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The map label for this gene is glpA [H]

Identifier: 50843684

GI number: 50843684

Start: 2433814

End: 2435448

Strand: Reverse

Name: glpA [H]

Synonym: PPA2250

Alternate gene names: 50843684

Gene position: 2435448-2433814 (Counterclockwise)

Preceding gene: 50843685

Following gene: 50843683

Centisome position: 95.12

GC content: 61.96

Gene sequence:

>1635_bases
ATGAGGACCATGGACGCAGACGTCGTTGTCATCGGTGGCGGTGCCACCGGTGCGGGCGTCGTGCGGGACGTCGCGATGCG
TGGATACCGCGCCGTCCTGTTGGACAAGGCCGACCTCGGCCAAGGAACCACCGGTCGTTACCACGGCCTGCTCCACTCTG
GTGGACGATACGTCGTCTCTGACCCCGGATCGGCGACGGAATGCGCTGAGGAAAATGAGATCGTCACCCGGATCCACGCT
GACGCCGTTGAGAAGACCGGCGGCTTGTTCGTGGTGACCCCAGAAGATGACTTGGAGTTCTCTGATCAGTGGGTTGAGGG
AGCCAAGAAGTCCAAGGTTCCCTTCGAGGAAATCTCCACCGCGCAGGCCCTGCGTCGCGAGCCTCGTCTGAACCCCGGTA
TTAAGCGCGCCTTCGCCGTTCAGGACGGTTCGGTCGATGGCTGGCAGATGGTGTGGGGCGCCGCCCACTCCGCCATCGAA
TACGGCGCCAAAGTCATGACCTACGCTGCCGTCACCGAGATCATTCGCGAGGGAGACCAGATCACCGCCGTGGTCGCCCA
CGACCTTAAGCACGACGAGCAGATCCGCATCGACTGCAAGTTCGTTATTAACACTGCTGGCCCGTGGGCGGGACGCATTG
CTGAGCTTGTCGGTTGCTATGACGTTGACGTTGTGCCAGGCCGCGGCATCATGATCGCGATGAACCACCGCCTGGTGAAC
ACGGTAGTCAACCGCTGTATCTACCCTGCTGACGGCGACATCCTAGTGCCGGTGCACACCGTGTCGATCATCGGCACCAC
CGACGTCAAAGCTGACGATCCGGAGCGGCTGGCCATTCCTCGCAACGAAGTGCAGCAGATGCTCGATTCCGGCGAGGCCC
TTGTCCCCGGATTCCGCGATGCCCGTGCCGTACATGCCTGGGCCGGTGCCCGCCCGCTATTCAAAGACAAGCGAGTCTCT
GCCACCGATACCCGCCACATGTCCCGCGGTATGAGCGTTCTCGACCACGGTTCTCGCGACGGTGTTAACGGCATCGTTTC
CATCATCGGCGGCAAGCTCACCACCTATCGTCTGATGGCCAAGAACGTTGTCGACGTCATGTGTGAGCAACTTGGCGACG
ACCGTCCCTGCCGTACCGCAGACGAGGCTGTGCCCGGATCGACCGTCGGCAAGAACTACCTCATCACCCACCGTCTGGGC
GAGAACGAAGAGCGTCGTGCCGGGACTGGTCTGGTCCGCGGTGGCGACCCGAAAACCGTGCCGTCATCGAAGAAGATTGA
CAACCAGGTCATCTGCGAATGCGAGCTCATGAGCCGCAAGATGTTCACCGATCTGCTAGCCGAGCAGCCCGACGCTACCT
TCGACGACCTGCGCCGCCAGCTGCGTTTGGGTATGGGTCCCTGCCAGGGTGGCTTCTGCTCGATGCGCGCTACCGGAATT
GCTGTTGAGGAGGGCACCATTGACGCCGAGCGCGCCACCGGTCTGCTGCGTCTGTTCCTCAAGAACCGGTGGATCGGATT
GTGGCCGATTCTCTACGGCGAGCAGGTTCGGCAGACCGCCCTTGACGATTGGATCTTCCAGGGCACCTTCGACGTTGAGC
ACCTTCCCACCCCGCAGCAGGAGGTTGAGCTGTGA

Upstream 100 bases:

>100_bases
TCGCTTTCCCTAACCTTGTCACGTACCTGGCAACGGTGGCGGGGCATCGAGATCCCTGAGCCACCCCCCACACGCCGGAT
GGTTTCGAAGGGAGCATTCA

Downstream 100 bases:

>100_bases
GCACCGCAACCGTTCCCACTAAGTCGGTTACTGCCGACCGTTTCGGCGCTCAGCACGTCGTCGTCATCGGATCCGGCCTC
GCCGGCCTAACCACCGCCCT

Product: anaerobic glycerol-3-phosphate dehydrogenase subunit A

Products: NA

Alternate protein names: G-3-P dehydrogenase [H]

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MRTMDADVVVIGGGATGAGVVRDVAMRGYRAVLLDKADLGQGTTGRYHGLLHSGGRYVVSDPGSATECAEENEIVTRIHA
DAVEKTGGLFVVTPEDDLEFSDQWVEGAKKSKVPFEEISTAQALRREPRLNPGIKRAFAVQDGSVDGWQMVWGAAHSAIE
YGAKVMTYAAVTEIIREGDQITAVVAHDLKHDEQIRIDCKFVINTAGPWAGRIAELVGCYDVDVVPGRGIMIAMNHRLVN
TVVNRCIYPADGDILVPVHTVSIIGTTDVKADDPERLAIPRNEVQQMLDSGEALVPGFRDARAVHAWAGARPLFKDKRVS
ATDTRHMSRGMSVLDHGSRDGVNGIVSIIGGKLTTYRLMAKNVVDVMCEQLGDDRPCRTADEAVPGSTVGKNYLITHRLG
ENEERRAGTGLVRGGDPKTVPSSKKIDNQVICECELMSRKMFTDLLAEQPDATFDDLRRQLRLGMGPCQGGFCSMRATGI
AVEEGTIDAERATGLLRLFLKNRWIGLWPILYGEQVRQTALDDWIFQGTFDVEHLPTPQQEVEL

Sequences:

>Translated_544_residues
MRTMDADVVVIGGGATGAGVVRDVAMRGYRAVLLDKADLGQGTTGRYHGLLHSGGRYVVSDPGSATECAEENEIVTRIHA
DAVEKTGGLFVVTPEDDLEFSDQWVEGAKKSKVPFEEISTAQALRREPRLNPGIKRAFAVQDGSVDGWQMVWGAAHSAIE
YGAKVMTYAAVTEIIREGDQITAVVAHDLKHDEQIRIDCKFVINTAGPWAGRIAELVGCYDVDVVPGRGIMIAMNHRLVN
TVVNRCIYPADGDILVPVHTVSIIGTTDVKADDPERLAIPRNEVQQMLDSGEALVPGFRDARAVHAWAGARPLFKDKRVS
ATDTRHMSRGMSVLDHGSRDGVNGIVSIIGGKLTTYRLMAKNVVDVMCEQLGDDRPCRTADEAVPGSTVGKNYLITHRLG
ENEERRAGTGLVRGGDPKTVPSSKKIDNQVICECELMSRKMFTDLLAEQPDATFDDLRRQLRLGMGPCQGGFCSMRATGI
AVEEGTIDAERATGLLRLFLKNRWIGLWPILYGEQVRQTALDDWIFQGTFDVEHLPTPQQEVEL
>Mature_544_residues
MRTMDADVVVIGGGATGAGVVRDVAMRGYRAVLLDKADLGQGTTGRYHGLLHSGGRYVVSDPGSATECAEENEIVTRIHA
DAVEKTGGLFVVTPEDDLEFSDQWVEGAKKSKVPFEEISTAQALRREPRLNPGIKRAFAVQDGSVDGWQMVWGAAHSAIE
YGAKVMTYAAVTEIIREGDQITAVVAHDLKHDEQIRIDCKFVINTAGPWAGRIAELVGCYDVDVVPGRGIMIAMNHRLVN
TVVNRCIYPADGDILVPVHTVSIIGTTDVKADDPERLAIPRNEVQQMLDSGEALVPGFRDARAVHAWAGARPLFKDKRVS
ATDTRHMSRGMSVLDHGSRDGVNGIVSIIGGKLTTYRLMAKNVVDVMCEQLGDDRPCRTADEAVPGSTVGKNYLITHRLG
ENEERRAGTGLVRGGDPKTVPSSKKIDNQVICECELMSRKMFTDLLAEQPDATFDDLRRQLRLGMGPCQGGFCSMRATGI
AVEEGTIDAERATGLLRLFLKNRWIGLWPILYGEQVRQTALDDWIFQGTFDVEHLPTPQQEVEL

