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The map label for this gene is thrS

Identifier: 50842554

GI number: 50842554

Start: 1171319

End: 1173373

Strand: Direct

Name: thrS

Synonym: PPA1076

Alternate gene names: 50842554

Gene position: 1171319-1173373 (Clockwise)

Preceding gene: 50842553

Following gene: 50842555

Centisome position: 45.75

GC content: 59.76

Gene sequence:

>2055_bases
GTGTCCATCAGCATCACCCTGCACCGTTCCGGTACCTCCAGGACCCAGCAGGTGGACACTACGACCACCGGACTGGATCT
CTTCGGCTCCGACCGTGCCGTCGTTGCCATGCGGGTCGACGGCAACCTCGTCGATCTGCAGCGTGAACTCCATGATGGCG
CCGAGGTGGAGCCGGTTGAGGCCACCAGCGAGGACGGGCTCAACATCATCCGGCACTCGGCTACCCACGTCATGGCTCAG
GCCGTCCAGCAGCTGTACCCCGAGGTGAACTTGGGTATTGGTCCGTTCATTACCGACGGGTTCTACTATGACTTCGGCAA
TATTGAGCCCGTCACCCCCGAGGTTCTTTCTGAGCTTGAGAAGCGGATGAAGCGGATCGTCAAAGAGAATCAGCGCTTCG
TGCGTCGGGTCACCACTGAGGAGTCCGCCCGCGAGGAGCTGGCCGACCAGCCTTACAAGTTGGAGCTCATTGGCACCAAG
GGTAAGGGTGCTGAGGGTGCCTCAGTCGAAGTCGGCGGTGGCGAGCTGACGATCTACGACAATGTGCGTCGCAATGGCGA
GGTGGCATGGAAGGATCTGTGCCGCGGCCCCCATGTGCCCTCGACCAAGTACTTGGCCAATACCTTCGCCCTGACAAAGT
TCTCGGCCGCGTACTGGAAGGGTGACCAAGCCAACGACCAGTTGCAGCGCATCTACGGAACAGCCTGGGCCAGCCGTGAG
GGCTTGGCGGCCTACCAACAGCGGATCAAAGAGGCCGAGCGGCGCGATCACCGCAAGCTGGGAGCCGAGCTCGATCTGTT
CTCCTTCCCTGAGGAAATCGGCCCGGGCCTGGTGGTGTTCCACCCTAAGGGCGCGATGCTGCGTCATCTCATCGAGGAAC
ACGTCATCGCTCGTCACATGGAGGCTGGGTTCAACTTTGTCCACACTCCGGAGATCACTAAGGGAGGTCTGTTCCACACC
TCGGGTCACTTGCCCTACTACGCCGACACTATGTTCCCGCCGATGCTTGTCGACGAGGAGCGAGATGAGGAGGGCAACGT
CACTCGAGCCGGTCAGGAGTATTACCTCAAGGCTATGAATTGCCCGATGCATAACCTCATATTCCGGTCACGGGGTCGGT
CGTACCGTGAGTTGCCGTTGCGGTTTTTCGAGATGGGCCACGATTATCGCTACGAGAAGTCGGGCGTCGTGCATGGACTG
ACTCGTATGCGGGGTTTTGCCCAGGACGACTCCCATACCTACTGCACCCGTGAGCAAGCCCCCGGCGAAATCAAGAAGCA
GATCGAGTTTTTCCTGTCGATCCTGGCCGATTTTGGCCTCAATGACTTTTACCTCGAGCTGTCTACTCGTGAGAGCGACA
GCGCGAAAAAGGAGAAATTCATCGGTTCCGATGAGGACTGGCAGGTCGCCACCGACACCCTCGACCAGGTGTGCCGTAGC
ACTGGTTTGCAGCTGGTCCCTGATCCGGGTGGTGCGGCTTTCTATGGCCCGAAGGTCTCGGTGCAGGTTAGGGATGCCAT
CGGGCGTACCTGGCAGATGTCGACGATTCAGTATGACTTTAACCAGCCTGAGCGGTTCGACTTGGAATACGCGGCTGCTG
ACGGCACCCATCAGCGTCCGATCATGCTGCACTCAGCCAAGTTGGGTAGTGTCGAGAGGTTTATTGGTGTGCTTACCGAG
CATTACGCCGGTGCTTTCCCGGTATGGCTCTCTCCGGTCCAGGTGCGCTTGGTGCCGGTGGCTGAGGCCTTTAACGACTA
CGTCACCGGGTTCGCAGAGGTGTTGGGTTCCCGCGGGATTCGGGTCGAGACGGACCTGTCCTCGGACCGGTTTGGCAAGA
AGATCCGCAACGCCTCTAAGGACAAGGTGCCTTTCATCCTCATCGCGGGCGGTGAGGATGCCGAGGCTGGTGCCGTATCC
TTCCGGCTGCGTGATGGCTCTCAGGTCAATGGCGTCGTCCTGGACGAGGCAGTGCGTATCATTGCAGCTTGGGACAGTCG
GCACCGCAACGACGATCCGACTGCCGAGACGCTGCGCGGAGTCGTTGATGACTGA

Upstream 100 bases:

>100_bases
TTCATTCGTTGACCCGGGGGTCGAATCAACCTCACCGGGTACGGCATGATTAGACAGTGTCCGGCACCAGTCGGACTGTA
ATCGAGTGAGGAAGTCAATC

Downstream 100 bases:

>100_bases
GGATTACCGTCTCGAGTTCGCCGAGGAACTGGTCGGGGTTCCGGATCCCTTCAGGAGGTTCTGGACCCCGTATCGGATGG
CGTATATCTCTGGTGAAAAT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MSISITLHRSGTSRTQQVDTTTTGLDLFGSDRAVVAMRVDGNLVDLQRELHDGAEVEPVEATSEDGLNIIRHSATHVMAQ
AVQQLYPEVNLGIGPFITDGFYYDFGNIEPVTPEVLSELEKRMKRIVKENQRFVRRVTTEESAREELADQPYKLELIGTK
GKGAEGASVEVGGGELTIYDNVRRNGEVAWKDLCRGPHVPSTKYLANTFALTKFSAAYWKGDQANDQLQRIYGTAWASRE
GLAAYQQRIKEAERRDHRKLGAELDLFSFPEEIGPGLVVFHPKGAMLRHLIEEHVIARHMEAGFNFVHTPEITKGGLFHT
SGHLPYYADTMFPPMLVDEERDEEGNVTRAGQEYYLKAMNCPMHNLIFRSRGRSYRELPLRFFEMGHDYRYEKSGVVHGL
TRMRGFAQDDSHTYCTREQAPGEIKKQIEFFLSILADFGLNDFYLELSTRESDSAKKEKFIGSDEDWQVATDTLDQVCRS
TGLQLVPDPGGAAFYGPKVSVQVRDAIGRTWQMSTIQYDFNQPERFDLEYAAADGTHQRPIMLHSAKLGSVERFIGVLTE
HYAGAFPVWLSPVQVRLVPVAEAFNDYVTGFAEVLGSRGIRVETDLSSDRFGKKIRNASKDKVPFILIAGGEDAEAGAVS
FRLRDGSQVNGVVLDEAVRIIAAWDSRHRNDDPTAETLRGVVDD

Sequences:

>Translated_684_residues
MSISITLHRSGTSRTQQVDTTTTGLDLFGSDRAVVAMRVDGNLVDLQRELHDGAEVEPVEATSEDGLNIIRHSATHVMAQ
AVQQLYPEVNLGIGPFITDGFYYDFGNIEPVTPEVLSELEKRMKRIVKENQRFVRRVTTEESAREELADQPYKLELIGTK
GKGAEGASVEVGGGELTIYDNVRRNGEVAWKDLCRGPHVPSTKYLANTFALTKFSAAYWKGDQANDQLQRIYGTAWASRE
GLAAYQQRIKEAERRDHRKLGAELDLFSFPEEIGPGLVVFHPKGAMLRHLIEEHVIARHMEAGFNFVHTPEITKGGLFHT
SGHLPYYADTMFPPMLVDEERDEEGNVTRAGQEYYLKAMNCPMHNLIFRSRGRSYRELPLRFFEMGHDYRYEKSGVVHGL
TRMRGFAQDDSHTYCTREQAPGEIKKQIEFFLSILADFGLNDFYLELSTRESDSAKKEKFIGSDEDWQVATDTLDQVCRS
TGLQLVPDPGGAAFYGPKVSVQVRDAIGRTWQMSTIQYDFNQPERFDLEYAAADGTHQRPIMLHSAKLGSVERFIGVLTE
HYAGAFPVWLSPVQVRLVPVAEAFNDYVTGFAEVLGSRGIRVETDLSSDRFGKKIRNASKDKVPFILIAGGEDAEAGAVS
FRLRDGSQVNGVVLDEAVRIIAAWDSRHRNDDPTAETLRGVVDD
>Mature_683_residues
SISITLHRSGTSRTQQVDTTTTGLDLFGSDRAVVAMRVDGNLVDLQRELHDGAEVEPVEATSEDGLNIIRHSATHVMAQA
VQQLYPEVNLGIGPFITDGFYYDFGNIEPVTPEVLSELEKRMKRIVKENQRFVRRVTTEESAREELADQPYKLELIGTKG
KGAEGASVEVGGGELTIYDNVRRNGEVAWKDLCRGPHVPSTKYLANTFALTKFSAAYWKGDQANDQLQRIYGTAWASREG
LAAYQQRIKEAERRDHRKLGAELDLFSFPEEIGPGLVVFHPKGAMLRHLIEEHVIARHMEAGFNFVHTPEITKGGLFHTS
GHLPYYADTMFPPMLVDEERDEEGNVTRAGQEYYLKAMNCPMHNLIFRSRGRSYRELPLRFFEMGHDYRYEKSGVVHGLT
RMRGFAQDDSHTYCTREQAPGEIKKQIEFFLSILADFGLNDFYLELSTRESDSAKKEKFIGSDEDWQVATDTLDQVCRST
GLQLVPDPGGAAFYGPKVSVQVRDAIGRTWQMSTIQYDFNQPERFDLEYAAADGTHQRPIMLHSAKLGSVERFIGVLTEH
YAGAFPVWLSPVQVRLVPVAEAFNDYVTGFAEVLGSRGIRVETDLSSDRFGKKIRNASKDKVPFILIAGGEDAEAGAVSF
RLRDGSQVNGVVLDEAVRIIAAWDSRHRNDDPTAETLRGVVDD

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=625, Percent_Identity=36.16, Blast_Score=371, Evalue=1e-102,
Organism=Homo sapiens, GI38202255, Length=625, Percent_Identity=36.8, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI20070344, Length=645, Percent_Identity=34.4186046511628, Blast_Score=329, Evalue=5e-90,
Organism=Escherichia coli, GI1788013, Length=630, Percent_Identity=37.1428571428571, Blast_Score=442, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI71984184, Length=633, Percent_Identity=35.2290679304897, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71984192, Length=633, Percent_Identity=35.2290679304897, Blast_Score=375, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6322112, Length=668, Percent_Identity=34.1317365269461, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6322654, Length=411, Percent_Identity=34.7931873479319, Blast_Score=236, Evalue=9e-63,
Organism=Drosophila melanogaster, GI24583842, Length=649, Percent_Identity=35.4391371340524, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI28574141, Length=649, Percent_Identity=35.4391371340524, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24583839, Length=649, Percent_Identity=35.4391371340524, Blast_Score=375, Evalue=1e-104,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_PROAC (Q6A8U3)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055781.1
- ProteinModelPortal:   Q6A8U3
- SMR:   Q6A8U3
- GeneID:   2930995
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1076
- NMPDR:   fig|267747.1.peg.1058
- HOGENOM:   HBG352811
- OMA:   RIYGAAF
- ProtClustDB:   PRK00413
- BioCyc:   PACN267747:PPA1076-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 76729; Mature: 76598

