Click here to switch to the map view.

The map label for this gene is ribD [H]

Identifier: 50843212

GI number: 50843212

Start: 1912584

End: 1913579

Strand: Reverse

Name: ribD [H]

Synonym: PPA1752

Alternate gene names: 50843212

Gene position: 1913579-1912584 (Counterclockwise)

Preceding gene: 50843213

Following gene: 50843211

Centisome position: 74.74

GC content: 66.37

Gene sequence:

>996_bases
ATGGATCAGCGATGGGACGACGCTATGGCGCTCGCCTTGGATATGGCCGCGAAATCACCATGCCCGGATCCGAACCCGCG
TGTCGGCTGTGTCATTGTCGCTGAGGACCGGGTGATAGGTCAGGGTTGGCACCGCGGAGCGGGAACTCCACACGCTGAGG
TGGAGGCACTGCGCCAGGCTGGCGATGATGCCAGGGGAGCCACCGCCGTCGTCACCTTGGAGCCCTGTCATCACACCGGG
CGTACCGGACCGTGCAGCCATGCCCTGGTCGACGCCGGGATTGCCCGGGTTGTCATCGCCCAGTCGGATCCCAACCCGGT
GGCATCCGGGGGAGAACAGTGGCTGCGTACCCACGGCGTCGAGGTGGTCACCGGGGTTCTTTCCGAGGAAGCCACAGCCC
TCAACGCCGATTGGACCTTCAGCCAGATCCACCGACGCCCCCGGGTGTGCTGGAAGTACGCCGCGAGCCTCGACGGACGC
AGCGCTGCCCCCGACGGAACCAGCCAGTGGATCACCGGGGAACAGGCCCGCCACCAGGTGCAGCTCGGCCGGGCTCGGTG
CGGGGCGATCATCGTCGGCACCGGAACTGCCTTGGCCGATAACCCGAGGCTGACGGTTCGGCTGCCCGGCGTCACCCACC
AACCCCTACGAGTCGTGGTGGGCATGCGAGAACCGCCTGCTGGGTGTCATTTGCGTGACGACTCGGCCTCGACCTTGCAC
ATTCCCAGCCACGACCCTGCTGAGGTGCTGGACCTCCTGTGGTGCCGCGGTGTTCACCGTGTCTGGCTGGAGGGCGGACC
ACAACTGGCCGGAGCCTTCCTCGCGGCCAACCTGGTCGACGAGGTCATCGCCCACATGGCACCGACGGTGTTGGGAGACG
GTCGAGCAGCAGTCGTCGACCCCACCGTCGCCACTTTGTCCCAGGCACACCACTTCGTCATCGACGACGTGACCCAGTTG
GGCCCCGACATCCAGATTCACGCACATCATGAGTGA

Upstream 100 bases:

>100_bases
AAAGTCCGGATGGGAGGTAGCACGGAAAGTGGCTGGCGTCGCCGTCAGCCCTGTGTGTCGTCCTTGCGCACCCCCGGAGC
CGCAACAGCTCAGGAGGACC

Downstream 100 bases:

>100_bases
GGAGACCATGTTCACCGGAATCATCGAGGAAATCGGCGAGGTGCTCGCCATCGAGAAGGGACGGGACTCCGCCCGACTCG
CCATCCGCGGGCCGCTGGTC

Product: riboflavin biosynthesis protein RibD

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MDQRWDDAMALALDMAAKSPCPDPNPRVGCVIVAEDRVIGQGWHRGAGTPHAEVEALRQAGDDARGATAVVTLEPCHHTG
RTGPCSHALVDAGIARVVIAQSDPNPVASGGEQWLRTHGVEVVTGVLSEEATALNADWTFSQIHRRPRVCWKYAASLDGR
SAAPDGTSQWITGEQARHQVQLGRARCGAIIVGTGTALADNPRLTVRLPGVTHQPLRVVVGMREPPAGCHLRDDSASTLH
IPSHDPAEVLDLLWCRGVHRVWLEGGPQLAGAFLAANLVDEVIAHMAPTVLGDGRAAVVDPTVATLSQAHHFVIDDVTQL
GPDIQIHAHHE

Sequences:

>Translated_331_residues
MDQRWDDAMALALDMAAKSPCPDPNPRVGCVIVAEDRVIGQGWHRGAGTPHAEVEALRQAGDDARGATAVVTLEPCHHTG
RTGPCSHALVDAGIARVVIAQSDPNPVASGGEQWLRTHGVEVVTGVLSEEATALNADWTFSQIHRRPRVCWKYAASLDGR
SAAPDGTSQWITGEQARHQVQLGRARCGAIIVGTGTALADNPRLTVRLPGVTHQPLRVVVGMREPPAGCHLRDDSASTLH
IPSHDPAEVLDLLWCRGVHRVWLEGGPQLAGAFLAANLVDEVIAHMAPTVLGDGRAAVVDPTVATLSQAHHFVIDDVTQL
GPDIQIHAHHE
>Mature_331_residues
MDQRWDDAMALALDMAAKSPCPDPNPRVGCVIVAEDRVIGQGWHRGAGTPHAEVEALRQAGDDARGATAVVTLEPCHHTG
RTGPCSHALVDAGIARVVIAQSDPNPVASGGEQWLRTHGVEVVTGVLSEEATALNADWTFSQIHRRPRVCWKYAASLDGR
SAAPDGTSQWITGEQARHQVQLGRARCGAIIVGTGTALADNPRLTVRLPGVTHQPLRVVVGMREPPAGCHLRDDSASTLH
IPSHDPAEVLDLLWCRGVHRVWLEGGPQLAGAFLAANLVDEVIAHMAPTVLGDGRAAVVDPTVATLSQAHHFVIDDVTQL
GPDIQIHAHHE

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=357, Percent_Identity=40.8963585434174, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI145693172, Length=143, Percent_Identity=37.0629370629371, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 35237; Mature: 35237

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQRWDDAMALALDMAAKSPCPDPNPRVGCVIVAEDRVIGQGWHRGAGTPHAEVEALRQA
CCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCHHHHHHHHHC
GDDARGATAVVTLEPCHHTGRTGPCSHALVDAGIARVVIAQSDPNPVASGGEQWLRTHGV
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHCCH
EVVTGVLSEEATALNADWTFSQIHRRPRVCWKYAASLDGRSAAPDGTSQWITGEQARHQV
HHHHHHHHCCCEEECCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
QLGRARCGAIIVGTGTALADNPRLTVRLPGVTHQPLRVVVGMREPPAGCHLRDDSASTLH
HHHHHHCCEEEEECCCEECCCCEEEEECCCCCCCCEEEEEECCCCCCCCEEECCCCCEEE
IPSHDPAEVLDLLWCRGVHRVWLEGGPQLAGAFLAANLVDEVIAHMAPTVLGDGRAAVVD
CCCCCHHHHHHHHHHCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEC
PTVATLSQAHHFVIDDVTQLGPDIQIHAHHE
CHHHHHHHCCHHEEHHHHHCCCCEEEEECCC
>Mature Secondary Structure
MDQRWDDAMALALDMAAKSPCPDPNPRVGCVIVAEDRVIGQGWHRGAGTPHAEVEALRQA
CCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCHHHHHHHHHC
GDDARGATAVVTLEPCHHTGRTGPCSHALVDAGIARVVIAQSDPNPVASGGEQWLRTHGV
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHCCH
EVVTGVLSEEATALNADWTFSQIHRRPRVCWKYAASLDGRSAAPDGTSQWITGEQARHQV
HHHHHHHHCCCEEECCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
QLGRARCGAIIVGTGTALADNPRLTVRLPGVTHQPLRVVVGMREPPAGCHLRDDSASTLH
HHHHHHCCEEEEECCCEECCCCEEEEECCCCCCCCEEEEEECCCCCCCCEEECCCCCEEE
IPSHDPAEVLDLLWCRGVHRVWLEGGPQLAGAFLAANLVDEVIAHMAPTVLGDGRAAVVD
CCCCCHHHHHHHHHHCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEC
PTVATLSQAHHFVIDDVTQLGPDIQIHAHHE
CHHHHHHHCCHHEEHHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]