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The map label for this gene is fumC

Identifier: 51596512

GI number: 51596512

Start: 2574258

End: 2575655

Strand: Direct

Name: fumC

Synonym: YPTB2186

Alternate gene names: 51596512

Gene position: 2574258-2575655 (Clockwise)

Preceding gene: 51596509

Following gene: 51596515

Centisome position: 54.26

GC content: 48.64

Gene sequence:

>1398_bases
ATGGCAACTACCCGCAGTGAAAAGGATTCTATGGGGTCTATCTATGTACCTGCAAACCAATTATGGGGGGCGCAAACTCA
ACGTTCATTGGCGCATTTTCGAATTTCACAAGAAAAAATGCCAACAGAGCTAATTCATGCATTGGCTCTGACCAAACGAG
CGGCAGCTCAAGTGAATATGGACCTAGGCTTGCTGCCAGCCGAGCGTGCAAAAGCGATTATGCGGGCCGCAGATGAAGTT
CTGGATGGCGCTCATCCAACCGAGTTCCCTCTCGCCATCTGGCAAACCGGGTCGGGTACTCAGACGAATATGAATATGAA
TGAGGTACTGGCAAACCGTGCGAGTGAGTTGCTCGGGGGGGCGCGGGGGAATAACCGTTTGGTTCATCCCAATGATGATG
TCAATAAAAGCCAAAGTTCAAATGATGTCTTCCCAACGGCGATGCATGTCGCTGCAGTGATGGGGGTGAGTGAACATCTT
CTTCCTGAACTGAAGGTGTTACAGAAAACCTTGGCCGACAAAGCAGAAGCTTATCGCGATATTGTAAAAATTGGCCGTAC
ACATTTACAAGATGCGACCCCTTTAACGTTGGGGCAGGAAATTTCCGGGTGGGCGGCAATGTTATCTCACAGTGTGCGGC
ATATTGAGGCGACCCTTCCTCACCTGTGTGAATTAGCGCTTGGGGGAACAGCGGTGGGGACTGGCCTCAATACGCATCCT
GAATATGCTGTACGAGTAGCTAATGAAATAGCCGCACTGACACGCCAACCGTTTATCACTGCCCCGAATAAATTTGAATC
ATTGGGAACCTGCGATGCATTGGTTCATGGTCACGGTGCGCTAAAAGGCTTAGCGGCATCCCTGATGAAAATTGCCAATG
ATGTCCGTTGGTTATCATCAGGCCCTCGCTGTGGTATTGGCGAAATATCTATTCCGGAAAATGAGCCAGGCAGTTCTATC
ATGCCAGGCAAAGTGAATCCAACACAGTGTGAAGCGATGACCATGCTATGTGCTCAAGTTATGGGTAATGATGTGGCTAT
CAATATCGGTGGGGCGTCCGGCAACTTTGAATTAAACGTGTTCCGTCCATTGGTCATCCATAACTTCCTGCAATCTGTTC
GTTTGTTGGCTGATGGAATGCGTGGTTTTAATGAGCACTGCGCTTTGGGAATTGAACCCAACCGCGACCGTATTACGCAA
TTGCTCAATGAATCGCTGATGTTAGTTACCGCGCTCAATACCCATATTGGCTACGATAAAGCAGCTGAAATCGCCAAAAA
GGCGCATAAAGAGGGGCTAACACTGAAAGCAGCAGCTATGGCATTGGGTTATCTTACCGATGCAGAGTTTGATGAATGGG
TTCGACCGGAAGATATGGTCGGCAGTATGAAGAAATAG

Upstream 100 bases:

>100_bases
TCGCATAAGCGCAATACTATCTGTGTCATTATAACCGCTATGTCGTAAGCCTATGCTAGCTCAACATCAATCTTTTGTTC
TAAATGCTAAGGAGGCAGTG

Downstream 100 bases:

>100_bases
CGGATAAACATTGTTATATTAACGCCGGGGTGGATTACCGGCGTTTTTACAGTGGCTAAGCCGCAATAAATGGCATTTTT
TACGGTTCCAGTTCGACATA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MATTRSEKDSMGSIYVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNMDLGLLPAERAKAIMRAADEV
LDGAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGGARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHL
LPELKVLQKTLADKAEAYRDIVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHP
EYAVRVANEIAALTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSSGPRCGIGEISIPENEPGSSI
MPGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNVFRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQ
LLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK

Sequences:

>Translated_465_residues
MATTRSEKDSMGSIYVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNMDLGLLPAERAKAIMRAADEV
LDGAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGGARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHL
LPELKVLQKTLADKAEAYRDIVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHP
EYAVRVANEIAALTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSSGPRCGIGEISIPENEPGSSI
MPGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNVFRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQ
LLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK
>Mature_464_residues
ATTRSEKDSMGSIYVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNMDLGLLPAERAKAIMRAADEVL
DGAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGGARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHLL
PELKVLQKTLADKAEAYRDIVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHPE
YAVRVANEIAALTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSSGPRCGIGEISIPENEPGSSIM
PGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNVFRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQL
LNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=459, Percent_Identity=60.5664488017429, Blast_Score=554, Evalue=1e-158,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=55.5555555555556, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1787896, Length=464, Percent_Identity=82.5431034482759, Blast_Score=785, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=459, Percent_Identity=38.3442265795207, Blast_Score=323, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=59.1792656587473, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=61.8461538461539, Blast_Score=428, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=55.6277056277056, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24640179, Length=460, Percent_Identity=58.9130434782609, Blast_Score=569, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24640177, Length=460, Percent_Identity=58.9130434782609, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=57.1428571428571, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=57.0498915401301, Blast_Score=543, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=50.8658008658009, Blast_Score=479, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50148; Mature: 50017

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTRSEKDSMGSIYVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNM
CCCCCCCCCCCCEEEECHHHHCCCHHHHHHHHHHHCHHHCHHHHHHHHHHHHHHHHHCCC
DLGLLPAERAKAIMRAADEVLDGAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGG
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
ARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHLLPELKVLQKTLADKAEAYRD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHP
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
EYAVRVANEIAALTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSS
HHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
GPRCGIGEISIPENEPGSSIMPGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
FRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQLLNESLMLVTALNTHIGYDK
HHHHHHHHHHHHHHHHHHHHHCHHHHEEECCCCCHHHHHHHHCCHHEEEEHHHHHCCCHH
AAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHCCCCC
>Mature Secondary Structure 
ATTRSEKDSMGSIYVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNM
CCCCCCCCCCCEEEECHHHHCCCHHHHHHHHHHHCHHHCHHHHHHHHHHHHHHHHHCCC
DLGLLPAERAKAIMRAADEVLDGAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGG
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
ARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHLLPELKVLQKTLADKAEAYRD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHP
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
EYAVRVANEIAALTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSS
HHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
GPRCGIGEISIPENEPGSSIMPGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
FRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQLLNESLMLVTALNTHIGYDK
HHHHHHHHHHHHHHHHHHHHHCHHHHEEECCCCCHHHHHHHHCCHHEEEEHHHHHCCCHH
AAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]