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The map label for this gene is reg1 [H]

Identifier: 50843030

GI number: 50843030

Start: 1673445

End: 1674530

Strand: Direct

Name: reg1 [H]

Synonym: PPA1555

Alternate gene names: 50843030

Gene position: 1673445-1674530 (Clockwise)

Preceding gene: 50843029

Following gene: 50843031

Centisome position: 65.36

GC content: 60.87

Gene sequence:

>1086_bases
ATGAGCGGACCAACTTTGGCTGACATTGCCTATCAAGCGGGCGTAAGCCAGGCGACCGTCTCGCGAGTCCTCAACGACAA
GCCTGGGGTATCTAGCCCCACCCGGCAGTGTGTCCTCACCGCCCTCGACGTACTGGGGTATCAACGCCCCACCCATCTCA
AACCCGTCGCTACCGGCCTGGTGGGGCTCATCGTTCCTGAACTCACTAATCCGGTCTTCGCGAATCACGCCCAAGCCATT
GAGACCTTGCTCTCTAGGGAGGGATACGCCACTGCGGTGTGTACCCAAGCCCCCGGTGGCATGCGTGAGGACGACTACAT
CCGGGTCCTGCGGTCGCGTCAGGTCGCCGGGATCATCGTCATATCGGGGTCTCACGCCGACACCACGGCAGACATGTCTA
CCTACCACGAACTGGTTGACGTCGGACTGCCGTTGGTTCTTGTCAACGGCTACTCCCCCAGCATTGCGGTTCCCCAGATC
AGTGACGACGATGTATCTGCCATGGATCAGGCCGTTGCGCACTTGGTTGGGTTAGGTCACAAGCACCTAGGTCTAGCCGT
CGGTCCGCGACGATACGTTCCGGTGCAACGTAAGGAACAGGGTTTGCGGGCTGCCGTGGATCGTCATCTCGAAGGACGGG
GCAGGGTCACCGTCAGCAATACGGTCTTCTCTGTTGACGGCGGGGCTCGTGCTGCCGTTGATTTGCTCGGCCAAGGGGCC
AACGCCATCATCTGCGGCTCTGACCTGATGGCCTTGGGAGCGATTCGCGCCGCAAGGGCGCAGGGATTATCGGTTCCCGA
TGATGTATCAGTGATTGGGTGCGATGACTCGGCCCTCATGAGGTACACCGATCCCCCATTAACGAGTCTTCGTCAGGACG
TCAAGCTTATTTCCACGATGGCGATCCAATCCCTCATGGGGTCAATTCGCGGCGACACCGCCTTCCTCGGTGAGCGTCTG
GTGCAACCCGAGCTCGTCATCCGGGGTACGACGGCACCGGCCCGAGTGCCGACCGTAAATCCCTCCTGTGAGCCGCAGAT
ACCGAGCCGCGCTGTGCCTATGAGCGATACCCGCTTCGCCCGGTGA

Upstream 100 bases:

>100_bases
CTGCCCCCGATGGTGTTATTCCTATGGCTACAGAAGTACATCGTCTCCGGTCTGACCGGCGGAGCCGTCAAATGATGCTG
ACACGTTGCCGGGAGGAAAT

Downstream 100 bases:

>100_bases
CATTCTGCACATCGCGACTCTGACTGCTGACAAGGGGACCATCACGTCATACGGTTAGAAGTAAGGCCTGCACGGATGCA
GGTGCACGAGAGCTCTCAGG

Product: MalR repressor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MSGPTLADIAYQAGVSQATVSRVLNDKPGVSSPTRQCVLTALDVLGYQRPTHLKPVATGLVGLIVPELTNPVFANHAQAI
ETLLSREGYATAVCTQAPGGMREDDYIRVLRSRQVAGIIVISGSHADTTADMSTYHELVDVGLPLVLVNGYSPSIAVPQI
SDDDVSAMDQAVAHLVGLGHKHLGLAVGPRRYVPVQRKEQGLRAAVDRHLEGRGRVTVSNTVFSVDGGARAAVDLLGQGA
NAIICGSDLMALGAIRAARAQGLSVPDDVSVIGCDDSALMRYTDPPLTSLRQDVKLISTMAIQSLMGSIRGDTAFLGERL
VQPELVIRGTTAPARVPTVNPSCEPQIPSRAVPMSDTRFAR

Sequences:

>Translated_361_residues
MSGPTLADIAYQAGVSQATVSRVLNDKPGVSSPTRQCVLTALDVLGYQRPTHLKPVATGLVGLIVPELTNPVFANHAQAI
ETLLSREGYATAVCTQAPGGMREDDYIRVLRSRQVAGIIVISGSHADTTADMSTYHELVDVGLPLVLVNGYSPSIAVPQI
SDDDVSAMDQAVAHLVGLGHKHLGLAVGPRRYVPVQRKEQGLRAAVDRHLEGRGRVTVSNTVFSVDGGARAAVDLLGQGA
NAIICGSDLMALGAIRAARAQGLSVPDDVSVIGCDDSALMRYTDPPLTSLRQDVKLISTMAIQSLMGSIRGDTAFLGERL
VQPELVIRGTTAPARVPTVNPSCEPQIPSRAVPMSDTRFAR
>Mature_360_residues
SGPTLADIAYQAGVSQATVSRVLNDKPGVSSPTRQCVLTALDVLGYQRPTHLKPVATGLVGLIVPELTNPVFANHAQAIE
TLLSREGYATAVCTQAPGGMREDDYIRVLRSRQVAGIIVISGSHADTTADMSTYHELVDVGLPLVLVNGYSPSIAVPQIS
DDDVSAMDQAVAHLVGLGHKHLGLAVGPRRYVPVQRKEQGLRAAVDRHLEGRGRVTVSNTVFSVDGGARAAVDLLGQGAN
AIICGSDLMALGAIRAARAQGLSVPDDVSVIGCDDSALMRYTDPPLTSLRQDVKLISTMAIQSLMGSIRGDTAFLGERLV
QPELVIRGTTAPARVPTVNPSCEPQIPSRAVPMSDTRFAR

Specific function: Transcription repressor involved in control of expression of alpha-amylase and chitinase genes and of actinorhodin production [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=332, Percent_Identity=31.9277108433735, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790194, Length=336, Percent_Identity=27.9761904761905, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1789202, Length=304, Percent_Identity=30.2631578947368, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788474, Length=339, Percent_Identity=28.023598820059, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787948, Length=336, Percent_Identity=26.4880952380952, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI48994940, Length=324, Percent_Identity=26.2345679012346, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786540, Length=354, Percent_Identity=28.5310734463277, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1789068, Length=319, Percent_Identity=27.8996865203762, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787580, Length=296, Percent_Identity=26.3513513513513, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790715, Length=313, Percent_Identity=23.3226837060703, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38065; Mature: 37934

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPTLADIAYQAGVSQATVSRVLNDKPGVSSPTRQCVLTALDVLGYQRPTHLKPVATGL
CCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
VGLIVPELTNPVFANHAQAIETLLSREGYATAVCTQAPGGMREDDYIRVLRSRQVAGIIV
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEEE
ISGSHADTTADMSTYHELVDVGLPLVLVNGYSPSIAVPQISDDDVSAMDQAVAHLVGLGH
EECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHCCC
KHLGLAVGPRRYVPVQRKEQGLRAAVDRHLEGRGRVTVSNTVFSVDGGARAAVDLLGQGA
HHCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECEEEEECCCHHHHHHHHCCCC
NAIICGSDLMALGAIRAARAQGLSVPDDVSVIGCDDSALMRYTDPPLTSLRQDVKLISTM
CEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHH
AIQSLMGSIRGDTAFLGERLVQPELVIRGTTAPARVPTVNPSCEPQIPSRAVPMSDTRFA
HHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
R
C
>Mature Secondary Structure 
SGPTLADIAYQAGVSQATVSRVLNDKPGVSSPTRQCVLTALDVLGYQRPTHLKPVATGL
CCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
VGLIVPELTNPVFANHAQAIETLLSREGYATAVCTQAPGGMREDDYIRVLRSRQVAGIIV
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEEE
ISGSHADTTADMSTYHELVDVGLPLVLVNGYSPSIAVPQISDDDVSAMDQAVAHLVGLGH
EECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHCCC
KHLGLAVGPRRYVPVQRKEQGLRAAVDRHLEGRGRVTVSNTVFSVDGGARAAVDLLGQGA
HHCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECEEEEECCCHHHHHHHHCCCC
NAIICGSDLMALGAIRAARAQGLSVPDDVSVIGCDDSALMRYTDPPLTSLRQDVKLISTM
CEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHH
AIQSLMGSIRGDTAFLGERLVQPELVIRGTTAPARVPTVNPSCEPQIPSRAVPMSDTRFA
HHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9335287 [H]