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The map label for this gene is norM [H]

Identifier: 50843692

GI number: 50843692

Start: 2445333

End: 2446679

Strand: Reverse

Name: norM [H]

Synonym: PPA2259

Alternate gene names: 50843692

Gene position: 2446679-2445333 (Counterclockwise)

Preceding gene: 50843693

Following gene: 50843689

Centisome position: 95.56

GC content: 62.14

Gene sequence:

>1347_bases
ATGGTTCGAGGGAGTCGCGATCCGGGCTCCGAGGTTGGGGCCGGATACCGTCAGATTCTGAATCTGGCAGTGCCTGCTTT
CTTGTCCCTGATTGCTGAGCCGCTGTTCCTCGTTGCAGACTCCGCAGTGGTCGGGCATCTGGGCACCGCCGAGTTGGCAG
GCCTGGGTGTGGCTTCGGCGGCCTTGACGACCTTCACAGGGCTTTTTGTTTTCCTTGCCTACGCGACGACGGCAACATCG
TCACGTCGAATGGGGGCGGGGGACCGTCAGGGAGCTGCCCAGGCTGGTGTGGATGGCTTGTGGCTGTCTGTCATCATTGG
CCTACTTGTGGCGATCATGCTGGTGGCTATTCCGACGACGGTGGCTGGTTGGTTTGGAGCTAGCGGCGCGGTTGCGGAAC
AGGCGGGACGCTATTTGCGCATCACTGGATTTGGGGTGCCCGCGATGCTCGCCACCATGGCGATCACAGGAGTGTTGCGT
GGGTTTCAAGACACTCGCACGCCCTTAGTTGTGACGGTCGTCACCTTTAGTGCGAACTTGGTGCTCAATCTGTGGTTCGT
GCTTGGTATGGGTTGGGGCATCCAGGGGTCCGCCATAGGCACCCTCGTCTGCCAGATAGCCATGGCGGTGGCTCTGGTGT
GGGTGCTGCGGATACGAACTCGCGGCCTCGACTTAAGTTTGGTGCCGCACCTGAGCGGCATTGCTTCAAGTTTGCGTGAT
GGTATCCCGTTGCTCATTCGAACCCTGGCGTTGCGTGCCGCTCTCTACGTGACAACCTGGGTCGCCGCGCGGTCTGGAGC
GATCACCATGGCGTCATATCAGGTGACGATGACGATGTGGAACTTGCTACTCATGGCCATGGACGCCCTGGGTATTGCCG
GCCAGGCCCTCACCGGGGCGAGCCTGGGAGCTGGTGACGTCCGTCGTACCCGGTCACTGACGGCCACGATGACGCGATGG
GGGCTTGTGGCGGGCGTTGTTATTGGCATCGTGCTGGCGGCTTTTCATCAGGTGGTTCCTGCCCTGTACACCGACGACCC
CGCCGTACACCGAGCGGTCGCTGCTGGTTTGCTTGTCGTGGCAGCTCAGCAGATCGTTGCTGGCCCGGCTTTCGTCCTCG
ATGGGGTGCTCATTGGGGCTGGCGACGGCCGATGGTTGTCGGGTGCTCAGGTTGTCATGCTCCTGGTGTATCTACCGATG
GCCTGGGCTGTGCACCTCTTGGCGCCGTCAGACCCGGCCGCTGCAGTGGTGTGGCTGTGGGTTGCCTTCAGCGGGTTCAT
GATCGTGCGGTGTGCAATCCTGGCATGGCGTGCGCGCGGAGACGCCTGGATGAGGACGGGCGCCTGA

Upstream 100 bases:

>100_bases
CGACTTCTGGTCCCCTGCGTGGTGAGAAAACTCCGGAGTGGGCTGACCGGGTTCTCGATGTCATTCGTGCGTCCCTGCGC
GGTGCGATAGCACGAGCTTG

Downstream 100 bases:

>100_bases
GCGGGTTTTGGGAGCTTGAAGGAGGGTTAGCGGCCTGTGGTCGACGGGCCATCCCAAAGTCACTCGAAGTCCACGCGCTG
CGCTCCGGGTACGGAGTCGT

Product: hypothetical protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MVRGSRDPGSEVGAGYRQILNLAVPAFLSLIAEPLFLVADSAVVGHLGTAELAGLGVASAALTTFTGLFVFLAYATTATS
SRRMGAGDRQGAAQAGVDGLWLSVIIGLLVAIMLVAIPTTVAGWFGASGAVAEQAGRYLRITGFGVPAMLATMAITGVLR
GFQDTRTPLVVTVVTFSANLVLNLWFVLGMGWGIQGSAIGTLVCQIAMAVALVWVLRIRTRGLDLSLVPHLSGIASSLRD
GIPLLIRTLALRAALYVTTWVAARSGAITMASYQVTMTMWNLLLMAMDALGIAGQALTGASLGAGDVRRTRSLTATMTRW
GLVAGVVIGIVLAAFHQVVPALYTDDPAVHRAVAAGLLVVAAQQIVAGPAFVLDGVLIGAGDGRWLSGAQVVMLLVYLPM
AWAVHLLAPSDPAAAVVWLWVAFSGFMIVRCAILAWRARGDAWMRTGA

Sequences:

>Translated_448_residues
MVRGSRDPGSEVGAGYRQILNLAVPAFLSLIAEPLFLVADSAVVGHLGTAELAGLGVASAALTTFTGLFVFLAYATTATS
SRRMGAGDRQGAAQAGVDGLWLSVIIGLLVAIMLVAIPTTVAGWFGASGAVAEQAGRYLRITGFGVPAMLATMAITGVLR
GFQDTRTPLVVTVVTFSANLVLNLWFVLGMGWGIQGSAIGTLVCQIAMAVALVWVLRIRTRGLDLSLVPHLSGIASSLRD
GIPLLIRTLALRAALYVTTWVAARSGAITMASYQVTMTMWNLLLMAMDALGIAGQALTGASLGAGDVRRTRSLTATMTRW
GLVAGVVIGIVLAAFHQVVPALYTDDPAVHRAVAAGLLVVAAQQIVAGPAFVLDGVLIGAGDGRWLSGAQVVMLLVYLPM
AWAVHLLAPSDPAAAVVWLWVAFSGFMIVRCAILAWRARGDAWMRTGA
>Mature_448_residues
MVRGSRDPGSEVGAGYRQILNLAVPAFLSLIAEPLFLVADSAVVGHLGTAELAGLGVASAALTTFTGLFVFLAYATTATS
SRRMGAGDRQGAAQAGVDGLWLSVIIGLLVAIMLVAIPTTVAGWFGASGAVAEQAGRYLRITGFGVPAMLATMAITGVLR
GFQDTRTPLVVTVVTFSANLVLNLWFVLGMGWGIQGSAIGTLVCQIAMAVALVWVLRIRTRGLDLSLVPHLSGIASSLRD
GIPLLIRTLALRAALYVTTWVAARSGAITMASYQVTMTMWNLLLMAMDALGIAGQALTGASLGAGDVRRTRSLTATMTRW
GLVAGVVIGIVLAAFHQVVPALYTDDPAVHRAVAAGLLVVAAQQIVAGPAFVLDGVLIGAGDGRWLSGAQVVMLLVYLPM
AWAVHLLAPSDPAAAVVWLWVAFSGFMIVRCAILAWRARGDAWMRTGA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790477, Length=368, Percent_Identity=28.5326086956522, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI226510954, Length=391, Percent_Identity=25.5754475703325, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 46602; Mature: 46602

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRGSRDPGSEVGAGYRQILNLAVPAFLSLIAEPLFLVADSAVVGHLGTAELAGLGVASA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHCHHHHH
ALTTFTGLFVFLAYATTATSSRRMGAGDRQGAAQAGVDGLWLSVIIGLLVAIMLVAIPTT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VAGWFGASGAVAEQAGRYLRITGFGVPAMLATMAITGVLRGFQDTRTPLVVTVVTFSANL
HHHHCCCCCHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHH
VLNLWFVLGMGWGIQGSAIGTLVCQIAMAVALVWVLRIRTRGLDLSLVPHLSGIASSLRD
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHC
GIPLLIRTLALRAALYVTTWVAARSGAITMASYQVTMTMWNLLLMAMDALGIAGQALTGA
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHCCC
SLGAGDVRRTRSLTATMTRWGLVAGVVIGIVLAAFHQVVPALYTDDPAVHRAVAAGLLVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AAQQIVAGPAFVLDGVLIGAGDGRWLSGAQVVMLLVYLPMAWAVHLLAPSDPAAAVVWLW
HHHHHHCCHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VAFSGFMIVRCAILAWRARGDAWMRTGA
HHHHHHHHHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure
MVRGSRDPGSEVGAGYRQILNLAVPAFLSLIAEPLFLVADSAVVGHLGTAELAGLGVASA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHCHHHHH
ALTTFTGLFVFLAYATTATSSRRMGAGDRQGAAQAGVDGLWLSVIIGLLVAIMLVAIPTT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VAGWFGASGAVAEQAGRYLRITGFGVPAMLATMAITGVLRGFQDTRTPLVVTVVTFSANL
HHHHCCCCCHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHH
VLNLWFVLGMGWGIQGSAIGTLVCQIAMAVALVWVLRIRTRGLDLSLVPHLSGIASSLRD
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHC
GIPLLIRTLALRAALYVTTWVAARSGAITMASYQVTMTMWNLLLMAMDALGIAGQALTGA
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHCCC
SLGAGDVRRTRSLTATMTRWGLVAGVVIGIVLAAFHQVVPALYTDDPAVHRAVAAGLLVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AAQQIVAGPAFVLDGVLIGAGDGRWLSGAQVVMLLVYLPMAWAVHLLAPSDPAAAVVWLW
HHHHHHCCHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VAFSGFMIVRCAILAWRARGDAWMRTGA
HHHHHHHHHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]