Click here to switch to the map view.

The map label for this gene is hemY

Identifier: 51594537

GI number: 51594537

Start: 218227

End: 219447

Strand: Reverse

Name: hemY

Synonym: YPTB0181

Alternate gene names: 51594537

Gene position: 219447-218227 (Counterclockwise)

Preceding gene: 51594538

Following gene: 51594521

Centisome position: 4.63

GC content: 52.33

Gene sequence:

>1221_bases
ATGCTGCGAGTCTTGCTGTTATTCCTTGTTTTAACTGTGGGTATCGTGCTTGGCCCAATGTTGGCCGGACATCAGGGTTA
TGTGCTGATCCAGACTGACAACTATAACGTTACAACCAGTGTGACCGGGTTAGCCATCATGCTGGTCCTGTTATTGGTGG
CTTTCTTTATTGTTGAATGGGTACTACGCCGTATTTTCCGCACAGGTGCCCGCACTCGTGGCTGGTTCCTTGGCCGTAAA
CGTACCCGCGCCCGTAACCAGATGAAAGCGGCGTTGATTAAGCTGGCTGAAGGTGATTTTCTGCAAGTTGAAAAGCTCCT
CACCCGCAATGCTGACCACGCGGAACAACCCATGGTTAACTACCTGCTGGCAGCCGAAGCCGCCCAGCAACGTGGAGATG
AGTTTCGTACCAATCAATATCTGGAGCGCGCGGCAGAAGTTGCCGATGGCGACCAACTGCCGGTGAATATCACCAGAGTG
CGTATTCAACTGGCGCAGGGGCATATTCATGCCGCCCGCCACGGTGTTGATCGCTTGTTGGATCAAGCGCCACGGCATCC
AGAAGTCCTGCGTCTGGCTGAACAGGCTTACCTGCGCTCCGGTGCTTATCGCTCATTACTGGACATTTTACCGGCGATGA
GTAAAACACAGATCCACACCCCTGAAGAAGTCGCGGCCCTTGAGCAACAAGCCTATATTGGCATCATGAATCAGTGCATG
GCGGACGAAGGCAGCGAAGGTCTGAAACGCTGGTGGAAAGATCAAAGCCGCAAAGTACGAAATGAGATCCCATTACAGGT
CGCATTAGCAGAGCATCTGATTGAATGTGATGATCATGATGTGGCCCAAAAGATCATTCTGGACAGCCTGAAACACCAAT
ATGATGAACGTCTGGTGCTGTTGATCCCGCGTCTGAAGGCAGGTAACCCAGAGCCGTTGGAAAAGTCTTTGCGCCAGCAA
ATCAAGCAGCATGGTGCCACACCGTTACTCAATAGTACCTTGGGTCAGTTGATGCTGAAACACGGTGAATGGGAGAAAGC
CAGCGAAGCCTTTAAAGCAGCGCTTGCGCAGCGGCCTGATGGCTATGATTACGCGTGGCTGGCGGATGCCTTGGATAAAC
TGCATCGCCCTGAGGATGCCGCTCAAGCGCGTCGTGAGGGGTTATTACTGACCCTGCGCCAGAATGGCGAATCATCCGCT
CTAACCAAATTAATACATTGA

Upstream 100 bases:

>100_bases
CGGATCAATTGAAAAGCCAGCCAATACTGGAAAAATTGATGCAAACCAGGGTCCGTAACTTACTGGCACAAACGCCAGTT
GATGCTCAGGGGGAATAAAT

Downstream 100 bases:

>100_bases
TGTTAGCCCGCAGATGAGGCCCATGGACGGGCCAAGTAACGACCGTAGCCAACACATGCTGCTTGAAGTGCGAAGCGCAC
CCAAAAAAAAAACACTTGCC

Product: protoheme IX biogenesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLRVLLLFLVLTVGIVLGPMLAGHQGYVLIQTDNYNVTTSVTGLAIMLVLLLVAFFIVEWVLRRIFRTGARTRGWFLGRK
RTRARNQMKAALIKLAEGDFLQVEKLLTRNADHAEQPMVNYLLAAEAAQQRGDEFRTNQYLERAAEVADGDQLPVNITRV
RIQLAQGHIHAARHGVDRLLDQAPRHPEVLRLAEQAYLRSGAYRSLLDILPAMSKTQIHTPEEVAALEQQAYIGIMNQCM
ADEGSEGLKRWWKDQSRKVRNEIPLQVALAEHLIECDDHDVAQKIILDSLKHQYDERLVLLIPRLKAGNPEPLEKSLRQQ
IKQHGATPLLNSTLGQLMLKHGEWEKASEAFKAALAQRPDGYDYAWLADALDKLHRPEDAAQARREGLLLTLRQNGESSA
LTKLIH

Sequences:

>Translated_406_residues
MLRVLLLFLVLTVGIVLGPMLAGHQGYVLIQTDNYNVTTSVTGLAIMLVLLLVAFFIVEWVLRRIFRTGARTRGWFLGRK
RTRARNQMKAALIKLAEGDFLQVEKLLTRNADHAEQPMVNYLLAAEAAQQRGDEFRTNQYLERAAEVADGDQLPVNITRV
RIQLAQGHIHAARHGVDRLLDQAPRHPEVLRLAEQAYLRSGAYRSLLDILPAMSKTQIHTPEEVAALEQQAYIGIMNQCM
ADEGSEGLKRWWKDQSRKVRNEIPLQVALAEHLIECDDHDVAQKIILDSLKHQYDERLVLLIPRLKAGNPEPLEKSLRQQ
IKQHGATPLLNSTLGQLMLKHGEWEKASEAFKAALAQRPDGYDYAWLADALDKLHRPEDAAQARREGLLLTLRQNGESSA
LTKLIH
>Mature_406_residues
MLRVLLLFLVLTVGIVLGPMLAGHQGYVLIQTDNYNVTTSVTGLAIMLVLLLVAFFIVEWVLRRIFRTGARTRGWFLGRK
RTRARNQMKAALIKLAEGDFLQVEKLLTRNADHAEQPMVNYLLAAEAAQQRGDEFRTNQYLERAAEVADGDQLPVNITRV
RIQLAQGHIHAARHGVDRLLDQAPRHPEVLRLAEQAYLRSGAYRSLLDILPAMSKTQIHTPEEVAALEQQAYIGIMNQCM
ADEGSEGLKRWWKDQSRKVRNEIPLQVALAEHLIECDDHDVAQKIILDSLKHQYDERLVLLIPRLKAGNPEPLEKSLRQQ
IKQHGATPLLNSTLGQLMLKHGEWEKASEAFKAALAQRPDGYDYAWLADALDKLHRPEDAAQARREGLLLTLRQNGESSA
LTKLIH

Specific function: Involved in a late step of protoheme IX synthesis [H]

COG id: COG3071

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Escherichia coli, GI1790234, Length=382, Percent_Identity=70.9424083769634, Blast_Score=569, Evalue=1e-163,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010817
- InterPro:   IPR005254
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR013105
- InterPro:   IPR019734 [H]

Pfam domain/function: PF07219 HemY_N; PF07719 TPR_2 [H]

EC number: NA

Molecular weight: Translated: 45895; Mature: 45895

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVLLLFLVLTVGIVLGPMLAGHQGYVLIQTDNYNVTTSVTGLAIMLVLLLVAFFIVEW
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHH
VLRRIFRTGARTRGWFLGRKRTRARNQMKAALIKLAEGDFLQVEKLLTRNADHAEQPMVN
HHHHHHHCCCCCCCHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHH
YLLAAEAAQQRGDEFRTNQYLERAAEVADGDQLPVNITRVRIQLAQGHIHAARHGVDRLL
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHEEHHHHCHHHHHHHHHHHHH
DQAPRHPEVLRLAEQAYLRSGAYRSLLDILPAMSKTQIHTPEEVAALEQQAYIGIMNQCM
HHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ADEGSEGLKRWWKDQSRKVRNEIPLQVALAEHLIECDDHDVAQKIILDSLKHQYDERLVL
HCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEE
LIPRLKAGNPEPLEKSLRQQIKQHGATPLLNSTLGQLMLKHGEWEKASEAFKAALAQRPD
EECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
GYDYAWLADALDKLHRPEDAAQARREGLLLTLRQNGESSALTKLIH
CCCHHHHHHHHHHHCCCCHHHHHHHCCEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure
MLRVLLLFLVLTVGIVLGPMLAGHQGYVLIQTDNYNVTTSVTGLAIMLVLLLVAFFIVEW
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHH
VLRRIFRTGARTRGWFLGRKRTRARNQMKAALIKLAEGDFLQVEKLLTRNADHAEQPMVN
HHHHHHHCCCCCCCHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHH
YLLAAEAAQQRGDEFRTNQYLERAAEVADGDQLPVNITRVRIQLAQGHIHAARHGVDRLL
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHEEHHHHCHHHHHHHHHHHHH
DQAPRHPEVLRLAEQAYLRSGAYRSLLDILPAMSKTQIHTPEEVAALEQQAYIGIMNQCM
HHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ADEGSEGLKRWWKDQSRKVRNEIPLQVALAEHLIECDDHDVAQKIILDSLKHQYDERLVL
HCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEE
LIPRLKAGNPEPLEKSLRQQIKQHGATPLLNSTLGQLMLKHGEWEKASEAFKAALAQRPD
EECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
GYDYAWLADALDKLHRPEDAAQARREGLLLTLRQNGESSALTKLIH
CCCHHHHHHHHHHHCCCCHHHHHHHCCEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]