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The map label for this gene is oxyR [H]

Identifier: 50843438

GI number: 50843438

Start: 2162709

End: 2163653

Strand: Direct

Name: oxyR [H]

Synonym: PPA1991

Alternate gene names: 50843438

Gene position: 2162709-2163653 (Clockwise)

Preceding gene: 50843437

Following gene: 50843443

Centisome position: 84.47

GC content: 63.17

Gene sequence:

>945_bases
GTGAACCTTCATGATCTGCGGTATTTCGTCGCCCTGGCCGAAGAACACCACTTCGGCCGGGCTGCGGCGTCATGCGGTGT
CAGCCAGCCCACCCTCTCAACTCAAATCCACCGGCTCGAGAACGAGCTCGGCGTGGTGCTGGCCGTGAGGGTGGGACGAC
GCATCGAGATCACCCCAGTGGGGGAACGCATCGCCCAAGCTGCCCGTGACATGTTGGTGCTATCCGACGACATCCGGACC
ATGGCGCGGGAGGAAGCCGACCGGATGACCCTCCAGCTGAGGGTCGGGGTATTCCCCACCTTAGGGCCGTTCGTGTTGCC
TCAGGTGATCGCCCGATGTGACCAGCACGAGCCTGGCGTGAACATCCATATCGTCGAGAAGCGCACGGCAGAGCTGTTGG
AGGCAATCCGCAACGGACAGTTAGACGTCGCCGCAGTGGCAGCCCCCGTTAATGATGACTCTTTGGTGACTATTCCCGTT
TTTCGGGAGGAGTTCTTGCTCGTGACGGGGGCTGACGATGAGTTGGCCCGTGAGGAACGACCAATCAATCCGCACGACGT
TCCCACCGAAGGGCTCATCCTCATGTCGGAGGGACACTGTCTAAGAGACCAGGTGCTTGAGGTGTGCAGCCCGTCTCATC
CGCTGCCTCCCGACACCCTCACGGCGGGATCCCTCGAGACGCTCCGCGAACTCGTATCGGTGGGCGCCGGTCAAACCCTC
ATGCCGCGCAGTGCGATCTCGGCACCACTTCATGCGGACCCGCGCATCGTGGTGCGGGAGTTCACCCACCCCAGACCCCA
CCGCGACATCGTGGTGGCTGGCAGACCGGCCACAATGCACCGTCCGGCGGTGCAGACCCTGACCACCATCCTGCGGCAGC
TACCAGGTGACGTCGTCGAGCCTCTCGGCGTTGCCGGAGCATCGTTGTGCTCTCACGGGATGTGA

Upstream 100 bases:

>100_bases
GTACAAGCAGATCATCATCTCGATGGGGGCCGGCGCCACCGCTGCTCTAGGCGCCTTCGACCACCTCATCCGTCAAAATC
CGACACAGAACTGAGGCCGT

Downstream 100 bases:

>100_bases
TGACAACGTGGTGCGTGCCCCGGCACGATCACCTCACAACACCAGACCAGGCAGGTAGTTGGCAGCCTTCGGGTATTCCC
GAACAATGTCCTCCACCTTG

Product: oxidative stress transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MNLHDLRYFVALAEEHHFGRAAASCGVSQPTLSTQIHRLENELGVVLAVRVGRRIEITPVGERIAQAARDMLVLSDDIRT
MAREEADRMTLQLRVGVFPTLGPFVLPQVIARCDQHEPGVNIHIVEKRTAELLEAIRNGQLDVAAVAAPVNDDSLVTIPV
FREEFLLVTGADDELAREERPINPHDVPTEGLILMSEGHCLRDQVLEVCSPSHPLPPDTLTAGSLETLRELVSVGAGQTL
MPRSAISAPLHADPRIVVREFTHPRPHRDIVVAGRPATMHRPAVQTLTTILRQLPGDVVEPLGVAGASLCSHGM

Sequences:

>Translated_314_residues
MNLHDLRYFVALAEEHHFGRAAASCGVSQPTLSTQIHRLENELGVVLAVRVGRRIEITPVGERIAQAARDMLVLSDDIRT
MAREEADRMTLQLRVGVFPTLGPFVLPQVIARCDQHEPGVNIHIVEKRTAELLEAIRNGQLDVAAVAAPVNDDSLVTIPV
FREEFLLVTGADDELAREERPINPHDVPTEGLILMSEGHCLRDQVLEVCSPSHPLPPDTLTAGSLETLRELVSVGAGQTL
MPRSAISAPLHADPRIVVREFTHPRPHRDIVVAGRPATMHRPAVQTLTTILRQLPGDVVEPLGVAGASLCSHGM
>Mature_314_residues
MNLHDLRYFVALAEEHHFGRAAASCGVSQPTLSTQIHRLENELGVVLAVRVGRRIEITPVGERIAQAARDMLVLSDDIRT
MAREEADRMTLQLRVGVFPTLGPFVLPQVIARCDQHEPGVNIHIVEKRTAELLEAIRNGQLDVAAVAAPVNDDSLVTIPV
FREEFLLVTGADDELAREERPINPHDVPTEGLILMSEGHCLRDQVLEVCSPSHPLPPDTLTAGSLETLRELVSVGAGQTL
MPRSAISAPLHADPRIVVREFTHPRPHRDIVVAGRPATMHRPAVQTLTTILRQLPGDVVEPLGVAGASLCSHGM

Specific function: Required for the induction of a regulon of hydrogen peroxide inducible genes such as catalase and glutathione- reductase [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=293, Percent_Identity=36.8600682593857, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI157672245, Length=238, Percent_Identity=31.5126050420168, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788887, Length=181, Percent_Identity=36.4640883977901, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787879, Length=252, Percent_Identity=30.1587301587302, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790208, Length=293, Percent_Identity=25.938566552901, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787806, Length=253, Percent_Identity=25.296442687747, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788748, Length=303, Percent_Identity=25.4125412541254, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082132, Length=255, Percent_Identity=26.2745098039216, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787530, Length=261, Percent_Identity=25.6704980842912, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI145693105, Length=181, Percent_Identity=27.6243093922652, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI2367136, Length=247, Percent_Identity=28.7449392712551, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788481, Length=252, Percent_Identity=23.015873015873, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787601, Length=143, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87081904, Length=145, Percent_Identity=28.2758620689655, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI145693193, Length=261, Percent_Identity=23.7547892720307, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34248; Mature: 34248

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLHDLRYFVALAEEHHFGRAAASCGVSQPTLSTQIHRLENELGVVLAVRVGRRIEITPV
CCHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHCEEEEEECCCEEEEEEH
GERIAQAARDMLVLSDDIRTMAREEADRMTLQLRVGVFPTLGPFVLPQVIARCDQHEPGV
HHHHHHHHHHHEEHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCC
NIHIVEKRTAELLEAIRNGQLDVAAVAAPVNDDSLVTIPVFREEFLLVTGADDELAREER
EEEEECHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEECCEEEEEECCCHHHHHHCC
PINPHDVPTEGLILMSEGHCLRDQVLEVCSPSHPLPPDTLTAGSLETLRELVSVGAGQTL
CCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
MPRSAISAPLHADPRIVVREFTHPRPHRDIVVAGRPATMHRPAVQTLTTILRQLPGDVVE
CCHHHHCCCCCCCCCCEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHH
PLGVAGASLCSHGM
HHHHHHHHHHHCCC
>Mature Secondary Structure
MNLHDLRYFVALAEEHHFGRAAASCGVSQPTLSTQIHRLENELGVVLAVRVGRRIEITPV
CCHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHCEEEEEECCCEEEEEEH
GERIAQAARDMLVLSDDIRTMAREEADRMTLQLRVGVFPTLGPFVLPQVIARCDQHEPGV
HHHHHHHHHHHEEHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCC
NIHIVEKRTAELLEAIRNGQLDVAAVAAPVNDDSLVTIPVFREEFLLVTGADDELAREER
EEEEECHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEECCEEEEEECCCHHHHHHCC
PINPHDVPTEGLILMSEGHCLRDQVLEVCSPSHPLPPDTLTAGSLETLRELVSVGAGQTL
CCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
MPRSAISAPLHADPRIVVREFTHPRPHRDIVVAGRPATMHRPAVQTLTTILRQLPGDVVE
CCHHHHCCCCCCCCCCEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHH
PLGVAGASLCSHGM
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 8890216 [H]