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The map label for this gene is cobB

Identifier: 50843609

GI number: 50843609

Start: 2354102

End: 2354836

Strand: Reverse

Name: cobB

Synonym: PPA2172

Alternate gene names: 50843609

Gene position: 2354836-2354102 (Counterclockwise)

Preceding gene: 50843610

Following gene: 50843601

Centisome position: 91.98

GC content: 60.27

Gene sequence:

>735_bases
ATGACCGGGGAACAGCTCGCGCATTGGATCGAGGAGTCGACGTCGACAGTGTTTTTCGGCGGCGCCGGAATGTCCACCGA
ATCAGGTATTCCGGACTTTCGCTCGGCTGGCGGGCTTTACACCACTCAGCATGACCTGCCCTTCCCCGCGGAGTACATGC
TCAGTCACAGCTGTTTAGTTGAGCATCCCGCGGAGTTCTTCGACTTCTACCGCACCTACCTCGTCCATCCTCAGGCCAGG
CCCAATGCTGGTCACCGTGCCCTGGCTGCCCTGGAACGAGCCGGGCAAGTCTCAACAATCATCACCCAGAATATCGACGG
TCTACACCAAGAAGCTGGGTCTCGTCAGGTGATCGAGTTGCACGGGTCGGTGCACCGCAACCGCTGCCTGGCTTGTGGGC
GGGCCCATCCACTTTCGGTGATCATGGACGCTCCTGGAGTCCCGCGGTGCTCGTGTGGGGGGATGGTGCGTCCCGAGGTC
GTTCTTTATGAGGAATCCCTGCGGAGCCAGGATCTCGACAACGCCACTACCGCGATCAGTACTGCCGATCTGCTTATCGT
TGGAGGCACTTCGCTCAACGTTTACCCGGCCGCAGCCTTGTTGAGGTTCTTCCGCGGCCGGCACCTGGTTTTTATTAACC
GTGAGGCCACCGGCTACGACCGGGCCGCCGACCTTGTCATCCACGATGGCTTAGGTAAGACGTTGTCTGCGGTTCAGCGT
GCCGTGATGCCCTGA

Upstream 100 bases:

>100_bases
GCTGGCAGCGCCCTGAGGTCGATGTCTCCAACGTCTTTGCCAGCCTTGACATGGTTAGCGAGCCCGACCTCGTCCGTACC
CTGCTGAGGCAAGCCTAACA

Downstream 100 bases:

>100_bases
CGGGTGGCCCTCGTGTGTGGCTTCGGCCTACCCCCGCATAGGCGGGGAATACACCAGCCGACTACGACTGATGCAGGAGC
AGTTACCAGATACGAGTGTA

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MTGEQLAHWIEESTSTVFFGGAGMSTESGIPDFRSAGGLYTTQHDLPFPAEYMLSHSCLVEHPAEFFDFYRTYLVHPQAR
PNAGHRALAALERAGQVSTIITQNIDGLHQEAGSRQVIELHGSVHRNRCLACGRAHPLSVIMDAPGVPRCSCGGMVRPEV
VLYEESLRSQDLDNATTAISTADLLIVGGTSLNVYPAAALLRFFRGRHLVFINREATGYDRAADLVIHDGLGKTLSAVQR
AVMP

Sequences:

>Translated_244_residues
MTGEQLAHWIEESTSTVFFGGAGMSTESGIPDFRSAGGLYTTQHDLPFPAEYMLSHSCLVEHPAEFFDFYRTYLVHPQAR
PNAGHRALAALERAGQVSTIITQNIDGLHQEAGSRQVIELHGSVHRNRCLACGRAHPLSVIMDAPGVPRCSCGGMVRPEV
VLYEESLRSQDLDNATTAISTADLLIVGGTSLNVYPAAALLRFFRGRHLVFINREATGYDRAADLVIHDGLGKTLSAVQR
AVMP
>Mature_243_residues
TGEQLAHWIEESTSTVFFGGAGMSTESGIPDFRSAGGLYTTQHDLPFPAEYMLSHSCLVEHPAEFFDFYRTYLVHPQARP
NAGHRALAALERAGQVSTIITQNIDGLHQEAGSRQVIELHGSVHRNRCLACGRAHPLSVIMDAPGVPRCSCGGMVRPEVV
LYEESLRSQDLDNATTAISTADLLIVGGTSLNVYPAAALLRFFRGRHLVFINREATGYDRAADLVIHDGLGKTLSAVQRA
VMP

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain

Homologues:

Organism=Homo sapiens, GI300795542, Length=192, Percent_Identity=36.4583333333333, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI13787215, Length=210, Percent_Identity=34.7619047619048, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI6912664, Length=210, Percent_Identity=34.7619047619048, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI6912662, Length=273, Percent_Identity=30.4029304029304, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI300797577, Length=241, Percent_Identity=34.0248962655602, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI63054862, Length=208, Percent_Identity=37.5, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI6912660, Length=213, Percent_Identity=37.0892018779343, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI13775602, Length=233, Percent_Identity=32.618025751073, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI13775600, Length=232, Percent_Identity=32.7586206896552, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI300797705, Length=207, Percent_Identity=32.8502415458937, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI300797597, Length=240, Percent_Identity=32.0833333333333, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI7657575, Length=213, Percent_Identity=31.924882629108, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI215982798, Length=150, Percent_Identity=31.3333333333333, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI308199517, Length=214, Percent_Identity=35.981308411215, Blast_Score=101, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17541892, Length=210, Percent_Identity=33.8095238095238, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17567771, Length=248, Percent_Identity=29.0322580645161, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71990482, Length=213, Percent_Identity=32.3943661971831, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71990487, Length=215, Percent_Identity=32.093023255814, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17505510, Length=224, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325242, Length=246, Percent_Identity=31.7073170731707, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24648389, Length=223, Percent_Identity=33.6322869955157, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24645650, Length=257, Percent_Identity=31.1284046692607, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571445, Length=216, Percent_Identity=31.4814814814815, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137536, Length=221, Percent_Identity=31.2217194570136, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571443, Length=147, Percent_Identity=31.2925170068027, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28571441, Length=147, Percent_Identity=31.2925170068027, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NPD_PROAC (Q6A5T5)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056836.1
- ProteinModelPortal:   Q6A5T5
- SMR:   Q6A5T5
- GeneID:   2932285
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA2172
- NMPDR:   fig|267747.1.peg.2113
- HOGENOM:   HBG641281
- OMA:   LSHSFFM
- ProtClustDB:   PRK00481
- BioCyc:   PACN267747:PPA2172-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01121
- InterPro:   IPR003000
- PANTHER:   PTHR11085

Pfam domain/function: PF02146 SIR2

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26529; Mature: 26398

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS50305 SIRTUIN

Important sites: ACT_SITE 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGEQLAHWIEESTSTVFFGGAGMSTESGIPDFRSAGGLYTTQHDLPFPAEYMLSHSCLV
CCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHCCCCEEECCCCCCCHHHHHHHHHHH
EHPAEFFDFYRTYLVHPQARPNAGHRALAALERAGQVSTIITQNIDGLHQEAGSRQVIEL
HCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCHHHHHCCCCEEEEE
HGSVHRNRCLACGRAHPLSVIMDAPGVPRCSCGGMVRPEVVLYEESLRSQDLDNATTAIS
CCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCHHHHHE
TADLLIVGGTSLNVYPAAALLRFFRGRHLVFINREATGYDRAADLVIHDGLGKTLSAVQR
ECCEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHEEEECCCCHHHHHHHH
AVMP
HHCC
>Mature Secondary Structure 
TGEQLAHWIEESTSTVFFGGAGMSTESGIPDFRSAGGLYTTQHDLPFPAEYMLSHSCLV
CHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHCCCCEEECCCCCCCHHHHHHHHHHH
EHPAEFFDFYRTYLVHPQARPNAGHRALAALERAGQVSTIITQNIDGLHQEAGSRQVIEL
HCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCHHHHHCCCCEEEEE
HGSVHRNRCLACGRAHPLSVIMDAPGVPRCSCGGMVRPEVVLYEESLRSQDLDNATTAIS
CCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCHHHHHE
TADLLIVGGTSLNVYPAAALLRFFRGRHLVFINREATGYDRAADLVIHDGLGKTLSAVQR
ECCEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHEEEECCCCHHHHHHHH
AVMP
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA