Click here to switch to the map view.

The map label for this gene is pdxK [H]

Identifier: 50843174

GI number: 50843174

Start: 1865099

End: 1866004

Strand: Reverse

Name: pdxK [H]

Synonym: PPA1712

Alternate gene names: 50843174

Gene position: 1866004-1865099 (Counterclockwise)

Preceding gene: 50843176

Following gene: 50843172

Centisome position: 72.88

GC content: 60.82

Gene sequence:

>906_bases
GTGGTGACGTTGCCATCGGCTATCCCACCAATTCTGGGCCACGTTGTGGTTACTCCTCGGCAATTCCCGACGTTACTGGG
AAGGCCTTCTAGACTTGACAGCGTGACGAAGATTGCACTTGCTATTGCCGGGTCCGAGGCGTCCGGTGGCGCTGGAGCCC
AGACCGACCTCAAGACTTTTCACCAGCTCGGGGTGTTCGGATGCACGTCCTTGACGTGCATCGTCTCGTTTGACCCTCAC
AATGACTGGGGGCACCGGTTTGTGCCGGTGGACCCGCAAGTCATCCATGATCAGATTGAGGCGGCCGTTGCCGTCCATGG
TCGGGTCGACGCCGTGAAGATCGGTATGCTCGGCACCCCGACGACGATTGGCGTCGTCGCTGAGGCTCTTGAGAGCTATC
AGTTCCCTAAGGTCATCCTTGATCCGGTGCTCATCTGTAAGGGTCAGGAGCCCGGTGCCGCCCTCGACACCGACAATGCT
TTGCGCGAGAAGCTCCTGCCACGAGCTGACGTCGTGACTCCGAACCTCTTCGAGACTCAGACCTTGGCCGGGGTGGACGA
GATCACCTCCGTGGAAGCCCTTAAAGATGCTGCCAAGCGGATCGGTGACCAGGGAGTTCCGGTCGTCATCGCCAAGGCCG
GCACCCTGCTGGACACTGGCACCGCTCTGGACGTCTACTACGACGGCCATGATTGCGAGGTCCTTGAAGTTCCTGCCGTC
GGCCAGGAGCGCGTCTCTGGTGCTGGATGCACCTTGGCTGCCGCGATCACCGCGGAGATTGCCAAGGGGGCCAGCGCCCT
CGATGCTGTCCGCACTGCTAAGCAGGTTGTCGTTTCGGCGATCGAAAACCGGATGCACGGCAACGCCCCGTTCGACTGCG
TTTACCAGGGTAATTACCGAGCCTGA

Upstream 100 bases:

>100_bases
ACCGTGAGTTCGCCGTCGGCCTGCCTGTCTGTGTCGGCGCAGCGCTTGTCGTGAGTTTCTTGTGCTCGCTCGTGCTCGGC
TGAGGGGGAAAGGATGAGCC

Downstream 100 bases:

>100_bases
AACCATCACAAGGTTCACATGATGTTGGCCCTGGCATGTGATGATGCTGGGGCCAACTTGCCCCCTGCGCCCTCTGATGG
CCCGGGTCGTGCTGCGGGGT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: PN/PL/PM kinase; Pyridoxal kinase; Pyridoxamine kinase; Vitamin B6 kinase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MVTLPSAIPPILGHVVVTPRQFPTLLGRPSRLDSVTKIALAIAGSEASGGAGAQTDLKTFHQLGVFGCTSLTCIVSFDPH
NDWGHRFVPVDPQVIHDQIEAAVAVHGRVDAVKIGMLGTPTTIGVVAEALESYQFPKVILDPVLICKGQEPGAALDTDNA
LREKLLPRADVVTPNLFETQTLAGVDEITSVEALKDAAKRIGDQGVPVVIAKAGTLLDTGTALDVYYDGHDCEVLEVPAV
GQERVSGAGCTLAAAITAEIAKGASALDAVRTAKQVVVSAIENRMHGNAPFDCVYQGNYRA

Sequences:

>Translated_301_residues
MVTLPSAIPPILGHVVVTPRQFPTLLGRPSRLDSVTKIALAIAGSEASGGAGAQTDLKTFHQLGVFGCTSLTCIVSFDPH
NDWGHRFVPVDPQVIHDQIEAAVAVHGRVDAVKIGMLGTPTTIGVVAEALESYQFPKVILDPVLICKGQEPGAALDTDNA
LREKLLPRADVVTPNLFETQTLAGVDEITSVEALKDAAKRIGDQGVPVVIAKAGTLLDTGTALDVYYDGHDCEVLEVPAV
GQERVSGAGCTLAAAITAEIAKGASALDAVRTAKQVVVSAIENRMHGNAPFDCVYQGNYRA
>Mature_301_residues
MVTLPSAIPPILGHVVVTPRQFPTLLGRPSRLDSVTKIALAIAGSEASGGAGAQTDLKTFHQLGVFGCTSLTCIVSFDPH
NDWGHRFVPVDPQVIHDQIEAAVAVHGRVDAVKIGMLGTPTTIGVVAEALESYQFPKVILDPVLICKGQEPGAALDTDNA
LREKLLPRADVVTPNLFETQTLAGVDEITSVEALKDAAKRIGDQGVPVVIAKAGTLLDTGTALDVYYDGHDCEVLEVPAV
GQERVSGAGCTLAAAITAEIAKGASALDAVRTAKQVVVSAIENRMHGNAPFDCVYQGNYRA

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates. Can also use hydroxymethylpyrimidine (HMP) as substrate [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=244, Percent_Identity=32.7868852459016, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6325378, Length=252, Percent_Identity=29.7619047619048, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324997, Length=279, Percent_Identity=29.0322580645161, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324517, Length=279, Percent_Identity=27.5985663082437, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 31517; Mature: 31517

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLPSAIPPILGHVVVTPRQFPTLLGRPSRLDSVTKIALAIAGSEASGGAGAQTDLKTF
CCCCCCHHHHHHHHEEECCHHHHHHHCCCHHHHHHHEEEEEEECCCCCCCCCCHHHHHHH
HQLGVFGCTSLTCIVSFDPHNDWGHRFVPVDPQVIHDQIEAAVAVHGRVDAVKIGMLGTP
HHHHHCCCCEEEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCCC
TTIGVVAEALESYQFPKVILDPVLICKGQEPGAALDTDNALREKLLPRADVVTPNLFETQ
HHHHHHHHHHHHCCCCHHHHCCEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHH
TLAGVDEITSVEALKDAAKRIGDQGVPVVIAKAGTLLDTGTALDVYYDGHDCEVLEVPAV
HHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEECCCEEEEEECCCCCEEEECCCC
GQERVSGAGCTLAAAITAEIAKGASALDAVRTAKQVVVSAIENRMHGNAPFDCVYQGNYR
CHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
A
C
>Mature Secondary Structure
MVTLPSAIPPILGHVVVTPRQFPTLLGRPSRLDSVTKIALAIAGSEASGGAGAQTDLKTF
CCCCCCHHHHHHHHEEECCHHHHHHHCCCHHHHHHHEEEEEEECCCCCCCCCCHHHHHHH
HQLGVFGCTSLTCIVSFDPHNDWGHRFVPVDPQVIHDQIEAAVAVHGRVDAVKIGMLGTP
HHHHHCCCCEEEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCCC
TTIGVVAEALESYQFPKVILDPVLICKGQEPGAALDTDNALREKLLPRADVVTPNLFETQ
HHHHHHHHHHHHCCCCHHHHCCEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHH
TLAGVDEITSVEALKDAAKRIGDQGVPVVIAKAGTLLDTGTALDVYYDGHDCEVLEVPAV
HHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEECCCEEEEEECCCCCEEEECCCC
GQERVSGAGCTLAAAITAEIAKGASALDAVRTAKQVVVSAIENRMHGNAPFDCVYQGNYR
CHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]