=34.020618556701, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1790315, Length=295, Percent_Identity=31.1864406779661, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789092, Length=286, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788341, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=272, Percent_Identity=36.0294117647059, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24655230, Length=280, Percent_Identity=36.0714285714286, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI19922568, Length=280, Percent_Identity=36.0714285714286, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=23.1316725978648, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30863; Mature: 30863

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMANLGFIGLGRMGRHMARNLIRAGHTVTLYNRSQAVVDELVAEGGRRAAGPAEVARDAR
CCCCCCEEEHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHCCE
VLFTCLTTPDVVESILRQALEGAQPGDIFVDHSTIGVRDAKRIAAMCAEKGVQFIDAPVS
EEEEECCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCC
GGPWGAEAGTLTIMCGGDRAAFEAVLPYLQVEGKAIHHLGPVGAGSVAKLCNNLLVGIHT
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHH
AAMAEAFVLGTKAGVDPKALYEIISNATGHSAQIARNIPQFVFPGKFDAAFSIDHLHKDV
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCHHCCCCCCCCEEEHHHHHHHH
ALAVELGKDENVRMVLGAVTQQLLAEARALGYGGSDQAALIRPLEELAGVKVRA
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMANLGFIGLGRMGRHMARNLIRAGHTVTLYNRSQAVVDELVAEGGRRAAGPAEVARDAR
CCCCCCEEEHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHCCE
VLFTCLTTPDVVESILRQALEGAQPGDIFVDHSTIGVRDAKRIAAMCAEKGVQFIDAPVS
EEEEECCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCC
GGPWGAEAGTLTIMCGGDRAAFEAVLPYLQVEGKAIHHLGPVGAGSVAKLCNNLLVGIHT
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHH
AAMAEAFVLGTKAGVDPKALYEIISNATGHSAQIARNIPQFVFPGKFDAAFSIDHLHKDV
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCHHCCCCCCCCEEEHHHHHHHH
ALAVELGKDENVRMVLGAVTQQLLAEARALGYGGSDQAALIRPLEELAGVKVRA
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA