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The map label for this gene is hemX

Identifier: 51594538

GI number: 51594538

Start: 219450

End: 220574

Strand: Reverse

Name: hemX

Synonym: YPTB0182

Alternate gene names: 51594538

Gene position: 220574-219450 (Counterclockwise)

Preceding gene: 51594539

Following gene: 51594537

Centisome position: 4.65

GC content: 50.31

Gene sequence:

>1125_bases
ATGACGGAACAAAATACCCCATCCGCACCAGTGGAAGAGCCAACCACTGCGGTTGAGAGGCCCCAACAGCCAGAACCAAA
AGGCCACCGTGAAAAACGGACTGGCCCAATTCTGGGTGTTATCGCTATCGCCTTGGTAATAGCACTGGGAGCGGGGCTTT
ATTATCATGGACAGCAGCAGGCCCAGTTACAGAGTGCGGAGAATATTGCGCTACAAGAGCAGTTAGTGGCACTAAAACAG
ACGCTATTGCAGGAAAAACAGCAACTGGAGTCCTTACTGCAACAGCAGGGGAAAGCGCTGGAGTCGGCAGAAAATCAACA
AGCCTCTCTGACACGCCAGCTCAATGAATTACAAGAAAAAGTCGCGACTATTTCAGGCAGCGATGCCAAAACCTGGCTGC
TGGCTCAGGCCGATTTCCTGGTAAAAATGGCCGGGCGCAAGCTGTGGAGTGATCAAGATGTCACCACCGCGGTCACCTTA
CTGAAAAGCGCCGATGCCAGTCTGGCCGATATGAATGACCCAAGTCTTATCGATGTCCGCCGCGCGATTACAGAAGATAT
CAGCGCACTCTCTGCCGTCAGTCAGGTGGATTTTGACGGTATTATCCTCAAGTTAAACCAGTTGTCTAATCAAGTGGATA
ACTTGCGTTTGGCCGATAACAATATTGATGACTCTCCCATGGATGCCAACAGTGACGAACTCTCCAGTTCACTCTCTGAA
TGGCGTCAGAATCTGAGTAAAAGCTGGCGCAGCTTTATGTCTGATTTCATTAGTATTCGCCGCCGTGATAGTAGCGCGGA
ACCTTTGCTGGCACCGAATCAGGACGTGTATCTGCGAGAAAATATTCGCTCCCGCCTGCTGGTTGCCGCTCAGGCAGTCC
CCCGCCATCAAGACGAAGTTTATAAGCAGTCATTGGAAACGATTTCTACGTGGGTCCGCGCTTATTTTGATGTGAACGAC
CCGAGTACCAAGGCGTTCTTGGATGAGCTGGAAAATCTAAGCCAGCAACCTATCTCAATGGACGTGCCGGATCAATTGAA
AAGCCAGCCAATACTGGAAAAATTGATGCAAACCAGGGTCCGTAACTTACTGGCACAAACGCCAGTTGATGCTCAGGGGG
AATAA

Upstream 100 bases:

>100_bases
GACGGAGGTCCGGGTAGCAGAAAATGCCGATAATGACGCACTGATCCGTGCGTTACAAGACCTTCAATAAACCTAAAACC
TGACTTATGGGATGCCCAAT

Downstream 100 bases:

>100_bases
ATATGCTGCGAGTCTTGCTGTTATTCCTTGTTTTAACTGTGGGTATCGTGCTTGGCCCAATGTTGGCCGGACATCAGGGT
TATGTGCTGATCCAGACTGA

Product: uroporphyrinogen III C-methyltransferase

Products: NA

Alternate protein names: Urogen-III methylase; ORF X [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MTEQNTPSAPVEEPTTAVERPQQPEPKGHREKRTGPILGVIAIALVIALGAGLYYHGQQQAQLQSAENIALQEQLVALKQ
TLLQEKQQLESLLQQQGKALESAENQQASLTRQLNELQEKVATISGSDAKTWLLAQADFLVKMAGRKLWSDQDVTTAVTL
LKSADASLADMNDPSLIDVRRAITEDISALSAVSQVDFDGIILKLNQLSNQVDNLRLADNNIDDSPMDANSDELSSSLSE
WRQNLSKSWRSFMSDFISIRRRDSSAEPLLAPNQDVYLRENIRSRLLVAAQAVPRHQDEVYKQSLETISTWVRAYFDVND
PSTKAFLDELENLSQQPISMDVPDQLKSQPILEKLMQTRVRNLLAQTPVDAQGE

Sequences:

>Translated_374_residues
MTEQNTPSAPVEEPTTAVERPQQPEPKGHREKRTGPILGVIAIALVIALGAGLYYHGQQQAQLQSAENIALQEQLVALKQ
TLLQEKQQLESLLQQQGKALESAENQQASLTRQLNELQEKVATISGSDAKTWLLAQADFLVKMAGRKLWSDQDVTTAVTL
LKSADASLADMNDPSLIDVRRAITEDISALSAVSQVDFDGIILKLNQLSNQVDNLRLADNNIDDSPMDANSDELSSSLSE
WRQNLSKSWRSFMSDFISIRRRDSSAEPLLAPNQDVYLRENIRSRLLVAAQAVPRHQDEVYKQSLETISTWVRAYFDVND
PSTKAFLDELENLSQQPISMDVPDQLKSQPILEKLMQTRVRNLLAQTPVDAQGE
>Mature_373_residues
TEQNTPSAPVEEPTTAVERPQQPEPKGHREKRTGPILGVIAIALVIALGAGLYYHGQQQAQLQSAENIALQEQLVALKQT
LLQEKQQLESLLQQQGKALESAENQQASLTRQLNELQEKVATISGSDAKTWLLAQADFLVKMAGRKLWSDQDVTTAVTLL
KSADASLADMNDPSLIDVRRAITEDISALSAVSQVDFDGIILKLNQLSNQVDNLRLADNNIDDSPMDANSDELSSSLSEW
RQNLSKSWRSFMSDFISIRRRDSSAEPLLAPNQDVYLRENIRSRLLVAAQAVPRHQDEVYKQSLETISTWVRAYFDVNDP
STKAFLDELENLSQQPISMDVPDQLKSQPILEKLMQTRVRNLLAQTPVDAQGE

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790235, Length=367, Percent_Identity=68.1198910081744, Blast_Score=475, Evalue=1e-135,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 41651; Mature: 41520

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQNTPSAPVEEPTTAVERPQQPEPKGHREKRTGPILGVIAIALVIALGAGLYYHGQQQ
CCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCHHCCCCHH
AQLQSAENIALQEQLVALKQTLLQEKQQLESLLQQQGKALESAENQQASLTRQLNELQEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VATISGSDAKTWLLAQADFLVKMAGRKLWSDQDVTTAVTLLKSADASLADMNDPSLIDVR
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHCCCCCHHHHHH
RAITEDISALSAVSQVDFDGIILKLNQLSNQVDNLRLADNNIDDSPMDANSDELSSSLSE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCHHHHHHHHHH
WRQNLSKSWRSFMSDFISIRRRDSSAEPLLAPNQDVYLRENIRSRLLVAAQAVPRHQDEV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
YKQSLETISTWVRAYFDVNDPSTKAFLDELENLSQQPISMDVPDQLKSQPILEKLMQTRV
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHH
RNLLAQTPVDAQGE
HHHHHHCCCCCCCC
>Mature Secondary Structure 
TEQNTPSAPVEEPTTAVERPQQPEPKGHREKRTGPILGVIAIALVIALGAGLYYHGQQQ
CCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCHHCCCCHH
AQLQSAENIALQEQLVALKQTLLQEKQQLESLLQQQGKALESAENQQASLTRQLNELQEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VATISGSDAKTWLLAQADFLVKMAGRKLWSDQDVTTAVTLLKSADASLADMNDPSLIDVR
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHCCCCCHHHHHH
RAITEDISALSAVSQVDFDGIILKLNQLSNQVDNLRLADNNIDDSPMDANSDELSSSLSE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCHHHHHHHHHH
WRQNLSKSWRSFMSDFISIRRRDSSAEPLLAPNQDVYLRENIRSRLLVAAQAVPRHQDEV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
YKQSLETISTWVRAYFDVNDPSTKAFLDELENLSQQPISMDVPDQLKSQPILEKLMQTRV
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHH
RNLLAQTPVDAQGE
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062586; 3054815; 1379743; 9278503; 9298646 [H]