Click here to switch to the map view.

The map label for this gene is atpA

Identifier: 50842721

GI number: 50842721

Start: 1348042

End: 1349679

Strand: Reverse

Name: atpA

Synonym: PPA1241

Alternate gene names: 50842721

Gene position: 1349679-1348042 (Counterclockwise)

Preceding gene: 50842722

Following gene: 50842720

Centisome position: 52.72

GC content: 58.42

Gene sequence:

>1638_bases
ATGGCGGAACTGACGATACGTCCGGAGGAGATCCGCGACGCCCTGGACAACTTCGTCCAGAATTACGAGCCGGAGACGGC
GGTCCGTGAGGAGGTCGGCACCGTCGTCACATCTGGCGACGGTATCGCCCACGTCGAGGGGCTTCCCTCGGCCATGGCCA
ACGAGTTGCTGCGCTTCGAGAATGGAACGATGGGCATTGCCCTTAACTTAGAAGAGCGGCAAATCGGTGTGGTCGTGCTC
GGCGATTCCGACGGTATTGATGAGGGATCGACTGTTCGTGGCACTGGGGAAGTGCTGTCTGTGCCGGTTGGCGAGGGATA
TCTCGGTCGCGTCGTGGACGCGATGGGTAACCCAGTTGATGGTCTCGGCGAGATCAAAGGTGTTGAGGGACGTCGTGCCC
TCGAGATCCAGGCTGCCGGCGTTATGGACCGTCAGGAAGTTCGTGAGCCGTTGCAGACTGGTCTTAAAGCCATCGACTCG
ATGATCCCGATTGGTCGTGGTCAGCGTCAGCTCATCATCGGTGACCGCAAGACTGGTAAGACCGCCATTGCGATCGACAC
CATCATCAACCAGAAGGGCAACTGGGAATCTGGCGATCCTCAGAAGCAGGTTCGCTGCATCTACGTCGCCATTGGACAGA
AGGGCTCGACTGTTGCGGAGGTGAAGGGTGCTCTGGAGAAGGCTGGTGCGATGGAGTACACCACCATCGTCCATGCCCCT
GCCTCCGATCCTGCTGGCTTTAAGTACATCGCTCCCTACGCCGGTTCGGCCATTGGTCAGCACTGGATGTACCAGGGTAA
GCACGTCCTGATCATCTTCGATGACCTGACCAAGCAGGCCGAGGCCTACCGAGCTATGTCGCTGCTGCTGCGTCGTCCTC
CGGGCCGTGAAGCTTATCCCGGTGATGTCTTTTACCTACACTCCCGCCTGCTGGAGCGTTGCGCGAAGCTGTCCGACGAC
TTGGGTGGCGGTTCGATGACCGGTTTGCCGATCATCGAGACCAAGGCCAACGACGTCTCGGCCTTCATTCCGACGAACGT
CATCTCTATTACCGATGGTCAGATCTTCCTCCAGTCGGATCTGTTCAACGCCAACCAGCGTCCGGCCGTCGACGTCGGTA
TCTCGGTTTCGCGAGTCGGTGGTGCTGCCCAGATTAAGGCAATGAAGTCGGTCGCTGGCACCTTGAAGATCTCTTTGGCT
CAGTACCGCGATATGCAGGCCTTTGCGATGTTTGCCTCCGATTTGGATGACACGTCCCGTCGCCAGCTGGATCGTGGCGC
TCGCCTTATGGAGCTACTCAAGCAGGGCCAATTCTCGCCCTACCCGGTAGAGGAGCAGGTCATTAGCGTGTGGGGTGGCA
CCACCGGCAAGTTCGACGATGTTCCGGTCGGCGATGTATTGCGGTTCGAGGGTGACGTTCTTGAGTACTTGCGTAGTCAC
AGCAACGTGCTCACGACGATCCGGGAAACCGGCAAGTTCGACGATGAGGCGAAAGATGCGGCGGCTGCTGCCTTTGAAGA
GGTCAAGAAGGGATTCAAGACCTCTGATGGAAAGATGCTGGCTGGTCATGAAGAGTTCTCGCCGATGGCTGATGAGGACA
TCGACCAGGCCAAGATCGTTCGCGCGAAGAAGGGCTGA

Upstream 100 bases:

>100_bases
CGACGGTGGCCCACCGTTTGGACCAAGCCCGACGAGAACTGGGCTGACATACGTGACCCTCACCTCGGGTGCGGGATGGG
GGAGCTTACAAGGAGACGCA

Downstream 100 bases:

>100_bases
GCCGTGGCGTCGAACCTGCGTGAACTGCGGGAGAGGCGGAACTCCGTCGCAACGACGAAGAAGATTACTCGCGCGATGGA
GTTGATTGCCTCATCGCGAA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAELTIRPEEIRDALDNFVQNYEPETAVREEVGTVVTSGDGIAHVEGLPSAMANELLRFENGTMGIALNLEERQIGVVVL
GDSDGIDEGSTVRGTGEVLSVPVGEGYLGRVVDAMGNPVDGLGEIKGVEGRRALEIQAAGVMDRQEVREPLQTGLKAIDS
MIPIGRGQRQLIIGDRKTGKTAIAIDTIINQKGNWESGDPQKQVRCIYVAIGQKGSTVAEVKGALEKAGAMEYTTIVHAP
ASDPAGFKYIAPYAGSAIGQHWMYQGKHVLIIFDDLTKQAEAYRAMSLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDD
LGGGSMTGLPIIETKANDVSAFIPTNVISITDGQIFLQSDLFNANQRPAVDVGISVSRVGGAAQIKAMKSVAGTLKISLA
QYRDMQAFAMFASDLDDTSRRQLDRGARLMELLKQGQFSPYPVEEQVISVWGGTTGKFDDVPVGDVLRFEGDVLEYLRSH
SNVLTTIRETGKFDDEAKDAAAAAFEEVKKGFKTSDGKMLAGHEEFSPMADEDIDQAKIVRAKKG

Sequences:

>Translated_545_residues
MAELTIRPEEIRDALDNFVQNYEPETAVREEVGTVVTSGDGIAHVEGLPSAMANELLRFENGTMGIALNLEERQIGVVVL
GDSDGIDEGSTVRGTGEVLSVPVGEGYLGRVVDAMGNPVDGLGEIKGVEGRRALEIQAAGVMDRQEVREPLQTGLKAIDS
MIPIGRGQRQLIIGDRKTGKTAIAIDTIINQKGNWESGDPQKQVRCIYVAIGQKGSTVAEVKGALEKAGAMEYTTIVHAP
ASDPAGFKYIAPYAGSAIGQHWMYQGKHVLIIFDDLTKQAEAYRAMSLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDD
LGGGSMTGLPIIETKANDVSAFIPTNVISITDGQIFLQSDLFNANQRPAVDVGISVSRVGGAAQIKAMKSVAGTLKISLA
QYRDMQAFAMFASDLDDTSRRQLDRGARLMELLKQGQFSPYPVEEQVISVWGGTTGKFDDVPVGDVLRFEGDVLEYLRSH
SNVLTTIRETGKFDDEAKDAAAAAFEEVKKGFKTSDGKMLAGHEEFSPMADEDIDQAKIVRAKKG
>Mature_544_residues
AELTIRPEEIRDALDNFVQNYEPETAVREEVGTVVTSGDGIAHVEGLPSAMANELLRFENGTMGIALNLEERQIGVVVLG
DSDGIDEGSTVRGTGEVLSVPVGEGYLGRVVDAMGNPVDGLGEIKGVEGRRALEIQAAGVMDRQEVREPLQTGLKAIDSM
IPIGRGQRQLIIGDRKTGKTAIAIDTIINQKGNWESGDPQKQVRCIYVAIGQKGSTVAEVKGALEKAGAMEYTTIVHAPA
SDPAGFKYIAPYAGSAIGQHWMYQGKHVLIIFDDLTKQAEAYRAMSLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDDL
GGGSMTGLPIIETKANDVSAFIPTNVISITDGQIFLQSDLFNANQRPAVDVGISVSRVGGAAQIKAMKSVAGTLKISLAQ
YRDMQAFAMFASDLDDTSRRQLDRGARLMELLKQGQFSPYPVEEQVISVWGGTTGKFDDVPVGDVLRFEGDVLEYLRSHS
NVLTTIRETGKFDDEAKDAAAAAFEEVKKGFKTSDGKMLAGHEEFSPMADEDIDQAKIVRAKKG

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=496, Percent_Identity=56.25, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI4757810, Length=496, Percent_Identity=56.25, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI19913428, Length=344, Percent_Identity=29.0697674418605, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI19913426, Length=414, Percent_Identity=27.7777777777778, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI32189394, Length=436, Percent_Identity=22.9357798165138, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1790172, Length=505, Percent_Identity=50.2970297029703, Blast_Score=492, Evalue=1e-140,
Organism=Escherichia coli, GI1788251, Length=344, Percent_Identity=27.0348837209302, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790170, Length=427, Percent_Identity=24.824355971897, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=475, Percent_Identity=58.5263157894737, Blast_Score=558, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI71988080, Length=475, Percent_Identity=58.5263157894737, Blast_Score=556, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI71988074, Length=475, Percent_Identity=54.7368421052632, Blast_Score=507, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17570191, Length=353, Percent_Identity=29.7450424929178, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17510931, Length=404, Percent_Identity=27.4752475247525, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144756, Length=403, Percent_Identity=22.0843672456576, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=60, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=514, Percent_Identity=52.7237354085603, Blast_Score=540, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6319603, Length=319, Percent_Identity=31.0344827586207, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322581, Length=420, Percent_Identity=23.0952380952381, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24658560, Length=497, Percent_Identity=55.7344064386318, Blast_Score=543, Evalue=1e-154,
Organism=Drosophila melanogaster, GI281361666, Length=369, Percent_Identity=29.810298102981, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646341, Length=369, Percent_Identity=29.810298102981, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17136796, Length=369, Percent_Identity=29.810298102981, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24638766, Length=413, Percent_Identity=22.5181598062954, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574560, Length=413, Percent_Identity=23.0024213075061, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_PROAC (Q6A8C5)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055948.1
- ProteinModelPortal:   Q6A8C5
- SMR:   Q6A8C5
- GeneID:   2932468
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1241
- NMPDR:   fig|267747.1.peg.1225
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- ProtClustDB:   PRK09281
- BioCyc:   PACN267747:PPA1241-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 58910; Mature: 58778

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELTIRPEEIRDALDNFVQNYEPETAVREEVGTVVTSGDGIAHVEGLPSAMANELLRFE
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCEEECCCCEEECCCCCHHHHHHHHHHC
NGTMGIALNLEERQIGVVVLGDSDGIDEGSTVRGTGEVLSVPVGEGYLGRVVDAMGNPVD
CCCEEEEEEECCCEEEEEEECCCCCCCCCCEEECCCCEEEEECCCCHHHHHHHHHCCCCC
GLGEIKGVEGRRALEIQAAGVMDRQEVREPLQTGLKAIDSMIPIGRGQRQLIIGDRKTGK
CCHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
TAIAIDTIINQKGNWESGDPQKQVRCIYVAIGQKGSTVAEVKGALEKAGAMEYTTIVHAP
EEEEEEHHHCCCCCCCCCCHHHHEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECC
ASDPAGFKYIAPYAGSAIGQHWMYQGKHVLIIFDDLTKQAEAYRAMSLLLRRPPGREAYP
CCCCCCCEEECCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCC
GDVFYLHSRLLERCAKLSDDLGGGSMTGLPIIETKANDVSAFIPTNVISITDGQIFLQSD
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEECCCCEEEEECCEEEEEEC
LFNANQRPAVDVGISVSRVGGAAQIKAMKSVAGTLKISLAQYRDMQAFAMFASDLDDTSR
CCCCCCCCCEEECCCHHHCCCHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHCCCHHHH
RQLDRGARLMELLKQGQFSPYPVEEQVISVWGGTTGKFDDVPVGDVLRFEGDVLEYLRSH
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCCHHHHHHHHC
SNVLTTIRETGKFDDEAKDAAAAAFEEVKKGFKTSDGKMLAGHEEFSPMADEDIDQAKIV
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCHHCCCCCCCCCCHHHHH
RAKKG
CCCCC
>Mature Secondary Structure 
AELTIRPEEIRDALDNFVQNYEPETAVREEVGTVVTSGDGIAHVEGLPSAMANELLRFE
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCEEECCCCEEECCCCCHHHHHHHHHHC
NGTMGIALNLEERQIGVVVLGDSDGIDEGSTVRGTGEVLSVPVGEGYLGRVVDAMGNPVD
CCCEEEEEEECCCEEEEEEECCCCCCCCCCEEECCCCEEEEECCCCHHHHHHHHHCCCCC
GLGEIKGVEGRRALEIQAAGVMDRQEVREPLQTGLKAIDSMIPIGRGQRQLIIGDRKTGK
CCHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
TAIAIDTIINQKGNWESGDPQKQVRCIYVAIGQKGSTVAEVKGALEKAGAMEYTTIVHAP
EEEEEEHHHCCCCCCCCCCHHHHEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECC
ASDPAGFKYIAPYAGSAIGQHWMYQGKHVLIIFDDLTKQAEAYRAMSLLLRRPPGREAYP
CCCCCCCEEECCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCC
GDVFYLHSRLLERCAKLSDDLGGGSMTGLPIIETKANDVSAFIPTNVISITDGQIFLQSD
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEECCCCEEEEECCEEEEEEC
LFNANQRPAVDVGISVSRVGGAAQIKAMKSVAGTLKISLAQYRDMQAFAMFASDLDDTSR
CCCCCCCCCEEECCCHHHCCCHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHCCCHHHH
RQLDRGARLMELLKQGQFSPYPVEEQVISVWGGTTGKFDDVPVGDVLRFEGDVLEYLRSH
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCCHHHHHHHHC
SNVLTTIRETGKFDDEAKDAAAAAFEEVKKGFKTSDGKMLAGHEEFSPMADEDIDQAKIV
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCHHCCCCCCCCCCHHHHH
RAKKG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA