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The map label for this gene is sdhA

Identifier: 50842917

GI number: 50842917

Start: 1554352

End: 1556379

Strand: Reverse

Name: sdhA

Synonym: PPA1438

Alternate gene names: 50842917

Gene position: 1556379-1554352 (Counterclockwise)

Preceding gene: 50842918

Following gene: 50842916

Centisome position: 60.79

GC content: 60.31

Gene sequence:

>2028_bases
ATGACTGCAACTGCTGCATCCAATAACAACGCCGCTCTCGCCGACCAGTACTGGACGACCGGCGACGAAATCCACGACAC
GAAGGCCAACCATGACCTTCCGATCGAGAAGATCTGGACTGATCGCCAGTTCACCTCGCGTCTGGTCAACCCGGCTAACC
GTCGCAAGATGACGGTCATCATTGTTGGTACCGGTCTAGCTGGTGGCGCTGCCGCCGCAACTCTCGGTGAGGCCGGTTAC
CGCGTCGAGAACTTCTGCTACCAGGACTCTCCGCGTCGCGCTCACTCGATCGCGGCCCAGGGCGGAATTAACGCCGCGAA
GAACTACAAGAATGACGGTGATTCGATCTACCGCCTGTTCTACGACACCGTCAAAGGTGGCGATTACCGCTCCCGCGAGA
CGAACGTTTACCGGCTCGCCGCGGTCAGCGCGAACATCATCGACCAGTGTGTCGCCCAGGGCGTTCCGTTCGCCCGTGAG
TACGGTGGCCTGCTCGACAACCGTTCCTTCGGTGGCGTCCAGGTGCAGCGCACCTTCTACGCTCGCGGCCAGACGGGCCA
GCAGCTGCTCATCGGCGCCTACCAAGCCCTCGAGCGGCAGGTTCACGCCGGCACCGTGCACATGCACACCCGTCACGAGA
TGGTCGAGCTCATCGTCGCCGACGGGCGAGCTCGCGGCATCGTGACTCGTGACATGGTTACCGGCAAGATCGAAGAGTGG
TTTGGTGACGCCGTCGTCCTGGCTACCGGTGGTTACGGCAACGTCTTCTTCCTGTCGACGAACGCCATGGGCTGCAATGC
CACCGCCTCGTGGCGTGCCCACCGTAAGGGCGCTTACTTCGGCAACCCCTGCTACACCCAGATCCACCCGACCTGCATCC
CGGTGCATGGTGAAAACCAGTCGAAGCTGACTCTGATGTCGGAGTCGCTGCGTAACGACGGCCGTATCTGGGTGCCCAAG
CGCGCGGAAGATTGTGAAAAGGATCCTCGCGACATCCCCGAGGAAGATCGCGACTACTACTTGGAGCGCATCTACCCGTC
CTTCGGCAACCTGGTTCCTCGTGACATTGCATCCCGTCAAGCCAAGTACCGCTGTGACGAGGGTCGTGGTGTCGGTCCGA
AGGTTCGTGAGGTCGATTCTGACGGCACCGAGCACATGCGTGCCCGTGGTGTGTACCTCGACTTCTCCGAGGCCATCCAG
CGTATGGGTAAGGATGCCGTGGAAAAGAAGTACGGCAACCTCTTCGACATGTACCAGCGGATTACCGACGAGAACCCGTA
TGAGGTTCCCATGCGTATCTACCCTGCGGTGCACTACACGATGGGTGGCCTGTGGGTCGACTATGACCTGCAGTCGACCA
TTCCGGGTCTGTTTGTCTGTGGTGAGGCCAACTTCTCCGATCACGGCGCTAACCGGCTCGGTGCTTCGGCCCTGATGCAG
GGTCTGGCTGATGGCTACTGGGTGCTGCCCAACACCATCACCGATTACCTGGCGGACTCTCCGAAGTTCGGCATGGTCGA
TGAGAAGCATCCGGCCGCGGTTGAAGCCCGTCAGGCTGTCGAGAGCCGTATCAACAAGCTGCTAACGATTAATGGAACCC
GTACCGTCGACTCGATCCACAAGGAACTTGGCCACATCATGTGGGAGTACTGCGGTATGGAGCGCAGCGAGGCCGGCCTC
ATTAAGGCTATTGGTCTCATCCGCAATCTGCGCAACGAGTTCTGGACCAACGTTAAGGTCACCGGCGTCAACGAGGAGCT
CAATCAGACCCTCGAGCGCGCTGGTCGGCTCGCCGACTTCTTGGAGCTCGGTGAACTGATGTGCATCGACGCTCTACACC
GTCGCGAGTCTTGTGGTGGTCACTTCCGCGCTGAGTCTCAGACCGAAGAGGGCGAGGCCATGCGTCACGACGACGAGTAT
CAGTACGTCGCTGCCTGGGAGTGGACTGGCGAAGGCCACAAGCCGACCCTGCACAAGGAGCCGCTGGTCTACAAGTCCAT
CCAGGTCAAGCAGAGGAGCTACAAGTGA

Upstream 100 bases:

>100_bases
CTCGCGCTGTGCTGCGCGTGTGTTCCTGGATCGTCGCCATCGTGATCTTCGTGGGCTTCATGACTCCTCCATTCCTGGTC
CTGTTCGGGGTGATCTCCTG

Downstream 100 bases:

>100_bases
AGATCAACCTGCGAATCTGGCGTCAGCGCAATTCCAAGGATCAGGGCCGCCTCGTCGAGTACACCCTGGACGGTGTTTCC
GGTGATATGTCCTTCCTTGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 675; Mature: 674

Protein sequence:

>675_residues
MTATAASNNNAALADQYWTTGDEIHDTKANHDLPIEKIWTDRQFTSRLVNPANRRKMTVIIVGTGLAGGAAAATLGEAGY
RVENFCYQDSPRRAHSIAAQGGINAAKNYKNDGDSIYRLFYDTVKGGDYRSRETNVYRLAAVSANIIDQCVAQGVPFARE
YGGLLDNRSFGGVQVQRTFYARGQTGQQLLIGAYQALERQVHAGTVHMHTRHEMVELIVADGRARGIVTRDMVTGKIEEW
FGDAVVLATGGYGNVFFLSTNAMGCNATASWRAHRKGAYFGNPCYTQIHPTCIPVHGENQSKLTLMSESLRNDGRIWVPK
RAEDCEKDPRDIPEEDRDYYLERIYPSFGNLVPRDIASRQAKYRCDEGRGVGPKVREVDSDGTEHMRARGVYLDFSEAIQ
RMGKDAVEKKYGNLFDMYQRITDENPYEVPMRIYPAVHYTMGGLWVDYDLQSTIPGLFVCGEANFSDHGANRLGASALMQ
GLADGYWVLPNTITDYLADSPKFGMVDEKHPAAVEARQAVESRINKLLTINGTRTVDSIHKELGHIMWEYCGMERSEAGL
IKAIGLIRNLRNEFWTNVKVTGVNEELNQTLERAGRLADFLELGELMCIDALHRRESCGGHFRAESQTEEGEAMRHDDEY
QYVAAWEWTGEGHKPTLHKEPLVYKSIQVKQRSYK

Sequences:

>Translated_675_residues
MTATAASNNNAALADQYWTTGDEIHDTKANHDLPIEKIWTDRQFTSRLVNPANRRKMTVIIVGTGLAGGAAAATLGEAGY
RVENFCYQDSPRRAHSIAAQGGINAAKNYKNDGDSIYRLFYDTVKGGDYRSRETNVYRLAAVSANIIDQCVAQGVPFARE
YGGLLDNRSFGGVQVQRTFYARGQTGQQLLIGAYQALERQVHAGTVHMHTRHEMVELIVADGRARGIVTRDMVTGKIEEW
FGDAVVLATGGYGNVFFLSTNAMGCNATASWRAHRKGAYFGNPCYTQIHPTCIPVHGENQSKLTLMSESLRNDGRIWVPK
RAEDCEKDPRDIPEEDRDYYLERIYPSFGNLVPRDIASRQAKYRCDEGRGVGPKVREVDSDGTEHMRARGVYLDFSEAIQ
RMGKDAVEKKYGNLFDMYQRITDENPYEVPMRIYPAVHYTMGGLWVDYDLQSTIPGLFVCGEANFSDHGANRLGASALMQ
GLADGYWVLPNTITDYLADSPKFGMVDEKHPAAVEARQAVESRINKLLTINGTRTVDSIHKELGHIMWEYCGMERSEAGL
IKAIGLIRNLRNEFWTNVKVTGVNEELNQTLERAGRLADFLELGELMCIDALHRRESCGGHFRAESQTEEGEAMRHDDEY
QYVAAWEWTGEGHKPTLHKEPLVYKSIQVKQRSYK
>Mature_674_residues
TATAASNNNAALADQYWTTGDEIHDTKANHDLPIEKIWTDRQFTSRLVNPANRRKMTVIIVGTGLAGGAAAATLGEAGYR
VENFCYQDSPRRAHSIAAQGGINAAKNYKNDGDSIYRLFYDTVKGGDYRSRETNVYRLAAVSANIIDQCVAQGVPFAREY
GGLLDNRSFGGVQVQRTFYARGQTGQQLLIGAYQALERQVHAGTVHMHTRHEMVELIVADGRARGIVTRDMVTGKIEEWF
GDAVVLATGGYGNVFFLSTNAMGCNATASWRAHRKGAYFGNPCYTQIHPTCIPVHGENQSKLTLMSESLRNDGRIWVPKR
AEDCEKDPRDIPEEDRDYYLERIYPSFGNLVPRDIASRQAKYRCDEGRGVGPKVREVDSDGTEHMRARGVYLDFSEAIQR
MGKDAVEKKYGNLFDMYQRITDENPYEVPMRIYPAVHYTMGGLWVDYDLQSTIPGLFVCGEANFSDHGANRLGASALMQG
LADGYWVLPNTITDYLADSPKFGMVDEKHPAAVEARQAVESRINKLLTINGTRTVDSIHKELGHIMWEYCGMERSEAGLI
KAIGLIRNLRNEFWTNVKVTGVNEELNQTLERAGRLADFLELGELMCIDALHRRESCGGHFRAESQTEEGEAMRHDDEYQ
YVAAWEWTGEGHKPTLHKEPLVYKSIQVKQRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=602, Percent_Identity=25.5813953488372, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1790597, Length=546, Percent_Identity=27.6556776556777, Blast_Score=185, Evalue=1e-47,
Organism=Escherichia coli, GI1786942, Length=556, Percent_Identity=25.1798561151079, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI1788928, Length=588, Percent_Identity=25.3401360544218, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17505833, Length=589, Percent_Identity=26.9949066213922, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17550100, Length=560, Percent_Identity=27.1428571428571, Blast_Score=152, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6322701, Length=589, Percent_Identity=26.4855687606112, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322416, Length=572, Percent_Identity=25.5244755244755, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI17137288, Length=587, Percent_Identity=25.7240204429302, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24655642, Length=587, Percent_Identity=25.7240204429302, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24655647, Length=587, Percent_Identity=25.7240204429302, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24663005, Length=603, Percent_Identity=25.5389718076285, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 75735; Mature: 75604

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATAASNNNAALADQYWTTGDEIHDTKANHDLPIEKIWTDRQFTSRLVNPANRRKMTVI
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCEEEEE
IVGTGLAGGAAAATLGEAGYRVENFCYQDSPRRAHSIAAQGGINAAKNYKNDGDSIYRLF
EEECCCCCCHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHH
YDTVKGGDYRSRETNVYRLAAVSANIIDQCVAQGVPFAREYGGLLDNRSFGGVQVQRTFY
HHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEEEEEEE
ARGQTGQQLLIGAYQALERQVHAGTVHMHTRHEMVELIVADGRARGIVTRDMVTGKIEEW
ECCCCCHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
FGDAVVLATGGYGNVFFLSTNAMGCNATASWRAHRKGAYFGNPCYTQIHPTCIPVHGENQ
CCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCCCCEEEECCEEEEECCCCC
SKLTLMSESLRNDGRIWVPKRAEDCEKDPRDIPEEDRDYYLERIYPSFGNLVPRDIASRQ
CHHHHHHHHHCCCCCEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
AKYRCDEGRGVGPKVREVDSDGTEHMRARGVYLDFSEAIQRMGKDAVEKKYGNLFDMYQR
HHCCCCCCCCCCCCHHCCCCCCHHHHHHCCEEEEHHHHHHHHCHHHHHHHHCCHHHHHHH
ITDENPYEVPMRIYPAVHYTMGGLWVDYDLQSTIPGLFVCGEANFSDHGANRLGASALMQ
HCCCCCCCCCEEEECCCEEEECCEEEEECHHHCCCCEEEECCCCCCCCCCHHHHHHHHHH
GLADGYWVLPNTITDYLADSPKFGMVDEKHPAAVEARQAVESRINKLLTINGTRTVDSIH
HHCCCEEECCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEECCCHHHHHHH
KELGHIMWEYCGMERSEAGLIKAIGLIRNLRNEFWTNVKVTGVNEELNQTLERAGRLADF
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
LELGELMCIDALHRRESCGGHFRAESQTEEGEAMRHDDEYQYVAAWEWTGEGHKPTLHKE
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCEEEEEEEEECCCCCCCCCCCC
PLVYKSIQVKQRSYK
CCEEHHHHHHHHCCC
>Mature Secondary Structure 
TATAASNNNAALADQYWTTGDEIHDTKANHDLPIEKIWTDRQFTSRLVNPANRRKMTVI
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCEEEEE
IVGTGLAGGAAAATLGEAGYRVENFCYQDSPRRAHSIAAQGGINAAKNYKNDGDSIYRLF
EEECCCCCCHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHH
YDTVKGGDYRSRETNVYRLAAVSANIIDQCVAQGVPFAREYGGLLDNRSFGGVQVQRTFY
HHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEEEEEEE
ARGQTGQQLLIGAYQALERQVHAGTVHMHTRHEMVELIVADGRARGIVTRDMVTGKIEEW
ECCCCCHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
FGDAVVLATGGYGNVFFLSTNAMGCNATASWRAHRKGAYFGNPCYTQIHPTCIPVHGENQ
CCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCCCCEEEECCEEEEECCCCC
SKLTLMSESLRNDGRIWVPKRAEDCEKDPRDIPEEDRDYYLERIYPSFGNLVPRDIASRQ
CHHHHHHHHHCCCCCEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
AKYRCDEGRGVGPKVREVDSDGTEHMRARGVYLDFSEAIQRMGKDAVEKKYGNLFDMYQR
HHCCCCCCCCCCCCHHCCCCCCHHHHHHCCEEEEHHHHHHHHCHHHHHHHHCCHHHHHHH
ITDENPYEVPMRIYPAVHYTMGGLWVDYDLQSTIPGLFVCGEANFSDHGANRLGASALMQ
HCCCCCCCCCEEEECCCEEEECCEEEEECHHHCCCCEEEECCCCCCCCCCHHHHHHHHHH
GLADGYWVLPNTITDYLADSPKFGMVDEKHPAAVEARQAVESRINKLLTINGTRTVDSIH
HHCCCEEECCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEECCCHHHHHHH
KELGHIMWEYCGMERSEAGLIKAIGLIRNLRNEFWTNVKVTGVNEELNQTLERAGRLADF
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
LELGELMCIDALHRRESCGGHFRAESQTEEGEAMRHDDEYQYVAAWEWTGEGHKPTLHKE
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCEEEEEEEEECCCCCCCCCCCC
PLVYKSIQVKQRSYK
CCEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]