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The map label for this gene is ribH

Identifier: 50843209

GI number: 50843209

Start: 1910170

End: 1910670

Strand: Reverse

Name: ribH

Synonym: PPA1749

Alternate gene names: 50843209

Gene position: 1910670-1910170 (Counterclockwise)

Preceding gene: 50843210

Following gene: 50843208

Centisome position: 74.63

GC content: 62.28

Gene sequence:

>501_bases
ATGAGTTCACGCACCACCCTCGGCCTCTCCGCACCCGACCTCAGCGGCCTCGATGGCAGCGGTCTTAAGGTTGCGGTCGT
CGCAGCCCAGTGGCACGGCACAGTGATGACTGGGCTACTTGACGGTGCCTTGCGCGGACTGGTCGATTCCGGAGTACACG
ACCCCGCCGTCATCCGAGTACCAGGATCCTTCGAGCTGCCGGTGGCCTGTGCCTCCTTGGCCGATCACTTTGACGCTCTC
GTCGCCCTCGGAGTGATTATCCGGGGAGGAACCCCGCACTTCGACTATGTCTGTGACGCTGCTACCCGCGGTATTACAGA
CGTCGCGGTGCGTACCAAGACCCCTATCGGTTTCGGCATTCTTACCTGTGACGATGAAGCCCAAGCCCTCGACCGTGCCG
GGCTCGAGGGATCCCACGAAGACAAGGGTTATGAGGCTGCCCAAGCAGCTATCGCTACCCTCACCGCGTTGTCCACTGCC
CTTGCGTCTGGCCCATCGTAG

Upstream 100 bases:

>100_bases
TGACACTCGGCGTCAGCCCGTCCGAGATGTCCACGCAGCCCCTGGCTAGTAGCCACACGACATCCACCACGCCCGCCCTG
ACCATCAAAGGAGACCGACC

Downstream 100 bases:

>100_bases
ACCCAGAGGGCTTAAGGTGGGGTTGTGGCCTTTCGCGTCGTCGTCCTCGTCTCAGGTACCGGAACCCTCTTGCAGTCCCT
CATCGACAACCTGCCCGAGC

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MSSRTTLGLSAPDLSGLDGSGLKVAVVAAQWHGTVMTGLLDGALRGLVDSGVHDPAVIRVPGSFELPVACASLADHFDAL
VALGVIIRGGTPHFDYVCDAATRGITDVAVRTKTPIGFGILTCDDEAQALDRAGLEGSHEDKGYEAAQAAIATLTALSTA
LASGPS

Sequences:

>Translated_166_residues
MSSRTTLGLSAPDLSGLDGSGLKVAVVAAQWHGTVMTGLLDGALRGLVDSGVHDPAVIRVPGSFELPVACASLADHFDAL
VALGVIIRGGTPHFDYVCDAATRGITDVAVRTKTPIGFGILTCDDEAQALDRAGLEGSHEDKGYEAAQAAIATLTALSTA
LASGPS
>Mature_165_residues
SSRTTLGLSAPDLSGLDGSGLKVAVVAAQWHGTVMTGLLDGALRGLVDSGVHDPAVIRVPGSFELPVACASLADHFDALV
ALGVIIRGGTPHFDYVCDAATRGITDVAVRTKTPIGFGILTCDDEAQALDRAGLEGSHEDKGYEAAQAAIATLTALSTAL
ASGPS

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=141, Percent_Identity=39.7163120567376, Blast_Score=99, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324429, Length=159, Percent_Identity=33.9622641509434, Blast_Score=101, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_PROAC (Q6A6Y6)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056436.1
- HSSP:   P66034
- ProteinModelPortal:   Q6A6Y6
- SMR:   Q6A6Y6
- GeneID:   2931356
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1749
- NMPDR:   fig|267747.1.peg.1713
- HOGENOM:   HBG311126
- OMA:   ARWHGEL
- ProtClustDB:   PRK00061
- BioCyc:   PACN267747:PPA1749-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16783; Mature: 16652

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRTTLGLSAPDLSGLDGSGLKVAVVAAQWHGTVMTGLLDGALRGLVDSGVHDPAVIRV
CCCCCEECCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
PGSFELPVACASLADHFDALVALGVIIRGGTPHFDYVCDAATRGITDVAVRTKTPIGFGI
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCCEEE
LTCDDEAQALDRAGLEGSHEDKGYEAAQAAIATLTALSTALASGPS
EEECCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSRTTLGLSAPDLSGLDGSGLKVAVVAAQWHGTVMTGLLDGALRGLVDSGVHDPAVIRV
CCCCEECCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
PGSFELPVACASLADHFDALVALGVIIRGGTPHFDYVCDAATRGITDVAVRTKTPIGFGI
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCCEEE
LTCDDEAQALDRAGLEGSHEDKGYEAAQAAIATLTALSTALASGPS
EEECCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA