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The map label for this gene is fmt

Identifier: 50842675

GI number: 50842675

Start: 1301835

End: 1302782

Strand: Direct

Name: fmt

Synonym: PPA1195

Alternate gene names: 50842675

Gene position: 1301835-1302782 (Clockwise)

Preceding gene: 50842674

Following gene: 50842676

Centisome position: 50.85

GC content: 61.08

Gene sequence:

>948_bases
GTGAGACTTCTTTTTGCTGGTACCCCGGACGTGGCCGTCCCAACGCTTACCGCCTTGGTAGCCGATCCCCGTCACGAGGT
AGCTGCCGTCCTGACGCGTCCGGATGCAGCAGTAGGACGGCACCGTACTCCACGTCCATGCCCGGTCGCCAAGGCTGCCG
AGGAACTCGGTATCCCCGCCATTAAGGCGACCAGCGTGAAGTCCGGCGAGGGTCACGATGCCATCACTTCCCTCGATGCC
GACGTAGCCGTCGTCGTGGCCTACGGAGGTCTCATTCCCGCCGATCTGCTGGCAGTACCACGACACGGCTGGATTAACTT
ACACTTTTCTCTCCTACCGCGATGGCGCGGCGCTGCTCCCATACAACGGGCCATCATGGCGGGGGATGAGGAGACGGGCG
CTTGTGTCTTTCAGCTAGTTGAAAGCCTCGATGCCGGGCCGGTATACCGCACCATGACGGTTCCTATAGGCCCGATGACA
ACAGCCGGTGAGCTTCTTGACGAGCTGGCTCATACCGCAACGCCTCTCGTCATTGAGGCCTTGGAGGACATTGAGGCGGG
AGTCGAGCCAACGCCACAATCTGTTGAAGGAGTGACAATCGCTCCACAAATCCATCCCGATGACGTCCGAGTTACCGTCA
CCGCTGCTGCCCAGGAGATCGACAACCTCGTCCGAGGGGTGTCCCCAACTCCTGGGGCGTGGGCTGAATTAGACGGCAAA
CGTTTCAAGATCCTGCGGACCCGCTGTCTTGAAGCCGGAGATGGCGTCCCGAGCACCGTGGCGACAGCCCAACCTGGTCA
ACTCGTCGCAACCCGAAAGCAGCTGTTTCTCGGTACTGGCTCGCAGCCCCTCGAGCTGCTGCAGGTGCAAGCTTTCGGTA
AGAGAGCTATGAGTGGGGCTGACTGGGCCCGAGGGGCCGACATCGACGCTGGAACTAGGCTGAGATGA

Upstream 100 bases:

>100_bases
ATTTCGGCTACGTTCCAAGCACACTATGAGCCGCGAGCCAGGAAGCTTACGCGTGGTCATCGACCCGGCCAACCTGTTGT
GAGGTCGGTAGGCTTGCGGT

Downstream 100 bases:

>100_bases
CTCAGCGTGTGCATCAGAAACGTCGTAAGGCTGACCCAGCGCGACGACTGGCCTATTCCGCTCTCTTAGCGGTGGAGACC
CACGGCGCCTATGCCAACCT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MRLLFAGTPDVAVPTLTALVADPRHEVAAVLTRPDAAVGRHRTPRPCPVAKAAEELGIPAIKATSVKSGEGHDAITSLDA
DVAVVVAYGGLIPADLLAVPRHGWINLHFSLLPRWRGAAPIQRAIMAGDEETGACVFQLVESLDAGPVYRTMTVPIGPMT
TAGELLDELAHTATPLVIEALEDIEAGVEPTPQSVEGVTIAPQIHPDDVRVTVTAAAQEIDNLVRGVSPTPGAWAELDGK
RFKILRTRCLEAGDGVPSTVATAQPGQLVATRKQLFLGTGSQPLELLQVQAFGKRAMSGADWARGADIDAGTRLR

Sequences:

