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The map label for this gene is ispB [H]

Identifier: 51598574

GI number: 51598574

Start: 319130

End: 320173

Strand: Direct

Name: ispB [H]

Synonym: BG0317

Alternate gene names: 51598574

Gene position: 319130-320173 (Clockwise)

Preceding gene: 51598523

Following gene: 51598575

Centisome position: 35.29

GC content: 25.67

Gene sequence:

>1044_bases
ATGCAAAATAAACTGTTTTTAAAAAATATTGAAAAAAATATTAACAGCATCTTTTCAACAACCAATTTTTTAAATTTATT
CAAAGATAAAGATTTAAATTTTACTTTTAAAATAAAAAAGGAAACCCTCGATTATATTAAATTCCCAGCAATTGAAATAA
TTAATAGAGGTGGAGACCGAATAAGACCAATGCTAATGATTCTTTTAGCATACGCATTGGGTTTAAAAGAAAAAAACGAC
AGACTAATATATAAATTAAGCTTACTGCTTGAACTTCCTCATTCTGGAAGTTTGATTATTGATGACATTGAAGACAATTC
GTTAAAAAGGCGAGGCAGATCAGCAATACATTTAATCTATGGAATAGATAACAGCATAAATGCTGGTAATTTAATTTATT
TTTTACCTGCAAAATTAATAGAAAGATCAAATTTAAAAGAAAATCAAAAATTATTGATTTATGAAAATTACTTTACAACT
CTTTCAAATCTCCATCTAGGACAAGGAATTGATATTAAATTTCACAACGAATCATACATTCCAAGCATCAAGGAATACAT
TTCCTTAGTAGAATTAAAAACAGCTTCGCTTTTCGGGATGGCCAGCTTTCTAGCTGCAATAATCACAAATAATGAAGACA
AAGCTAAAAAGCTTTACAGCACATTCTTAAAACTCGGTGTTTATTTCCAAATAATAGACGATATTAAAAATATAAAAAAT
AAAATTAATGGCAAAGAATTCGGAGACGATTTAATTGAAGGAAAAAAAAGTTTGCCAATAATTTATTTTTTACAAGAAAA
AAAATTTGAACCAAAAATTATTGCAAAATTTAATCAAATAAAAAATGCCCAAACCACTACAGAAAGAAAAGAAATATTTA
AACTAACAGAGATGATAAATTCATCAAAATCAATAAGGAATTCAACTACTATTGCTTTAAAATATCTAAACGAGTTTAAA
ACCGAACTCAATTTATACCCATTAAAAAATAGATATAAAAATATACTAATAGATATTGTCGAACAAATAAAAGAAGGAAT
ATAA

Upstream 100 bases:

>100_bases
TACCCTTCTCTTTTAGCTTTTTGAGAATACTCATCACCCAAATGATACACATCAATCCCTTTAATACACTTTATAATACT
TTTTCATAATAATTCTTATT

Downstream 100 bases:

>100_bases
TGAGAAAAACAATAATAATAGCGCTTTTCTATGGTTTGATCACAAATATTTACCCTGAAATAAAATCAACATCAAAGCTC
AATGAACAAGCAAACAAATA

Product: octaprenyl-diphosphate synthase

Products: NA

Alternate protein names: (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl pyrophosphate synthase; FPP synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MQNKLFLKNIEKNINSIFSTTNFLNLFKDKDLNFTFKIKKETLDYIKFPAIEIINRGGDRIRPMLMILLAYALGLKEKND
RLIYKLSLLLELPHSGSLIIDDIEDNSLKRRGRSAIHLIYGIDNSINAGNLIYFLPAKLIERSNLKENQKLLIYENYFTT
LSNLHLGQGIDIKFHNESYIPSIKEYISLVELKTASLFGMASFLAAIITNNEDKAKKLYSTFLKLGVYFQIIDDIKNIKN
KINGKEFGDDLIEGKKSLPIIYFLQEKKFEPKIIAKFNQIKNAQTTTERKEIFKLTEMINSSKSIRNSTTIALKYLNEFK
TELNLYPLKNRYKNILIDIVEQIKEGI

Sequences:

>Translated_347_residues
MQNKLFLKNIEKNINSIFSTTNFLNLFKDKDLNFTFKIKKETLDYIKFPAIEIINRGGDRIRPMLMILLAYALGLKEKND
RLIYKLSLLLELPHSGSLIIDDIEDNSLKRRGRSAIHLIYGIDNSINAGNLIYFLPAKLIERSNLKENQKLLIYENYFTT
LSNLHLGQGIDIKFHNESYIPSIKEYISLVELKTASLFGMASFLAAIITNNEDKAKKLYSTFLKLGVYFQIIDDIKNIKN
KINGKEFGDDLIEGKKSLPIIYFLQEKKFEPKIIAKFNQIKNAQTTTERKEIFKLTEMINSSKSIRNSTTIALKYLNEFK
TELNLYPLKNRYKNILIDIVEQIKEGI
>Mature_347_residues
MQNKLFLKNIEKNINSIFSTTNFLNLFKDKDLNFTFKIKKETLDYIKFPAIEIINRGGDRIRPMLMILLAYALGLKEKND
RLIYKLSLLLELPHSGSLIIDDIEDNSLKRRGRSAIHLIYGIDNSINAGNLIYFLPAKLIERSNLKENQKLLIYENYFTT
LSNLHLGQGIDIKFHNESYIPSIKEYISLVELKTASLFGMASFLAAIITNNEDKAKKLYSTFLKLGVYFQIIDDIKNIKN
KINGKEFGDDLIEGKKSLPIIYFLQEKKFEPKIIAKFNQIKNAQTTTERKEIFKLTEMINSSKSIRNSTTIALKYLNEFK
TELNLYPLKNRYKNILIDIVEQIKEGI

Specific function: Supplies Octaprenyl Diphosphate, The Precursor For The Side Chain Of The Isoprenoid Quinones Ubiquinone And Menaquinone. [C]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI4758430, Length=207, Percent_Identity=36.231884057971, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI83700220, Length=207, Percent_Identity=36.231884057971, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1789578, Length=225, Percent_Identity=30.6666666666667, Blast_Score=88, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6325188, Length=229, Percent_Identity=33.1877729257642, Blast_Score=109, Evalue=6e-25,
Organism=Drosophila melanogaster, GI281365769, Length=193, Percent_Identity=34.7150259067358, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24660002, Length=193, Percent_Identity=34.7150259067358, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24651612, Length=270, Percent_Identity=23.7037037037037, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.10 [H]

Molecular weight: Translated: 40227; Mature: 40227

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKLFLKNIEKNINSIFSTTNFLNLFKDKDLNFTFKIKKETLDYIKFPAIEIINRGGDR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCHHHHHHCCCHH
IRPMLMILLAYALGLKEKNDRLIYKLSLLLELPHSGSLIIDDIEDNSLKRRGRSAIHLIY
HHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCCCCCCCEEEECCCCCHHHHCCCCEEEEEE
GIDNSINAGNLIYFLPAKLIERSNLKENQKLLIYENYFTTLSNLHLGQGIDIKFHNESYI
ECCCCCCCCCEEEECCHHHHHHCCCCCCCEEEEEEHHHHHHHCCCCCCCCEEEECCCCCC
PSIKEYISLVELKTASLFGMASFLAAIITNNEDKAKKLYSTFLKLGVYFQIIDDIKNIKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KINGKEFGDDLIEGKKSLPIIYFLQEKKFEPKIIAKFNQIKNAQTTTERKEIFKLTEMIN
HCCCHHCCHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SSKSIRNSTTIALKYLNEFKTELNLYPLKNRYKNILIDIVEQIKEGI
CCHHHCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNKLFLKNIEKNINSIFSTTNFLNLFKDKDLNFTFKIKKETLDYIKFPAIEIINRGGDR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCHHHHHHCCCHH
IRPMLMILLAYALGLKEKNDRLIYKLSLLLELPHSGSLIIDDIEDNSLKRRGRSAIHLIY
HHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCCCCCCCEEEECCCCCHHHHCCCCEEEEEE
GIDNSINAGNLIYFLPAKLIERSNLKENQKLLIYENYFTTLSNLHLGQGIDIKFHNESYI
ECCCCCCCCCEEEECCHHHHHHCCCCCCCEEEEEEHHHHHHHCCCCCCCCEEEECCCCCC
PSIKEYISLVELKTASLFGMASFLAAIITNNEDKAKKLYSTFLKLGVYFQIIDDIKNIKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KINGKEFGDDLIEGKKSLPIIYFLQEKKFEPKIIAKFNQIKNAQTTTERKEIFKLTEMIN
HCCCHHCCHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SSKSIRNSTTIALKYLNEFKTELNLYPLKNRYKNILIDIVEQIKEGI
CCHHHCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]