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The map label for this gene is nuoD

Identifier: 50843383

GI number: 50843383

Start: 2094636

End: 2095937

Strand: Reverse

Name: nuoD

Synonym: PPA1933

Alternate gene names: 50843383

Gene position: 2095937-2094636 (Counterclockwise)

Preceding gene: 50843384

Following gene: 50843382

Centisome position: 81.86

GC content: 59.22

Gene sequence:

>1302_bases
ATGAGCGAGAATCACGAGTACTTGTCCCAGGGCGGCGACTGGGCCCAGATCGTTGATGAGGCTGCCGAGCGAGGCGACGA
GACCGTCGTCGTGAATTTCGGGCCTTCCCACCCGTCCACTCACGGTGTCATGAGGCTCATCATTGAGCTTGATGGCGAGT
CAGTGTCAGACCTGCGAGTCGGGATTGGATTCCTCCACACCGGTATCGAAAAGAACATGGAATTTCGCACCTGGACTCAG
GGCGTCACCTTCATGACCCGGTGCAACTATGTTGCGAACTTCTTCAACGAGTTGGTGTATTGCCTGGCGGTCGAGAAACT
GCTCGGTATTACCGACGATGTCCCCGAGCGTGCTCGCGTACTTCGGGTCATGATTACCGAGTTGAACCGCATTTCATCCC
ACCTCATTGCGGTGGGTACTGGCGGTCTGGAGCTTGGTGCTTCCTCGGTGGCTGAGGTTGGCCTGAGGGAACGCGAGATC
ATTCTGGAGTTCAACCAGGCCGTCACTGGTCTGCGCATGAACAACGCGTGGATTCGTCCTGGCGGCGTCGCTACCGACCT
GCCCGAGACCGGGCTCGACCAGTTGCGTGACCTCATCAAGCGGATGGAAAAGTACCTCCCCGAGATCGGTCAGTTCTGCA
ATGAGAATCCGATCTTTAAGGCCCGCACTCAGGGCATTGGTTACGCTGATCTGTCTACCTGTATGGCCCTGGGAGTTACT
GGTCCTGCTCTGCGCGCTACCGGCCTGCCGTGGGACCTGCGCAAGACCCAGCCCTATTGCGATTACGACACGTATGACTT
CGACGTCGCCACCTGGGATACCTGTGACTGTTACGGGCGTTTCCGCATCCGCCTGGAAGAGATGGACCAGTCGGTGCGCA
TTCTCAAGCAATGCCTCAAACGCCTCGAGGACACCCAGGGTGACCGTCATATGGTCGAGGACCCGCACATCGCATGGCCG
GCTGAGCTAGCTTTGGGCCCCGACGGTCAGGGCAATTCTAATGAGCACATTCGCCATATCATGGGCGAGTCGATGGAAGC
TCTCATCCATCACTTCAAGATTGTCACCGAGGGCTTCCGGGTGCCTGCTGGCCAGGTGTACCAGGCCATTGAGGGAGCCG
GCGGCGAGCTCGGCTGCCACCTTGTTTCTGACGGTGGCGTCCGGCCTTACCGCTCCCACCTGCGCGATCCCGGATTCGTC
AACGTGCAGTCCCTGCCCGCCATGTGTGAGGGCGGAATGCTTTCTGACGTGGTGCCGTCTCTGGCATCCTTGGACCCCGT
CATGGGAGGAGTCGACCGATGA

Upstream 100 bases:

>100_bases
TCGGCCATCCGCAGCGCAAGGACTACCCGCTTGGCGGTATCCCGATCGAGTACAAGGGTGCCGTCGTGCCACCGCCGGAC
CAGCGCAGGAGCTACAACTG

Downstream 100 bases:

>100_bases
GCGATCGCGAACCCGTCAACCTGGGATACCCCTACGTCGAGTCTTTCCACTCGGACTTCTCGGGGACCGGCGGAGTCGAT
CAGACCGACCGTTCTACCAA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MSENHEYLSQGGDWAQIVDEAAERGDETVVVNFGPSHPSTHGVMRLIIELDGESVSDLRVGIGFLHTGIEKNMEFRTWTQ
GVTFMTRCNYVANFFNELVYCLAVEKLLGITDDVPERARVLRVMITELNRISSHLIAVGTGGLELGASSVAEVGLREREI
ILEFNQAVTGLRMNNAWIRPGGVATDLPETGLDQLRDLIKRMEKYLPEIGQFCNENPIFKARTQGIGYADLSTCMALGVT
GPALRATGLPWDLRKTQPYCDYDTYDFDVATWDTCDCYGRFRIRLEEMDQSVRILKQCLKRLEDTQGDRHMVEDPHIAWP
AELALGPDGQGNSNEHIRHIMGESMEALIHHFKIVTEGFRVPAGQVYQAIEGAGGELGCHLVSDGGVRPYRSHLRDPGFV
NVQSLPAMCEGGMLSDVVPSLASLDPVMGGVDR

Sequences:

>Translated_433_residues
MSENHEYLSQGGDWAQIVDEAAERGDETVVVNFGPSHPSTHGVMRLIIELDGESVSDLRVGIGFLHTGIEKNMEFRTWTQ
GVTFMTRCNYVANFFNELVYCLAVEKLLGITDDVPERARVLRVMITELNRISSHLIAVGTGGLELGASSVAEVGLREREI
ILEFNQAVTGLRMNNAWIRPGGVATDLPETGLDQLRDLIKRMEKYLPEIGQFCNENPIFKARTQGIGYADLSTCMALGVT
GPALRATGLPWDLRKTQPYCDYDTYDFDVATWDTCDCYGRFRIRLEEMDQSVRILKQCLKRLEDTQGDRHMVEDPHIAWP
AELALGPDGQGNSNEHIRHIMGESMEALIHHFKIVTEGFRVPAGQVYQAIEGAGGELGCHLVSDGGVRPYRSHLRDPGFV
NVQSLPAMCEGGMLSDVVPSLASLDPVMGGVDR
>Mature_432_residues
SENHEYLSQGGDWAQIVDEAAERGDETVVVNFGPSHPSTHGVMRLIIELDGESVSDLRVGIGFLHTGIEKNMEFRTWTQG
VTFMTRCNYVANFFNELVYCLAVEKLLGITDDVPERARVLRVMITELNRISSHLIAVGTGGLELGASSVAEVGLREREII
LEFNQAVTGLRMNNAWIRPGGVATDLPETGLDQLRDLIKRMEKYLPEIGQFCNENPIFKARTQGIGYADLSTCMALGVTG
PALRATGLPWDLRKTQPYCDYDTYDFDVATWDTCDCYGRFRIRLEEMDQSVRILKQCLKRLEDTQGDRHMVEDPHIAWPA
ELALGPDGQGNSNEHIRHIMGESMEALIHHFKIVTEGFRVPAGQVYQAIEGAGGELGCHLVSDGGVRPYRSHLRDPGFVN
VQSLPAMCEGGMLSDVVPSLASLDPVMGGVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=416, Percent_Identity=41.5865384615385, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI260898743, Length=401, Percent_Identity=41.645885286783, Blast_Score=302, Evalue=5e-82,
Organism=Escherichia coli, GI145693162, Length=417, Percent_Identity=37.6498800959233, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1789076, Length=435, Percent_Identity=25.0574712643678, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788832, Length=307, Percent_Identity=26.7100977198697, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17555284, Length=413, Percent_Identity=38.9830508474576, Blast_Score=308, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI17568379, Length=413, Percent_Identity=38.7409200968523, Blast_Score=306, Evalue=1e-83,
Organism=Drosophila melanogaster, GI221459469, Length=411, Percent_Identity=41.6058394160584, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI24638644, Length=411, Percent_Identity=41.1192214111922, Blast_Score=323, Evalue=1e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_PROAC (Q6A6G1)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056610.1
- HSSP:   Q56220
- ProteinModelPortal:   Q6A6G1
- SMR:   Q6A6G1
- GeneID:   2931269
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1933
- NMPDR:   fig|267747.1.peg.1887
- HOGENOM:   HBG459705
- OMA:   SEIHRIC
- ProtClustDB:   PRK06075
- BioCyc:   PACN267747:PPA1933-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 47983; Mature: 47852

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENHEYLSQGGDWAQIVDEAAERGDETVVVNFGPSHPSTHGVMRLIIELDGESVSDLRV
CCCCHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHEEEEEEECCCCHHHHHH
GIGFLHTGIEKNMEFRTWTQGVTFMTRCNYVANFFNELVYCLAVEKLLGITDDVPERARV
HHHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LRVMITELNRISSHLIAVGTGGLELGASSVAEVGLREREIILEFNQAVTGLRMNNAWIRP
HHHHHHHHHHHHHHEEEEECCCHHHCHHHHHHHCCCHHHHHHHHHHHHHCEEECCCEECC
GGVATDLPETGLDQLRDLIKRMEKYLPEIGQFCNENPIFKARTQGIGYADLSTCMALGVT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHCCC
GPALRATGLPWDLRKTQPYCDYDTYDFDVATWDTCDCYGRFRIRLEEMDQSVRILKQCLK
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEHHHHHHHHHHHHHHHH
RLEDTQGDRHMVEDPHIAWPAELALGPDGQGNSNEHIRHIMGESMEALIHHFKIVTEGFR
HHHHCCCCCCCCCCCCCCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
VPAGQVYQAIEGAGGELGCHLVSDGGVRPYRSHLRDPGFVNVQSLPAMCEGGMLSDVVPS
CCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHCCCCCCEEHHHCHHHHCCCCHHHHHHH
LASLDPVMGGVDR
HHHHHHHHCCCCC
>Mature Secondary Structure 
SENHEYLSQGGDWAQIVDEAAERGDETVVVNFGPSHPSTHGVMRLIIELDGESVSDLRV
CCCHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHEEEEEEECCCCHHHHHH
GIGFLHTGIEKNMEFRTWTQGVTFMTRCNYVANFFNELVYCLAVEKLLGITDDVPERARV
HHHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LRVMITELNRISSHLIAVGTGGLELGASSVAEVGLREREIILEFNQAVTGLRMNNAWIRP
HHHHHHHHHHHHHHEEEEECCCHHHCHHHHHHHCCCHHHHHHHHHHHHHCEEECCCEECC
GGVATDLPETGLDQLRDLIKRMEKYLPEIGQFCNENPIFKARTQGIGYADLSTCMALGVT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHCCC
GPALRATGLPWDLRKTQPYCDYDTYDFDVATWDTCDCYGRFRIRLEEMDQSVRILKQCLK
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEHHHHHHHHHHHHHHHH
RLEDTQGDRHMVEDPHIAWPAELALGPDGQGNSNEHIRHIMGESMEALIHHFKIVTEGFR
HHHHCCCCCCCCCCCCCCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
VPAGQVYQAIEGAGGELGCHLVSDGGVRPYRSHLRDPGFVNVQSLPAMCEGGMLSDVVPS
CCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHCCCCCCEEHHHCHHHHCCCCHHHHHHH
LASLDPVMGGVDR
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA