Click here to switch to the map view.

The map label for this gene is manP [H]

Identifier: 50843667

GI number: 50843667

Start: 2414767

End: 2415228

Strand: Reverse

Name: manP [H]

Synonym: PPA2232

Alternate gene names: 50843667

Gene position: 2415228-2414767 (Counterclockwise)

Preceding gene: 50843668

Following gene: 50843666

Centisome position: 94.34

GC content: 61.04

Gene sequence:

>462_bases
ATGGCTACCATCGCAGATCTGCTTGACGAGAGATCTATCGATCTATCCCTCAGCTCAGGAGACAAGGACGACGCTATCGA
GAGGATGGTCGATCTCGTCGATGCTAGTGGCGCCTTGCTTGACCGCGACGTGCTTATCAAAGCGGTCCGCGCCCGTGAGG
AGGCAGGCACCACAGGACTCGGCGACGGCATCGCTATCCCGCACGGTAAGTGCGACGGTGTCGACCGCCCGGCACTGGCT
TTTGCCCGTAGTGACGAGGGTGTGAGGTGGGGAGCCCCGGACGGTTCTTTGGCCAGCCTGGTCTTCCTCATCGCTGTTCC
CGAGGCTGCCGCTGGTAATGAACACTTGCGGATTCTCGCTTCGTTGGCGCGTTCCCTAGTCAAGGCTGATTTCCGTAACC
AGCTCCTGGCCGCCTCTACTCCTCAGGAGGTTCGCGAGGTGCTGGCTGGCATCAGCGCCTGA

Upstream 100 bases:

>100_bases
CTTTGGTGACGGCTTTCATGTCCCTGGCCCTCAAGAGAATTACCGCCCGCAAGAAGGATCGCGCTGTCACCGCGTGAGTC
ACCTCGAAAGGAGTTATGAC

Downstream 100 bases:

>100_bases
CATATTCCAGCCCGACGATGTTTGACGAAGTCGGGCGGGAGTGACCATTTTTGTCAGCTGGCCTGGGGGATGGGCACCAC
CGTTCCCCAGGCTGCGCCGT

Product: PTS system, fructose/mannitol specific IIA subunit

Products: NA

Alternate protein names: EIIBCA-Man; EII-Man; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific EIIB component; Mannose permease IIC component; PTS system mannose-specific EIIC component; Mannose-specific phosphotransferase enzyme IIA component; PTS system mannose-specific EIIA component [H]

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MATIADLLDERSIDLSLSSGDKDDAIERMVDLVDASGALLDRDVLIKAVRAREEAGTTGLGDGIAIPHGKCDGVDRPALA
FARSDEGVRWGAPDGSLASLVFLIAVPEAAAGNEHLRILASLARSLVKADFRNQLLAASTPQEVREVLAGISA

Sequences:

>Translated_153_residues
MATIADLLDERSIDLSLSSGDKDDAIERMVDLVDASGALLDRDVLIKAVRAREEAGTTGLGDGIAIPHGKCDGVDRPALA
FARSDEGVRWGAPDGSLASLVFLIAVPEAAAGNEHLRILASLARSLVKADFRNQLLAASTPQEVREVLAGISA
>Mature_152_residues
ATIADLLDERSIDLSLSSGDKDDAIERMVDLVDASGALLDRDVLIKAVRAREEAGTTGLGDGIAIPHGKCDGVDRPALAF
ARSDEGVRWGAPDGSLASLVFLIAVPEAAAGNEHLRILASLARSLVKADFRNQLLAASTPQEVREVLAGISA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1762

COG function: function code GT; Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1786951, Length=149, Percent_Identity=30.8724832214765, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI2367327, Length=135, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=8e-16,
Organism=Escherichia coli, GI48994992, Length=136, Percent_Identity=30.8823529411765, Blast_Score=71, Evalue=3e-14,
Organism=Escherichia coli, GI1788494, Length=135, Percent_Identity=34.0740740740741, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1788726, Length=128, Percent_Identity=31.25, Blast_Score=64, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 15986; Mature: 15855

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIADLLDERSIDLSLSSGDKDDAIERMVDLVDASGALLDRDVLIKAVRAREEAGTTGL
CCHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
GDGIAIPHGKCDGVDRPALAFARSDEGVRWGAPDGSLASLVFLIAVPEAAAGNEHLRILA
CCCCCCCCCCCCCCCCCHHHHCCCCCCCEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHH
SLARSLVKADFRNQLLAASTPQEVREVLAGISA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
ATIADLLDERSIDLSLSSGDKDDAIERMVDLVDASGALLDRDVLIKAVRAREEAGTTGL
CHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
GDGIAIPHGKCDGVDRPALAFARSDEGVRWGAPDGSLASLVFLIAVPEAAAGNEHLRILA
CCCCCCCCCCCCCCCCCHHHHCCCCCCCEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHH
SLARSLVKADFRNQLLAASTPQEVREVLAGISA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]