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The map label for this gene is adk [H]

Identifier: 51598674

GI number: 51598674

Start: 428611

End: 429246

Strand: Direct

Name: adk [H]

Synonym: BG0420

Alternate gene names: 51598674

Gene position: 428611-429246 (Clockwise)

Preceding gene: 51598673

Following gene: 51598675

Centisome position: 47.4

GC content: 26.26

Gene sequence:

>636_bases
ATGGGACTTGTATTTTTAGGTCCTCCAGGTTCTGGAAAGGGGACTATTTCAAAAATTATTTCTAACGAATTTAAATACCA
TCACATTTCAACAGGAGATTTATTTAGAGAAAATATTTTAAATTCTACAACCCTTGGGAAAGAAATAAAAAAAATTGTTG
AAAAAGGAGAACTGGTCCCTGACCAAATTACAATCAAAATAGTAAAAGATAAAATTAAAGCTATTAAAAAGAATGATAAT
TTTATTTTAGATGGATTTCCGCGCAATATTTGCCAAGCTGAAGCTCTTGATAAGTTTTTGCCAAATGTAAAAATAATAAA
CTTTTTAATTAATGAAGAATTAGTAATAAAAAGACTTTCGGGAAGAAGAATTTGTAAATCTTGTAACAATATTTTCAATA
TATATACCTTAGCCACAAAAAAAAATGGCATTTGCGATGTTTGCAAAGGAGATCTTTACCAGCGAGAAGATGATAAAGAA
GAATGCTTAAAAACAAGACTTAAAGAATATAAATTACAAACAAAACCACTAATAGAATTTTACTCAAAATGCTCTAGACT
TAACAATGTTGATGCATCTGTTGAAATTGATGAAATTAAAAAAAAAATAATTAAAATAATGTTAAAAAAAAATTAA

Upstream 100 bases:

>100_bases
ACCTTGGATCTACAATTGGAACAATTGTAGGGCTTAAATTTTTATTAAATGTTTTCAAATAAACCCTTAAAACAATAAAT
ATCTACACAGGAGTATATAT

Downstream 100 bases:

>100_bases
ATGGAAAAGGTAAAAAAAATAAATGGAAAAGGTATTTAAAATAAAAAAAATTTGCTTTTGTTTGCTGCTTCTTTTGCAAG
CAAAAATAGTTCTTGCCCAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MGLVFLGPPGSGKGTISKIISNEFKYHHISTGDLFRENILNSTTLGKEIKKIVEKGELVPDQITIKIVKDKIKAIKKNDN
FILDGFPRNICQAEALDKFLPNVKIINFLINEELVIKRLSGRRICKSCNNIFNIYTLATKKNGICDVCKGDLYQREDDKE
ECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDASVEIDEIKKKIIKIMLKKN

Sequences:

>Translated_211_residues
MGLVFLGPPGSGKGTISKIISNEFKYHHISTGDLFRENILNSTTLGKEIKKIVEKGELVPDQITIKIVKDKIKAIKKNDN
FILDGFPRNICQAEALDKFLPNVKIINFLINEELVIKRLSGRRICKSCNNIFNIYTLATKKNGICDVCKGDLYQREDDKE
ECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDASVEIDEIKKKIIKIMLKKN
>Mature_210_residues
GLVFLGPPGSGKGTISKIISNEFKYHHISTGDLFRENILNSTTLGKEIKKIVEKGELVPDQITIKIVKDKIKAIKKNDNF
ILDGFPRNICQAEALDKFLPNVKIINFLINEELVIKRLSGRRICKSCNNIFNIYTLATKKNGICDVCKGDLYQREDDKEE
CLKTRLKEYKLQTKPLIEFYSKCSRLNNVDASVEIDEIKKKIIKIMLKKN

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI19923437, Length=180, Percent_Identity=40, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI310110345, Length=190, Percent_Identity=38.4210526315789, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI53832003, Length=190, Percent_Identity=38.4210526315789, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI8051579, Length=190, Percent_Identity=38.4210526315789, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI53832001, Length=190, Percent_Identity=38.4210526315789, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI7524346, Length=213, Percent_Identity=33.8028169014084, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=33.8028169014084, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4502011, Length=196, Percent_Identity=29.0816326530612, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI7706497, Length=215, Percent_Identity=29.3023255813954, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI28144897, Length=197, Percent_Identity=24.8730964467005, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI28144899, Length=197, Percent_Identity=24.8730964467005, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI22749187, Length=213, Percent_Identity=26.7605633802817, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=35.6807511737089, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17552384, Length=211, Percent_Identity=33.175355450237, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=197, Percent_Identity=28.4263959390863, Blast_Score=97, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17533833, Length=207, Percent_Identity=29.4685990338164, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=180, Percent_Identity=27.7777777777778, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=207, Percent_Identity=29.4685990338164, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320432, Length=201, Percent_Identity=40.2985074626866, Blast_Score=146, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=30.7692307692308, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322828, Length=202, Percent_Identity=27.2277227722772, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=35.377358490566, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI17737899, Length=180, Percent_Identity=41.1111111111111, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24645822, Length=180, Percent_Identity=41.1111111111111, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=26.9767441860465, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=26.9767441860465, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647141, Length=207, Percent_Identity=22.7053140096618, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24663208, Length=207, Percent_Identity=22.7053140096618, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24152; Mature: 24021

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00011 GLA_1 ; PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLVFLGPPGSGKGTISKIISNEFKYHHISTGDLFRENILNSTTLGKEIKKIVEKGELVP
CCEEEECCCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCC
DQITIKIVKDKIKAIKKNDNFILDGFPRNICQAEALDKFLPNVKIINFLINEELVIKRLS
CHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GRRICKSCNNIFNIYTLATKKNGICDVCKGDLYQREDDKEECLKTRLKEYKLQTKPLIEF
CHHHHHHHHHHEEEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHH
YSKCSRLNNVDASVEIDEIKKKIIKIMLKKN
HHHHHHCCCCCCCEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GLVFLGPPGSGKGTISKIISNEFKYHHISTGDLFRENILNSTTLGKEIKKIVEKGELVP
CEEEECCCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCC
DQITIKIVKDKIKAIKKNDNFILDGFPRNICQAEALDKFLPNVKIINFLINEELVIKRLS
CHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GRRICKSCNNIFNIYTLATKKNGICDVCKGDLYQREDDKEECLKTRLKEYKLQTKPLIEF
CHHHHHHHHHHEEEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHH
YSKCSRLNNVDASVEIDEIKKKIIKIMLKKN
HHHHHHCCCCCCCEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]