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The map label for this gene is pgi

Identifier: 50843569

GI number: 50843569

Start: 2307646

End: 2309328

Strand: Reverse

Name: pgi

Synonym: PPA2131

Alternate gene names: 50843569

Gene position: 2309328-2307646 (Counterclockwise)

Preceding gene: 50843571

Following gene: 50843568

Centisome position: 90.2

GC content: 60.84

Gene sequence:

>1683_bases
ATGCCGACTCTCATCGACGCTACGTCCACCCCCGCATGGGGCACACTCTCCGGCCTAAAGTCCCGCTTCGCTGACGGGCC
ACATAAACTGCGCCGTTTGTTCGACGCCGACCCTCACCGCGCTGAGCGCTACACCCTTGACGTCGCGGATTTGCACGTCG
ATTTATCCAAGAACCTCCTTACCGACGAGATTCGTGACGCTCTTCTCGAACTGGCTGCGCAGATGCGCGTCACCGAGCGT
CGTGACGCGATGTATGCCGGTGAGCACATCAACGTCACCGAGGACCGCGCCGTCCTCCATACCGCGCTGCGTCGTTCCCG
CACTGACGAGCTGCATGTTGACGGCCAGGACGCCGTTGCCGATGTTCACGAGGTGCTCGACAAGATTTACGCCTTTGCGG
ATAAGGTGCGTTCGGGTGAGTGGAAGGGAGTCACCGGCAAGCCGATTCGCACTGTCATCAACGTGGGCATTGGCGGCTCT
GATCTTGGCCCCGTGATGGCCTATGAGGCCCTCAAGCCCTACGTCAAGGACGGTCTGGAGTGCCGCTTCATCTCCAACAT
TGACCCGACCGATGCCGCCGTCAAGACTGCTGATCTTGACCCCGAGACGACCCTGGTCATTATTGCCTCTAAGACCTTCA
CTACTTTGGAGACTCTGACCAACGCTCGGTGCGTGCGTGCGTGGCTGCTTGACGGCCTGGTCGCTGCCGGTGCGATTTCC
GACACCGAGCAGGCTCGACGTGACGCCGTCGCCAAGCACTTTGTCGCCGTCTCGACGGCCTTGGACAAGGTTGAGGAGTT
CGGTATCGACCCAGTGAATGCCTTTGGGTTCTGGAGCTGGGTGGGCGGCCGCTACTCGGTGGATTCCGCCGTCGGGACTT
CGCTTGCCGTCGCGATCGGGCCGAAGGGTTTCGAGGACTTCCTGGCCGGATTTCACGCCGTCGACGAGCACTTCGCCACT
GCCGAGCCGGAGCGCAATGTGCCGTTGTTCATGGGTCTACTCAACATCTGGTACACCAATTTCTGGGATGCGCATTCCCA
TGCGGTGCTTCCATATTCACAGTATTTGCACCGTTTCCCGGCTTATTTGCAGCAGCTGACTATGGAGTCGAATGGCAAGT
CGGTGCGCTGGGATGGTTCAGCAGTGACCACCGACACCGGCGAGATTTTCTGGGGTGAGCCAGGCACCAACGGTCAGCAC
GCCTTCTATCAGCTCATCCACCAAGGCACTCGCGTCATTCCGGCCGATTTCATCGCGGTGGCTAATCCAGTCCATCCGAC
CAAGGATGGCGGTACCGACGTCCACGAGCTGTTCCTCAGCAACTTCTTCGCCCAGACCGCCGCGTTGGCGTTCGGTAAGA
CCGCCGACGAGGTGCGTGCCGAGGGCACTGATGAGGCCATTGTGCCCGCTCGGGTCTTTGCTGGAGACCGTCCGACAACG
TCAATCATGGCCGACGAACTCTCCCCGAAGGTCCTCGGAGAACTCATCGCTTTGTACGAGCACATCACCTTCGTGCAGGG
CGTCGTATGGGGTATCGATTCCTTCGACCAGTGGGGTGTCGAGCTCGGCAAGAAGCTCGCCCTGCAGATTGCCCCGGCGG
TCAGCGGTAACGACGAGGCCCTGGCCACCCAGGACCCGTCCACCCAGGGTCTGGTGACGTGGTATCGCGAGCATCGGCGG
TGA

Upstream 100 bases:

>100_bases
GCGCTCACGCGTCCTCCTTCAGTCGATCGCGAATATGATAGGCGAAGCGACGTGATGGTGTGACGACACGAGCACTGCCC
CATCTCCTAGGCTTAGGGTT

Downstream 100 bases:

