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The map label for this gene is glpK [H]

Identifier: 50843741

GI number: 50843741

Start: 2502581

End: 2504128

Strand: Reverse

Name: glpK [H]

Synonym: PPA2304

Alternate gene names: 50843741

Gene position: 2504128-2502581 (Counterclockwise)

Preceding gene: 50843742

Following gene: 50843736

Centisome position: 97.81

GC content: 60.14

Gene sequence:

>1548_bases
ATGCAGATAAGAAAGGCAACCAACATGAGCGATGAGAAGTTTGTACTCGCCATTGACGAGGGCACTACTTCCGCCCGTGC
CATCATCTTTAACCACGCCGGCCAGATCATGGCCGTTGGCCAGCAGGAGTTCGAGCAGATCTTCCCGCGTGCTGGATGGG
TTGAGCATGACCCGATCGAGATCTGGGAGGCCGTTCGCGACGTCGTTGGGCTCGCCCTGACCAAGGCCAACATCAACCGC
CACCAGCTGGCTGCTGCTGGTATCACCAACCAGCGCGAGACCGCAGTGGTGTGGGACAAGAACACCGGTGAGCCGGTTTA
TAACGCCATCGTGTGGCAGGACACGCGCACTCAAAAGATCTGTAACGAACTAGCTGGTGACAAGGGCGCCGACCGCTACA
AGGAGATCTGTGGTCTGGGCCTGTCGACCTATTTCTCTGGCCCGAAGGTCAAATGGATTCTCGACAACGTTGAGGGAGCC
CGTGCGAGGGCCGAGGCCGGCGATCTGCTCTTCGGTAACATGGACACTTGGGTGCTGTGGAACCTGACTGGCGGTACTAA
CGGTGGCGTGCACATCACCGATCCGACCAACGCGTCCCGAACCATGCTCATGGACGTCCGAAAGCTGCAGTGGGACGACT
CGATGTGCGAGGTCATGGGGATTCCGAAGTCCATGCTTCCTGAGATCAAGTCCTCCTCCGAGATCTACGGCTATGGTCGC
AAGAACGGCCTGCTGATCGATACCCCGATCTCCGGCATTCTTGGCGATCAGCAGGCCGCCACTTTTGGCCAGGCTTGCTT
CCAAAAGGGCATGGCGAAGAACACGTACGGCACCGGCTGCTTCATGCTCATGAACACAGGTGAGGAGGCCATCTTCTCCG
AGAACGGTCTGCTGACCACCGTCTGCTACAAGATCGGTGACCAGCCCACCGTCTATGCCCTGGAAGGTTCGATTGCCGTC
GCTGGATCGCTGGTACAGTGGCTGCGCGACAACCTCAAGATGTTCGAGACCGCCCCGCAAATCGAAGCTCTCGCTAACAC
CGTCGAGGACAATGGTGGCGCCTACTTTGTGCCGGCCTTCTCTGGCCTGTTCGCGCCGTACTGGCGTCCAGACGCCCGTG
GTGCCCTCGTGGGCTTGACCCGCTACGTCAACCGTGGCCACATTGCCCGCGCCGTGCTCGAGTCAACCGCCTTCCAGACT
CGCGAGGTTCTTGAGGCTATGAACGCCGACTCCGGTGTGCCGCTGACGGAGCTGCGCGTCGACGGTGGCATGACCGCCAA
CGAAACCCTCATGCAGTTCCAGGCCGACCAGGTCAATGTGCCGGTGGTTCGCCCCGTGGTCGCCGAAACCACCGCTCTGG
GCGCCGCCTACGCCGCTGGCATCGCTGTCGGTTTCTGGGAAGGCGAGAATGACGTCACCGACAACTGGGCCGAGGACAAG
CGCTGGGAACCCAAGATGGACAAGAATGAGCGCGAACGTCTGTTCCGCAACTGGAAGAAGGCTGTCACTAAGACCTTCGA
CTGGGTGGACGACGACGTCAAGGAGTGA

Upstream 100 bases:

>100_bases
TGCTGTCCTGGCCGCTCTCACCTACTCCATTTTCTGGTGAGTGGGAATACCTCTCGTGACACACTGATTGCGCGTCAGCC
GTAATGTGTCAGACACGTCA

Downstream 100 bases:

>100_bases
TCTTGCTCTGATCCTGATGAACTGTTGACAGGTGGTGCCCCGTGCCTTCCAGCGCGGGGCACCACTGCGTCCAGTTCCTC
GTGCCATTGCCGGGCGCTTG

Product: glycerol kinase 2

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MQIRKATNMSDEKFVLAIDEGTTSARAIIFNHAGQIMAVGQQEFEQIFPRAGWVEHDPIEIWEAVRDVVGLALTKANINR
HQLAAAGITNQRETAVVWDKNTGEPVYNAIVWQDTRTQKICNELAGDKGADRYKEICGLGLSTYFSGPKVKWILDNVEGA
RARAEAGDLLFGNMDTWVLWNLTGGTNGGVHITDPTNASRTMLMDVRKLQWDDSMCEVMGIPKSMLPEIKSSSEIYGYGR
KNGLLIDTPISGILGDQQAATFGQACFQKGMAKNTYGTGCFMLMNTGEEAIFSENGLLTTVCYKIGDQPTVYALEGSIAV
AGSLVQWLRDNLKMFETAPQIEALANTVEDNGGAYFVPAFSGLFAPYWRPDARGALVGLTRYVNRGHIARAVLESTAFQT
REVLEAMNADSGVPLTELRVDGGMTANETLMQFQADQVNVPVVRPVVAETTALGAAYAAGIAVGFWEGENDVTDNWAEDK
RWEPKMDKNERERLFRNWKKAVTKTFDWVDDDVKE

Sequences:

>Translated_515_residues
MQIRKATNMSDEKFVLAIDEGTTSARAIIFNHAGQIMAVGQQEFEQIFPRAGWVEHDPIEIWEAVRDVVGLALTKANINR
HQLAAAGITNQRETAVVWDKNTGEPVYNAIVWQDTRTQKICNELAGDKGADRYKEICGLGLSTYFSGPKVKWILDNVEGA
RARAEAGDLLFGNMDTWVLWNLTGGTNGGVHITDPTNASRTMLMDVRKLQWDDSMCEVMGIPKSMLPEIKSSSEIYGYGR
KNGLLIDTPISGILGDQQAATFGQACFQKGMAKNTYGTGCFMLMNTGEEAIFSENGLLTTVCYKIGDQPTVYALEGSIAV
AGSLVQWLRDNLKMFETAPQIEALANTVEDNGGAYFVPAFSGLFAPYWRPDARGALVGLTRYVNRGHIARAVLESTAFQT
REVLEAMNADSGVPLTELRVDGGMTANETLMQFQADQVNVPVVRPVVAETTALGAAYAAGIAVGFWEGENDVTDNWAEDK
RWEPKMDKNERERLFRNWKKAVTKTFDWVDDDVKE
>Mature_515_residues
MQIRKATNMSDEKFVLAIDEGTTSARAIIFNHAGQIMAVGQQEFEQIFPRAGWVEHDPIEIWEAVRDVVGLALTKANINR
HQLAAAGITNQRETAVVWDKNTGEPVYNAIVWQDTRTQKICNELAGDKGADRYKEICGLGLSTYFSGPKVKWILDNVEGA
RARAEAGDLLFGNMDTWVLWNLTGGTNGGVHITDPTNASRTMLMDVRKLQWDDSMCEVMGIPKSMLPEIKSSSEIYGYGR
KNGLLIDTPISGILGDQQAATFGQACFQKGMAKNTYGTGCFMLMNTGEEAIFSENGLLTTVCYKIGDQPTVYALEGSIAV
AGSLVQWLRDNLKMFETAPQIEALANTVEDNGGAYFVPAFSGLFAPYWRPDARGALVGLTRYVNRGHIARAVLESTAFQT
REVLEAMNADSGVPLTELRVDGGMTANETLMQFQADQVNVPVVRPVVAETTALGAAYAAGIAVGFWEGENDVTDNWAEDK
RWEPKMDKNERERLFRNWKKAVTKTFDWVDDDVKE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=512, Percent_Identity=51.3671875, Blast_Score=515, Evalue=1e-146,
Organism=Homo sapiens, GI4504007, Length=512, Percent_Identity=51.3671875, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI42794763, Length=517, Percent_Identity=50.8704061895551, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI41393575, Length=511, Percent_Identity=50.0978473581213, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI88196792, Length=513, Percent_Identity=32.3586744639376, Blast_Score=300, Evalue=3e-81,
Organism=Escherichia coli, GI1790361, Length=508, Percent_Identity=54.7244094488189, Blast_Score=563, Evalue=1e-161,
Organism=Escherichia coli, GI1789987, Length=431, Percent_Identity=24.5939675174014, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787789, Length=531, Percent_Identity=24.105461393597, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790005, Length=511, Percent_Identity=22.3091976516634, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1789168, Length=464, Percent_Identity=23.4913793103448, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17535599, Length=505, Percent_Identity=42.970297029703, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71986140, Length=526, Percent_Identity=24.5247148288973, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71986147, Length=302, Percent_Identity=27.4834437086093, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6321755, Length=553, Percent_Identity=37.0705244122966, Blast_Score=328, Evalue=1e-90,
Organism=Drosophila melanogaster, GI17864214, Length=507, Percent_Identity=46.1538461538462, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24654573, Length=435, Percent_Identity=46.4367816091954, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24655555, Length=519, Percent_Identity=39.8843930635838, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24655560, Length=519, Percent_Identity=39.8843930635838, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24655570, Length=519, Percent_Identity=39.8843930635838, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24655574, Length=519, Percent_Identity=39.8843930635838, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24655565, Length=519, Percent_Identity=39.8843930635838, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19922058, Length=535, Percent_Identity=36.0747663551402, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24652871, Length=501, Percent_Identity=36.7265469061876, Blast_Score=312, Evalue=4e-85,
Organism=Drosophila melanogaster, GI24656367, Length=515, Percent_Identity=27.7669902912621, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI21357867, Length=526, Percent_Identity=26.8060836501901, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24656372, Length=350, Percent_Identity=30, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45552909, Length=260, Percent_Identity=29.6153846153846, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 56842; Mature: 56842

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIRKATNMSDEKFVLAIDEGTTSARAIIFNHAGQIMAVGQQEFEQIFPRAGWVEHDPIE
CCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCEEECCHHHHHHHCCCCCCCCCCHHH
IWEAVRDVVGLALTKANINRHQLAAAGITNQRETAVVWDKNTGEPVYNAIVWQDTRTQKI
HHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCEEEEEECCCCCHHHEEEEECCCHHHHH
CNELAGDKGADRYKEICGLGLSTYFSGPKVKWILDNVEGARARAEAGDLLFGNMDTWVLW
HHHHCCCCCHHHHHHHHCCCHHHHCCCCEEEEEEECCCCCHHHCCCCCEEECCCCEEEEE
NLTGGTNGGVHITDPTNASRTMLMDVRKLQWDDSMCEVMGIPKSMLPEIKSSSEIYGYGR
EECCCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHCCCCCEEEECC
KNGLLIDTPISGILGDQQAATFGQACFQKGMAKNTYGTGCFMLMNTGEEAIFSENGLLTT
CCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHEECCCCCEEE
VCYKIGDQPTVYALEGSIAVAGSLVQWLRDNLKMFETAPQIEALANTVEDNGGAYFVPAF
HHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECH
SGLFAPYWRPDARGALVGLTRYVNRGHIARAVLESTAFQTREVLEAMNADSGVPLTELRV
HHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
DGGMTANETLMQFQADQVNVPVVRPVVAETTALGAAYAAGIAVGFWEGENDVTDNWAEDK
CCCCCCCHHHHHEECCCCCCCEECHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCC
RWEPKMDKNERERLFRNWKKAVTKTFDWVDDDVKE
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MQIRKATNMSDEKFVLAIDEGTTSARAIIFNHAGQIMAVGQQEFEQIFPRAGWVEHDPIE
CCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCEEECCHHHHHHHCCCCCCCCCCHHH
IWEAVRDVVGLALTKANINRHQLAAAGITNQRETAVVWDKNTGEPVYNAIVWQDTRTQKI
HHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCEEEEEECCCCCHHHEEEEECCCHHHHH
CNELAGDKGADRYKEICGLGLSTYFSGPKVKWILDNVEGARARAEAGDLLFGNMDTWVLW
HHHHCCCCCHHHHHHHHCCCHHHHCCCCEEEEEEECCCCCHHHCCCCCEEECCCCEEEEE
NLTGGTNGGVHITDPTNASRTMLMDVRKLQWDDSMCEVMGIPKSMLPEIKSSSEIYGYGR
EECCCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHCCCCCEEEECC
KNGLLIDTPISGILGDQQAATFGQACFQKGMAKNTYGTGCFMLMNTGEEAIFSENGLLTT
CCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHEECCCCCEEE
VCYKIGDQPTVYALEGSIAVAGSLVQWLRDNLKMFETAPQIEALANTVEDNGGAYFVPAF
HHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECH
SGLFAPYWRPDARGALVGLTRYVNRGHIARAVLESTAFQTREVLEAMNADSGVPLTELRV
HHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
DGGMTANETLMQFQADQVNVPVVRPVVAETTALGAAYAAGIAVGFWEGENDVTDNWAEDK
CCCCCCCHHHHHEECCCCCCCEECHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCC
RWEPKMDKNERERLFRNWKKAVTKTFDWVDDDVKE
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA