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The map label for this gene is pcaR [H]

Identifier: 50843652

GI number: 50843652

Start: 2401911

End: 2402675

Strand: Reverse

Name: pcaR [H]

Synonym: PPA2217

Alternate gene names: 50843652

Gene position: 2402675-2401911 (Counterclockwise)

Preceding gene: 50843653

Following gene: 50843651

Centisome position: 93.84

GC content: 58.3

Gene sequence:

>765_bases
GTGTTCATGGAACCCAGCCGGTCAACAATTACGGCACTTGAGGTGTTGGGTGCTTTGTCTGAGCACGTTGAGCCACAATA
TGCAAGTGCCTTGGCGCGGCGGCTGGGCATTCCGAGAACTACGACGTACCGAATACTTGCTGCGCTCGTGAGCGAGGGCT
ACGCCGTCCATGATTCAGAGTTGGGTAGGTATTCGCTTGGCCCAGCGGCCTACGAGTTGGCCGCTGCGTACCAACGGCAG
GAGCCGTTGCGCCGCGTGAGTCTCCCGATTATCGACCATCTTGTGGACGAAACCCATTCGAGTATTCACCTTGCATTACT
TCGAGGATCTGAAGTCATATACGTTGTGGAGCAGCGGGGCATTCATACCCCCTCACTCATAACTGAGGTCGGGGTTCGGC
TCCCGGCTGAAATTACTGCGAGCGGGAGGGCGATGCTGTCCTGCCTGTCATGGACCCAGGTGGATGCGCTGTACCCGAGT
TCGGCCGAATTGTCGGCTGGTCATTCAAATTCGCCGACGTCGACTACTGAGCTTCATGCGATGCTCGCTGAAACACGAAA
ACGCGGGTGGGCGCGCGAAATCGATTCGGTGACGGTCGGATGGTCGACTCTGGCTGTCCCAGTTGTAGATGTCTCGGGCT
ATCCGTTGGCTTCGCTTGCCACGACGTACAGAACGGCGCTTGAGAGCAGCCAGCTCGATCAGGCGCTCCTTGGCCATCTC
TTCGCGGCTGCTCGAGCGATCCAGTATCGACTGGGTGCGCGCTGA

Upstream 100 bases:

>100_bases
TTTAGTGCCCGAGCTCATACTCGATTGTGCATGGATCACTAGCACTGCGCGCAGTGATCATGGGACCCACATCGAGACCA
GGTGGGGAAGTAGCTAGCCT

Downstream 100 bases:

>100_bases
GCTGCCGAAATTGATATAAAGATCACACTGTACAAGAAATTGCGTCAGATTTGTCACTAAATTGTGGCGGTGTTTCTCAT
CTGGAACTGACTATTTCTTA

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MFMEPSRSTITALEVLGALSEHVEPQYASALARRLGIPRTTTYRILAALVSEGYAVHDSELGRYSLGPAAYELAAAYQRQ
EPLRRVSLPIIDHLVDETHSSIHLALLRGSEVIYVVEQRGIHTPSLITEVGVRLPAEITASGRAMLSCLSWTQVDALYPS
SAELSAGHSNSPTSTTELHAMLAETRKRGWAREIDSVTVGWSTLAVPVVDVSGYPLASLATTYRTALESSQLDQALLGHL
FAAARAIQYRLGAR

Sequences:

>Translated_254_residues
MFMEPSRSTITALEVLGALSEHVEPQYASALARRLGIPRTTTYRILAALVSEGYAVHDSELGRYSLGPAAYELAAAYQRQ
EPLRRVSLPIIDHLVDETHSSIHLALLRGSEVIYVVEQRGIHTPSLITEVGVRLPAEITASGRAMLSCLSWTQVDALYPS
SAELSAGHSNSPTSTTELHAMLAETRKRGWAREIDSVTVGWSTLAVPVVDVSGYPLASLATTYRTALESSQLDQALLGHL
FAAARAIQYRLGAR
>Mature_254_residues
MFMEPSRSTITALEVLGALSEHVEPQYASALARRLGIPRTTTYRILAALVSEGYAVHDSELGRYSLGPAAYELAAAYQRQ
EPLRRVSLPIIDHLVDETHSSIHLALLRGSEVIYVVEQRGIHTPSLITEVGVRLPAEITASGRAMLSCLSWTQVDALYPS
SAELSAGHSNSPTSTTELHAMLAETRKRGWAREIDSVTVGWSTLAVPVVDVSGYPLASLATTYRTALESSQLDQALLGHL
FAAARAIQYRLGAR

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=194, Percent_Identity=26.8041237113402, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788131, Length=246, Percent_Identity=26.4227642276423, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786468, Length=246, Percent_Identity=24.390243902439, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786715, Length=198, Percent_Identity=21.7171717171717, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 27565; Mature: 27565

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMEPSRSTITALEVLGALSEHVEPQYASALARRLGIPRTTTYRILAALVSEGYAVHDSE
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEECCCC
LGRYSLGPAAYELAAAYQRQEPLRRVSLPIIDHLVDETHSSIHLALLRGSEVIYVVEQRG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEEECCC
IHTPSLITEVGVRLPAEITASGRAMLSCLSWTQVDALYPSSAELSAGHSNSPTSTTELHA
CCCHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
MLAETRKRGWAREIDSVTVGWSTLAVPVVDVSGYPLASLATTYRTALESSQLDQALLGHL
HHHHHHHCCHHHHHCCEEECHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FAAARAIQYRLGAR
HHHHHHHHHHHCCC
>Mature Secondary Structure
MFMEPSRSTITALEVLGALSEHVEPQYASALARRLGIPRTTTYRILAALVSEGYAVHDSE
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEECCCC
LGRYSLGPAAYELAAAYQRQEPLRRVSLPIIDHLVDETHSSIHLALLRGSEVIYVVEQRG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEEECCC
IHTPSLITEVGVRLPAEITASGRAMLSCLSWTQVDALYPSSAELSAGHSNSPTSTTELHA
CCCHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
MLAETRKRGWAREIDSVTVGWSTLAVPVVDVSGYPLASLATTYRTALESSQLDQALLGHL
HHHHHHHCCHHHHHCCEEECHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FAAARAIQYRLGAR
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]