>100_bases
TCACTGCGGGGTGGTGTTTGGCGGCAGGGATACCGTCCATACCTTCAATTTCGGGGGGGGGGGGGAGTCTTTCTGATGCT
CACTTTGAAAGGCTATCTCC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MPTLIDATSTPAWGTLSGLKSRFADGPHKLRRLFDADPHRAERYTLDVADLHVDLSKNLLTDEIRDALLELAAQMRVTER
RDAMYAGEHINVTEDRAVLHTALRRSRTDELHVDGQDAVADVHEVLDKIYAFADKVRSGEWKGVTGKPIRTVINVGIGGS
DLGPVMAYEALKPYVKDGLECRFISNIDPTDAAVKTADLDPETTLVIIASKTFTTLETLTNARCVRAWLLDGLVAAGAIS
DTEQARRDAVAKHFVAVSTALDKVEEFGIDPVNAFGFWSWVGGRYSVDSAVGTSLAVAIGPKGFEDFLAGFHAVDEHFAT
AEPERNVPLFMGLLNIWYTNFWDAHSHAVLPYSQYLHRFPAYLQQLTMESNGKSVRWDGSAVTTDTGEIFWGEPGTNGQH
AFYQLIHQGTRVIPADFIAVANPVHPTKDGGTDVHELFLSNFFAQTAALAFGKTADEVRAEGTDEAIVPARVFAGDRPTT
SIMADELSPKVLGELIALYEHITFVQGVVWGIDSFDQWGVELGKKLALQIAPAVSGNDEALATQDPSTQGLVTWYREHRR

Sequences:

>Translated_560_residues
MPTLIDATSTPAWGTLSGLKSRFADGPHKLRRLFDADPHRAERYTLDVADLHVDLSKNLLTDEIRDALLELAAQMRVTER
RDAMYAGEHINVTEDRAVLHTALRRSRTDELHVDGQDAVADVHEVLDKIYAFADKVRSGEWKGVTGKPIRTVINVGIGGS
DLGPVMAYEALKPYVKDGLECRFISNIDPTDAAVKTADLDPETTLVIIASKTFTTLETLTNARCVRAWLLDGLVAAGAIS
DTEQARRDAVAKHFVAVSTALDKVEEFGIDPVNAFGFWSWVGGRYSVDSAVGTSLAVAIGPKGFEDFLAGFHAVDEHFAT
AEPERNVPLFMGLLNIWYTNFWDAHSHAVLPYSQYLHRFPAYLQQLTMESNGKSVRWDGSAVTTDTGEIFWGEPGTNGQH
AFYQLIHQGTRVIPADFIAVANPVHPTKDGGTDVHELFLSNFFAQTAALAFGKTADEVRAEGTDEAIVPARVFAGDRPTT
SIMADELSPKVLGELIALYEHITFVQGVVWGIDSFDQWGVELGKKLALQIAPAVSGNDEALATQDPSTQGLVTWYREHRR
>Mature_559_residues
PTLIDATSTPAWGTLSGLKSRFADGPHKLRRLFDADPHRAERYTLDVADLHVDLSKNLLTDEIRDALLELAAQMRVTERR
DAMYAGEHINVTEDRAVLHTALRRSRTDELHVDGQDAVADVHEVLDKIYAFADKVRSGEWKGVTGKPIRTVINVGIGGSD
LGPVMAYEALKPYVKDGLECRFISNIDPTDAAVKTADLDPETTLVIIASKTFTTLETLTNARCVRAWLLDGLVAAGAISD
TEQARRDAVAKHFVAVSTALDKVEEFGIDPVNAFGFWSWVGGRYSVDSAVGTSLAVAIGPKGFEDFLAGFHAVDEHFATA
EPERNVPLFMGLLNIWYTNFWDAHSHAVLPYSQYLHRFPAYLQQLTMESNGKSVRWDGSAVTTDTGEIFWGEPGTNGQHA
FYQLIHQGTRVIPADFIAVANPVHPTKDGGTDVHELFLSNFFAQTAALAFGKTADEVRAEGTDEAIVPARVFAGDRPTTS
IMADELSPKVLGELIALYEHITFVQGVVWGIDSFDQWGVELGKKLALQIAPAVSGNDEALATQDPSTQGLVTWYREHRR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=544, Percent_Identity=50.7352941176471, Blast_Score=537, Evalue=1e-153,
Organism=Homo sapiens, GI296080693, Length=544, Percent_Identity=46.875, Blast_Score=479, Evalue=1e-135,
Organism=Escherichia coli, GI1790457, Length=564, Percent_Identity=48.758865248227, Blast_Score=511, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI71996708, Length=542, Percent_Identity=49.2619926199262, Blast_Score=499, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71996703, Length=542, Percent_Identity=49.2619926199262, Blast_Score=499, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6319673, Length=557, Percent_Identity=49.9102333931777, Blast_Score=526, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24651916, Length=540, Percent_Identity=51.6666666666667, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24651914, Length=540, Percent_Identity=51.6666666666667, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI17737445, Length=540, Percent_Identity=51.6666666666667, Blast_Score=536, Evalue=1e-152,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_PROAC (Q6A5X5)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056796.1
- ProteinModelPortal:   Q6A5X5
- SMR:   Q6A5X5
- GeneID:   2932472
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA2131
- NMPDR:   fig|267747.1.peg.2073
- HOGENOM:   HBG352954
- OMA:   HITFVQG
- ProtClustDB:   PRK00179
- BioCyc:   PACN267747:PPA2131-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 61458; Mature: 61326

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 369-369 ACT_SITE 400-400 ACT_SITE 524-524

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLIDATSTPAWGTLSGLKSRFADGPHKLRRLFDADPHRAERYTLDVADLHVDLSKNLL
CCCEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEHHHEEEHHHHHHH
TDEIRDALLELAAQMRVTERRDAMYAGEHINVTEDRAVLHTALRRSRTDELHVDGQDAVA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEECCHHHHH
DVHEVLDKIYAFADKVRSGEWKGVTGKPIRTVINVGIGGSDLGPVMAYEALKPYVKDGLE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCC
CRFISNIDPTDAAVKTADLDPETTLVIIASKTFTTLETLTNARCVRAWLLDGLVAAGAIS
EEEECCCCCCCHHEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DTEQARRDAVAKHFVAVSTALDKVEEFGIDPVNAFGFWSWVGGRYSVDSAVGTSLAVAIG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEECCHHHCCEEEEEEC
PKGFEDFLAGFHAVDEHFATAEPERNVPLFMGLLNIWYTNFWDAHSHAVLPYSQYLHRFP
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHH
AYLQQLTMESNGKSVRWDGSAVTTDTGEIFWGEPGTNGQHAFYQLIHQGTRVIPADFIAV
HHHHHHHHCCCCCEEEECCCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHH
ANPVHPTKDGGTDVHELFLSNFFAQTAALAFGKTADEVRAEGTDEAIVPARVFAGDRPTT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHCCCCCCH
SIMADELSPKVLGELIALYEHITFVQGVVWGIDSFDQWGVELGKKLALQIAPAVSGNDEA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECCCCCCCCE
LATQDPSTQGLVTWYREHRR
EECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PTLIDATSTPAWGTLSGLKSRFADGPHKLRRLFDADPHRAERYTLDVADLHVDLSKNLL
CCEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEHHHEEEHHHHHHH
TDEIRDALLELAAQMRVTERRDAMYAGEHINVTEDRAVLHTALRRSRTDELHVDGQDAVA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEECCHHHHH
DVHEVLDKIYAFADKVRSGEWKGVTGKPIRTVINVGIGGSDLGPVMAYEALKPYVKDGLE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCC
CRFISNIDPTDAAVKTADLDPETTLVIIASKTFTTLETLTNARCVRAWLLDGLVAAGAIS
EEEECCCCCCCHHEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DTEQARRDAVAKHFVAVSTALDKVEEFGIDPVNAFGFWSWVGGRYSVDSAVGTSLAVAIG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEECCHHHCCEEEEEEC
PKGFEDFLAGFHAVDEHFATAEPERNVPLFMGLLNIWYTNFWDAHSHAVLPYSQYLHRFP
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHH
AYLQQLTMESNGKSVRWDGSAVTTDTGEIFWGEPGTNGQHAFYQLIHQGTRVIPADFIAV
HHHHHHHHCCCCCEEEECCCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHH
ANPVHPTKDGGTDVHELFLSNFFAQTAALAFGKTADEVRAEGTDEAIVPARVFAGDRPTT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHCCCCCCH
SIMADELSPKVLGELIALYEHITFVQGVVWGIDSFDQWGVELGKKLALQIAPAVSGNDEA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECCCCCCCCE
LATQDPSTQGLVTWYREHRR
EECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA