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The map label for this gene is pyrG

Identifier: 50842872

GI number: 50842872

Start: 1509392

End: 1511080

Strand: Reverse

Name: pyrG

Synonym: PPA1390

Alternate gene names: 50842872

Gene position: 1511080-1509392 (Counterclockwise)

Preceding gene: 50842873

Following gene: 50842871

Centisome position: 59.02

GC content: 61.99

Gene sequence:

>1689_bases
GTGGGCACCGACAATCACTGCAGCAAGCACGTTTTCGTCACTGGAGGGGTCGTTTCCTCCCTGGGAAAGGGGCTCACGGC
CTCCTCCCTCGGGTCGCTTCTGAAGGCGCGTGGCCTTAAGGTCACAATGCAGAAGCTGGACCCTTACCTCAACGTCGATC
CGGGAACGATGAACCCGTTCCAGCATGGCGAGGTGTTCGTCACCGAGGACGGCGCGGAGACTGACCTCGACATCGGCCAC
TACGAGCGTTTCCTTAACGAGAACTTGTCAGGGCAGGCCAATGTGACCACTGGCAAGGTGTACTCCGCGGTCATCGCCAA
GGAGCGTCGGGGCGACTACCTGGGAGACACCGTCCAGGTGATCCCCCATATCACTAACGAGATCAAGGAACGTATGTTGG
CGATGGAGGAGGGCCATCCCGATGTTGTCATCCACGAGATCGGTGGCACCGTCGGCGACATCGAGTCGCTTCCTTTCCTC
GAGGCCGCCCGCCAGGTGCGTCACGAGATCGGCCGGGAGAATGTTTTCTTCCTGCACGTCTCGCTTGTTCCTTACATCAA
GCCGTCCGGCGAGATGAAGACCAAGCCCACCCAGCATTCGGTGGCCGCGTTACGTGAGGTCGGCATCCAGCCCGACGCCA
TCGTGTGTCGATCCGAGCGTCCAATTGGCAAGGGCATCAAGTCGAAGATCGCTCTCATGTGCGACGTCGAGGGCCCGGCC
GTCGTCTCCTGTCCGGACGCTCCGTCGATCTACCTCATTCCGAAGGTTCTGCACCGTGAAGGTCTCGACGCCTACGTCGT
GCAGAAGTTGAGCCTGTTTTTCCGCGACGTCGACTGGACAACCTGGGACGACCTGCTGGATCGCGTCCGTAAGCCGCGCA
GCGAGGTGACCGTGGCCTTGGTCGGCAAGTACATCGACTTGCCGGACGCTTACCTGTCGGTGACCGAGGCGCTGCGAGCC
GGCGGATTCGCCAACAAGGCGAAGGTCAACGTGGTGTGGGTGGCCTCCGATTCCTGCGCCACTGCCGAAGGTGCTGCCCA
GCAGTTACGTGATGCTGATGCCATCTGCGTTCCGGGCGGGTTCGGGATCCGCGGTGTTGAGGGCAAAGTCGGTGCCATCC
GCTACGCCCGCGAACACAAGGTTCCCTTCCTGGGGCTGTGCCTTGGCATGCAGTGCGCCGTCATTGAGGTTGCCCGCGAT
CTGGCTGGCATCAAGGATGCCGCATCCAGTGAGTTCGACTCACAAACCCCCGATCCGGTCATCGCGACGATGGCAGAGCA
GGTCGAGGCAGTGGCCGGCAAGGCCGATCTCGGTGGAACGATGCGTCTGGGGGCCTACCCGGCCAAGCTTGCCAAGGACT
CCCTGGTCGCCGAATTGTATGGCACGACGACAGTTACCGAACGCCACCGTCACCGTTACGAGGTCAACAACGCCTACCGT
GACCGTCTGGAGCAGGCTGGGCTGCGTATTAGTGGTACTTCCCCCGATGGCGGCCTTGTTGAGTTTGTCGAGTTGGACCG
TCAGACCCATCCGTACTTCGTGGCCACCCAGGCTCATCCTGAGCTCAAGTCCCGTCCGACTCACGCCCACCCGCTGTTCC
GCGGACTCGTCGCAGCGGCCGTCGGGCATGCCAAAGCAGCATCGAAGGGAGCGGCCAAGGAGTCCTCCACCAAGGTGGCC
GACAAGTGA

Upstream 100 bases:

>100_bases
GATTGACCATACAGGCGCGCTATGATCCTCAGCGTCGCGAGTCGGGTACGGTCGTGGGGGCTTGCCCCGAAGTCGTGGTG
ATCGGTTAGGCTGGAGGTCC

Downstream 100 bases:

>100_bases
GTCAGGAGCGCTGGGATAAGGACGAGTATTGGCAGGTCGTTGACCACCAGGTAAAGGCCACGGGACAGGTGTGCGATTTC
ATTGATGACGCGGTCATTAC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 562; Mature: 561

Protein sequence:

>562_residues
MGTDNHCSKHVFVTGGVVSSLGKGLTASSLGSLLKARGLKVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDIGH
YERFLNENLSGQANVTTGKVYSAVIAKERRGDYLGDTVQVIPHITNEIKERMLAMEEGHPDVVIHEIGGTVGDIESLPFL
EAARQVRHEIGRENVFFLHVSLVPYIKPSGEMKTKPTQHSVAALREVGIQPDAIVCRSERPIGKGIKSKIALMCDVEGPA
VVSCPDAPSIYLIPKVLHREGLDAYVVQKLSLFFRDVDWTTWDDLLDRVRKPRSEVTVALVGKYIDLPDAYLSVTEALRA
GGFANKAKVNVVWVASDSCATAEGAAQQLRDADAICVPGGFGIRGVEGKVGAIRYAREHKVPFLGLCLGMQCAVIEVARD
LAGIKDAASSEFDSQTPDPVIATMAEQVEAVAGKADLGGTMRLGAYPAKLAKDSLVAELYGTTTVTERHRHRYEVNNAYR
DRLEQAGLRISGTSPDGGLVEFVELDRQTHPYFVATQAHPELKSRPTHAHPLFRGLVAAAVGHAKAASKGAAKESSTKVA
DK

Sequences:

>Translated_562_residues
MGTDNHCSKHVFVTGGVVSSLGKGLTASSLGSLLKARGLKVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDIGH
YERFLNENLSGQANVTTGKVYSAVIAKERRGDYLGDTVQVIPHITNEIKERMLAMEEGHPDVVIHEIGGTVGDIESLPFL
EAARQVRHEIGRENVFFLHVSLVPYIKPSGEMKTKPTQHSVAALREVGIQPDAIVCRSERPIGKGIKSKIALMCDVEGPA
VVSCPDAPSIYLIPKVLHREGLDAYVVQKLSLFFRDVDWTTWDDLLDRVRKPRSEVTVALVGKYIDLPDAYLSVTEALRA
GGFANKAKVNVVWVASDSCATAEGAAQQLRDADAICVPGGFGIRGVEGKVGAIRYAREHKVPFLGLCLGMQCAVIEVARD
LAGIKDAASSEFDSQTPDPVIATMAEQVEAVAGKADLGGTMRLGAYPAKLAKDSLVAELYGTTTVTERHRHRYEVNNAYR
DRLEQAGLRISGTSPDGGLVEFVELDRQTHPYFVATQAHPELKSRPTHAHPLFRGLVAAAVGHAKAASKGAAKESSTKVA
DK
>Mature_561_residues
GTDNHCSKHVFVTGGVVSSLGKGLTASSLGSLLKARGLKVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDIGHY
ERFLNENLSGQANVTTGKVYSAVIAKERRGDYLGDTVQVIPHITNEIKERMLAMEEGHPDVVIHEIGGTVGDIESLPFLE
AARQVRHEIGRENVFFLHVSLVPYIKPSGEMKTKPTQHSVAALREVGIQPDAIVCRSERPIGKGIKSKIALMCDVEGPAV
VSCPDAPSIYLIPKVLHREGLDAYVVQKLSLFFRDVDWTTWDDLLDRVRKPRSEVTVALVGKYIDLPDAYLSVTEALRAG
GFANKAKVNVVWVASDSCATAEGAAQQLRDADAICVPGGFGIRGVEGKVGAIRYAREHKVPFLGLCLGMQCAVIEVARDL
AGIKDAASSEFDSQTPDPVIATMAEQVEAVAGKADLGGTMRLGAYPAKLAKDSLVAELYGTTTVTERHRHRYEVNNAYRD
RLEQAGLRISGTSPDGGLVEFVELDRQTHPYFVATQAHPELKSRPTHAHPLFRGLVAAAVGHAKAASKGAAKESSTKVAD
K

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI28559085, Length=570, Percent_Identity=44.9122807017544, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI28559083, Length=570, Percent_Identity=44.9122807017544, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI221316689, Length=570, Percent_Identity=44.9122807017544, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI148491070, Length=555, Percent_Identity=45.045045045045, Blast_Score=476, Evalue=1e-134,
Organism=Escherichia coli, GI1789142, Length=548, Percent_Identity=55.4744525547445, Blast_Score=594, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI25148299, Length=617, Percent_Identity=37.6012965964344, Blast_Score=386, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322563, Length=569, Percent_Identity=43.9367311072056, Blast_Score=442, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319432, Length=571, Percent_Identity=44.1330998248687, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24664469, Length=576, Percent_Identity=45.4861111111111, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI21357815, Length=521, Percent_Identity=44.1458733205374, Blast_Score=408, Evalue=1e-114,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_PROAC (Q6A7X4)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056099.1
- HSSP:   P17812
- ProteinModelPortal:   Q6A7X4
- SMR:   Q6A7X4
- GeneID:   2932148
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1390
- NMPDR:   fig|267747.1.peg.1376
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   PACN267747:PPA1390-MONOMER
- BRENDA:   6.3.4.2
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60689; Mature: 60558

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 387-387 ACT_SITE 519-519 ACT_SITE 521-521

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTDNHCSKHVFVTGGVVSSLGKGLTASSLGSLLKARGLKVTMQKLDPYLNVDPGTMNPF
CCCCCCCCCEEEEECHHHHHHCCCCCHHHHHHHHHHCCCEEEHHHCCCCEECCCCCCCCC
QHGEVFVTEDGAETDLDIGHYERFLNENLSGQANVTTGKVYSAVIAKERRGDYLGDTVQV
CCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHH
IPHITNEIKERMLAMEEGHPDVVIHEIGGTVGDIESLPFLEAARQVRHEIGRENVFFLHV
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
SLVPYIKPSGEMKTKPTQHSVAALREVGIQPDAIVCRSERPIGKGIKSKIALMCDVEGPA
EEECEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCE
VVSCPDAPSIYLIPKVLHREGLDAYVVQKLSLFFRDVDWTTWDDLLDRVRKPRSEVTVAL
EEECCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHEEEEE
VGKYIDLPDAYLSVTEALRAGGFANKAKVNVVWVASDSCATAEGAAQQLRDADAICVPGG
EHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCEEECCC
FGIRGVEGKVGAIRYAREHKVPFLGLCLGMQCAVIEVARDLAGIKDAASSEFDSQTPDPV
CCCCCCCCCHHHEEEHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
IATMAEQVEAVAGKADLGGTMRLGAYPAKLAKDSLVAELYGTTTVTERHRHRYEVNNAYR
HHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DRLEQAGLRISGTSPDGGLVEFVELDRQTHPYFVATQAHPELKSRPTHAHPLFRGLVAAA
HHHHHCCCEEECCCCCCCEEHHHHHCCCCCCEEEEECCCCHHHCCCCCCHHHHHHHHHHH
VGHAKAASKGAAKESSTKVADK
HHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GTDNHCSKHVFVTGGVVSSLGKGLTASSLGSLLKARGLKVTMQKLDPYLNVDPGTMNPF
CCCCCCCCEEEEECHHHHHHCCCCCHHHHHHHHHHCCCEEEHHHCCCCEECCCCCCCCC
QHGEVFVTEDGAETDLDIGHYERFLNENLSGQANVTTGKVYSAVIAKERRGDYLGDTVQV
CCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHH
IPHITNEIKERMLAMEEGHPDVVIHEIGGTVGDIESLPFLEAARQVRHEIGRENVFFLHV
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
SLVPYIKPSGEMKTKPTQHSVAALREVGIQPDAIVCRSERPIGKGIKSKIALMCDVEGPA
EEECEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCE
VVSCPDAPSIYLIPKVLHREGLDAYVVQKLSLFFRDVDWTTWDDLLDRVRKPRSEVTVAL
EEECCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHEEEEE
VGKYIDLPDAYLSVTEALRAGGFANKAKVNVVWVASDSCATAEGAAQQLRDADAICVPGG
EHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCEEECCC
FGIRGVEGKVGAIRYAREHKVPFLGLCLGMQCAVIEVARDLAGIKDAASSEFDSQTPDPV
CCCCCCCCCHHHEEEHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
IATMAEQVEAVAGKADLGGTMRLGAYPAKLAKDSLVAELYGTTTVTERHRHRYEVNNAYR
HHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DRLEQAGLRISGTSPDGGLVEFVELDRQTHPYFVATQAHPELKSRPTHAHPLFRGLVAAA
HHHHHCCCEEECCCCCCCEEHHHHHCCCCCCEEEEECCCCHHHCCCCCCHHHHHHHHHHH
VGHAKAASKGAAKESSTKVADK
HHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA