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The map label for this gene is yrpG [H]

Identifier: 50842903

GI number: 50842903

Start: 1541134

End: 1542108

Strand: Direct

Name: yrpG [H]

Synonym: PPA1422

Alternate gene names: 50842903

Gene position: 1541134-1542108 (Clockwise)

Preceding gene: 50842897

Following gene: 50842906

Centisome position: 60.19

GC content: 61.33

Gene sequence:

>975_bases
ATGCACATGCGCATGAGAACCGTCGGGGCCAGCGGCCTCAAGGTATCTGCCATTGGGCTAGGGTCCCTGACATGGGGCGG
GCAAACCGACGCTCGTGAGGTTCGCTCGTTGGTTCGTCGCTTCGTTGACGCCGGTGGCAATCTCGTCGATACCGCACCAG
CGTATGGAGGCGGGTTCGCCGAACAACTCATCGGAAAGCTCACCCATACCGATATCAGTCGAGATGACCTTGTCATAGCG
ACCAAGGCGGGATTCATTGTTGAAGGTCATAAGAGAATCGTCGATACGTCACGCAGTGCGCTGCTGCGTGACCTCGAAGG
GTCCCTGCGCCGTCTCCACACCGATCACGTCGATCTTTGGCAAGTTCATGCCTGGGGAGATGCCCCCATCGAAGAAACCT
GTGCGGCACTCGACCATGCCGTGACATCGGGAATGGCCCGGTACGTCGGGGTCTCCAACTTCGTGGGTTGGCAGGCCGCC
ACGGCAGCGACCTGGCAGCGGGCAACCGGAACACGGACCCCTCTAGTCAGTAACCAGGTGGAATACTCCTTGCTGGCTCG
ACGTGCTGAAATCGAGGTCGTTCCTTCGGCCCAGCACCACGGGATGGGACTTCTGGCATGGTCAGCGCTAGGTCGCGGCG
TGCTGGGAGGCCGGTACCGACACGGAACCCCTAAGGATTCCCGGGGCGGTTCTGATCGCCTGTCTTGGTTCGTGCAGCCC
TATCTGACGCGCAAGTCCAACGCTGTCGTCGAGGCTATTGTGAAAGCGGCCGACGGGCTGGGAGCGACGGTCCCGCAAAT
CGCGCTGGCATGGGTGCGTGATGCCCCTGTAGTCGCCTCGGCTCTTGTCGGACCGAGGACCACCTCACAGCTCGAAGAAT
TGCTCAGAGCTGACGAGGTCAGTCTTCCTAAGGAGATCACCTCAGCCCTCGACGACATCACCGGCGGGCCAAACCTCGCC
CGCGAAGAAGCCTAG

Upstream 100 bases:

>100_bases
CGTCGGGGTGCCAATGAAGAGCTTGGAGACGTCAGGCTTCGCTGTTCTGTCTCAAGGTCGGCTTGAGGGTGCTCCGTTAG
GGTGATCGGGGACGAGGAGG

Downstream 100 bases:

>100_bases
GGTCAAATAGCTCAGCGCTCGCCGCGTGGCACCCACGGAGTCGATACCGGACCATCGTAAAGCTCGCGAGGACGGGAAAT
CCTCGTTGTCGGATCCTCAA

Product: putative oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MHMRMRTVGASGLKVSAIGLGSLTWGGQTDAREVRSLVRRFVDAGGNLVDTAPAYGGGFAEQLIGKLTHTDISRDDLVIA
TKAGFIVEGHKRIVDTSRSALLRDLEGSLRRLHTDHVDLWQVHAWGDAPIEETCAALDHAVTSGMARYVGVSNFVGWQAA
TAATWQRATGTRTPLVSNQVEYSLLARRAEIEVVPSAQHHGMGLLAWSALGRGVLGGRYRHGTPKDSRGGSDRLSWFVQP
YLTRKSNAVVEAIVKAADGLGATVPQIALAWVRDAPVVASALVGPRTTSQLEELLRADEVSLPKEITSALDDITGGPNLA
REEA

Sequences:

>Translated_324_residues
MHMRMRTVGASGLKVSAIGLGSLTWGGQTDAREVRSLVRRFVDAGGNLVDTAPAYGGGFAEQLIGKLTHTDISRDDLVIA
TKAGFIVEGHKRIVDTSRSALLRDLEGSLRRLHTDHVDLWQVHAWGDAPIEETCAALDHAVTSGMARYVGVSNFVGWQAA
TAATWQRATGTRTPLVSNQVEYSLLARRAEIEVVPSAQHHGMGLLAWSALGRGVLGGRYRHGTPKDSRGGSDRLSWFVQP
YLTRKSNAVVEAIVKAADGLGATVPQIALAWVRDAPVVASALVGPRTTSQLEELLRADEVSLPKEITSALDDITGGPNLA
REEA
>Mature_324_residues
MHMRMRTVGASGLKVSAIGLGSLTWGGQTDAREVRSLVRRFVDAGGNLVDTAPAYGGGFAEQLIGKLTHTDISRDDLVIA
TKAGFIVEGHKRIVDTSRSALLRDLEGSLRRLHTDHVDLWQVHAWGDAPIEETCAALDHAVTSGMARYVGVSNFVGWQAA
TAATWQRATGTRTPLVSNQVEYSLLARRAEIEVVPSAQHHGMGLLAWSALGRGVLGGRYRHGTPKDSRGGSDRLSWFVQP
YLTRKSNAVVEAIVKAADGLGATVPQIALAWVRDAPVVASALVGPRTTSQLEELLRADEVSLPKEITSALDDITGGPNLA
REEA

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436964, Length=321, Percent_Identity=33.6448598130841, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI27436962, Length=321, Percent_Identity=33.6448598130841, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI27436966, Length=321, Percent_Identity=33.6448598130841, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI27436969, Length=334, Percent_Identity=33.2335329341317, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI4504825, Length=331, Percent_Identity=33.2326283987915, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI27436971, Length=324, Percent_Identity=29.9382716049383, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI223718702, Length=299, Percent_Identity=31.1036789297659, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI41327764, Length=298, Percent_Identity=31.5436241610738, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI41152114, Length=300, Percent_Identity=27.3333333333333, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI223718708, Length=168, Percent_Identity=33.9285714285714, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI87081735, Length=322, Percent_Identity=32.6086956521739, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1789375, Length=305, Percent_Identity=32.7868852459016, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1789199, Length=345, Percent_Identity=30.7246376811594, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1788070, Length=322, Percent_Identity=25.4658385093168, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788081, Length=274, Percent_Identity=30.2919708029197, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI48994888, Length=314, Percent_Identity=26.7515923566879, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323998, Length=329, Percent_Identity=29.7872340425532, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6325169, Length=331, Percent_Identity=26.5861027190332, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319958, Length=298, Percent_Identity=30.2013422818792, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319951, Length=340, Percent_Identity=28.5294117647059, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6322615, Length=251, Percent_Identity=29.0836653386454, Blast_Score=93, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646155, Length=308, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646159, Length=222, Percent_Identity=30.6306306306306, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24640980, Length=337, Percent_Identity=24.3323442136499, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45549126, Length=337, Percent_Identity=24.3323442136499, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 34696; Mature: 34696

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHMRMRTVGASGLKVSAIGLGSLTWGGQTDAREVRSLVRRFVDAGGNLVDTAPAYGGGFA
CCCEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHH
EQLIGKLTHTDISRDDLVIATKAGFIVEGHKRIVDTSRSALLRDLEGSLRRLHTDHVDLW
HHHHHHHHHCCCCCCCEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
QVHAWGDAPIEETCAALDHAVTSGMARYVGVSNFVGWQAATAATWQRATGTRTPLVSNQV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHH
EYSLLARRAEIEVVPSAQHHGMGLLAWSALGRGVLGGRYRHGTPKDSRGGSDRLSWFVQP
HHHHHHHHHHEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
YLTRKSNAVVEAIVKAADGLGATVPQIALAWVRDAPVVASALVGPRTTSQLEELLRADEV
HHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCC
SLPKEITSALDDITGGPNLAREEA
CCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MHMRMRTVGASGLKVSAIGLGSLTWGGQTDAREVRSLVRRFVDAGGNLVDTAPAYGGGFA
CCCEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHH
EQLIGKLTHTDISRDDLVIATKAGFIVEGHKRIVDTSRSALLRDLEGSLRRLHTDHVDLW
HHHHHHHHHCCCCCCCEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
QVHAWGDAPIEETCAALDHAVTSGMARYVGVSNFVGWQAATAATWQRATGTRTPLVSNQV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHH
EYSLLARRAEIEVVPSAQHHGMGLLAWSALGRGVLGGRYRHGTPKDSRGGSDRLSWFVQP
HHHHHHHHHHEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
YLTRKSNAVVEAIVKAADGLGATVPQIALAWVRDAPVVASALVGPRTTSQLEELLRADEV
HHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCC
SLPKEITSALDDITGGPNLAREEA
CCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]