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=405, Percent_Identity=25.679012345679, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI285002231, Length=405, Percent_Identity=25.679012345679, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1788574, Length=544, Percent_Identity=38.2352941176471, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI2367226, Length=271, Percent_Identity=24.7232472324723, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17509253, Length=402, Percent_Identity=27.6119402985075, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI115534726, Length=433, Percent_Identity=23.3256351039261, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 59444; Mature: 59444

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTMDADVVVIGGGATGAGVVRDVAMRGYRAVLLDKADLGQGTTGRYHGLLHSGGRYVVS
CCCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEECCCEEEEE
DPGSATECAEENEIVTRIHADAVEKTGGLFVVTPEDDLEFSDQWVEGAKKSKVPFEEIST
CCCCCHHHCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHCCCHHCCCCHHHHHH
AQALRREPRLNPGIKRAFAVQDGSVDGWQMVWGAAHSAIEYGAKVMTYAAVTEIIREGDQ
HHHHHHCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ITAVVAHDLKHDEQIRIDCKFVINTAGPWAGRIAELVGCYDVDVVPGRGIMIAMNHRLVN
EEEEEECCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHCEEEEECCCCEEEEECHHHHH
TVVNRCIYPADGDILVPVHTVSIIGTTDVKADDPERLAIPRNEVQQMLDSGEALVPGFRD
HHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCEECCCCHH
ARAVHAWAGARPLFKDKRVSATDTRHMSRGMSVLDHGSRDGVNGIVSIIGGKLTTYRLMA
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCHHHHHHHH
KNVVDVMCEQLGDDRPCRTADEAVPGSTVGKNYLITHRLGENEERRAGTGLVRGGDPKTV
HHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCEEEEECCCCCCHHHHCCCCEECCCCCCC
PSSKKIDNQVICECELMSRKMFTDLLAEQPDATFDDLRRQLRLGMGPCQGGFCSMRATGI
CCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECEE
AVEEGTIDAERATGLLRLFLKNRWIGLWPILYGEQVRQTALDDWIFQGTFDVEHLPTPQQ
EEECCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
EVEL
HCCC
>Mature Secondary Structure
MRTMDADVVVIGGGATGAGVVRDVAMRGYRAVLLDKADLGQGTTGRYHGLLHSGGRYVVS
CCCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEECCCEEEEE
DPGSATECAEENEIVTRIHADAVEKTGGLFVVTPEDDLEFSDQWVEGAKKSKVPFEEIST
CCCCCHHHCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHCCCHHCCCCHHHHHH
AQALRREPRLNPGIKRAFAVQDGSVDGWQMVWGAAHSAIEYGAKVMTYAAVTEIIREGDQ
HHHHHHCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ITAVVAHDLKHDEQIRIDCKFVINTAGPWAGRIAELVGCYDVDVVPGRGIMIAMNHRLVN
EEEEEECCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHCEEEEECCCCEEEEECHHHHH
TVVNRCIYPADGDILVPVHTVSIIGTTDVKADDPERLAIPRNEVQQMLDSGEALVPGFRD
HHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCEECCCCHH
ARAVHAWAGARPLFKDKRVSATDTRHMSRGMSVLDHGSRDGVNGIVSIIGGKLTTYRLMA
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCHHHHHHHH
KNVVDVMCEQLGDDRPCRTADEAVPGSTVGKNYLITHRLGENEERRAGTGLVRGGDPKTV
HHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCEEEEECCCCCCHHHHCCCCEECCCCCCC
PSSKKIDNQVICECELMSRKMFTDLLAEQPDATFDDLRRQLRLGMGPCQGGFCSMRATGI
CCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECEE
AVEEGTIDAERATGLLRLFLKNRWIGLWPILYGEQVRQTALDDWIFQGTFDVEHLPTPQQ
EEECCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
EVEL
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]