>Translated_315_residues
MRLLFAGTPDVAVPTLTALVADPRHEVAAVLTRPDAAVGRHRTPRPCPVAKAAEELGIPAIKATSVKSGEGHDAITSLDA
DVAVVVAYGGLIPADLLAVPRHGWINLHFSLLPRWRGAAPIQRAIMAGDEETGACVFQLVESLDAGPVYRTMTVPIGPMT
TAGELLDELAHTATPLVIEALEDIEAGVEPTPQSVEGVTIAPQIHPDDVRVTVTAAAQEIDNLVRGVSPTPGAWAELDGK
RFKILRTRCLEAGDGVPSTVATAQPGQLVATRKQLFLGTGSQPLELLQVQAFGKRAMSGADWARGADIDAGTRLR
>Mature_315_residues
MRLLFAGTPDVAVPTLTALVADPRHEVAAVLTRPDAAVGRHRTPRPCPVAKAAEELGIPAIKATSVKSGEGHDAITSLDA
DVAVVVAYGGLIPADLLAVPRHGWINLHFSLLPRWRGAAPIQRAIMAGDEETGACVFQLVESLDAGPVYRTMTVPIGPMT
TAGELLDELAHTATPLVIEALEDIEAGVEPTPQSVEGVTIAPQIHPDDVRVTVTAAAQEIDNLVRGVSPTPGAWAELDGK
RFKILRTRCLEAGDGVPSTVATAQPGQLVATRKQLFLGTGSQPLELLQVQAFGKRAMSGADWARGADIDAGTRLR

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=277, Percent_Identity=27.7978339350181, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI164663775, Length=205, Percent_Identity=31.7073170731707, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI21614513, Length=294, Percent_Identity=26.8707482993197, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1789683, Length=303, Percent_Identity=37.6237623762376, Blast_Score=197, Evalue=6e-52,
Organism=Escherichia coli, GI1788589, Length=322, Percent_Identity=28.2608695652174, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI133930964, Length=302, Percent_Identity=24.1721854304636, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550868, Length=310, Percent_Identity=28.7096774193548, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28571984, Length=231, Percent_Identity=31.1688311688312, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_PROAC (Q6A8H1)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055902.1
- ProteinModelPortal:   Q6A8H1
- SMR:   Q6A8H1
- GeneID:   2931489
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1195
- NMPDR:   fig|267747.1.peg.1179
- HOGENOM:   HBG571560
- OMA:   ADARCET
- ProtClustDB:   CLSK2763806
- BioCyc:   PACN267747:PPA1195-MONOMER
- BRENDA:   2.1.2.9
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 33096; Mature: 33096

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLFAGTPDVAVPTLTALVADPRHEVAAVLTRPDAAVGRHRTPRPCPVAKAAEELGIPA
CEEEECCCCCHHHHHHHHHHCCCHHHHHHEEECCCHHHCCCCCCCCCCHHHHHHHHCCCC
IKATSVKSGEGHDAITSLDADVAVVVAYGGLIPADLLAVPRHGWINLHFSLLPRWRGAAP
EEECCCCCCCCCHHHHHCCCCEEEEEEECCCCCHHHHHCCCCCEEEEEEEECCCCCCCCH
IQRAIMAGDEETGACVFQLVESLDAGPVYRTMTVPIGPMTTAGELLDELAHTATPLVIEA
HHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHH
LEDIEAGVEPTPQSVEGVTIAPQIHPDDVRVTVTAAAQEIDNLVRGVSPTPGAWAELDGK
HHHHHCCCCCCCCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCH
RFKILRTRCLEAGDGVPSTVATAQPGQLVATRKQLFLGTGSQPLELLQVQAFGKRAMSGA
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCC
DWARGADIDAGTRLR
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MRLLFAGTPDVAVPTLTALVADPRHEVAAVLTRPDAAVGRHRTPRPCPVAKAAEELGIPA
CEEEECCCCCHHHHHHHHHHCCCHHHHHHEEECCCHHHCCCCCCCCCCHHHHHHHHCCCC
IKATSVKSGEGHDAITSLDADVAVVVAYGGLIPADLLAVPRHGWINLHFSLLPRWRGAAP
EEECCCCCCCCCHHHHHCCCCEEEEEEECCCCCHHHHHCCCCCEEEEEEEECCCCCCCCH
IQRAIMAGDEETGACVFQLVESLDAGPVYRTMTVPIGPMTTAGELLDELAHTATPLVIEA
HHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHH
LEDIEAGVEPTPQSVEGVTIAPQIHPDDVRVTVTAAAQEIDNLVRGVSPTPGAWAELDGK
HHHHHCCCCCCCCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCH
RFKILRTRCLEAGDGVPSTVATAQPGQLVATRKQLFLGTGSQPLELLQVQAFGKRAMSGA
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCC
DWARGADIDAGTRLR
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA