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The map label for this gene is fucP [H]

Identifier: 50842694

GI number: 50842694

Start: 1321679

End: 1323112

Strand: Reverse

Name: fucP [H]

Synonym: PPA1213

Alternate gene names: 50842694

Gene position: 1323112-1321679 (Counterclockwise)

Preceding gene: 50842695

Following gene: 50842693

Centisome position: 51.68

GC content: 53.42

Gene sequence:

>1434_bases
GTGATCACCAAAGACACCACTGTCGTCAACGACACGGACGTGGATCGTGGCATCCCCAACGCGTCGTGGGGCCTCATCAA
GGACCACACCTTGCAGTTGCGTGACGGATACCTGAATCGCACCCCACTCTTCCAATTCATTCTGCTGTCGATATGTTTCC
CGATGTGGGGAATGGCGGCGAGCATGAACGACATCCTCATCACCCAATTTAAGGCTGTGTTTGCTCTTTCGGATCTTGCT
AGTGCATTCGTGCAGTCAGCCTTTTACGGCGGCTATTTCCTTATCGCCATACCTGCGAGCCGAGTAATTCGTCGCACCAG
CTACAAGACGGGCCTGCTCATTGGTTTGAGTGTGTACATTCTCGGATGCCTGTTGTTTTTCCCGGCTTCGCGTGTGGCTA
CGTATACGGTATTCTTAGCTGCCCTGTTTTCCATCGCCGTTGGCTTGTCTTTCTTGGAGACTTCAGCGAACACATATTCG
TCGATGATCGGTGATCGGAAACATGCAACTCTGCGCCTTAATATTTCTCAGACATTCACGTCGTTGGGATTCTTGGGTGG
GGCCCTCATGGGAAAATTCCTCGTGTTCACCGACGGCGCTGCGCTGCACGAGCGCGTAGCCCACGCCCACACGGTGGCTG
AGCGCGAGGCTATCACCGCCGAAGCGTTGGGGCGTACGCTCGATCCCTACAGGATTATCATCATTATGTTGATAGTGCTC
GTGGTGCTCATCGCCATCACCCAGTACCCGCACTCCAAGCCGTTGCGCAACGACGCGGAAGAAGCCAAAGCCCCCATCGG
TGAAACTCTTGCATACCTAGCGAAGAACCGTTTGTTCCGTGCTGGAATTTTTACACAGTTCCTCTATGTGGGCTTGCAGA
CGTCATTATGGACCTTCACCATCCGGCTGGCTTTGAATCTTGATCCGGCATTAAACGAGCGTACTGCCGCGAACTATTTG
ATTGCTGCATTCATTTCTTTCTTCCTTGGAAAAACCATCGCCAACCTGCTCATGACCCGAATGAGCGAGAACGGCATTCT
CATGGCGTATTCGTTGCTCGGAGTGTTATGTATCACTTACATCGTCGTGGTGCCAAGCTTCACAACCGTCTATGCAGCGG
TGATCGCCTCGGCGCTGTTGGGGCCGGGATGGGCGACGATCTTCGCACGAAACCTTGACCTCATCGAGGACAAGCGCTAC
ACCGAGACTGGCGGTGCGATCATCATTATGTCGATCATCGGTGGTGCTGCCATTCCAGTAGTGCAGGGCTTCCTGTCCGA
CACCACAGGATCCATGAGACTCAGTTTTATCGTAAACGCCTTCTGCTTCACCGCGATCTTCGTGTTCTTCTTAGTCGTCG
ATCGTCGCGATCAGAAACAAATCTGTGACATCGCACCTGCTGCTCTGAAGGAGGCCCCTCATGCCAACCACTGA

Upstream 100 bases:

>100_bases
GCATTCGTACCCACAACGACGTGGCGACGATGCTAAGGGCTGGTGCCACCCGCATCGGTGCCTCCGCCGGGGTCGCCCTC
CTTGTTGACGAGGAGGCACT

Downstream 100 bases:

>100_bases
CCTCGAGATCATCCTGTACCCAGAACTGTTTGACGAAAGGCGACGTGACGTTCTCCGAACGGGTGAATGGATCGTAACTG
CGTGGCGGTACTCCACCGGG

Product: L-fucose permease

Products: Proton [Cytoplasm]; L-fucose [Cytoplasm] [C]

Alternate protein names: 6-deoxy-L-galactose permease; L-fucose permease [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MITKDTTVVNDTDVDRGIPNASWGLIKDHTLQLRDGYLNRTPLFQFILLSICFPMWGMAASMNDILITQFKAVFALSDLA
SAFVQSAFYGGYFLIAIPASRVIRRTSYKTGLLIGLSVYILGCLLFFPASRVATYTVFLAALFSIAVGLSFLETSANTYS
SMIGDRKHATLRLNISQTFTSLGFLGGALMGKFLVFTDGAALHERVAHAHTVAEREAITAEALGRTLDPYRIIIIMLIVL
VVLIAITQYPHSKPLRNDAEEAKAPIGETLAYLAKNRLFRAGIFTQFLYVGLQTSLWTFTIRLALNLDPALNERTAANYL
IAAFISFFLGKTIANLLMTRMSENGILMAYSLLGVLCITYIVVVPSFTTVYAAVIASALLGPGWATIFARNLDLIEDKRY
TETGGAIIIMSIIGGAAIPVVQGFLSDTTGSMRLSFIVNAFCFTAIFVFFLVVDRRDQKQICDIAPAALKEAPHANH

Sequences:

>Translated_477_residues
MITKDTTVVNDTDVDRGIPNASWGLIKDHTLQLRDGYLNRTPLFQFILLSICFPMWGMAASMNDILITQFKAVFALSDLA
SAFVQSAFYGGYFLIAIPASRVIRRTSYKTGLLIGLSVYILGCLLFFPASRVATYTVFLAALFSIAVGLSFLETSANTYS
SMIGDRKHATLRLNISQTFTSLGFLGGALMGKFLVFTDGAALHERVAHAHTVAEREAITAEALGRTLDPYRIIIIMLIVL
VVLIAITQYPHSKPLRNDAEEAKAPIGETLAYLAKNRLFRAGIFTQFLYVGLQTSLWTFTIRLALNLDPALNERTAANYL
IAAFISFFLGKTIANLLMTRMSENGILMAYSLLGVLCITYIVVVPSFTTVYAAVIASALLGPGWATIFARNLDLIEDKRY
TETGGAIIIMSIIGGAAIPVVQGFLSDTTGSMRLSFIVNAFCFTAIFVFFLVVDRRDQKQICDIAPAALKEAPHANH
>Mature_477_residues
MITKDTTVVNDTDVDRGIPNASWGLIKDHTLQLRDGYLNRTPLFQFILLSICFPMWGMAASMNDILITQFKAVFALSDLA
SAFVQSAFYGGYFLIAIPASRVIRRTSYKTGLLIGLSVYILGCLLFFPASRVATYTVFLAALFSIAVGLSFLETSANTYS
SMIGDRKHATLRLNISQTFTSLGFLGGALMGKFLVFTDGAALHERVAHAHTVAEREAITAEALGRTLDPYRIIIIMLIVL
VVLIAITQYPHSKPLRNDAEEAKAPIGETLAYLAKNRLFRAGIFTQFLYVGLQTSLWTFTIRLALNLDPALNERTAANYL
IAAFISFFLGKTIANLLMTRMSENGILMAYSLLGVLCITYIVVVPSFTTVYAAVIASALLGPGWATIFARNLDLIEDKRY
TETGGAIIIMSIIGGAAIPVVQGFLSDTTGSMRLSFIVNAFCFTAIFVFFLVVDRRDQKQICDIAPAALKEAPHANH

Specific function: Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-

COG id: COG0738

COG function: function code G; Fucose permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family [H]

Homologues:

Organism=Escherichia coli, GI1789166, Length=422, Percent_Identity=33.4123222748815, Blast_Score=249, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005275
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52247; Mature: 52247

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITKDTTVVNDTDVDRGIPNASWGLIKDHTLQLRDGYLNRTPLFQFILLSICFPMWGMAA
CCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
SMNDILITQFKAVFALSDLASAFVQSAFYGGYFLIAIPASRVIRRTSYKTGLLIGLSVYI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHCCCCHHHHHHHHHH
LGCLLFFPASRVATYTVFLAALFSIAVGLSFLETSANTYSSMIGDRKHATLRLNISQTFT
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHH
SLGFLGGALMGKFLVFTDGAALHERVAHAHTVAEREAITAEALGRTLDPYRIIIIMLIVL
HHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
VVLIAITQYPHSKPLRNDAEEAKAPIGETLAYLAKNRLFRAGIFTQFLYVGLQTSLWTFT
HHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
IRLALNLDPALNERTAANYLIAAFISFFLGKTIANLLMTRMSENGILMAYSLLGVLCITY
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IVVVPSFTTVYAAVIASALLGPGWATIFARNLDLIEDKRYTETGGAIIIMSIIGGAAIPV
HHHHCCHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHCCCCCCCCCEEEEHHHHCCHHHHH
VQGFLSDTTGSMRLSFIVNAFCFTAIFVFFLVVDRRDQKQICDIAPAALKEAPHANH
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHCCCCCCC
>Mature Secondary Structure
MITKDTTVVNDTDVDRGIPNASWGLIKDHTLQLRDGYLNRTPLFQFILLSICFPMWGMAA
CCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
SMNDILITQFKAVFALSDLASAFVQSAFYGGYFLIAIPASRVIRRTSYKTGLLIGLSVYI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHCCCCHHHHHHHHHH
LGCLLFFPASRVATYTVFLAALFSIAVGLSFLETSANTYSSMIGDRKHATLRLNISQTFT
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHH
SLGFLGGALMGKFLVFTDGAALHERVAHAHTVAEREAITAEALGRTLDPYRIIIIMLIVL
HHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
VVLIAITQYPHSKPLRNDAEEAKAPIGETLAYLAKNRLFRAGIFTQFLYVGLQTSLWTFT
HHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
IRLALNLDPALNERTAANYLIAAFISFFLGKTIANLLMTRMSENGILMAYSLLGVLCITY
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IVVVPSFTTVYAAVIASALLGPGWATIFARNLDLIEDKRYTETGGAIIIMSIIGGAAIPV
HHHHCCHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHCCCCCCCCCEEEEHHHHCCHHHHH
VQGFLSDTTGSMRLSFIVNAFCFTAIFVFFLVVDRRDQKQICDIAPAALKEAPHANH
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-fucose [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-fucose [Periplasm] = Proton [Cytoplasm] + L-fucose [Cytoplasm] [C]

General reaction: Permease [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2664711; 9278503; 2553671; 8052131; 2829831; 7783647 [H]