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The map label for this gene is pheS

Identifier: 50842891

GI number: 50842891

Start: 1532517

End: 1533626

Strand: Reverse

Name: pheS

Synonym: PPA1409

Alternate gene names: 50842891

Gene position: 1533626-1532517 (Counterclockwise)

Preceding gene: 50842892

Following gene: 50842890

Centisome position: 59.9

GC content: 61.17

Gene sequence:

>1110_bases
ATGAGTGGCCCCAACACGAATTATGACCCGGTCCAGGTAAGCGCCCTGGACGCCGATCAGGTCGAGGCCCGGGTGGCCGA
GGCCTTGGAGGCGATTGCCCGGGCTTCTACTACTGCTGAGCTTAAGCAGGTGCGTATCACTCATACCGGTGACCGGTCTG
CGCTGGCTCTGGCCAACCGCGAGATTGGTGCGCTGCCGCCTGCTGCCCGCAAGGATGCCGGTAAGCGCATTGGGCAGGCT
CGAGGGCGGGTGAATCAGGCCTTAAAGGCTCGCCAACAGGAACTTGCCGAGGCTGAGCTTGAGGCTCGACTCGCAGCGGA
AACCACCGACGTTACGTTACCGGTTGTTACTTCGCCTCAAGGTGCTCCGCACCCGATCACGGCTCTTATTGACAACGTCT
GCGACGTGTTCACTGCTATGGGTTGGGAAGTTGCTGAGGGTCCCGAAGCTGAATCCGAGTGGTTCAACTTCGACGCTCTG
AACCTTGGCACTGATCACCCGGCTCGTGCCTTGCAGGACACGCTGTGGCTCGACCCGGTTGATGACGGTAAGTGCATGCG
CACAGCTACCAGTCCGGTGCAGATCCACACCTTGCTTAAGCAGCAACCTCCGGTGCGCATTATCAGCCCGGGCAAGGTTT
TCCGTGCCGATGAGTACGATGCCACTCACCTTCCAGTCTTCCATCAAGTCGAGGGATTGTGCGTCGACAAGGGCATCACC
ATGGGTCACCTCAAGGGCACCGTCGACGCTTTTGCCCGCGCCATGTTCGGTGCCGTGCGCACCCGTTTCCGTCCACACTA
CTTCCCCTTCACCGAGCCCAGCGCTGAGGTCGACCTGGAATGTTTCGTCTGTCATGGGGCCTCGGTTGGCAACCCTGATC
GTCCGTGCCGCACCTGCCGTTCCGAGGGGTGGATCGAGTGGGGCGGCTGCGGGGTCGTCAACCCACGGGTACTTATTGCC
TGCGGTATCGACACGGACGTCTACTCCGGCTTCGCCTTTGGCATGGGCATCGATCGCACGGTGATGTTCCGCAACAATGC
CCCCGACCTGCGCGACTTCGTCGAGGGTGACGTTCGATTCAGCCGCTCACTGAGGGGAGGAGCACGATGA

Upstream 100 bases:

>100_bases
TGTTGACGGCGTCGACGCCACTAGACTTATGTCCATTAGTCGTACACGTGTGTCCGGAACACGCGCGTTGTCCAACGTCA
ACCCATCAGGGGGAAGGCCC

Downstream 100 bases:

>100_bases
AGGTTCCTATGTCATGGCTGCAGGCCATGGTTAATCTGCCAGACGGCACCACTACTGACAAGGTGGCCAAGGCGCTGACC
AACCACACAGCGACCGTTGA

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSGPNTNYDPVQVSALDADQVEARVAEALEAIARASTTAELKQVRITHTGDRSALALANREIGALPPAARKDAGKRIGQA
RGRVNQALKARQQELAEAELEARLAAETTDVTLPVVTSPQGAPHPITALIDNVCDVFTAMGWEVAEGPEAESEWFNFDAL
NLGTDHPARALQDTLWLDPVDDGKCMRTATSPVQIHTLLKQQPPVRIISPGKVFRADEYDATHLPVFHQVEGLCVDKGIT
MGHLKGTVDAFARAMFGAVRTRFRPHYFPFTEPSAEVDLECFVCHGASVGNPDRPCRTCRSEGWIEWGGCGVVNPRVLIA
CGIDTDVYSGFAFGMGIDRTVMFRNNAPDLRDFVEGDVRFSRSLRGGAR

Sequences:

>Translated_369_residues
MSGPNTNYDPVQVSALDADQVEARVAEALEAIARASTTAELKQVRITHTGDRSALALANREIGALPPAARKDAGKRIGQA
RGRVNQALKARQQELAEAELEARLAAETTDVTLPVVTSPQGAPHPITALIDNVCDVFTAMGWEVAEGPEAESEWFNFDAL
NLGTDHPARALQDTLWLDPVDDGKCMRTATSPVQIHTLLKQQPPVRIISPGKVFRADEYDATHLPVFHQVEGLCVDKGIT
MGHLKGTVDAFARAMFGAVRTRFRPHYFPFTEPSAEVDLECFVCHGASVGNPDRPCRTCRSEGWIEWGGCGVVNPRVLIA
CGIDTDVYSGFAFGMGIDRTVMFRNNAPDLRDFVEGDVRFSRSLRGGAR
>Mature_368_residues
SGPNTNYDPVQVSALDADQVEARVAEALEAIARASTTAELKQVRITHTGDRSALALANREIGALPPAARKDAGKRIGQAR
GRVNQALKARQQELAEAELEARLAAETTDVTLPVVTSPQGAPHPITALIDNVCDVFTAMGWEVAEGPEAESEWFNFDALN
LGTDHPARALQDTLWLDPVDDGKCMRTATSPVQIHTLLKQQPPVRIISPGKVFRADEYDATHLPVFHQVEGLCVDKGITM
GHLKGTVDAFARAMFGAVRTRFRPHYFPFTEPSAEVDLECFVCHGASVGNPDRPCRTCRSEGWIEWGGCGVVNPRVLIAC
GIDTDVYSGFAFGMGIDRTVMFRNNAPDLRDFVEGDVRFSRSLRGGAR

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily

Homologues:

Organism=Homo sapiens, GI4758340, Length=276, Percent_Identity=30.0724637681159, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1788007, Length=342, Percent_Identity=47.3684210526316, Blast_Score=302, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17508957, Length=283, Percent_Identity=28.9752650176678, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32563657, Length=283, Percent_Identity=28.9752650176678, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321087, Length=280, Percent_Identity=29.6428571428571, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18858079, Length=278, Percent_Identity=29.136690647482, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYFA_PROAC (Q6A7V5)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056118.1
- ProteinModelPortal:   Q6A7V5
- SMR:   Q6A7V5
- GeneID:   2931899
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1409
- NMPDR:   fig|267747.1.peg.1395
- HOGENOM:   HBG284353
- OMA:   FRASYFP
- ProtClustDB:   CLSK2763961
- BioCyc:   PACN267747:PPA1409-MONOMER
- BRENDA:   6.1.1.20
- GO:   GO:0005737
- HAMAP:   MF_00281
- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978
- PANTHER:   PTHR11538
- TIGRFAMs:   TIGR00468

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d; SSF46589 tRNA_binding_arm

EC number: =6.1.1.20

Molecular weight: Translated: 40149; Mature: 40018

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPNTNYDPVQVSALDADQVEARVAEALEAIARASTTAELKQVRITHTGDRSALALANR
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEECCCCCEEEECCC
EIGALPPAARKDAGKRIGQARGRVNQALKARQQELAEAELEARLAAETTDVTLPVVTSPQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GAPHPITALIDNVCDVFTAMGWEVAEGPEAESEWFNFDALNLGTDHPARALQDTLWLDPV
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCEEEECCCCCHHHHHHHHHCCCCC
DDGKCMRTATSPVQIHTLLKQQPPVRIISPGKVFRADEYDATHLPVFHQVEGLCVDKGIT
CCCCEEECCCCCHHHHHHHHCCCCEEEECCCCEEECCCCCCCCCCHHHHHCCEEECCCCE
MGHLKGTVDAFARAMFGAVRTRFRPHYFPFTEPSAEVDLECFVCHGASVGNPDRPCRTCR
EHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHH
SEGWIEWGGCGVVNPRVLIACGIDTDVYSGFAFGMGIDRTVMFRNNAPDLRDFVEGDVRF
HCCCEEECCCCCCCCCEEEEECCCHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
SRSLRGGAR
HHHHCCCCC
>Mature Secondary Structure 
SGPNTNYDPVQVSALDADQVEARVAEALEAIARASTTAELKQVRITHTGDRSALALANR
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEECCCCCEEEECCC
EIGALPPAARKDAGKRIGQARGRVNQALKARQQELAEAELEARLAAETTDVTLPVVTSPQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GAPHPITALIDNVCDVFTAMGWEVAEGPEAESEWFNFDALNLGTDHPARALQDTLWLDPV
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCEEEECCCCCHHHHHHHHHCCCCC
DDGKCMRTATSPVQIHTLLKQQPPVRIISPGKVFRADEYDATHLPVFHQVEGLCVDKGIT
CCCCEEECCCCCHHHHHHHHCCCCEEEECCCCEEECCCCCCCCCCHHHHHCCEEECCCCE
MGHLKGTVDAFARAMFGAVRTRFRPHYFPFTEPSAEVDLECFVCHGASVGNPDRPCRTCR
EHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHH
SEGWIEWGGCGVVNPRVLIACGIDTDVYSGFAFGMGIDRTVMFRNNAPDLRDFVEGDVRF
HCCCEEECCCCCCCCCEEEEECCCHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
SRSLRGGAR
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA