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The map label for this gene is apt

Identifier: 51595341

GI number: 51595341

Start: 1190088

End: 1190651

Strand: Direct

Name: apt

Synonym: YPTB0991

Alternate gene names: 51595341

Gene position: 1190088-1190651 (Clockwise)

Preceding gene: 51595340

Following gene: 51595342

Centisome position: 25.08

GC content: 48.58

Gene sequence:

>564_bases
ATGACCGTTTCTGCATCTAAGACAGCACAACAGCTTAAATATATAAAAGACAGTATCAAAACTATCCCCGATTATCCAAA
AGCGGGAATATTGTTCCGTGATGTGACCAGCTTGCTGGAGAATCCAAAGGCCTATTCCGCCAGCATCGAACTGCTGTCTG
AACACTATAGTGAGTCCGGTGTGACAAAAGTCGTGGGTACTGAAGCTCGCGGTTTTTTGTTTGGTGCCCCGGTGGCACTG
GCGCTGGGGGTAGGTTTTGTTCCGGTGCGTAAACCGGGAAAATTGCCACGTGAAACGATCAGTGAAAGCTATGAATTAGA
ATACGGCACTGACACTTTAGAGATCCATACGGATAGCATCCAACCGGGTGATAAAGTCTTGGTTGTTGATGATCTATTGG
CGACTGGCGGCACCATTGAAGCCACGGTTAAGCTTATTCGCCGCTTGGGGGGGGAAGTGGTTCACGCGGCATTTATTATT
AATTTACCTGAACTGGGGGGCGAGGCTCGCCTGACTCAGCAAGGGATTCATTGCTACAGCCTCGTTTCTTTCGACGGTCA
TTGA

Upstream 100 bases:

>100_bases
TTATCGAAACTTTTCGGTGGCCTATGTCACTCAGATAACGCTATTTTCGCATTATCTGGCCGCGCTTTAGTATGTCCAGC
AGTTTTATCAGGCACAAATT

Downstream 100 bases:

>100_bases
TTGCATTGAAAACAACAGCCTCGCTATCTATATAGAATCAGTCCAATAGCGGGGCTGTTGAGTCCATAATTCCGATCACC
CAGCCTCATCTTCTGGCCTG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MTVSASKTAQQLKYIKDSIKTIPDYPKAGILFRDVTSLLENPKAYSASIELLSEHYSESGVTKVVGTEARGFLFGAPVAL
ALGVGFVPVRKPGKLPRETISESYELEYGTDTLEIHTDSIQPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVVHAAFII
NLPELGGEARLTQQGIHCYSLVSFDGH

Sequences:

>Translated_187_residues
MTVSASKTAQQLKYIKDSIKTIPDYPKAGILFRDVTSLLENPKAYSASIELLSEHYSESGVTKVVGTEARGFLFGAPVAL
ALGVGFVPVRKPGKLPRETISESYELEYGTDTLEIHTDSIQPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVVHAAFII
NLPELGGEARLTQQGIHCYSLVSFDGH
>Mature_186_residues
TVSASKTAQQLKYIKDSIKTIPDYPKAGILFRDVTSLLENPKAYSASIELLSEHYSESGVTKVVGTEARGFLFGAPVALA
LGVGFVPVRKPGKLPRETISESYELEYGTDTLEIHTDSIQPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVVHAAFIIN
LPELGGEARLTQQGIHCYSLVSFDGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=178, Percent_Identity=39.8876404494382, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=44.1860465116279, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI1786675, Length=182, Percent_Identity=80.2197802197802, Blast_Score=296, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=43.9306358381503, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323619, Length=174, Percent_Identity=40.8045977011494, Blast_Score=125, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320649, Length=176, Percent_Identity=36.3636363636364, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17136334, Length=185, Percent_Identity=43.7837837837838, Blast_Score=144, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20143; Mature: 20012

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSASKTAQQLKYIKDSIKTIPDYPKAGILFRDVTSLLENPKAYSASIELLSEHYSESG
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
VTKVVGTEARGFLFGAPVALALGVGFVPVRKPGKLPRETISESYELEYGTDTLEIHTDSI
CEEEECCCCCCEEECCHHHHHHCCCCEECCCCCCCCHHHHCCCEEEEECCCEEEEEECCC
QPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVVHAAFIINLPELGGEARLTQQGIHCYS
CCCCEEEEEEHHHHCCCCHHHHHHHHHHHCHHHEEHHHEEECCCCCCCCHHHHCCCEEEE
LVSFDGH
EEEECCC
>Mature Secondary Structure 
TVSASKTAQQLKYIKDSIKTIPDYPKAGILFRDVTSLLENPKAYSASIELLSEHYSESG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
VTKVVGTEARGFLFGAPVALALGVGFVPVRKPGKLPRETISESYELEYGTDTLEIHTDSI
CEEEECCCCCCEEECCHHHHHHCCCCEECCCCCCCCHHHHCCCEEEEECCCEEEEEECCC
QPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVVHAAFIINLPELGGEARLTQQGIHCYS
CCCCEEEEEEHHHHCCCCHHHHHHHHHHHCHHHEEHHHEEECCCCCCCCHHHHCCCEEEE
LVSFDGH
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA