Click here to switch to the map view.

The map label for this gene is manP [H]

Identifier: 50843668

GI number: 50843668

Start: 2415252

End: 2416811

Strand: Reverse

Name: manP [H]

Synonym: PPA2233

Alternate gene names: 50843668

Gene position: 2416811-2415252 (Counterclockwise)

Preceding gene: 50843669

Following gene: 50843667

Centisome position: 94.4

GC content: 59.49

Gene sequence:

>1560_bases
ATGGAGGTCGGCAGCAACCATTCCAGCGCTCGCTGGCAGCCGGGCGAGCGCGTCCCCTCAACAAGGAGAACGATGAAGAA
ATACGTCGGAATCACAGCATGTCCGACCGGTATTGCCCACACCTACATGGCTGCCGAGAAGCTGGAGGAAACCGCCAAGG
AGACCGGTAACCAGATCAAGGTTGAGACCCAGGGATCGATTGGTGTTGAGAATGAGCTCACAGCTGATGACATTCGCGAG
GCTGATGCTGTGGTTGTTGCCGCCGACACTGAGGTCGATCTGTCCCGCTTCGACGGCAAGCGGGTCCTGGTAACCGGCGT
TCAGGACGGTATTTCACGCCCAGCCGAGCTTTTGGAACAGGCCTTAACCGCTCCGACCCGTGGGGGCGCTGGGGCTGCCG
AACCTTCCGACGAGCCAGCCGCCGAAACGGGAACTACCTCGGCCAGTAAGGATGGCAAGGAGTCCGTTGGTCACACCTTG
TACACCGCCCTCATGGCTGGCGTGTCCCACATGATCCCGTTTGTGGTCTGCGGCGGCATCATGATTGCTCTGGCTTTGGG
CATCGGTGGTAAACCCACTGCTGGTGGCGTCGCCGTTCCTGAGGACAGTTTCTGGCAGACTATCCTGCAAGTTGGCACGT
TGGCCTTCTCCCTCATGATCCCGATACTCGCCGGTTTCATCGCCCAGGCCATTGCTGACCGTCCTGGTCTTGTCGTCGGT
ATGGTCTCCGGTTTCATCGCCAATAGCGGCGCACAGTTTCCCTACCTGACAACAACAGGCCCCGGTGGCACAAAGACCGG
CCTCAATACCGGATTTATCGGTGCCATCGTTATCGGCTTCATCGCTGGCTACGTCGCCAAGTGGATGAGGAAGATCCCGT
GGCACGAGTACGTCAAGCCGATCGTGCCGATCCTGATCGTCCCGATTTTCGGCACTGCGATCGTCTCGCTGCTGTACGTC
TATGTGCTCGGCCGTCCGCTAGCTGCCCTGTTTAACGGGTTAACCCACTTCCTGGCCAGCATGACAACGTCGTCGATAAC
CGTCCTCGCTATCATCATTGGCCTCATGGTCAGCTTCGATATGGGCGGTCCAGTCAATAAGGTCGCCTTCCTCTTCGCCG
GGGGCATGATTGCCGTTGATCAGGGCAAGGTCATGGGACTGGCCGCGGCTGCCATCCCGGTTGCCCCGCTCGGCATGGGC
CTGGCCACTCTCATCGATCGTCGTCTGTTCACCAAGCAAGAGCGTGACGCCGGTATTGCTGCCCTCTTTATGGGCTTGTT
TGGCATCACCGAAGGTGCGATCCCCTTTGCCGCGGCTGACCCAGCCCGCGTGATCCCGTCGAACATGGTGGGTGGAGCCG
TTGCCGCTGTGCTGGCTGGCATGTTTGGCGTTCATGACGTCGTCATGCATGGCGGTCCGATTGTCGGTGTTCTCGGAGCG
TGCAAACCTCTGCTTGGGTTCTTTACGGCGATCCTCATTGGCGCTTTGGTGACGGCTTTCATGTCCCTGGCCCTCAAGAG
AATTACCGCCCGCAAGAAGGATCGCGCTGTCACCGCGTGA

Upstream 100 bases:

>100_bases
TAGTAGAATCTTGATGAGTGCCGACCCCGCTGAACAAGGTGGCTTTCCGGGCGCCCACGTCGCCGTGTGATGGCTCGGTG
CCGGTGGGGCTACGCCGGCC

Downstream 100 bases:

>100_bases
GTCACCTCGAAAGGAGTTATGACATGGCTACCATCGCAGATCTGCTTGACGAGAGATCTATCGATCTATCCCTCAGCTCA
GGAGACAAGGACGACGCTAT

Product: PTS system, fructose-specific IIBC component

Products: NA

Alternate protein names: EIIBCA-Man; EII-Man; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific EIIB component; Mannose permease IIC component; PTS system mannose-specific EIIC component; Mannose-specific phosphotransferase enzyme IIA component; PTS system mannose-specific EIIA component [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MEVGSNHSSARWQPGERVPSTRRTMKKYVGITACPTGIAHTYMAAEKLEETAKETGNQIKVETQGSIGVENELTADDIRE
ADAVVVAADTEVDLSRFDGKRVLVTGVQDGISRPAELLEQALTAPTRGGAGAAEPSDEPAAETGTTSASKDGKESVGHTL
YTALMAGVSHMIPFVVCGGIMIALALGIGGKPTAGGVAVPEDSFWQTILQVGTLAFSLMIPILAGFIAQAIADRPGLVVG
MVSGFIANSGAQFPYLTTTGPGGTKTGLNTGFIGAIVIGFIAGYVAKWMRKIPWHEYVKPIVPILIVPIFGTAIVSLLYV
YVLGRPLAALFNGLTHFLASMTTSSITVLAIIIGLMVSFDMGGPVNKVAFLFAGGMIAVDQGKVMGLAAAAIPVAPLGMG
LATLIDRRLFTKQERDAGIAALFMGLFGITEGAIPFAAADPARVIPSNMVGGAVAAVLAGMFGVHDVVMHGGPIVGVLGA
CKPLLGFFTAILIGALVTAFMSLALKRITARKKDRAVTA

Sequences:

>Translated_519_residues
MEVGSNHSSARWQPGERVPSTRRTMKKYVGITACPTGIAHTYMAAEKLEETAKETGNQIKVETQGSIGVENELTADDIRE
ADAVVVAADTEVDLSRFDGKRVLVTGVQDGISRPAELLEQALTAPTRGGAGAAEPSDEPAAETGTTSASKDGKESVGHTL
YTALMAGVSHMIPFVVCGGIMIALALGIGGKPTAGGVAVPEDSFWQTILQVGTLAFSLMIPILAGFIAQAIADRPGLVVG
MVSGFIANSGAQFPYLTTTGPGGTKTGLNTGFIGAIVIGFIAGYVAKWMRKIPWHEYVKPIVPILIVPIFGTAIVSLLYV
YVLGRPLAALFNGLTHFLASMTTSSITVLAIIIGLMVSFDMGGPVNKVAFLFAGGMIAVDQGKVMGLAAAAIPVAPLGMG
LATLIDRRLFTKQERDAGIAALFMGLFGITEGAIPFAAADPARVIPSNMVGGAVAAVLAGMFGVHDVVMHGGPIVGVLGA
CKPLLGFFTAILIGALVTAFMSLALKRITARKKDRAVTA
>Mature_519_residues
MEVGSNHSSARWQPGERVPSTRRTMKKYVGITACPTGIAHTYMAAEKLEETAKETGNQIKVETQGSIGVENELTADDIRE
ADAVVVAADTEVDLSRFDGKRVLVTGVQDGISRPAELLEQALTAPTRGGAGAAEPSDEPAAETGTTSASKDGKESVGHTL
YTALMAGVSHMIPFVVCGGIMIALALGIGGKPTAGGVAVPEDSFWQTILQVGTLAFSLMIPILAGFIAQAIADRPGLVVG
MVSGFIANSGAQFPYLTTTGPGGTKTGLNTGFIGAIVIGFIAGYVAKWMRKIPWHEYVKPIVPILIVPIFGTAIVSLLYV
YVLGRPLAALFNGLTHFLASMTTSSITVLAIIIGLMVSFDMGGPVNKVAFLFAGGMIAVDQGKVMGLAAAAIPVAPLGMG
LATLIDRRLFTKQERDAGIAALFMGLFGITEGAIPFAAADPARVIPSNMVGGAVAAVLAGMFGVHDVVMHGGPIVGVLGA
CKPLLGFFTAILIGALVTAFMSLALKRITARKKDRAVTA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=487, Percent_Identity=41.6837782340862, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI87082348, Length=500, Percent_Identity=34.6, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1790386, Length=317, Percent_Identity=44.794952681388, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1786951, Length=494, Percent_Identity=33.6032388663968, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1788729, Length=417, Percent_Identity=29.7362110311751, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790387, Length=97, Percent_Identity=47.4226804123711, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788730, Length=96, Percent_Identity=43.75, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790390, Length=107, Percent_Identity=35.5140186915888, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 53693; Mature: 53693

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVGSNHSSARWQPGERVPSTRRTMKKYVGITACPTGIAHTYMAAEKLEETAKETGNQIK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEE
VETQGSIGVENELTADDIREADAVVVAADTEVDLSRFDGKRVLVTGVQDGISRPAELLEQ
EEECCCCCCCCCCCHHHHHCCCEEEEEECCCCHHHHCCCCEEEEECCHHHHCHHHHHHHH
ALTAPTRGGAGAAEPSDEPAAETGTTSASKDGKESVGHTLYTALMAGVSHMIPFVVCGGI
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIALALGIGGKPTAGGVAVPEDSFWQTILQVGTLAFSLMIPILAGFIAQAIADRPGLVVG
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHH
MVSGFIANSGAQFPYLTTTGPGGTKTGLNTGFIGAIVIGFIAGYVAKWMRKIPWHEYVKP
HHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IVPILIVPIFGTAIVSLLYVYVLGRPLAALFNGLTHFLASMTTSSITVLAIIIGLMVSFD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MGGPVNKVAFLFAGGMIAVDQGKVMGLAAAAIPVAPLGMGLATLIDRRLFTKQERDAGIA
CCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ALFMGLFGITEGAIPFAAADPARVIPSNMVGGAVAAVLAGMFGVHDVVMHGGPIVGVLGA
HHHHHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
CKPLLGFFTAILIGALVTAFMSLALKRITARKKDRAVTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEVGSNHSSARWQPGERVPSTRRTMKKYVGITACPTGIAHTYMAAEKLEETAKETGNQIK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEE
VETQGSIGVENELTADDIREADAVVVAADTEVDLSRFDGKRVLVTGVQDGISRPAELLEQ
EEECCCCCCCCCCCHHHHHCCCEEEEEECCCCHHHHCCCCEEEEECCHHHHCHHHHHHHH
ALTAPTRGGAGAAEPSDEPAAETGTTSASKDGKESVGHTLYTALMAGVSHMIPFVVCGGI
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIALALGIGGKPTAGGVAVPEDSFWQTILQVGTLAFSLMIPILAGFIAQAIADRPGLVVG
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHH
MVSGFIANSGAQFPYLTTTGPGGTKTGLNTGFIGAIVIGFIAGYVAKWMRKIPWHEYVKP
HHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IVPILIVPIFGTAIVSLLYVYVLGRPLAALFNGLTHFLASMTTSSITVLAIIIGLMVSFD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MGGPVNKVAFLFAGGMIAVDQGKVMGLAAAAIPVAPLGMGLATLIDRRLFTKQERDAGIA
CCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ALFMGLFGITEGAIPFAAADPARVIPSNMVGGAVAAVLAGMFGVHDVVMHGGPIVGVLGA
HHHHHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
CKPLLGFFTAILIGALVTAFMSLALKRITARKKDRAVTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]