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The map label for this gene is gdh [H]

Identifier: 50842991

GI number: 50842991

Start: 1636283

End: 1637620

Strand: Reverse

Name: gdh [H]

Synonym: PPA1513

Alternate gene names: 50842991

Gene position: 1637620-1636283 (Counterclockwise)

Preceding gene: 50842992

Following gene: 50842988

Centisome position: 63.96

GC content: 59.04

Gene sequence:

>1338_bases
ATGGATAGGCAACTCGAAAACGCGTACGAATCGGTGTTGCGTCGCAACCCAGGGGAGGCCGAGTTCCACCAGGCTGTGCG
GGAGATCTTTGAATCTCTCGGCCCGGTGCTCGACACGAATCCGCAGTACGTGGAGGCAGCCGTGTTGTCGCGCATCTGCG
AACCGGAACGCCAGATCATTTTCCGGGTGCCGTGGGTTGACGACGAGGGCAAGATCCGTATCAACCGTGGCTTCCGCGTT
GAATATTCGTCGGTGCTGGGGCCGTATAAGGGTGGATTGCGATTCCACCCCTCGGTGTACTTAGGAACGATTAAGTTCCT
TGGTTTTGAGCAGATCTTCAAAAATGCTCTGACTGGCATGCCGATCGGTGGCGCGAAGGGTGGGTCGGACTTTGATCCCC
ATGACGCGTCCGAGGCTGAGGTCATGCGATTCTGCCAGTCCTTCATGACCGAGCTCTACCGTCACCTTGGTGAACACACC
GACGTGCCAGCTGGTGATATCGGCGTTGGCAGTCGTGAGATCGGATTCCTCTTCGGCCAATACAAGCGCATTACTAACCG
TCATGAGTCCGGTGTGCTCACCGGTAAAGGACTCACCTGGGGTGGATCCTTGGTGCGCACTGAAGCTACCGGATATGGCA
CAGTCTTCTTCGTCCAACGAATGCTGGCGACCAACGGCAAGTCTTTAGACGGCCTGCGAGTTACCGTCTCCGGGTCGGGC
AACGTCGCGATCTACGCCATCGAGAAGGCTCAGGATCTCGGAGCCACCGTGGTTGCGTGCTCAGATTCCAGCGGTTACGT
CGTTGACGAGAAAGGTATCGACGTCGCCCTGCTTAAGCAGATCAAGGAGGTGGAACGGGCCCGCATCTGCGAGTATGCCG
CTCGACGCGACTCGGCTACTTTCCACTCCGACGGATCGATCTGGGATGTGCCGGTCGACGTCGCCTTGCCCTGTGCCACT
CAGAACGAGCTCAATGGTCAGGCTGCCGCCACCCTCATCCGCAACGGTGTGGTCGCTGTCGCTGAAGGTGCCAACATGCC
CTGCACTCCTGAGGCGGTGCATTCCTTCCAGGACGCCGGCGTCATTTTCGCCCCGGGTAAGGCATCTAATGCGGGTGGCG
TCGCTACTTCGGCCCTCGAGATGCAACAGAATGCCGCGCGCGACTCCTGGGATTTCGACGCGACCGAAGCTAGACTGCAG
CAGATTATGGCCGACATCCACGATCGTTGCATCGAGACCGCCGACGAGTATGGCCACCCGGGGGATTACGTTATGGGTGC
CAACATCGCCGGGTTCACCAAGGTGGCTGACGCCGTTATCGCGATGGGTGTCGTCTGA

Upstream 100 bases:

>100_bases
AGGACTAGGCAGCTAACGGTTTGCGGCGGCCCCGGTGACAGTCCCGGTGTGCCTCGAGCGTCACAATCGTCCACACAGAA
ATACAGAAGGGATTCACCGT

Downstream 100 bases:

>100_bases
GTGCCGCTACTGCCTCGTCGACGGTGTCGACGAGGCGAATGCGGTGAGGGTGGTCCCGTGACATGCTGTGCAGCAGCGGC
CAGGCCGGTAGGGTCTGGCT

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MDRQLENAYESVLRRNPGEAEFHQAVREIFESLGPVLDTNPQYVEAAVLSRICEPERQIIFRVPWVDDEGKIRINRGFRV
EYSSVLGPYKGGLRFHPSVYLGTIKFLGFEQIFKNALTGMPIGGAKGGSDFDPHDASEAEVMRFCQSFMTELYRHLGEHT
DVPAGDIGVGSREIGFLFGQYKRITNRHESGVLTGKGLTWGGSLVRTEATGYGTVFFVQRMLATNGKSLDGLRVTVSGSG
NVAIYAIEKAQDLGATVVACSDSSGYVVDEKGIDVALLKQIKEVERARICEYAARRDSATFHSDGSIWDVPVDVALPCAT
QNELNGQAAATLIRNGVVAVAEGANMPCTPEAVHSFQDAGVIFAPGKASNAGGVATSALEMQQNAARDSWDFDATEARLQ
QIMADIHDRCIETADEYGHPGDYVMGANIAGFTKVADAVIAMGVV

Sequences:

>Translated_445_residues
MDRQLENAYESVLRRNPGEAEFHQAVREIFESLGPVLDTNPQYVEAAVLSRICEPERQIIFRVPWVDDEGKIRINRGFRV
EYSSVLGPYKGGLRFHPSVYLGTIKFLGFEQIFKNALTGMPIGGAKGGSDFDPHDASEAEVMRFCQSFMTELYRHLGEHT
DVPAGDIGVGSREIGFLFGQYKRITNRHESGVLTGKGLTWGGSLVRTEATGYGTVFFVQRMLATNGKSLDGLRVTVSGSG
NVAIYAIEKAQDLGATVVACSDSSGYVVDEKGIDVALLKQIKEVERARICEYAARRDSATFHSDGSIWDVPVDVALPCAT
QNELNGQAAATLIRNGVVAVAEGANMPCTPEAVHSFQDAGVIFAPGKASNAGGVATSALEMQQNAARDSWDFDATEARLQ
QIMADIHDRCIETADEYGHPGDYVMGANIAGFTKVADAVIAMGVV
>Mature_445_residues
MDRQLENAYESVLRRNPGEAEFHQAVREIFESLGPVLDTNPQYVEAAVLSRICEPERQIIFRVPWVDDEGKIRINRGFRV
EYSSVLGPYKGGLRFHPSVYLGTIKFLGFEQIFKNALTGMPIGGAKGGSDFDPHDASEAEVMRFCQSFMTELYRHLGEHT
DVPAGDIGVGSREIGFLFGQYKRITNRHESGVLTGKGLTWGGSLVRTEATGYGTVFFVQRMLATNGKSLDGLRVTVSGSG
NVAIYAIEKAQDLGATVVACSDSSGYVVDEKGIDVALLKQIKEVERARICEYAARRDSATFHSDGSIWDVPVDVALPCAT
QNELNGQAAATLIRNGVVAVAEGANMPCTPEAVHSFQDAGVIFAPGKASNAGGVATSALEMQQNAARDSWDFDATEARLQ
QIMADIHDRCIETADEYGHPGDYVMGANIAGFTKVADAVIAMGVV

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=354, Percent_Identity=28.5310734463277, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI4885281, Length=354, Percent_Identity=27.683615819209, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1788059, Length=444, Percent_Identity=58.7837837837838, Blast_Score=523, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17544676, Length=381, Percent_Identity=25.4593175853018, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324951, Length=455, Percent_Identity=48.5714285714286, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319256, Length=459, Percent_Identity=48.5838779956427, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24649283, Length=418, Percent_Identity=26.7942583732057, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45549226, Length=358, Percent_Identity=28.2122905027933, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI45553475, Length=358, Percent_Identity=28.2122905027933, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24649460, Length=293, Percent_Identity=27.9863481228669, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 48143; Mature: 48143

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRQLENAYESVLRRNPGEAEFHQAVREIFESLGPVLDTNPQYVEAAVLSRICEPERQII
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEE
FRVPWVDDEGKIRINRGFRVEYSSVLGPYKGGLRFHPSVYLGTIKFLGFEQIFKNALTGM
EECCCCCCCCCEEECCCCEEEHHHHCCCCCCCCEECCCEEEHHHHHHHHHHHHHHHHCCC
PIGGAKGGSDFDPHDASEAEVMRFCQSFMTELYRHLGEHTDVPAGDIGVGSREIGFLFGQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
YKRITNRHESGVLTGKGLTWGGSLVRTEATGYGTVFFVQRMLATNGKSLDGLRVTVSGSG
HHHHHCCCCCCEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCC
NVAIYAIEKAQDLGATVVACSDSSGYVVDEKGIDVALLKQIKEVERARICEYAARRDSAT
CEEEEEEECCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
FHSDGSIWDVPVDVALPCATQNELNGQAAATLIRNGVVAVAEGANMPCTPEAVHSFQDAG
CCCCCCEEECCCCEEECCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCC
VIFAPGKASNAGGVATSALEMQQNAARDSWDFDATEARLQQIMADIHDRCIETADEYGHP
EEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GDYVMGANIAGFTKVADAVIAMGVV
CCEEECCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDRQLENAYESVLRRNPGEAEFHQAVREIFESLGPVLDTNPQYVEAAVLSRICEPERQII
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEE
FRVPWVDDEGKIRINRGFRVEYSSVLGPYKGGLRFHPSVYLGTIKFLGFEQIFKNALTGM
EECCCCCCCCCEEECCCCEEEHHHHCCCCCCCCEECCCEEEHHHHHHHHHHHHHHHHCCC
PIGGAKGGSDFDPHDASEAEVMRFCQSFMTELYRHLGEHTDVPAGDIGVGSREIGFLFGQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
YKRITNRHESGVLTGKGLTWGGSLVRTEATGYGTVFFVQRMLATNGKSLDGLRVTVSGSG
HHHHHCCCCCCEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCC
NVAIYAIEKAQDLGATVVACSDSSGYVVDEKGIDVALLKQIKEVERARICEYAARRDSAT
CEEEEEEECCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
FHSDGSIWDVPVDVALPCATQNELNGQAAATLIRNGVVAVAEGANMPCTPEAVHSFQDAG
CCCCCCEEECCCCEEECCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCC
VIFAPGKASNAGGVATSALEMQQNAARDSWDFDATEARLQQIMADIHDRCIETADEYGHP
EEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GDYVMGANIAGFTKVADAVIAMGVV
CCEEECCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]