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The map label for this gene is HlyB

Identifier: 51596353

GI number: 51596353

Start: 2385477

End: 2387138

Strand: Direct

Name: HlyB

Synonym: YPTB2027

Alternate gene names: 51596353

Gene position: 2385477-2387138 (Clockwise)

Preceding gene: 51596352

Following gene: 51596354

Centisome position: 50.28

GC content: 38.33

Gene sequence:

>1662_bases
ATGAATATCGCGCTCAGAAAAGAATGTGTAATTATTTTGTTGCTCAGTAATACTGTTTGGGCAACGGAAAGCGATCAAAT
TATATTGAATAAAAATATGGCATCGCACACCGAGATTAATACGATCCATAAATATAAAGAGGAACACACCAACGTCGGGA
AACATTTCTTATCTACAAACCGTCATGAGACTGCATCACAGGAAAAAATATCCCCAGAGAAAATATGCCTGCCAATTACT
GGGGTATTTTTACAAGGGAATACACGACTGTCATCGCAAGACTTAAATCAGATTGATCATATTCTTGGTGAATGCATTAG
TGAAAATGATATTAATTCCTTAGCTAAGGAAGTGACTCGATTATATTTGTCTAAAGGTTATCTGGCGGCCAGAGTCAATT
TCATTCCATTAAATAATGCGGGGGAGTTGGGACTGAATGTGACTGAGGGTATTGTTGAAAAAATTGAAGGTGGAGGACGA
AGAGTCAACCCTTATTTTATATTCCCTAACTTTATTGATAAACCCCTTCGGTTATCCGAGCTTGATCAGGCCATCGATCA
GGCTAACAGACTACGATCAAATAAAGTAAACGTCGATATCTTACCAGGAAGTCAGGCGGGCAAATCAATTATTAGAATTA
ATAATGTCAATAATAAACCTTGGAGCTTATCGACCGTCATTGATAATTATGGTTATAAAAATTCTGATGAGTGGCAAGCA
AGAGTGTCACTGGCTTTAGATAGCCCATTTGGGCTATCTGACGCTATTAATTTTAATGCTAACCGCACGCTAGAGAATGC
GAAGAGTCGCTACAAGAATGATTTTACTGTTTCTTATTCGGTACCTTATGGTGCATTAACTGTCAGCGCCCTTGCTAACC
ATCTGGAATACCGGCGCTATGAGAAATTAAAAAATGGGACAGTGAATTTTAATGGTAACTCACAGCAGTATAACTTCCGT
ACTGACTATATGTTCCATCGTGCACAAAAGCAGATAAACAGTTTAAGTATGCAAGTAGAGCACAAACAGATTAATAACTA
TGTCGATGAGGCAAAAGTAGGTGTCTACAGTTATCGATTTACTAATCTTGAATTAGGTGTCAATCAATTTCGTATTCTTC
CTCATGGTTCAGTGAATGTTAATGCGGCAATAAAAAGAGGTGTGCCATGGTTTGGTACTCATCAGAAAAATAAAATAAAT
GCAGTACAATTTACCACAGGAAAATTGATGGTTAATTTTAATCACAATTTCTCTCTATTAAATTCGTCGTACCAATTTGA
TCATGCTTTAGTTGGGCAATACAGTAAGAATTATGCGCCTTCTCCTGAGTGGATAAATTTGACTGAACGTAATGCCATTA
GAGGATTTAGTCGTAGTTCGCAATCGGCAGATAACGGTTGGTATATAAAAAATACGTTATCCCGCCACTTCTTTATGGGA
AATGTGCTTTTTACCCCTCGTATTGGCATTGATGCTGGGCGTGCTTTAAGACAAGACAGCCAACAAGGGTGGCAAAGTAA
TACCGGTGTAAGTGCCGGGATATCAATGCGTTACCATAATGCATTTTTTGATGTGGAAGCCAGTCGTGGTTGGTGGCTTT
CCGATAGTAATAAACAGAACGAACCTGTACAGGTATTGGGCCGTATAGCTTATACCTTCTAA

Upstream 100 bases:

>100_bases
AAAACTAAACTTTGGTTTAACCCGCACATCTAGTGTGTTGTTAATCATCTGTTTTTTTGATTCTCTCGTATATTGAATTT
ATTCATGGGTATTATAATAA

Downstream 100 bases:

>100_bases
CTCAACGTAATTTAAATAAGGTTATTTTAATGAAAATAAATAAATTTAAACTTTCCCCAGCAGGAAAGTTGACGGTTATC
TTATCTTTAATTCTTACTCC

Product: hemolysin activator protein HlyB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MNIALRKECVIILLLSNTVWATESDQIILNKNMASHTEINTIHKYKEEHTNVGKHFLSTNRHETASQEKISPEKICLPIT
GVFLQGNTRLSSQDLNQIDHILGECISENDINSLAKEVTRLYLSKGYLAARVNFIPLNNAGELGLNVTEGIVEKIEGGGR
RVNPYFIFPNFIDKPLRLSELDQAIDQANRLRSNKVNVDILPGSQAGKSIIRINNVNNKPWSLSTVIDNYGYKNSDEWQA
RVSLALDSPFGLSDAINFNANRTLENAKSRYKNDFTVSYSVPYGALTVSALANHLEYRRYEKLKNGTVNFNGNSQQYNFR
TDYMFHRAQKQINSLSMQVEHKQINNYVDEAKVGVYSYRFTNLELGVNQFRILPHGSVNVNAAIKRGVPWFGTHQKNKIN
AVQFTTGKLMVNFNHNFSLLNSSYQFDHALVGQYSKNYAPSPEWINLTERNAIRGFSRSSQSADNGWYIKNTLSRHFFMG
NVLFTPRIGIDAGRALRQDSQQGWQSNTGVSAGISMRYHNAFFDVEASRGWWLSDSNKQNEPVQVLGRIAYTF

Sequences:

>Translated_553_residues
MNIALRKECVIILLLSNTVWATESDQIILNKNMASHTEINTIHKYKEEHTNVGKHFLSTNRHETASQEKISPEKICLPIT
GVFLQGNTRLSSQDLNQIDHILGECISENDINSLAKEVTRLYLSKGYLAARVNFIPLNNAGELGLNVTEGIVEKIEGGGR
RVNPYFIFPNFIDKPLRLSELDQAIDQANRLRSNKVNVDILPGSQAGKSIIRINNVNNKPWSLSTVIDNYGYKNSDEWQA
RVSLALDSPFGLSDAINFNANRTLENAKSRYKNDFTVSYSVPYGALTVSALANHLEYRRYEKLKNGTVNFNGNSQQYNFR
TDYMFHRAQKQINSLSMQVEHKQINNYVDEAKVGVYSYRFTNLELGVNQFRILPHGSVNVNAAIKRGVPWFGTHQKNKIN
AVQFTTGKLMVNFNHNFSLLNSSYQFDHALVGQYSKNYAPSPEWINLTERNAIRGFSRSSQSADNGWYIKNTLSRHFFMG
NVLFTPRIGIDAGRALRQDSQQGWQSNTGVSAGISMRYHNAFFDVEASRGWWLSDSNKQNEPVQVLGRIAYTF
>Mature_553_residues
MNIALRKECVIILLLSNTVWATESDQIILNKNMASHTEINTIHKYKEEHTNVGKHFLSTNRHETASQEKISPEKICLPIT
GVFLQGNTRLSSQDLNQIDHILGECISENDINSLAKEVTRLYLSKGYLAARVNFIPLNNAGELGLNVTEGIVEKIEGGGR
RVNPYFIFPNFIDKPLRLSELDQAIDQANRLRSNKVNVDILPGSQAGKSIIRINNVNNKPWSLSTVIDNYGYKNSDEWQA
RVSLALDSPFGLSDAINFNANRTLENAKSRYKNDFTVSYSVPYGALTVSALANHLEYRRYEKLKNGTVNFNGNSQQYNFR
TDYMFHRAQKQINSLSMQVEHKQINNYVDEAKVGVYSYRFTNLELGVNQFRILPHGSVNVNAAIKRGVPWFGTHQKNKIN
AVQFTTGKLMVNFNHNFSLLNSSYQFDHALVGQYSKNYAPSPEWINLTERNAIRGFSRSSQSADNGWYIKNTLSRHFFMG
NVLFTPRIGIDAGRALRQDSQQGWQSNTGVSAGISMRYHNAFFDVEASRGWWLSDSNKQNEPVQVLGRIAYTF

Specific function: Member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin [H]

COG id: COG2831

COG function: function code U; Hemolysin activation/secretion protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tpsB (TC 1.B.20) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005565
- InterPro:   IPR013686 [H]

Pfam domain/function: PF08479 POTRA_2; PF03865 ShlB [H]

EC number: NA

Molecular weight: Translated: 62728; Mature: 62728

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIALRKECVIILLLSNTVWATESDQIILNKNMASHTEINTIHKYKEEHTNVGKHFLSTN
CCCEECCCEEEEEEECCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
RHETASQEKISPEKICLPITGVFLQGNTRLSSQDLNQIDHILGECISENDINSLAKEVTR
CCCCCHHHCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LYLSKGYLAARVNFIPLNNAGELGLNVTEGIVEKIEGGGRRVNPYFIFPNFIDKPLRLSE
HHHHCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEECEEEECHHHCCCCCCHHH
LDQAIDQANRLRSNKVNVDILPGSQAGKSIIRINNVNNKPWSLSTVIDNYGYKNSDEWQA
HHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCCEEHHHHHHCCCCCCCCCCEE
RVSLALDSPFGLSDAINFNANRTLENAKSRYKNDFTVSYSVPYGALTVSALANHLEYRRY
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
EKLKNGTVNFNGNSQQYNFRTDYMFHRAQKQINSLSMQVEHKQINNYVDEAKVGVYSYRF
HHHCCCEEEECCCCCEEEECHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHEEEEEEEE
TNLELGVNQFRILPHGSVNVNAAIKRGVPWFGTHQKNKINAVQFTTGKLMVNFNHNFSLL
EEEEECCCEEEEECCCCCEEEHHHHCCCCCCCCCCCCCEEEEEEEECEEEEEECCCEEEE
NSSYQFDHALVGQYSKNYAPSPEWINLTERNAIRGFSRSSQSADNGWYIKNTLSRHFFMG
CCCCCCCHHHHHHHCCCCCCCCCEEECCHHHHHHCCCCCCCCCCCCEEEEHHHHHHEEEC
NVLFTPRIGIDAGRALRQDSQQGWQSNTGVSAGISMRYHNAFFDVEASRGWWLSDSNKQN
CEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECEEEEEECCCCEEECCCCCCC
EPVQVLGRIAYTF
CHHHHHHHHHHCC
>Mature Secondary Structure
MNIALRKECVIILLLSNTVWATESDQIILNKNMASHTEINTIHKYKEEHTNVGKHFLSTN
CCCEECCCEEEEEEECCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
RHETASQEKISPEKICLPITGVFLQGNTRLSSQDLNQIDHILGECISENDINSLAKEVTR
CCCCCHHHCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LYLSKGYLAARVNFIPLNNAGELGLNVTEGIVEKIEGGGRRVNPYFIFPNFIDKPLRLSE
HHHHCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEECEEEECHHHCCCCCCHHH
LDQAIDQANRLRSNKVNVDILPGSQAGKSIIRINNVNNKPWSLSTVIDNYGYKNSDEWQA
HHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCCEEHHHHHHCCCCCCCCCCEE
RVSLALDSPFGLSDAINFNANRTLENAKSRYKNDFTVSYSVPYGALTVSALANHLEYRRY
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
EKLKNGTVNFNGNSQQYNFRTDYMFHRAQKQINSLSMQVEHKQINNYVDEAKVGVYSYRF
HHHCCCEEEECCCCCEEEECHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHEEEEEEEE
TNLELGVNQFRILPHGSVNVNAAIKRGVPWFGTHQKNKINAVQFTTGKLMVNFNHNFSLL
EEEEECCCEEEEECCCCCEEEHHHHCCCCCCCCCCCCCEEEEEEEECEEEEEECCCEEEE
NSSYQFDHALVGQYSKNYAPSPEWINLTERNAIRGFSRSSQSADNGWYIKNTLSRHFFMG
CCCCCCCHHHHHHHCCCCCCCCCEEECCHHHHHHCCCCCCCCCCCCEEEEHHHHHHEEEC
NVLFTPRIGIDAGRALRQDSQQGWQSNTGVSAGISMRYHNAFFDVEASRGWWLSDSNKQN
CEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECEEEEEECCCCEEECCCCCCC
EPVQVLGRIAYTF
CHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3290200 [H]