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The map label for this gene is dnaX

Identifier: 51595342

GI number: 51595342

Start: 1191307

End: 1193283

Strand: Direct

Name: dnaX

Synonym: YPTB0992

Alternate gene names: 51595342

Gene position: 1191307-1193283 (Clockwise)

Preceding gene: 51595341

Following gene: 51595343

Centisome position: 25.11

GC content: 52.05

Gene sequence:

>1977_bases
ATGAGCTATCAGGTCCTTGCCCGTAAGTGGCGCCCTCAAACGTTCGCCGACGTCGTTGGTCAGGAACATGTCCTGACAGC
GCTGGCTAATGGCCTTTCATTAGGGCGAATTCATCACGCCTATTTATTTTCAGGTACTCGCGGTGTGGGTAAAACCTCGA
TAGCCAGATTGCTGGCTAAAGGCCTCAACTGCGAAACCGGTATTACTGCGACCCCTTGCGGTACCTGCGCCAATTGCCAG
GAGATTGAGCAGGGGCGTTTTGTTGATCTGATCGAGATAGACGCCGCCTCCCGGACTAAGGTTGAGGACACCCGAGAGCT
GTTGGATAATGTCCAATATGCCCCTGCCCGTGGTCGCTTCAAGGTCTATTTGATCGATGAAGTGCATATGCTATCGCGGC
ACAGTTTCAACGCGTTGCTGAAAACACTTGAAGAGCCGCCTGCACATGTAAAATTTCTGTTGGCGACCACTGATCCACAA
AAGTTACCTGTTACGATCCTTTCCCGATGTTTGCAATTCCACCTAAAAGCATTGGATGTTGAGCAGATCCGTGCACAACT
TGAAAAAGTGTTGCTGGCTGAACAAATCACGAGTGATGCCAGAGCCTTGCAATTACTGGCCCGAGCGGCTGATGGCAGCA
TGCGAGATGCGCTAAGCTTAACCGATCAGGCTGTATCAATGGGGCAAGGGCAGGTCACGACAGTAACAGTTAGCCAAATG
CTGGGAACGCTGGATGACGAACAGCCTCTTGCCATTATTGAGGCGTTGGTCAGTGCTGATGGTGCCCGGGTTATGGCTCA
GATAGAACAGGCGGCATCGCGGGGTGTCGACTGGGAAAACCTGTTGGTGGAAAGCTTAAGCCTGCTGCACAAAATTGCGA
TGGTACAGTTGTTGCCTTCGATGCTGGATAACCACTATGCAGCTATTGAACCCCGTTTACGGGAACTGGCCCGCACATTA
CCGCCTGCTGATATTCAGCTGTATTATCAAACCTTGCTGGTAGGCCGCAAAGAACTGGCTTATGCGCCGGATCGCCGTAT
GGGGGTTGAAATGACCTTATTACGCGCGCTGGCTTTTCATCCTAAAGCCATCATTGCGGAGCCCCAAATAGCGCATGTTG
CCGCGCCATCTGCAATAGCCGATAACGCTGTGCCCACCTCTCAGGGGGGGCAACATAGGCAGGAACCCGCATCAGTACCG
CCGAGTTCCCATCAAGAGGCTCCGCCGTTAGGTGCTGTAGCGTCCAGCGTCCAACTTCCGGAATCGACAGCGCAATTGCT
TCAGGCGCGTACGCAGTTACTGCGACAGTCGGGGACGACCACAACAAAAAAGAATGAGCCGGCGGCGCCAGGAAAAGCGC
GGCCGGCAAACTCAGCACTGGAGCGTTTAGCTTCGGTGACTGAGCGTAGCCAGCAGCGCCTGGCAGCCAAAACAACGGAA
GAGAAGAAACCAGCGAAAAAAGAAGCTTATCGCTGGACCGCGAAAAATCAACCTGAGGTAGCGGCTGAACCTATCGCTAC
GCCTAAAGCGTTGCGTTCTGCGCTAGAACATGAAAAAACACCAGAGCTTTCCGCTAAATTGGCTGAGGAGGCGATCGCCC
GTGATCCTTGGGCTGCAGAGGTCAATAAGTTACAGCTCCCTAAATTAGTCCAGCAGCTTGCACTGAATGCATTTAAACAA
GAAATAGAACCGGGTAATATTTGCCTGCATCTGCGTTCTGCTCAACGTCATTTGAATTCAGCGTCAGCACAAAAAGCGCT
GAGTGATGCATTGAGTGAATTACACGGTAACGCGGTGACACTGAGCGTTATTGAAGATGACAATCCGGCGGAACGTACCC
CGCTGGAATGGCGGCAGGCCATCTATGAAGAAAAGCTGGCACAAGCACGTCAGTCAATTATTGCGGATAATAATATTCAG
ACACTGCGTCGATTCTTCGATGCCGAGCTGGATGAAGACAGTATCCGACCAATTTAA

Upstream 100 bases:

>100_bases
GCGTAGGTTTGCAAATAAACCAAATCAGATATACTTGGTTAAATCATGGTTTTTTCATTAGTGATTAAATTATCCATCAT
AAATCAACGATGAAGTATTA

Downstream 100 bases:

>100_bases
CCGCTGCGATAAGTGCATGGTGCACTGACGCAGCCCTTTGCGATGAGAGATAACTATGTTTGGTAAAGGCGGTATTGGCA
ATTTAATGAAACAAGCCCAG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGTCANCQ
EIEQGRFVDLIEIDAASRTKVEDTRELLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQ
KLPVTILSRCLQFHLKALDVEQIRAQLEKVLLAEQITSDARALQLLARAADGSMRDALSLTDQAVSMGQGQVTTVTVSQM
LGTLDDEQPLAIIEALVSADGARVMAQIEQAASRGVDWENLLVESLSLLHKIAMVQLLPSMLDNHYAAIEPRLRELARTL
PPADIQLYYQTLLVGRKELAYAPDRRMGVEMTLLRALAFHPKAIIAEPQIAHVAAPSAIADNAVPTSQGGQHRQEPASVP
PSSHQEAPPLGAVASSVQLPESTAQLLQARTQLLRQSGTTTTKKNEPAAPGKARPANSALERLASVTERSQQRLAAKTTE
EKKPAKKEAYRWTAKNQPEVAAEPIATPKALRSALEHEKTPELSAKLAEEAIARDPWAAEVNKLQLPKLVQQLALNAFKQ
EIEPGNICLHLRSAQRHLNSASAQKALSDALSELHGNAVTLSVIEDDNPAERTPLEWRQAIYEEKLAQARQSIIADNNIQ
TLRRFFDAELDEDSIRPI

Sequences:

>Translated_658_residues
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGTCANCQ
EIEQGRFVDLIEIDAASRTKVEDTRELLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQ
KLPVTILSRCLQFHLKALDVEQIRAQLEKVLLAEQITSDARALQLLARAADGSMRDALSLTDQAVSMGQGQVTTVTVSQM
LGTLDDEQPLAIIEALVSADGARVMAQIEQAASRGVDWENLLVESLSLLHKIAMVQLLPSMLDNHYAAIEPRLRELARTL
PPADIQLYYQTLLVGRKELAYAPDRRMGVEMTLLRALAFHPKAIIAEPQIAHVAAPSAIADNAVPTSQGGQHRQEPASVP
PSSHQEAPPLGAVASSVQLPESTAQLLQARTQLLRQSGTTTTKKNEPAAPGKARPANSALERLASVTERSQQRLAAKTTE
EKKPAKKEAYRWTAKNQPEVAAEPIATPKALRSALEHEKTPELSAKLAEEAIARDPWAAEVNKLQLPKLVQQLALNAFKQ
EIEPGNICLHLRSAQRHLNSASAQKALSDALSELHGNAVTLSVIEDDNPAERTPLEWRQAIYEEKLAQARQSIIADNNIQ
TLRRFFDAELDEDSIRPI
>Mature_657_residues
SYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGTCANCQE
IEQGRFVDLIEIDAASRTKVEDTRELLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQK
LPVTILSRCLQFHLKALDVEQIRAQLEKVLLAEQITSDARALQLLARAADGSMRDALSLTDQAVSMGQGQVTTVTVSQML
GTLDDEQPLAIIEALVSADGARVMAQIEQAASRGVDWENLLVESLSLLHKIAMVQLLPSMLDNHYAAIEPRLRELARTLP
PADIQLYYQTLLVGRKELAYAPDRRMGVEMTLLRALAFHPKAIIAEPQIAHVAAPSAIADNAVPTSQGGQHRQEPASVPP
SSHQEAPPLGAVASSVQLPESTAQLLQARTQLLRQSGTTTTKKNEPAAPGKARPANSALERLASVTERSQQRLAAKTTEE
KKPAKKEAYRWTAKNQPEVAAEPIATPKALRSALEHEKTPELSAKLAEEAIARDPWAAEVNKLQLPKLVQQLALNAFKQE
IEPGNICLHLRSAQRHLNSASAQKALSDALSELHGNAVTLSVIEDDNPAERTPLEWRQAIYEEKLAQARQSIIADNNIQT
LRRFFDAELDEDSIRPI

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=308, Percent_Identity=24.025974025974, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI194306571, Length=311, Percent_Identity=23.7942122186495, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194306567, Length=311, Percent_Identity=23.7942122186495, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786676, Length=660, Percent_Identity=72.5757575757576, Blast_Score=921, Evalue=0.0,
Organism=Escherichia coli, GI1787341, Length=139, Percent_Identity=33.8129496402878, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=217, Percent_Identity=25.8064516129032, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=292, Percent_Identity=22.2602739726027, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921076, Length=320, Percent_Identity=27.5, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 72147; Mature: 72016

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAK
CCHHHHHHHCCCCHHHHHHCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
GLNCETGITATPCGTCANCQEIEQGRFVDLIEIDAASRTKVEDTRELLDNVQYAPARGRF
CCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQKLPVTILSRCLQFHLKALDV
EEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
EQIRAQLEKVLLAEQITSDARALQLLARAADGSMRDALSLTDQAVSMGQGQVTTVTVSQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHH
LGTLDDEQPLAIIEALVSADGARVMAQIEQAASRGVDWENLLVESLSLLHKIAMVQLLPS
HCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLDNHYAAIEPRLRELARTLPPADIQLYYQTLLVGRKELAYAPDRRMGVEMTLLRALAFH
HHCCCHHHHCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHC
PKAIIAEPQIAHVAAPSAIADNAVPTSQGGQHRQEPASVPPSSHQEAPPLGAVASSVQLP
CCHHCCCCCHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCC
ESTAQLLQARTQLLRQSGTTTTKKNEPAAPGKARPANSALERLASVTERSQQRLAAKTTE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKKPAKKEAYRWTAKNQPEVAAEPIATPKALRSALEHEKTPELSAKLAEEAIARDPWAAE
HCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHH
VNKLQLPKLVQQLALNAFKQEIEPGNICLHLRSAQRHLNSASAQKALSDALSELHGNAVT
HHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LSVIEDDNPAERTPLEWRQAIYEEKLAQARQSIIADNNIQTLRRFFDAELDEDSIRPI
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAK
CHHHHHHHCCCCHHHHHHCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
GLNCETGITATPCGTCANCQEIEQGRFVDLIEIDAASRTKVEDTRELLDNVQYAPARGRF
CCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQKLPVTILSRCLQFHLKALDV
EEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
EQIRAQLEKVLLAEQITSDARALQLLARAADGSMRDALSLTDQAVSMGQGQVTTVTVSQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHH
LGTLDDEQPLAIIEALVSADGARVMAQIEQAASRGVDWENLLVESLSLLHKIAMVQLLPS
HCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLDNHYAAIEPRLRELARTLPPADIQLYYQTLLVGRKELAYAPDRRMGVEMTLLRALAFH
HHCCCHHHHCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHC
PKAIIAEPQIAHVAAPSAIADNAVPTSQGGQHRQEPASVPPSSHQEAPPLGAVASSVQLP
CCHHCCCCCHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCC
ESTAQLLQARTQLLRQSGTTTTKKNEPAAPGKARPANSALERLASVTERSQQRLAAKTTE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKKPAKKEAYRWTAKNQPEVAAEPIATPKALRSALEHEKTPELSAKLAEEAIARDPWAAE
HCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHH
VNKLQLPKLVQQLALNAFKQEIEPGNICLHLRSAQRHLNSASAQKALSDALSELHGNAVT
HHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LSVIEDDNPAERTPLEWRQAIYEEKLAQARQSIIADNNIQTLRRFFDAELDEDSIRPI
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]