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The map label for this gene is trxB [H]

Identifier: 50843746

GI number: 50843746

Start: 2508494

End: 2509546

Strand: Direct

Name: trxB [H]

Synonym: PPA2309

Alternate gene names: 50843746

Gene position: 2508494-2509546 (Clockwise)

Preceding gene: 50843743

Following gene: 50843748

Centisome position: 97.98

GC content: 63.82

Gene sequence:

>1053_bases
ATGACCACTCAGGCCCTTACACCCAACACCATCCTCGGCAACATTTCGCTGTCCGATCCCTCGGAAATCGACACCACCCA
GCCCTTCCCTGAGACCGTCGGCGCCGACGTCCACGGTAATGACGAGCCGCGCGACGTCATCATCGTAGGGTCTGGGCCAG
CCGGATACACCGCCGCTGTCTACACCGCCCGCGCCGGACTGAAGCCGCTGGTATTTGAAGGGTCAATGGATGCCGGCGGC
GCCCTCATGCAGACCACCGAGGTCGAAAACTACCCGGGCTTCTCCGAAGGGATCATGGGCCCCGACCTCATGGCGCAGAT
GCGTGCCCAGGCCGAACGGTTCGGAGCCGAGCTCATCGCCGACGACGTCACCGATATCGACCTCACCGGTGAGATCAAGA
AGCTCGTCGACACCGACGGAAACACCTACAAGGCGCACGTTGTTATCCTCGCCATGGGATCGGCCTACCGCAAACTCGGG
CTTGAGGATGAGCCGCGGTTGTCCGGGCGCGGCGTGTCGTGGTGCGCCACCTGTGACGGGTTCTTCTTCACCGGCAAAGA
CATCGCCGTCGTTGGTGGCGGTGACTCCGCGGTTGAGGAAGCCACTTTCCTTACCCGGTTCGCCAACTCGGTGACCCTCG
TGCATCGCCGCGACCAATTGCGCGCCTCTCAGATCATGGCCGACCGTGCCGCAGCCGACCCCAAGATCACCTTCGCGTGG
AATAGTGAGGTCGTCGCCATGCAGGGCGAGTCGAAGCTCGAGTCGATCACCCTGCGGGACACCAAAACCGGCGAGGAGCG
TCAACTCGAAGTTGCCGGCGTTTTTGAGGCCATCGGCCATGACCCGCGCTCCGAGCTGGTGCGCGGCCAGGTCGATCTGG
ACGATGCTGGCTACGTCGTGTGCGCCGAGCCATCCACCCGCACCAACGTGCCGGGAGTTTTCGCCTGCGGCGACCTGGTC
GACTCCCACTACCAACAAGCCGTCACCGCGGCCGGGTCCGGGTGCCGTGCTGCCCTAGATGCCGAAAGGTTCCTCACTGA
ACTAGGTCGCTGA

Upstream 100 bases:

>100_bases
TGGAAGCCCCACGCCGGGCGTAAAACCCTCCGGGAATGCCGTAACAGCTTCATGCGCTAAATAGGTTGATCCCCGAACCA
GTCACTAACCAGGAGACGCC

Downstream 100 bases:

>100_bases
GGTACTCGACAGTTTTCGCCGCACCACCCGCGCGCAAGGTGGTGCGGCGAAATGCTGTGCGGGCGCCATGGACGCGACGT
GGTATAGGTAAGCGGCATGC

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTTQALTPNTILGNISLSDPSEIDTTQPFPETVGADVHGNDEPRDVIIVGSGPAGYTAAVYTARAGLKPLVFEGSMDAGG
ALMQTTEVENYPGFSEGIMGPDLMAQMRAQAERFGAELIADDVTDIDLTGEIKKLVDTDGNTYKAHVVILAMGSAYRKLG
LEDEPRLSGRGVSWCATCDGFFFTGKDIAVVGGGDSAVEEATFLTRFANSVTLVHRRDQLRASQIMADRAAADPKITFAW
NSEVVAMQGESKLESITLRDTKTGEERQLEVAGVFEAIGHDPRSELVRGQVDLDDAGYVVCAEPSTRTNVPGVFACGDLV
DSHYQQAVTAAGSGCRAALDAERFLTELGR

Sequences:

>Translated_350_residues
MTTQALTPNTILGNISLSDPSEIDTTQPFPETVGADVHGNDEPRDVIIVGSGPAGYTAAVYTARAGLKPLVFEGSMDAGG
ALMQTTEVENYPGFSEGIMGPDLMAQMRAQAERFGAELIADDVTDIDLTGEIKKLVDTDGNTYKAHVVILAMGSAYRKLG
LEDEPRLSGRGVSWCATCDGFFFTGKDIAVVGGGDSAVEEATFLTRFANSVTLVHRRDQLRASQIMADRAAADPKITFAW
NSEVVAMQGESKLESITLRDTKTGEERQLEVAGVFEAIGHDPRSELVRGQVDLDDAGYVVCAEPSTRTNVPGVFACGDLV
DSHYQQAVTAAGSGCRAALDAERFLTELGR
>Mature_349_residues
TTQALTPNTILGNISLSDPSEIDTTQPFPETVGADVHGNDEPRDVIIVGSGPAGYTAAVYTARAGLKPLVFEGSMDAGGA
LMQTTEVENYPGFSEGIMGPDLMAQMRAQAERFGAELIADDVTDIDLTGEIKKLVDTDGNTYKAHVVILAMGSAYRKLGL
EDEPRLSGRGVSWCATCDGFFFTGKDIAVVGGGDSAVEEATFLTRFANSVTLVHRRDQLRASQIMADRAAADPKITFAWN
SEVVAMQGESKLESITLRDTKTGEERQLEVAGVFEAIGHDPRSELVRGQVDLDDAGYVVCAEPSTRTNVPGVFACGDLVD
SHYQQAVTAAGSGCRAALDAERFLTELGR

Specific function: Component of the thioredoxin-thioredoxin reductase system which may be involved in biosynthesis of penicillins and cephalosporins and may be important in determining the thiol- disulfide redox balance [H]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=316, Percent_Identity=43.6708860759494, Blast_Score=257, Evalue=8e-70,
Organism=Escherichia coli, GI87081763, Length=308, Percent_Identity=31.4935064935065, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320560, Length=313, Percent_Identity=46.3258785942492, Blast_Score=284, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6321898, Length=313, Percent_Identity=44.408945686901, Blast_Score=271, Evalue=2e-73,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 37263; Mature: 37132

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQALTPNTILGNISLSDPSEIDTTQPFPETVGADVHGNDEPRDVIIVGSGPAGYTAAV
CCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCEEEEECCCCCCCEEEE
YTARAGLKPLVFEGSMDAGGALMQTTEVENYPGFSEGIMGPDLMAQMRAQAERFGAELIA
EEHHCCCCEEEEECCCCCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHCHHHHH
DDVTDIDLTGEIKKLVDTDGNTYKAHVVILAMGSAYRKLGLEDEPRLSGRGVSWCATCDG
CCCCCCCCCHHHHHHHCCCCCEEEEEEEEEEECCHHHHCCCCCCCCCCCCCCEEEEECCC
FFFTGKDIAVVGGGDSAVEEATFLTRFANSVTLVHRRDQLRASQIMADRAAADPKITFAW
EEEECCEEEEECCCCHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHCCCCEEEEEE
NSEVVAMQGESKLESITLRDTKTGEERQLEVAGVFEAIGHDPRSELVRGQVDLDDAGYVV
CCEEEEEECCCCCEEEEEECCCCCCHHEEHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEE
CAEPSTRTNVPGVFACGDLVDSHYQQAVTAAGSGCRAALDAERFLTELGR
ECCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTQALTPNTILGNISLSDPSEIDTTQPFPETVGADVHGNDEPRDVIIVGSGPAGYTAAV
CCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCEEEEECCCCCCCEEEE
YTARAGLKPLVFEGSMDAGGALMQTTEVENYPGFSEGIMGPDLMAQMRAQAERFGAELIA
EEHHCCCCEEEEECCCCCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHCHHHHH
DDVTDIDLTGEIKKLVDTDGNTYKAHVVILAMGSAYRKLGLEDEPRLSGRGVSWCATCDG
CCCCCCCCCHHHHHHHCCCCCEEEEEEEEEEECCHHHHCCCCCCCCCCCCCCEEEEECCC
FFFTGKDIAVVGGGDSAVEEATFLTRFANSVTLVHRRDQLRASQIMADRAAADPKITFAW
EEEECCEEEEECCCCHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHCCCCEEEEEE
NSEVVAMQGESKLESITLRDTKTGEERQLEVAGVFEAIGHDPRSELVRGQVDLDDAGYVV
CCEEEEEECCCCCEEEEEECCCCCCHHEEHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEE
CAEPSTRTNVPGVFACGDLVDSHYQQAVTAAGSGCRAALDAERFLTELGR
ECCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8349555; 8423136 [H]