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The map label for this gene is dxr

Identifier: 50842988

GI number: 50842988

Start: 1632533

End: 1633756

Strand: Reverse

Name: dxr

Synonym: PPA1510

Alternate gene names: 50842988

Gene position: 1633756-1632533 (Counterclockwise)

Preceding gene: 50842991

Following gene: 50842987

Centisome position: 63.81

GC content: 61.52

Gene sequence:

>1224_bases
GTGAAGAAGGTCATCATTCTCGGCTCCACCGGATCGATCGGAACCCAAACTCTAGAGGTCATTTCGTCACGTCGTGACCA
GTTTGAGGTCGCTGGCATATCGGCAGGTGGCTCGGATGTTGGCTCACTAGCTCAGCAGATAATCGACTTCTCTATCCCCG
TCGTAGCTGTCGCTCGTGAGGATGCCGCTGAGGAGCTTCAGCGGGCTTTGGCCGTGCAGGCTGGATCACGGGGCCGTATC
GTGCCCAATCCTCGGATCCTTACTGGCCCGGATGCGTCGACAGAGCTGGCAGCTATGCCCGCTGATGTTGTCTGTAATGC
CATTACCGGCGCGGCTGGTTTGCGACCGACCCTCGCCACCTTGGCCGCAGGGACCACTTTGGCCTTAGCGAACAAGGAGT
CGTTGGTCATTGGTGGCAGGCTCGTTACTCAGGCGGCCGCCTCAGGACAGATTGTCCCCGTGGATTCTGAGCACTCCGCC
TTCGCCCAGTGCCTACGAGGGGGCGGGCGCAACGAGGTGCGTCGCCTTGTTCTGACCGCATCCGGCGGACCTTTCCGCGG
TCGCGACCGTGCCTCCCTGGCCGATGTCAGCGCTGCCGAGGCCATGAAGCATCCCACCTGGAATATGGGCCGGGTCATCA
CCATTAACTCGTCGACTCTGGTGAATAAGGGTCTGGAGCTGCTCGAGGCGGCCCTACTTTATGATGTTGATCTCGACGAC
ATCACCGTCGTCGTCCATCCTCAATCCATCGTCCACTCGATGGTGGAGTTCTGGGATGGCGCCACTATTGCTCAGGCTTC
GCCTCCCGACATGAGATTGCCGATTGCCTTGGGACTGTCTTGGCCGGATCGCCTTCCTGACGCAGCTGCCGGCTGCGACT
GGTCGACGGCTACTCAGTGGACCTTCGAACCCCTTGACAACGACACTTTCGGGGCCGTCGAACTAGCCCGACGCGCTGGT
CATGCTGCGGGTACTGCGCCGGCCGTGTTCAATGCCGCTAACGAGTCCTGTGTCGACGCCTTCTGTGCCGGAAGTATCGG
TTTCCTCGACATTACCGACACCATTGCCGCGGTCCTTGACGAGCACCTATCCGGTGACGAGAACGACACCCTTGGTGCTC
GACATGTCGGTGACGAGGCCCTCACCCTCGATGCCGTGTTGGCCGCCGACGCCTGGGGTCGTCGTCGCGCCGCCGAGGTG
TGTGCCCGGGGGATTCGCCGGTGA

Upstream 100 bases:

>100_bases
CGCTGTCAGTCATGGTTTCCACTCTAGGGCCGTTGATGAGTGCTGTGGGCACCGAAGAACAGGACTGTGGATTGTGGGAA
CGCCGTGACACACTGGCAGG

Downstream 100 bases:

>100_bases
TAGTTGTAGTCGAAGTGCTGGCTGGAATCGTCTTCTTCGGCCTCATCATCCTCTCGGTGCTACTTCATGAGTGCGGTCAC
TTCATCCCGGCGAAGATCTT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKKVIILGSTGSIGTQTLEVISSRRDQFEVAGISAGGSDVGSLAQQIIDFSIPVVAVAREDAAEELQRALAVQAGSRGRI
VPNPRILTGPDASTELAAMPADVVCNAITGAAGLRPTLATLAAGTTLALANKESLVIGGRLVTQAAASGQIVPVDSEHSA
FAQCLRGGGRNEVRRLVLTASGGPFRGRDRASLADVSAAEAMKHPTWNMGRVITINSSTLVNKGLELLEAALLYDVDLDD
ITVVVHPQSIVHSMVEFWDGATIAQASPPDMRLPIALGLSWPDRLPDAAAGCDWSTATQWTFEPLDNDTFGAVELARRAG
HAAGTAPAVFNAANESCVDAFCAGSIGFLDITDTIAAVLDEHLSGDENDTLGARHVGDEALTLDAVLAADAWGRRRAAEV
CARGIRR

Sequences:

>Translated_407_residues
MKKVIILGSTGSIGTQTLEVISSRRDQFEVAGISAGGSDVGSLAQQIIDFSIPVVAVAREDAAEELQRALAVQAGSRGRI
VPNPRILTGPDASTELAAMPADVVCNAITGAAGLRPTLATLAAGTTLALANKESLVIGGRLVTQAAASGQIVPVDSEHSA
FAQCLRGGGRNEVRRLVLTASGGPFRGRDRASLADVSAAEAMKHPTWNMGRVITINSSTLVNKGLELLEAALLYDVDLDD
ITVVVHPQSIVHSMVEFWDGATIAQASPPDMRLPIALGLSWPDRLPDAAAGCDWSTATQWTFEPLDNDTFGAVELARRAG
HAAGTAPAVFNAANESCVDAFCAGSIGFLDITDTIAAVLDEHLSGDENDTLGARHVGDEALTLDAVLAADAWGRRRAAEV
CARGIRR
>Mature_407_residues
MKKVIILGSTGSIGTQTLEVISSRRDQFEVAGISAGGSDVGSLAQQIIDFSIPVVAVAREDAAEELQRALAVQAGSRGRI
VPNPRILTGPDASTELAAMPADVVCNAITGAAGLRPTLATLAAGTTLALANKESLVIGGRLVTQAAASGQIVPVDSEHSA
FAQCLRGGGRNEVRRLVLTASGGPFRGRDRASLADVSAAEAMKHPTWNMGRVITINSSTLVNKGLELLEAALLYDVDLDD
ITVVVHPQSIVHSMVEFWDGATIAQASPPDMRLPIALGLSWPDRLPDAAAGCDWSTATQWTFEPLDNDTFGAVELARRAG
HAAGTAPAVFNAANESCVDAFCAGSIGFLDITDTIAAVLDEHLSGDENDTLGARHVGDEALTLDAVLAADAWGRRRAAEV
CARGIRR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=374, Percent_Identity=40.3743315508021, Blast_Score=246, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_PROAC (Q6A7K8)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056215.1
- ProteinModelPortal:   Q6A7K8
- SMR:   Q6A7K8
- GeneID:   2932365
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1510
- NMPDR:   fig|267747.1.peg.1492
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   PACN267747:PPA1510-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42399; Mature: 42399

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00216 SUGAR_TRANSPORT_1

Important sites: BINDING 132-132 BINDING 157-157 BINDING 181-181 BINDING 204-204 BINDING 226-226

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVIILGSTGSIGTQTLEVISSRRDQFEVAGISAGGSDVGSLAQQIIDFSIPVVAVARE
CCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEHH
DAAEELQRALAVQAGSRGRIVPNPRILTGPDASTELAAMPADVVCNAITGAAGLRPTLAT
HHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHCCCHHHHHHHHHCCCCCCHHHHH
LAAGTTLALANKESLVIGGRLVTQAAASGQIVPVDSEHSAFAQCLRGGGRNEVRRLVLTA
HHCCCEEEEECCCCEEECCHHHHHHCCCCCEEECCCCHHHHHHHHHCCCHHHEEEEEEEE
SGGPFRGRDRASLADVSAAEAMKHPTWNMGRVITINSSTLVNKGLELLEAALLYDVDLDD
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHEECCCCC
ITVVVHPQSIVHSMVEFWDGATIAQASPPDMRLPIALGLSWPDRLPDAAAGCDWSTATQW
EEEEECCHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCCCHHCCCHHCCCCCCCCCCE
TFEPLDNDTFGAVELARRAGHAAGTAPAVFNAANESCVDAFCAGSIGFLDITDTIAAVLD
EECCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHCCCCCEEEHHHHHHHHHH
EHLSGDENDTLGARHVGDEALTLDAVLAADAWGRRRAAEVCARGIRR
HHHCCCCCCCCCCHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKVIILGSTGSIGTQTLEVISSRRDQFEVAGISAGGSDVGSLAQQIIDFSIPVVAVARE
CCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEHH
DAAEELQRALAVQAGSRGRIVPNPRILTGPDASTELAAMPADVVCNAITGAAGLRPTLAT
HHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHCCCHHHHHHHHHCCCCCCHHHHH
LAAGTTLALANKESLVIGGRLVTQAAASGQIVPVDSEHSAFAQCLRGGGRNEVRRLVLTA
HHCCCEEEEECCCCEEECCHHHHHHCCCCCEEECCCCHHHHHHHHHCCCHHHEEEEEEEE
SGGPFRGRDRASLADVSAAEAMKHPTWNMGRVITINSSTLVNKGLELLEAALLYDVDLDD
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHEECCCCC
ITVVVHPQSIVHSMVEFWDGATIAQASPPDMRLPIALGLSWPDRLPDAAAGCDWSTATQW
EEEEECCHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCCCHHCCCHHCCCCCCCCCCE
TFEPLDNDTFGAVELARRAGHAAGTAPAVFNAANESCVDAFCAGSIGFLDITDTIAAVLD
EECCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHCCCCCEEEHHHHHHHHHH
EHLSGDENDTLGARHVGDEALTLDAVLAADAWGRRRAAEVCARGIRR
HHHCCCCCCCCCCHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA