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The map label for this gene is nuoF [H]

Identifier: 50843381

GI number: 50843381

Start: 2092523

End: 2093857

Strand: Reverse

Name: nuoF [H]

Synonym: PPA1931

Alternate gene names: 50843381

Gene position: 2093857-2092523 (Counterclockwise)

Preceding gene: 50843382

Following gene: 50843380

Centisome position: 81.78

GC content: 61.42

Gene sequence:

>1335_bases
GTGACCGATCCACTGACCCCGGTTCTGTCGGCCAATTGGGATGAAGAGCGCAGTTGGAAGCTGCTTAACTACGAGCGACA
GGGCGGATACACCGGCCTTCGTAAGGCTTTGACGATGCCGCCTGACGACGTTGTCTCGCTGGTTAAGGACGCTAACCTGC
GTGGCCGTGGTGGCGCCGGGTTCCCCACCGGCATGAAGTGGTCCTTCGTGCCTAAGGACAATCCCAACCCGACCTACCTC
GTTGTCAACGGCGACGAGTCTGAGCCGGGCACGTGCAAGGACATGCCGCTCATGATGGCCTCCCCGCACACCCTCGTCGA
GGGCGTCATCATTGCCTCCTACGCCATCAAGGCCAAGATGGCCTTCATCTACATCCGCGGTGAGGTGCTGCACGTCGTCC
GACGCGTGCAGCAGGCCGTGCGGGAGGCCTACTCGGCTGGTTACATTGGCAAAAACATCCTCGGTTCCGGGTACGACCTT
GACGTTGTCGTCCATGCCGGCGCAGGCGCCTACATCTGTGGCGAGGAGACGGCTCTGCTGGATTCCTTGGAGGGGCGTCG
TGGTCAGCCTCGTCTGCGCCCGCCTTTCCCGGCCGTTGCCGGCCTGTACGCCAGTCCGACGGTCATTAACAACGTCGAGT
CCATCTCGACGGTGCCGTCGATCCTGCGCAACGGCAAGGAATGGTTCAAGTCCATGGGCACCGAGAAGTCCGATGGTTTC
ACCATCTACTCTTTGTCTGGGCACTTGGCTCACCCTGGGCAGTATGAGGCCCCGATGGGCACTACGCTGCGTCAGCTCCT
CGACATCTCCGGTGGCATGCGACAGGGACATGAACTGAAGTTCTTCACCCCCGGTGGTTCCTCGACCCCGATCCTGACCA
AGGACGACATCGACCTCCCGCTCGACTACGAGGGGATGGCTGGGGCCAAGACGATGCTCGGCACGAAAGCTCTGCAGTGC
TTCGACGAGACGACCTCGGTGGTTCGCGTCACGTTGCGGTGGTTGGAGTTTTACAAGCACGAATCCTGCGGTAAATGCAC
CCCGTGCCGTGAGGGCACCTGGTGGGTTGTCCAGATGTTGCGTCGCATCGAGGCTGGTGAGGGCCAAGAGGGTGACGTCG
ACAAGTTGATGGACATTGCCGACAATATCGGTGGCCGTTCTTTCTGCGCTTTGGCCGACGGTGCCGTGGGCTGTTTGCGC
GGGGCTATTGGCCACTTCCGTGACGAGTTCGAAGCTGGATGTCGGGGGATTCCCGCTTGGCAGTATCTGCCCTATGAGCG
CAGCTCGATCTTCAACGACGCCGATCGCCGAGTCCTGGAGGGGGCCGGAGCATGA

Upstream 100 bases:

>100_bases
CATCTCTGCAGGGTGTCCGGCTAGCTAAGCAGAGCGGCTGGAAGGCTCCAGATCCGAATAACCTGCCCGCTCCCGCTGAG
CCCGTGGAAGAGGAGAAGAA

Downstream 100 bases:

>100_bases
GCGAAAACAAGCCCGTCGAACTCGTGACGTGCACCATCGACGGTCAGCAGGTGAGCGTACCCAAGGGGACCCTCATTATT
CGCGCTGCCGAATCCATCGG

Product: NADH dehydrogenase I chain F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTDPLTPVLSANWDEERSWKLLNYERQGGYTGLRKALTMPPDDVVSLVKDANLRGRGGAGFPTGMKWSFVPKDNPNPTYL
VVNGDESEPGTCKDMPLMMASPHTLVEGVIIASYAIKAKMAFIYIRGEVLHVVRRVQQAVREAYSAGYIGKNILGSGYDL
DVVVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYASPTVINNVESISTVPSILRNGKEWFKSMGTEKSDGF
TIYSLSGHLAHPGQYEAPMGTTLRQLLDISGGMRQGHELKFFTPGGSSTPILTKDDIDLPLDYEGMAGAKTMLGTKALQC
FDETTSVVRVTLRWLEFYKHESCGKCTPCREGTWWVVQMLRRIEAGEGQEGDVDKLMDIADNIGGRSFCALADGAVGCLR
GAIGHFRDEFEAGCRGIPAWQYLPYERSSIFNDADRRVLEGAGA

Sequences:

>Translated_444_residues
MTDPLTPVLSANWDEERSWKLLNYERQGGYTGLRKALTMPPDDVVSLVKDANLRGRGGAGFPTGMKWSFVPKDNPNPTYL
VVNGDESEPGTCKDMPLMMASPHTLVEGVIIASYAIKAKMAFIYIRGEVLHVVRRVQQAVREAYSAGYIGKNILGSGYDL
DVVVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYASPTVINNVESISTVPSILRNGKEWFKSMGTEKSDGF
TIYSLSGHLAHPGQYEAPMGTTLRQLLDISGGMRQGHELKFFTPGGSSTPILTKDDIDLPLDYEGMAGAKTMLGTKALQC
FDETTSVVRVTLRWLEFYKHESCGKCTPCREGTWWVVQMLRRIEAGEGQEGDVDKLMDIADNIGGRSFCALADGAVGCLR
GAIGHFRDEFEAGCRGIPAWQYLPYERSSIFNDADRRVLEGAGA
>Mature_443_residues
TDPLTPVLSANWDEERSWKLLNYERQGGYTGLRKALTMPPDDVVSLVKDANLRGRGGAGFPTGMKWSFVPKDNPNPTYLV
VNGDESEPGTCKDMPLMMASPHTLVEGVIIASYAIKAKMAFIYIRGEVLHVVRRVQQAVREAYSAGYIGKNILGSGYDLD
VVVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYASPTVINNVESISTVPSILRNGKEWFKSMGTEKSDGFT
IYSLSGHLAHPGQYEAPMGTTLRQLLDISGGMRQGHELKFFTPGGSSTPILTKDDIDLPLDYEGMAGAKTMLGTKALQCF
DETTSVVRVTLRWLEFYKHESCGKCTPCREGTWWVVQMLRRIEAGEGQEGDVDKLMDIADNIGGRSFCALADGAVGCLRG
AIGHFRDEFEAGCRGIPAWQYLPYERSSIFNDADRRVLEGAGA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=397, Percent_Identity=45.8438287153652, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI20149568, Length=397, Percent_Identity=45.8438287153652, Blast_Score=371, Evalue=1e-103,
Organism=Escherichia coli, GI1788620, Length=443, Percent_Identity=46.0496613995485, Blast_Score=397, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17531727, Length=397, Percent_Identity=44.080604534005, Blast_Score=353, Evalue=8e-98,
Organism=Drosophila melanogaster, GI19920794, Length=397, Percent_Identity=46.8513853904282, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI45550452, Length=397, Percent_Identity=43.5768261964735, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24653819, Length=399, Percent_Identity=32.5814536340852, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24653817, Length=352, Percent_Identity=32.1022727272727, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48518; Mature: 48387

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPLTPVLSANWDEERSWKLLNYERQGGYTGLRKALTMPPDDVVSLVKDANLRGRGGAG
CCCCCCCHHCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC
FPTGMKWSFVPKDNPNPTYLVVNGDESEPGTCKDMPLMMASPHTLVEGVIIASYAIKAKM
CCCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHEEEE
AFIYIRGEVLHVVRRVQQAVREAYSAGYIGKNILGSGYDLDVVVHAGAGAYICGEETALL
EEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCEEEECCHHHHH
DSLEGRRGQPRLRPPFPAVAGLYASPTVINNVESISTVPSILRNGKEWFKSMGTEKSDGF
HHHCCCCCCCCCCCCCHHHHCCCCCCHHHHCHHHHHHHHHHHHCHHHHHHHCCCCCCCCE
TIYSLSGHLAHPGQYEAPMGTTLRQLLDISGGMRQGHELKFFTPGGSSTPILTKDDIDLP
EEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEECCCCCCC
LDYEGMAGAKTMLGTKALQCFDETTSVVRVTLRWLEFYKHESCGKCTPCREGTWWVVQML
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
RRIEAGEGQEGDVDKLMDIADNIGGRSFCALADGAVGCLRGAIGHFRDEFEAGCRGIPAW
HHHHCCCCCCCCHHHHHHHHHCCCCCEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC
QYLPYERSSIFNDADRRVLEGAGA
CCCCCHHHHHHCHHHHHHHHCCCC
>Mature Secondary Structure 
TDPLTPVLSANWDEERSWKLLNYERQGGYTGLRKALTMPPDDVVSLVKDANLRGRGGAG
CCCCCCHHCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC
FPTGMKWSFVPKDNPNPTYLVVNGDESEPGTCKDMPLMMASPHTLVEGVIIASYAIKAKM
CCCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHEEEE
AFIYIRGEVLHVVRRVQQAVREAYSAGYIGKNILGSGYDLDVVVHAGAGAYICGEETALL
EEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCEEEECCHHHHH
DSLEGRRGQPRLRPPFPAVAGLYASPTVINNVESISTVPSILRNGKEWFKSMGTEKSDGF
HHHCCCCCCCCCCCCCHHHHCCCCCCHHHHCHHHHHHHHHHHHCHHHHHHHCCCCCCCCE
TIYSLSGHLAHPGQYEAPMGTTLRQLLDISGGMRQGHELKFFTPGGSSTPILTKDDIDLP
EEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEECCCCCCC
LDYEGMAGAKTMLGTKALQCFDETTSVVRVTLRWLEFYKHESCGKCTPCREGTWWVVQML
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
RRIEAGEGQEGDVDKLMDIADNIGGRSFCALADGAVGCLRGAIGHFRDEFEAGCRGIPAW
HHHHCCCCCCCCHHHHHHHHHCCCCCEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC
QYLPYERSSIFNDADRRVLEGAGA
CCCCCHHHHHHCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]