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The map label for this gene is apt

Identifier: 50842644

GI number: 50842644

Start: 1264736

End: 1265269

Strand: Direct

Name: apt

Synonym: PPA1164

Alternate gene names: 50842644

Gene position: 1264736-1265269 (Clockwise)

Preceding gene: 50842643

Following gene: 50842645

Centisome position: 49.4

GC content: 59.18

Gene sequence:

>534_bases
ATGACCTACCGTAAGGACCTCATTGCCAGCCTGATCCGGGATGTCCCGGACTTTCCGGAGCCCGGGGTCACTTTTAAGGA
CATCACTCCGCTACTGGCAAATCCCAATGGCTATGCGGCTGCGATCTCTGAACTCGTAGACACTGCTTCTCGTGACGTGG
ACGTCGTCCTCGGTATGGAGGCACGTGGATTCATGTTCGCCGGGCCGGTAGCTCTCTCCCTCGGAGCCGGATTTGTTCCT
GTCCGCAAACCCGGGAAACTTCCTGGTGACGTCTACTCTCAGTCATTCGTGCTGGAGTACGGCTCTGCGACCCTGACAGT
CCATCAGGATGCGGTGCAGCCCGGTTCCAAGGTGCTCATCGTCGATGACGTCCTCGCGACAGCCGGCACAGTTCGCGCTA
CGGCCTCCCTCGTGGAGCAGTTGGGCGCAGAACTGGTTGGTGTATCGGTACTCATAGAGCTGTCGGCTCTGGGCGGTCGC
GAGAAACTCGATCGCGCCGGAATCGGTCCTGTCAACGCAGTTCTCACAATCTGA

Upstream 100 bases:

>100_bases
CCGCTGAGACCGTTGCCGCGGAAGGTCCACGCGACGTTACGACTATCACCGGGAGCGATCGTCACCAGCCACGTCGTTCT
ACCCGTGCCGAGAGGAAGAA

Downstream 100 bases:

>100_bases
TCATGGTCTCGGAATCACCCGAATCCTCGGGGCGCCATAGCGTCTTCGAACAGACCGCTCTGGTCAAGCTTCCATTCAAA
GCGACTGAACCTTTTTGGGA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MTYRKDLIASLIRDVPDFPEPGVTFKDITPLLANPNGYAAAISELVDTASRDVDVVLGMEARGFMFAGPVALSLGAGFVP
VRKPGKLPGDVYSQSFVLEYGSATLTVHQDAVQPGSKVLIVDDVLATAGTVRATASLVEQLGAELVGVSVLIELSALGGR
EKLDRAGIGPVNAVLTI

Sequences:

>Translated_177_residues
MTYRKDLIASLIRDVPDFPEPGVTFKDITPLLANPNGYAAAISELVDTASRDVDVVLGMEARGFMFAGPVALSLGAGFVP
VRKPGKLPGDVYSQSFVLEYGSATLTVHQDAVQPGSKVLIVDDVLATAGTVRATASLVEQLGAELVGVSVLIELSALGGR
EKLDRAGIGPVNAVLTI
>Mature_176_residues
TYRKDLIASLIRDVPDFPEPGVTFKDITPLLANPNGYAAAISELVDTASRDVDVVLGMEARGFMFAGPVALSLGAGFVPV
RKPGKLPGDVYSQSFVLEYGSATLTVHQDAVQPGSKVLIVDDVLATAGTVRATASLVEQLGAELVGVSVLIELSALGGRE
KLDRAGIGPVNAVLTI

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=162, Percent_Identity=45.0617283950617, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=45.6, Blast_Score=115, Evalue=2e-26,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=47.5609756097561, Blast_Score=165, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17509087, Length=159, Percent_Identity=45.2830188679245, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=177, Percent_Identity=39.5480225988701, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=179, Percent_Identity=34.6368715083799, Blast_Score=94, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17136334, Length=162, Percent_Identity=38.8888888888889, Blast_Score=119, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PROAC (Q6A8K3)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055871.1
- ProteinModelPortal:   Q6A8K3
- SMR:   Q6A8K3
- GeneID:   2931796
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1164
- NMPDR:   fig|267747.1.peg.1148
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   PACN267747:PPA1164-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18419; Mature: 18288

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYRKDLIASLIRDVPDFPEPGVTFKDITPLLANPNGYAAAISELVDTASRDVDVVLGME
CCHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHCCCCCHHHHHHHHHHHCCCCEEEEEECC
ARGFMFAGPVALSLGAGFVPVRKPGKLPGDVYSQSFVLEYGSATLTVHQDAVQPGSKVLI
CCCEEEECHHHHHCCCCCCCCCCCCCCCCHHHCCEEEEEECCEEEEEEHHCCCCCCEEEE
VDDVLATAGTVRATASLVEQLGAELVGVSVLIELSALGGREKLDRAGIGPVNAVLTI
EEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEC
>Mature Secondary Structure 
TYRKDLIASLIRDVPDFPEPGVTFKDITPLLANPNGYAAAISELVDTASRDVDVVLGME
CHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHCCCCCHHHHHHHHHHHCCCCEEEEEECC
ARGFMFAGPVALSLGAGFVPVRKPGKLPGDVYSQSFVLEYGSATLTVHQDAVQPGSKVLI
CCCEEEECHHHHHCCCCCCCCCCCCCCCCHHHCCEEEEEECCEEEEEEHHCCCCCCEEEE
VDDVLATAGTVRATASLVEQLGAELVGVSVLIELSALGGREKLDRAGIGPVNAVLTI
EEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA