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The map label for this gene is ribBA [H]

Identifier: 50843210

GI number: 50843210

Start: 1910667

End: 1911983

Strand: Reverse

Name: ribBA [H]

Synonym: PPA1750

Alternate gene names: 50843210

Gene position: 1911983-1910667 (Counterclockwise)

Preceding gene: 50843211

Following gene: 50843209

Centisome position: 74.68

GC content: 64.62

Gene sequence:

>1317_bases
ATGCTGAACACTATTGAGGAGGTCCTGGCTGAGCTACGTGCCGGACGACCGGTGCTCGTTACCGACGATGCCGACCGGGA
GAACGAGGGGGACGCCATCCTGGCCGCAGAACTCGCTGATCCGCGCTGGGTCGGCTGGATGGTGCGCCACACTTCCGGCT
ACTTGTGTGCACCCATGACCGAGGAAAGGGCCGATCAGCTCGATCTGCCCCTCATGTGGCCGGCGAGCCAGGACCCATTG
CGCACTCGCTACACCGTTGCTGTCGACGCGGCCCACGGGATCACCACAGGGATCGACGCCGTCCAGCGTGCCCGTACCGC
CCGGGTCCTGGCCGATCCTTCCTCCACCCCGTCGGACTTGGTGCGTCCCGGTCACGTGCTGCCTCTGCGGGCTCGGGCTG
GGGGAGTGTTGGAGAGGCGCGGCCACACTGAGGCTGCCGTCGATCTGGCGCGGCTGGCGGGTCTAGAACCTGTCGGTCTC
ATCGGTGAACTTGTCGGAGATGACGGCATGTGCCTGCGTGCTGACGCGATTGCTGATCTGGCCCGCACTGAGGGCTTGGC
TTTGACTACCATCGACCAGCTCGCCCAATGGCGTCAGGCCCATGATCCGGGCCCGGCCGTCCCGACCCAGCGAGTGACAG
CACTGGCCAGCGCTCACTTGCCGACCCGTCACGGTCAGTTCGCGATAACTGGCTACCGGGATAATTGTACCGGGGTCGAG
CATGTGCTGCTGGTAGGCGAGAAGGGAATCGACGCTGACGACGGTGGTCCCGCCTGGGTGAGGGTGCACTCGGAATGTCT
CACCGGGGACGCCTTGGGGTCGTTGCGCTGTGACTGTGGCGACCAGTTGGCGGCCGCCCAGCAGCACGTCTGCCGCCATG
GTGGGGCAATCATCCTGCTGCGTGACCATGAGGGACGTGCTACCGGCTTACTCAACAAAATTGCGGCCTACAAAGCCCAG
GATGGCGGTCTGGACACCGTCGACGCTCAGACCCACCTCGGTTTGCCCGTCGATGCCCGCGAGTACGGGGCAGCCGTCGC
AATCCTGGCGAATATTGGGATTACGAGCGTCCGGCTACTTACAAACAACCCGGCTAAAGCTGAGGCGCTGCGCGATGGGG
GACTTGAGGTGACGATGTCCCCCCTCGAGACCTCGACTCGTCCTGAGGACGAACGTTACCTGCGCACGAAACGCGATCGG
ATGGGACACGCGCTGACACTCGGCGTCAGCCCGTCCGAGATGTCCACGCAGCCCCTGGCTAGTAGCCACACGACATCCAC
CACGCCCGCCCTGACCATCAAAGGAGACCGACCATGA

Upstream 100 bases:

>100_bases
CCGGAACCGTCTTGGGGGCGCTGTCGCCCGGTGATGAGGTCAACGTCGAAGTCGACATCATTGCAAAGTACTTGGAAGCC
CTGACGAACAAGGAGAGGTC

Downstream 100 bases:

>100_bases
GTTCACGCACCACCCTCGGCCTCTCCGCACCCGACCTCAGCGGCCTCGATGGCAGCGGTCTTAAGGTTGCGGTCGTCGCA
GCCCAGTGGCACGGCACAGT

Product: riboflavin biosynthesis protein RibA

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MLNTIEEVLAELRAGRPVLVTDDADRENEGDAILAAELADPRWVGWMVRHTSGYLCAPMTEERADQLDLPLMWPASQDPL
RTRYTVAVDAAHGITTGIDAVQRARTARVLADPSSTPSDLVRPGHVLPLRARAGGVLERRGHTEAAVDLARLAGLEPVGL
IGELVGDDGMCLRADAIADLARTEGLALTTIDQLAQWRQAHDPGPAVPTQRVTALASAHLPTRHGQFAITGYRDNCTGVE
HVLLVGEKGIDADDGGPAWVRVHSECLTGDALGSLRCDCGDQLAAAQQHVCRHGGAIILLRDHEGRATGLLNKIAAYKAQ
DGGLDTVDAQTHLGLPVDAREYGAAVAILANIGITSVRLLTNNPAKAEALRDGGLEVTMSPLETSTRPEDERYLRTKRDR
MGHALTLGVSPSEMSTQPLASSHTTSTTPALTIKGDRP

Sequences:

>Translated_438_residues
MLNTIEEVLAELRAGRPVLVTDDADRENEGDAILAAELADPRWVGWMVRHTSGYLCAPMTEERADQLDLPLMWPASQDPL
RTRYTVAVDAAHGITTGIDAVQRARTARVLADPSSTPSDLVRPGHVLPLRARAGGVLERRGHTEAAVDLARLAGLEPVGL
IGELVGDDGMCLRADAIADLARTEGLALTTIDQLAQWRQAHDPGPAVPTQRVTALASAHLPTRHGQFAITGYRDNCTGVE
HVLLVGEKGIDADDGGPAWVRVHSECLTGDALGSLRCDCGDQLAAAQQHVCRHGGAIILLRDHEGRATGLLNKIAAYKAQ
DGGLDTVDAQTHLGLPVDAREYGAAVAILANIGITSVRLLTNNPAKAEALRDGGLEVTMSPLETSTRPEDERYLRTKRDR
MGHALTLGVSPSEMSTQPLASSHTTSTTPALTIKGDRP
>Mature_438_residues
MLNTIEEVLAELRAGRPVLVTDDADRENEGDAILAAELADPRWVGWMVRHTSGYLCAPMTEERADQLDLPLMWPASQDPL
RTRYTVAVDAAHGITTGIDAVQRARTARVLADPSSTPSDLVRPGHVLPLRARAGGVLERRGHTEAAVDLARLAGLEPVGL
IGELVGDDGMCLRADAIADLARTEGLALTTIDQLAQWRQAHDPGPAVPTQRVTALASAHLPTRHGQFAITGYRDNCTGVE
HVLLVGEKGIDADDGGPAWVRVHSECLTGDALGSLRCDCGDQLAAAQQHVCRHGGAIILLRDHEGRATGLLNKIAAYKAQ
DGGLDTVDAQTHLGLPVDAREYGAAVAILANIGITSVRLLTNNPAKAEALRDGGLEVTMSPLETSTRPEDERYLRTKRDR
MGHALTLGVSPSEMSTQPLASSHTTSTTPALTIKGDRP

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=48.4848484848485, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1787533, Length=197, Percent_Identity=45.1776649746193, Blast_Score=162, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6320695, Length=205, Percent_Identity=49.7560975609756, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6319438, Length=198, Percent_Identity=39.8989898989899, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 46654; Mature: 46654

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNTIEEVLAELRAGRPVLVTDDADRENEGDAILAAELADPRWVGWMVRHTSGYLCAPMT
CCCHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCCCEEEEEEECCCEEECCCC
EERADQLDLPLMWPASQDPLRTRYTVAVDAAHGITTGIDAVQRARTARVLADPSSTPSDL
HHHHHHCCCCEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHEEEECCCCCHHHH
VRPGHVLPLRARAGGVLERRGHTEAAVDLARLAGLEPVGLIGELVGDDGMCLRADAIADL
CCCCCEEEEECCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEHHHHHHH
ARTEGLALTTIDQLAQWRQAHDPGPAVPTQRVTALASAHLPTRHGQFAITGYRDNCTGVE
HHHCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCE
HVLLVGEKGIDADDGGPAWVRVHSECLTGDALGSLRCDCGDQLAAAQQHVCRHGGAIILL
EEEEECCCCCCCCCCCCEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
RDHEGRATGLLNKIAAYKAQDGGLDTVDAQTHLGLPVDAREYGAAVAILANIGITSVRLL
ECCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHHCCEEEEEECCCCEEEEEE
TNNPAKAEALRDGGLEVTMSPLETSTRPEDERYLRTKRDRMGHALTLGVSPSEMSTQPLA
ECCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
SSHTTSTTPALTIKGDRP
CCCCCCCCCEEEEECCCC
>Mature Secondary Structure
MLNTIEEVLAELRAGRPVLVTDDADRENEGDAILAAELADPRWVGWMVRHTSGYLCAPMT
CCCHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCCCEEEEEEECCCEEECCCC
EERADQLDLPLMWPASQDPLRTRYTVAVDAAHGITTGIDAVQRARTARVLADPSSTPSDL
HHHHHHCCCCEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHEEEECCCCCHHHH
VRPGHVLPLRARAGGVLERRGHTEAAVDLARLAGLEPVGLIGELVGDDGMCLRADAIADL
CCCCCEEEEECCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEHHHHHHH
ARTEGLALTTIDQLAQWRQAHDPGPAVPTQRVTALASAHLPTRHGQFAITGYRDNCTGVE
HHHCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCE
HVLLVGEKGIDADDGGPAWVRVHSECLTGDALGSLRCDCGDQLAAAQQHVCRHGGAIILL
EEEEECCCCCCCCCCCCEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
RDHEGRATGLLNKIAAYKAQDGGLDTVDAQTHLGLPVDAREYGAAVAILANIGITSVRLL
ECCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHHCCEEEEEECCCCEEEEEE
TNNPAKAEALRDGGLEVTMSPLETSTRPEDERYLRTKRDRMGHALTLGVSPSEMSTQPLA
ECCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
SSHTTSTTPALTIKGDRP
CCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA