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The map label for this gene is cycA [H]

Identifier: 50843702

GI number: 50843702

Start: 2456880

End: 2458379

Strand: Direct

Name: cycA [H]

Synonym: PPA2269

Alternate gene names: 50843702

Gene position: 2456880-2458379 (Clockwise)

Preceding gene: 50843700

Following gene: 50843703

Centisome position: 95.96

GC content: 54.6

Gene sequence:

>1500_bases
ATGAGTCACATGGATAGCGCCACCCAGGCCACAACTCCAACTGAAGGGCCAACTGAAGAACCCCAGCTTCAGCGCGGCCT
CAAGAACCGGCATCTCCAGCTCATTGCCATCGGAGGCGCCATTGGAACAGGCCTCTTTCTGGGATCCGGGAAGACCATCT
CCCTAGCGGGTCCGTCTATTTTGCTGGTCTACCTCATCATCGGAGCAGTACTCTTCTTCGTCATGCGGGCCATGGGGGAG
CTACTGCTGTCGAACCTGGCCTACAAGTCTTTCGCCGACTTCGCAACAGACCTCGTTGGCCCCGGCGCCGGGTTCTACAT
GGGGTGGACATATTGGATGTGTTGGGTCGTCATAGGTAACGCCGACACCATCGCGATGTGCGGATACTTGGCCGCTTGGT
TCCCTCATCTCGATAAATGGATACCCGCCACATGCATCGTCTTACTATTGACATGTCTTAATATGGTAGCCGTAAAACTT
TTTGGCGAGATGGAATTTTGGTTTGCGATGATTAAGATCGTCACCATCATCGCATTAATCCTTGTCGGCGGCTACCTTGC
GATCACCGGGTTCCAGCCACCCCGCAGCGGGGTTCCGGCTGCGTCATTTTCTCATTTGTGGGACCGTGGCGGGTTCTTCC
CCACCGGATTCATGGGATTCATAGCCGGCTTCCAAATTGCCATTTTCTCGTTCCAAGGTATTGAGATGGCAGGCACCGCA
GCAGCGGAAACAGCAGACCCTGAACACAATCTTCCTAAGGCTATCAACTCAATCCCGGCTCGTGTCCTTATCTTCTATGT
TCTGGCCCTAGGCGTCATCATGGCAGTTCAGCCGTGGGATCTCATCAATCCGCAGGCAAGTCCTTTCGTCGAAATGTTTA
GCTTTATTGGGATCCTTATTGCCTTCCATATCGTCAACTTTGTTGTGCTCACCTCCGCTGCATCTTCAGCGAACTCGGGA
GTTTTCTCTACTTCCCGAATCCTCTACGGGCTAGCACGCGAGAAAGACGCCCCGCCAGTCTTCGCCAAGTTGTCCAGTCG
TCACATTCCTCGCAATGCCCTCATCCTCACTGCGATGTGCATTGCGCCAGCCATCGTCCTCGTCACCCTTGAAGACTCAG
TCATGGATGCTTTTTCCCTCGTTGCAGGAGTCTCCTCGGTGCTCTATCTGTCGGTGTGGGGACTCATTCTGGTCTGCTAC
CTCAAGTACTTAGGTAAGCATCCCCAACGCCATGCGGAATCAGCCTTCAAGATGCCTGCTGGCCGTGTGATGTCGTGGGT
CGGCATCCTCTTCTTCATCACCATCCTCATCATGCTGGGCTTCTCGGCAGATTCTCGTCAGGCCCTTATCGCCGCTCCTG
TCTGGGTGATATTTATGATGGTGCTATACCGCCTTTTGGCTTCCACCCGTGCCGATCACACTCGTATCGACTTCGACGCC
GAGCGGATCCGTGCCCTCGAGGAGCTCCACCGCACGCAAGAGGATGAGCACCAAGCCTGA

Upstream 100 bases:

>100_bases
ACTACCGGCCCCAGTGAACCTATGCAACGTCTAAACTTGTGTTGGTTCTTTGTTCCGCAATGATGCGAGCAGGGGCACCG
TTGATACCGGGAGGGTGTAG

Downstream 100 bases:

>100_bases
CCGCAGCAATCTGGTCCACAGCCGCTTTCAGCCTCGCGACTCATGACCTCCTAGCTCTACGAGAATGACGGAGTTACTTC
AAGTAGACCGGAGAGTGCCG

Product: D-serine/D-alanine/glycine transporter

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MSHMDSATQATTPTEGPTEEPQLQRGLKNRHLQLIAIGGAIGTGLFLGSGKTISLAGPSILLVYLIIGAVLFFVMRAMGE
LLLSNLAYKSFADFATDLVGPGAGFYMGWTYWMCWVVIGNADTIAMCGYLAAWFPHLDKWIPATCIVLLLTCLNMVAVKL
FGEMEFWFAMIKIVTIIALILVGGYLAITGFQPPRSGVPAASFSHLWDRGGFFPTGFMGFIAGFQIAIFSFQGIEMAGTA
AAETADPEHNLPKAINSIPARVLIFYVLALGVIMAVQPWDLINPQASPFVEMFSFIGILIAFHIVNFVVLTSAASSANSG
VFSTSRILYGLAREKDAPPVFAKLSSRHIPRNALILTAMCIAPAIVLVTLEDSVMDAFSLVAGVSSVLYLSVWGLILVCY
LKYLGKHPQRHAESAFKMPAGRVMSWVGILFFITILIMLGFSADSRQALIAAPVWVIFMMVLYRLLASTRADHTRIDFDA
ERIRALEELHRTQEDEHQA

Sequences:

>Translated_499_residues
MSHMDSATQATTPTEGPTEEPQLQRGLKNRHLQLIAIGGAIGTGLFLGSGKTISLAGPSILLVYLIIGAVLFFVMRAMGE
LLLSNLAYKSFADFATDLVGPGAGFYMGWTYWMCWVVIGNADTIAMCGYLAAWFPHLDKWIPATCIVLLLTCLNMVAVKL
FGEMEFWFAMIKIVTIIALILVGGYLAITGFQPPRSGVPAASFSHLWDRGGFFPTGFMGFIAGFQIAIFSFQGIEMAGTA
AAETADPEHNLPKAINSIPARVLIFYVLALGVIMAVQPWDLINPQASPFVEMFSFIGILIAFHIVNFVVLTSAASSANSG
VFSTSRILYGLAREKDAPPVFAKLSSRHIPRNALILTAMCIAPAIVLVTLEDSVMDAFSLVAGVSSVLYLSVWGLILVCY
LKYLGKHPQRHAESAFKMPAGRVMSWVGILFFITILIMLGFSADSRQALIAAPVWVIFMMVLYRLLASTRADHTRIDFDA
ERIRALEELHRTQEDEHQA
>Mature_498_residues
SHMDSATQATTPTEGPTEEPQLQRGLKNRHLQLIAIGGAIGTGLFLGSGKTISLAGPSILLVYLIIGAVLFFVMRAMGEL
LLSNLAYKSFADFATDLVGPGAGFYMGWTYWMCWVVIGNADTIAMCGYLAAWFPHLDKWIPATCIVLLLTCLNMVAVKLF
GEMEFWFAMIKIVTIIALILVGGYLAITGFQPPRSGVPAASFSHLWDRGGFFPTGFMGFIAGFQIAIFSFQGIEMAGTAA
AETADPEHNLPKAINSIPARVLIFYVLALGVIMAVQPWDLINPQASPFVEMFSFIGILIAFHIVNFVVLTSAASSANSGV
FSTSRILYGLAREKDAPPVFAKLSSRHIPRNALILTAMCIAPAIVLVTLEDSVMDAFSLVAGVSSVLYLSVWGLILVCYL
KYLGKHPQRHAESAFKMPAGRVMSWVGILFFITILIMLGFSADSRQALIAAPVWVIFMMVLYRLLASTRADHTRIDFDAE
RIRALEELHRTQEDEHQA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=361, Percent_Identity=25.4847645429363, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1790653, Length=472, Percent_Identity=54.4491525423729, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1786302, Length=456, Percent_Identity=37.719298245614, Blast_Score=325, Evalue=5e-90,
Organism=Escherichia coli, GI1786789, Length=463, Percent_Identity=37.5809935205184, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1786602, Length=450, Percent_Identity=36.4444444444444, Blast_Score=301, Evalue=5e-83,
Organism=Escherichia coli, GI48994972, Length=452, Percent_Identity=37.1681415929204, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI87081915, Length=411, Percent_Identity=37.4695863746959, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI1788480, Length=381, Percent_Identity=39.6325459317585, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI87081708, Length=436, Percent_Identity=33.0275229357798, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1789017, Length=438, Percent_Identity=32.1917808219178, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI2367353, Length=367, Percent_Identity=26.158038147139, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17531343, Length=442, Percent_Identity=24.2081447963801, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=367, Percent_Identity=25.3405994550409, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324924, Length=426, Percent_Identity=31.6901408450704, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324990, Length=521, Percent_Identity=29.3666026871401, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6324061, Length=510, Percent_Identity=28.8235294117647, Blast_Score=182, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6320772, Length=511, Percent_Identity=29.1585127201566, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6322892, Length=440, Percent_Identity=28.4090909090909, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6324059, Length=519, Percent_Identity=27.9383429672447, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320717, Length=522, Percent_Identity=23.3716475095785, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324553, Length=347, Percent_Identity=31.1239193083574, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6321629, Length=438, Percent_Identity=27.1689497716895, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320251, Length=535, Percent_Identity=23.9252336448598, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319824, Length=550, Percent_Identity=24.1818181818182, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6321053, Length=519, Percent_Identity=25.626204238921, Blast_Score=134, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6319543, Length=436, Percent_Identity=25.6880733944954, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319542, Length=526, Percent_Identity=23.0038022813688, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322967, Length=413, Percent_Identity=27.1186440677966, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319608, Length=350, Percent_Identity=27.7142857142857, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=570, Percent_Identity=23.6842105263158, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324981, Length=510, Percent_Identity=25.0980392156863, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54489; Mature: 54358

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHMDSATQATTPTEGPTEEPQLQRGLKNRHLQLIAIGGAIGTGLFLGSGKTISLAGPSI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCHHHHHEEECCCCEEEECCHHH
LLVYLIIGAVLFFVMRAMGELLLSNLAYKSFADFATDLVGPGAGFYMGWTYWMCWVVIGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
ADTIAMCGYLAAWFPHLDKWIPATCIVLLLTCLNMVAVKLFGEMEFWFAMIKIVTIIALI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGGYLAITGFQPPRSGVPAASFSHLWDRGGFFPTGFMGFIAGFQIAIFSFQGIEMAGTA
HHHHHHEEECCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCC
AAETADPEHNLPKAINSIPARVLIFYVLALGVIMAVQPWDLINPQASPFVEMFSFIGILI
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AFHIVNFVVLTSAASSANSGVFSTSRILYGLAREKDAPPVFAKLSSRHIPRNALILTAMC
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHH
IAPAIVLVTLEDSVMDAFSLVAGVSSVLYLSVWGLILVCYLKYLGKHPQRHAESAFKMPA
HHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCH
GRVMSWVGILFFITILIMLGFSADSRQALIAAPVWVIFMMVLYRLLASTRADHTRIDFDA
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
ERIRALEELHRTQEDEHQA
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SHMDSATQATTPTEGPTEEPQLQRGLKNRHLQLIAIGGAIGTGLFLGSGKTISLAGPSI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCHHHHHEEECCCCEEEECCHHH
LLVYLIIGAVLFFVMRAMGELLLSNLAYKSFADFATDLVGPGAGFYMGWTYWMCWVVIGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
ADTIAMCGYLAAWFPHLDKWIPATCIVLLLTCLNMVAVKLFGEMEFWFAMIKIVTIIALI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGGYLAITGFQPPRSGVPAASFSHLWDRGGFFPTGFMGFIAGFQIAIFSFQGIEMAGTA
HHHHHHEEECCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCC
AAETADPEHNLPKAINSIPARVLIFYVLALGVIMAVQPWDLINPQASPFVEMFSFIGILI
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AFHIVNFVVLTSAASSANSGVFSTSRILYGLAREKDAPPVFAKLSSRHIPRNALILTAMC
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHH
IAPAIVLVTLEDSVMDAFSLVAGVSSVLYLSVWGLILVCYLKYLGKHPQRHAESAFKMPA
HHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCH
GRVMSWVGILFFITILIMLGFSADSRQALIAAPVWVIFMMVLYRLLASTRADHTRIDFDA
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
ERIRALEELHRTQEDEHQA
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]