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The map label for this gene is deoA

Identifier: 50842851

GI number: 50842851

Start: 1489808

End: 1491097

Strand: Direct

Name: deoA

Synonym: PPA1367

Alternate gene names: 50842851

Gene position: 1489808-1491097 (Clockwise)

Preceding gene: 50842848

Following gene: 50842853

Centisome position: 58.19

GC content: 64.42

Gene sequence:

>1290_bases
ATGACCAGCACCTATTCCGTCGTCGACCTTATCCGCGCTAAGCGCGAAGGCCAGACTCTCAACTCCGACCAAATCGCATG
GCTTATCCGCGCCTACACCGACGACATCGTCGCCGACGAGCAGATGTCTGCCATGGCGATGGCGGTGTACTTCCAGGGGC
TCGACGACGCTGAGCTGTCAGCCTGGACGACGGCCATGATCAAGTCGGGCGAGCGGATGTCCTTCGCTGGGCTGTCCCGC
CCCACTGTCGACAAGCACTCCACTGGCGGCGTGGGCGACAAAATTACCTTGCCGCTGGCTCCCCTGGTGGCCGCGTGCGG
TGCTGCCGTCCCACAGCTGTCTGGGCGTGGCCTGGGCCACACCGGAGGCACCCTCGACAAGATGGAGGCCATTCCCGGAT
GGCGGGCGGATCTCTCTCATGACGAGATGGTCGCCCAGCTCGAGAAAGTCGGCGCCGTCATCTGCGCAGCGGGCCCGGGA
CTAGCCCCTGCTGACAAGAAGCTCTACGCCCTGCGCGACGTTACCGGCACCGTCGAGTCCATCCCGCTGATCGCTTCGTC
CATCATGAGCAAGAAGATCGCAGAGGGCACCGACAGCCTCGTCCTCGATGTCAAGACCGGCTCGGGTGCCTTCATGAAGA
CAGATAAGGACGCCCGCGAACTCGCCAGCCGTCTCGTCGAGCTAGGTGAAGCCGCCGGGGTGCGTACCACCGCCCTACTG
ACCCACATGGACGTCCCACTGGGTTACGCCTGCGGTAACGGCATCGAGGTTGCCGAATCCCTCGAAGTGTTAGCCGGCGG
AGGTCCTGCCGACGTCGTCGAGCTCACCGTCGCCCTGGCCCGTCACATGGTGAAGGTGGCTGGATTGGACGGCATCGACC
CGGCCGATGTACTCGCCAGTGGCCAGGCAATGGATGTCTGGCGCAACATGGTTCGTGCCCAGGGCGGCGACCCTGACGCT
CCACTACCGATGGCCCACCACACCCAGGACATCGTCGCCACCGAGGCTGGCGTCATCACCGGGATTGATGCCATGTCCGT
TGGCCTAGCTGCCTGGCGTTTGGGTGCCGGACGCGCCCGCAAAGAGGATCCGGTGCAAGCTGCGGCTGGCATCATGTTAA
GAGTTCGCCCCGGCGACCGCGTTGTCACAGGCCAGCCATTGGCCACCCTGCTCACCGACACCCCCGACTCCATTGCGCGG
GCCGAGGATGCCATGACCAACGCGTTCACCGTCGGGCAAACCTTCCAGCCGCAAGACATTGTCATCGACACCGTCGTAGC
CCAGTCGTGA

Upstream 100 bases:

>100_bases
ACAAACCGGGCAATACGCATGAGTTAAGACTAACGACATAACGCGACATAACCGGGGCATCCACGCACTGAAGAAGGGTA
AGCCCTGTCATACTTGCGCC

Downstream 100 bases:

>100_bases
ACATATCATTGGGGCCGGCCCCAATGGACGTCGACGCCGTCAGCAGACTCGCTTCAACCAGCCACGGGTGTCCTCAGCGC
GTCCGAACTGGATATCCAGC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTSTYSVVDLIRAKREGQTLNSDQIAWLIRAYTDDIVADEQMSAMAMAVYFQGLDDAELSAWTTAMIKSGERMSFAGLSR
PTVDKHSTGGVGDKITLPLAPLVAACGAAVPQLSGRGLGHTGGTLDKMEAIPGWRADLSHDEMVAQLEKVGAVICAAGPG
LAPADKKLYALRDVTGTVESIPLIASSIMSKKIAEGTDSLVLDVKTGSGAFMKTDKDARELASRLVELGEAAGVRTTALL
THMDVPLGYACGNGIEVAESLEVLAGGGPADVVELTVALARHMVKVAGLDGIDPADVLASGQAMDVWRNMVRAQGGDPDA
PLPMAHHTQDIVATEAGVITGIDAMSVGLAAWRLGAGRARKEDPVQAAAGIMLRVRPGDRVVTGQPLATLLTDTPDSIAR
AEDAMTNAFTVGQTFQPQDIVIDTVVAQS

Sequences:

>Translated_429_residues
MTSTYSVVDLIRAKREGQTLNSDQIAWLIRAYTDDIVADEQMSAMAMAVYFQGLDDAELSAWTTAMIKSGERMSFAGLSR
PTVDKHSTGGVGDKITLPLAPLVAACGAAVPQLSGRGLGHTGGTLDKMEAIPGWRADLSHDEMVAQLEKVGAVICAAGPG
LAPADKKLYALRDVTGTVESIPLIASSIMSKKIAEGTDSLVLDVKTGSGAFMKTDKDARELASRLVELGEAAGVRTTALL
THMDVPLGYACGNGIEVAESLEVLAGGGPADVVELTVALARHMVKVAGLDGIDPADVLASGQAMDVWRNMVRAQGGDPDA
PLPMAHHTQDIVATEAGVITGIDAMSVGLAAWRLGAGRARKEDPVQAAAGIMLRVRPGDRVVTGQPLATLLTDTPDSIAR
AEDAMTNAFTVGQTFQPQDIVIDTVVAQS
>Mature_428_residues
TSTYSVVDLIRAKREGQTLNSDQIAWLIRAYTDDIVADEQMSAMAMAVYFQGLDDAELSAWTTAMIKSGERMSFAGLSRP
TVDKHSTGGVGDKITLPLAPLVAACGAAVPQLSGRGLGHTGGTLDKMEAIPGWRADLSHDEMVAQLEKVGAVICAAGPGL
APADKKLYALRDVTGTVESIPLIASSIMSKKIAEGTDSLVLDVKTGSGAFMKTDKDARELASRLVELGEAAGVRTTALLT
HMDVPLGYACGNGIEVAESLEVLAGGGPADVVELTVALARHMVKVAGLDGIDPADVLASGQAMDVWRNMVRAQGGDPDAP
LPMAHHTQDIVATEAGVITGIDAMSVGLAAWRLGAGRARKEDPVQAAAGIMLRVRPGDRVVTGQPLATLLTDTPDSIARA
EDAMTNAFTVGQTFQPQDIVIDTVVAQS

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=408, Percent_Identity=40.1960784313725, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI4503445, Length=408, Percent_Identity=40.1960784313725, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI166158922, Length=408, Percent_Identity=40.1960784313725, Blast_Score=261, Evalue=9e-70,
Organism=Escherichia coli, GI1790842, Length=399, Percent_Identity=40.8521303258145, Blast_Score=274, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 44693; Mature: 44561

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTYSVVDLIRAKREGQTLNSDQIAWLIRAYTDDIVADEQMSAMAMAVYFQGLDDAELS
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AWTTAMIKSGERMSFAGLSRPTVDKHSTGGVGDKITLPLAPLVAACGAAVPQLSGRGLGH
HHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCC
TGGTLDKMEAIPGWRADLSHDEMVAQLEKVGAVICAAGPGLAPADKKLYALRDVTGTVES
CCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCEEEEECCCCCCCCCCCEEEHHHHHCCHHH
IPLIASSIMSKKIAEGTDSLVLDVKTGSGAFMKTDKDARELASRLVELGEAAGVRTTALL
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHCCCHHHHHH
THMDVPLGYACGNGIEVAESLEVLAGGGPADVVELTVALARHMVKVAGLDGIDPADVLAS
HHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
GQAMDVWRNMVRAQGGDPDAPLPMAHHTQDIVATEAGVITGIDAMSVGLAAWRLGAGRAR
CCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCEECCHHHHHHHHHHHHCCCCCC
KEDPVQAAAGIMLRVRPGDRVVTGQPLATLLTDTPDSIARAEDAMTNAFTVGQTFQPQDI
CCCHHHHHCCEEEEECCCCEEECCCCHHHHHCCCCHHHHHHHHHHHHHEECCCCCCCCHH
VIDTVVAQS
EEEEHCCCC
>Mature Secondary Structure 
TSTYSVVDLIRAKREGQTLNSDQIAWLIRAYTDDIVADEQMSAMAMAVYFQGLDDAELS
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AWTTAMIKSGERMSFAGLSRPTVDKHSTGGVGDKITLPLAPLVAACGAAVPQLSGRGLGH
HHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCC
TGGTLDKMEAIPGWRADLSHDEMVAQLEKVGAVICAAGPGLAPADKKLYALRDVTGTVES
CCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCEEEEECCCCCCCCCCCEEEHHHHHCCHHH
IPLIASSIMSKKIAEGTDSLVLDVKTGSGAFMKTDKDARELASRLVELGEAAGVRTTALL
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHCCCHHHHHH
THMDVPLGYACGNGIEVAESLEVLAGGGPADVVELTVALARHMVKVAGLDGIDPADVLAS
HHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
GQAMDVWRNMVRAQGGDPDAPLPMAHHTQDIVATEAGVITGIDAMSVGLAAWRLGAGRAR
CCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCEECCHHHHHHHHHHHHCCCCCC
KEDPVQAAAGIMLRVRPGDRVVTGQPLATLLTDTPDSIARAEDAMTNAFTVGQTFQPQDI
CCCHHHHHCCEEEEECCCCEEECCCCHHHHHCCCCHHHHHHHHHHHHHEECCCCCCCCHH
VIDTVVAQS
EEEEHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]