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The map label for this gene is wecA [H]

Identifier: 50842728

GI number: 50842728

Start: 1353115

End: 1354218

Strand: Reverse

Name: wecA [H]

Synonym: PPA1248

Alternate gene names: 50842728

Gene position: 1354218-1353115 (Counterclockwise)

Preceding gene: 50842729

Following gene: 50842727

Centisome position: 52.89

GC content: 57.25

Gene sequence:

>1104_bases
ATGCGTGAATACCTCTTGGTGATGCTGACATCGGGTTTGACAACTTATCTGCTGTCTGGCTTGTGTCGGCAGGCTGCCCT
CAGGTGGGGAGCTGTCGCCAAAGTGCGTTCACGGGATGTCCATACCGTCCCTATTCCTTACTTTGGCGGGGTGGCCATGC
TGGGGGGAGTGGCCTTGGCGTGTCTGCTGGCCCGCAATATGCCTTTCCTGGGCCGCCATCTTCTGGTTGCTGACGACGCG
TTGACGATCTGTCTGGCTGGTGTAGTGATCTGCGCTGTGGGTGTCGTCGATGACCTGCTCGACCTTCCTGCCTTGGCCAA
GGCAGCTGGCCAGGTATTAGCGGCCGGCATCGTCGTCACGGGCGGAGTGCGAATGTTTTGGATCCCGCTGCCGAACTCCA
TCATTGCTTTGGGGACGCCTACTTCGATCTTGGTGACGGTGTTCTTCATTGTGTTGTGCGCCAATGCGGTGAATTTCATT
GATGGACTTGACGGCCTGGCATCCGGTGTGGTGGCCATCGGGTCCTTGGCTTTCTTCTCATACACCTACCTGCTGGCTCA
CGAACAGGACTTTGTTGTTGCGACGACTACCAGTCTCATTACGGCTGCGACGGCGGGCGCCTGTCTCGGTTTTTTGCCCC
ACAACTGGCATCCGGCGAGGATGTTCATGGGTGATTCCGGAGCTCTGCTACTTGGCTTATTGCTAGCTACCTCGACGATC
TCGTTGACCGGACAGATCGATTCGACGGCTCTGACAGCACGGGGCGGCGGATTGGTCCCCGCTTACTTGCCAATCGTCGT
GCCACTGATGGTGCTGGCCATCCCTTTTCTGGACCTTGTCATGGGCTATGTCCGGAGGACATGGCGAGGGACGTGGTTCT
TCGTTGCGGACAAGCAACACCTTCATCACCGCTTATTGCAACGAGGCCACTCTCACATGCGGGCTGTCTTGCTGATGTAT
CTATGGACCACCGTGCTCACCTTTGGGACGGTGTTTATTGGCCTGGAACAAACATGGTGGGCGATCGTAATCGTGGTAAC
GGGACTCGGAATGTGCGTACTCCTCACTATGGCGAATTCACATCACCCAGCCGCCCAGGCCTGA

Upstream 100 bases:

>100_bases
CGCCGGCTATCGACCAAGATTCGTCCGAAAATCATGGTTCTGATGTTGCCCCGACCGAGGCCACATCGACGCAGTCAGAG
ATCGAGGGCTGACACTCGTC

Downstream 100 bases:

>100_bases
GATGACGACATCGTCACGCGTCATGTGTTACCTTTTCATCGAGGATGTCCTCAGCAGGCATACCGCCACTCGATTCATAG
CGTCGCGTTGCCGAGTCCAG

Product: putative undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MREYLLVMLTSGLTTYLLSGLCRQAALRWGAVAKVRSRDVHTVPIPYFGGVAMLGGVALACLLARNMPFLGRHLLVADDA
LTICLAGVVICAVGVVDDLLDLPALAKAAGQVLAAGIVVTGGVRMFWIPLPNSIIALGTPTSILVTVFFIVLCANAVNFI
DGLDGLASGVVAIGSLAFFSYTYLLAHEQDFVVATTTSLITAATAGACLGFLPHNWHPARMFMGDSGALLLGLLLATSTI
SLTGQIDSTALTARGGGLVPAYLPIVVPLMVLAIPFLDLVMGYVRRTWRGTWFFVADKQHLHHRLLQRGHSHMRAVLLMY
LWTTVLTFGTVFIGLEQTWWAIVIVVTGLGMCVLLTMANSHHPAAQA

Sequences:

>Translated_367_residues
MREYLLVMLTSGLTTYLLSGLCRQAALRWGAVAKVRSRDVHTVPIPYFGGVAMLGGVALACLLARNMPFLGRHLLVADDA
LTICLAGVVICAVGVVDDLLDLPALAKAAGQVLAAGIVVTGGVRMFWIPLPNSIIALGTPTSILVTVFFIVLCANAVNFI
DGLDGLASGVVAIGSLAFFSYTYLLAHEQDFVVATTTSLITAATAGACLGFLPHNWHPARMFMGDSGALLLGLLLATSTI
SLTGQIDSTALTARGGGLVPAYLPIVVPLMVLAIPFLDLVMGYVRRTWRGTWFFVADKQHLHHRLLQRGHSHMRAVLLMY
LWTTVLTFGTVFIGLEQTWWAIVIVVTGLGMCVLLTMANSHHPAAQA
>Mature_367_residues
MREYLLVMLTSGLTTYLLSGLCRQAALRWGAVAKVRSRDVHTVPIPYFGGVAMLGGVALACLLARNMPFLGRHLLVADDA
LTICLAGVVICAVGVVDDLLDLPALAKAAGQVLAAGIVVTGGVRMFWIPLPNSIIALGTPTSILVTVFFIVLCANAVNFI
DGLDGLASGVVAIGSLAFFSYTYLLAHEQDFVVATTTSLITAATAGACLGFLPHNWHPARMFMGDSGALLLGLLLATSTI
SLTGQIDSTALTARGGGLVPAYLPIVVPLMVLAIPFLDLVMGYVRRTWRGTWFFVADKQHLHHRLLQRGHSHMRAVLLMY
LWTTVLTFGTVFIGLEQTWWAIVIVVTGLGMCVLLTMANSHHPAAQA

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55), the lipid intermediate involved in the synthesis of various bacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=310, Percent_Identity=26.4516129032258, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 39133; Mature: 39133

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREYLLVMLTSGLTTYLLSGLCRQAALRWGAVAKVRSRDVHTVPIPYFGGVAMLGGVALA
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHH
CLLARNMPFLGRHLLVADDALTICLAGVVICAVGVVDDLLDLPALAKAAGQVLAAGIVVT
HHHHCCCCHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEE
GGVRMFWIPLPNSIIALGTPTSILVTVFFIVLCANAVNFIDGLDGLASGVVAIGSLAFFS
CCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTYLLAHEQDFVVATTTSLITAATAGACLGFLPHNWHPARMFMGDSGALLLGLLLATSTI
HHHHEECCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHE
SLTGQIDSTALTARGGGLVPAYLPIVVPLMVLAIPFLDLVMGYVRRTWRGTWFFVADKQH
EEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHH
LHHRLLQRGHSHMRAVLLMYLWTTVLTFGTVFIGLEQTWWAIVIVVTGLGMCVLLTMANS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HHPAAQA
CCCCCCC
>Mature Secondary Structure
MREYLLVMLTSGLTTYLLSGLCRQAALRWGAVAKVRSRDVHTVPIPYFGGVAMLGGVALA
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHH
CLLARNMPFLGRHLLVADDALTICLAGVVICAVGVVDDLLDLPALAKAAGQVLAAGIVVT
HHHHCCCCHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEE
GGVRMFWIPLPNSIIALGTPTSILVTVFFIVLCANAVNFIDGLDGLASGVVAIGSLAFFS
CCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTYLLAHEQDFVVATTTSLITAATAGACLGFLPHNWHPARMFMGDSGALLLGLLLATSTI
HHHHEECCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHE
SLTGQIDSTALTARGGGLVPAYLPIVVPLMVLAIPFLDLVMGYVRRTWRGTWFFVADKQH
EEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHH
LHHRLLQRGHSHMRAVLLMYLWTTVLTFGTVFIGLEQTWWAIVIVVTGLGMCVLLTMANS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HHPAAQA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]