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The map label for this gene is aaeR [H]

Identifier: 51597840

GI number: 51597840

Start: 4215748

End: 4216659

Strand: Direct

Name: aaeR [H]

Synonym: YPTB3549

Alternate gene names: 51597840

Gene position: 4215748-4216659 (Clockwise)

Preceding gene: 51597833

Following gene: 51597841

Centisome position: 88.85

GC content: 47.92

Gene sequence:

>912_bases
ATGGAAAGATTAAAACAGATGTCTGTTTTTGCGAAGGTGGTGGAGTGCGGCTCTTTTACTGCCGCAGCACGACGACTGGA
GAACAGTGTCTCTTCCATCAGCCAAACGGTATCAAAACTGGAAAATGAGCTTAACGTTAAGCTACTAAATCGTAGTACTC
GACGTATTGGCTTAACGGAAGCGGGCCGGATTTATTACCAAGGCTGCCGGCGTATGTTGCAGGAGGTGCAGCAAGTTCAC
GAACAATTGTATGCTTTTAATAATACCCCAACCGGCACATTACGCATTGGTTGCTCCTCCACCATGGCACAAAATGTGCT
GGCCACCATGACAGCCGATATGCTCAAAGCCTATCCCGGTTTATCAGTGAATCTGGTTGCCGGTATTCCTGCACCGGATC
TGATAGCTGATGGCCTGGATGTGGTGATCCGCGTCGGTGCCTTGCAAAACTCAGGGCTGTTTTCGCGCCGCCTCGGTGCT
ATGCCTATGGTGGTGTGTGCAGCAAAAAGTTATTTGTCACAATATGGCACGCCAGCAAAACCCAGTGACATGGCCAATTT
TTCCTGGTTGGAGTATAACGTCCGCCCAGATAGCAATTTTGAGCTGATCGCACCAGAAGGTATCACCACCCAAATATCAC
CGCAGGGTCGTTTTGTCACCAATGACTCACAAACCATGATCCGTTGGTTAAAGGCCGGGGCGGGTATCGCCTATGCTCCC
TTAATGTGGGTGATTGAAGAAATTAAACGTGGCGAGGTTGAGATTCTATTTAAACACTATCACTCCGACCCGCGCCCGGT
ATATGCGCTTTATACTGAAAAAGATAAAATGCCACTGAAAGTTCAGGTCTGCATTGATTATTTGACCGAGTATTTCAAAC
GGGTCGCTGAAGTTTATCAGGATTATCGCTAA

Upstream 100 bases:

>100_bases
TCCCGACAACAGTATATTAGCCTGCTTATTATCAAGTTATCTACGATGTGTGATCTAAATCACTTTTAAGCCAGAGTTAA
TAATACAGATGGAATAAGTA

Downstream 100 bases:

>100_bases
CGGTATGTTATATCAAATAACAAATTAACCTGATGATTAAAAATCATCTTGAAATAAGAAATAACTGTTAAATAAGATAT
TTATTATGCTAATTTACGTA

Product: DNA-binding transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MERLKQMSVFAKVVECGSFTAAARRLENSVSSISQTVSKLENELNVKLLNRSTRRIGLTEAGRIYYQGCRRMLQEVQQVH
EQLYAFNNTPTGTLRIGCSSTMAQNVLATMTADMLKAYPGLSVNLVAGIPAPDLIADGLDVVIRVGALQNSGLFSRRLGA
MPMVVCAAKSYLSQYGTPAKPSDMANFSWLEYNVRPDSNFELIAPEGITTQISPQGRFVTNDSQTMIRWLKAGAGIAYAP
LMWVIEEIKRGEVEILFKHYHSDPRPVYALYTEKDKMPLKVQVCIDYLTEYFKRVAEVYQDYR

Sequences:

>Translated_303_residues
MERLKQMSVFAKVVECGSFTAAARRLENSVSSISQTVSKLENELNVKLLNRSTRRIGLTEAGRIYYQGCRRMLQEVQQVH
EQLYAFNNTPTGTLRIGCSSTMAQNVLATMTADMLKAYPGLSVNLVAGIPAPDLIADGLDVVIRVGALQNSGLFSRRLGA
MPMVVCAAKSYLSQYGTPAKPSDMANFSWLEYNVRPDSNFELIAPEGITTQISPQGRFVTNDSQTMIRWLKAGAGIAYAP
LMWVIEEIKRGEVEILFKHYHSDPRPVYALYTEKDKMPLKVQVCIDYLTEYFKRVAEVYQDYR
>Mature_303_residues
MERLKQMSVFAKVVECGSFTAAARRLENSVSSISQTVSKLENELNVKLLNRSTRRIGLTEAGRIYYQGCRRMLQEVQQVH
EQLYAFNNTPTGTLRIGCSSTMAQNVLATMTADMLKAYPGLSVNLVAGIPAPDLIADGLDVVIRVGALQNSGLFSRRLGA
MPMVVCAAKSYLSQYGTPAKPSDMANFSWLEYNVRPDSNFELIAPEGITTQISPQGRFVTNDSQTMIRWLKAGAGIAYAP
LMWVIEEIKRGEVEILFKHYHSDPRPVYALYTEKDKMPLKVQVCIDYLTEYFKRVAEVYQDYR

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=301, Percent_Identity=80.7308970099668, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI145693193, Length=297, Percent_Identity=28.6195286195286, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786401, Length=290, Percent_Identity=30.6896551724138, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081978, Length=302, Percent_Identity=30.794701986755, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787128, Length=288, Percent_Identity=26.3888888888889, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789440, Length=293, Percent_Identity=25.5972696245734, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787589, Length=274, Percent_Identity=26.6423357664234, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790262, Length=263, Percent_Identity=27.7566539923954, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI157672245, Length=121, Percent_Identity=33.8842975206612, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788481, Length=147, Percent_Identity=31.9727891156463, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788706, Length=141, Percent_Identity=30.4964539007092, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789173, Length=250, Percent_Identity=24.8, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786448, Length=143, Percent_Identity=31.4685314685315, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788297, Length=114, Percent_Identity=31.5789473684211, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34004; Mature: 34004

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLKQMSVFAKVVECGSFTAAARRLENSVSSISQTVSKLENELNVKLLNRSTRRIGLTE
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEECCCH
AGRIYYQGCRRMLQEVQQVHEQLYAFNNTPTGTLRIGCSSTMAQNVLATMTADMLKAYPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCC
LSVNLVAGIPAPDLIADGLDVVIRVGALQNSGLFSRRLGAMPMVVCAAKSYLSQYGTPAK
CEEEEEECCCCHHHHHCCHHHHHEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCC
PSDMANFSWLEYNVRPDSNFELIAPEGITTQISPQGRFVTNDSQTMIRWLKAGAGIAYAP
CCCCCCCEEEEEECCCCCCCEEECCCCCEEEECCCCCEEECCHHHHHHHHHHCCCHHHHH
LMWVIEEIKRGEVEILFKHYHSDPRPVYALYTEKDKMPLKVQVCIDYLTEYFKRVAEVYQ
HHHHHHHHCCCCCEEHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
DYR
CCC
>Mature Secondary Structure
MERLKQMSVFAKVVECGSFTAAARRLENSVSSISQTVSKLENELNVKLLNRSTRRIGLTE
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEECCCH
AGRIYYQGCRRMLQEVQQVHEQLYAFNNTPTGTLRIGCSSTMAQNVLATMTADMLKAYPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCC
LSVNLVAGIPAPDLIADGLDVVIRVGALQNSGLFSRRLGAMPMVVCAAKSYLSQYGTPAK
CEEEEEECCCCHHHHHCCHHHHHEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCC
PSDMANFSWLEYNVRPDSNFELIAPEGITTQISPQGRFVTNDSQTMIRWLKAGAGIAYAP
CCCCCCCEEEEEECCCCCCCEEECCCCCEEEECCCCCEEECCHHHHHHHHHHCCCHHHHH
LMWVIEEIKRGEVEILFKHYHSDPRPVYALYTEKDKMPLKVQVCIDYLTEYFKRVAEVYQ
HHHHHHHHCCCCCEEHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
DYR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]