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISITLHRSGTSRTQQVDTTTTGLDLFGSDRAVVAMRVDGNLVDLQRELHDGAEVEPVE
CEEEEEEECCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCHHHHHHHHCCCCCCCCCC
ATSEDGLNIIRHSATHVMAQAVQQLYPEVNLGIGPFITDGFYYDFGNIEPVTPEVLSELE
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEECCCCCCCCHHHHHHHH
KRMKRIVKENQRFVRRVTTEESAREELADQPYKLELIGTKGKGAEGASVEVGGGELTIYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCEEEEEE
NVRRNGEVAWKDLCRGPHVPSTKYLANTFALTKFSAAYWKGDQANDQLQRIYGTAWASRE
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
GLAAYQQRIKEAERRDHRKLGAELDLFSFPEEIGPGLVVFHPKGAMLRHLIEEHVIARHM
CHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHCCCEEEECCCCHHHHHHHHHHHHHHHH
EAGFNFVHTPEITKGGLFHTSGHLPYYADTMFPPMLVDEERDEEGNVTRAGQEYYLKAMN
HHCCCEEECCCCCCCCEEEECCCCCEEHHCCCCCCEECCCCCCCCCEEECCHHHHHHHHC
CPMHNLIFRSRGRSYRELPLRFFEMGHDYRYEKSGVVHGLTRMRGFAQDDSHTYCTREQA
CCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEECCCCC
PGEIKKQIEFFLSILADFGLNDFYLELSTRESDSAKKEKFIGSDEDWQVATDTLDQVCRS
CHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHH
TGLQLVPDPGGAAFYGPKVSVQVRDAIGRTWQMSTIQYDFNQPERFDLEYAAADGTHQRP
CCCEEEECCCCCEEECCEEEEEEHHHHCCEEEEEEEEECCCCCCCCCEEEEECCCCCCCC
IMLHSAKLGSVERFIGVLTEHYAGAFPVWLSPVQVRLVPVAEAFNDYVTGFAEVLGSRGI
EEEECCCCCHHHHHHHHHHHHHCCCCCEEECCEEEEEEEHHHHHHHHHHHHHHHHCCCCC
RVETDLSSDRFGKKIRNASKDKVPFILIAGGEDAEAGAVSFRLRDGSQVNGVVLDEAVRI
EEEECCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCEEHHHHHHH
IAAWDSRHRNDDPTAETLRGVVDD
HHHHCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SISITLHRSGTSRTQQVDTTTTGLDLFGSDRAVVAMRVDGNLVDLQRELHDGAEVEPVE
EEEEEEECCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCHHHHHHHHCCCCCCCCCC
ATSEDGLNIIRHSATHVMAQAVQQLYPEVNLGIGPFITDGFYYDFGNIEPVTPEVLSELE
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEECCCCCCCCHHHHHHHH
KRMKRIVKENQRFVRRVTTEESAREELADQPYKLELIGTKGKGAEGASVEVGGGELTIYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCEEEEEE
NVRRNGEVAWKDLCRGPHVPSTKYLANTFALTKFSAAYWKGDQANDQLQRIYGTAWASRE
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
GLAAYQQRIKEAERRDHRKLGAELDLFSFPEEIGPGLVVFHPKGAMLRHLIEEHVIARHM
CHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHCCCEEEECCCCHHHHHHHHHHHHHHHH
EAGFNFVHTPEITKGGLFHTSGHLPYYADTMFPPMLVDEERDEEGNVTRAGQEYYLKAMN
HHCCCEEECCCCCCCCEEEECCCCCEEHHCCCCCCEECCCCCCCCCEEECCHHHHHHHHC
CPMHNLIFRSRGRSYRELPLRFFEMGHDYRYEKSGVVHGLTRMRGFAQDDSHTYCTREQA
CCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEECCCCC
PGEIKKQIEFFLSILADFGLNDFYLELSTRESDSAKKEKFIGSDEDWQVATDTLDQVCRS
CHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHH
TGLQLVPDPGGAAFYGPKVSVQVRDAIGRTWQMSTIQYDFNQPERFDLEYAAADGTHQRP
CCCEEEECCCCCEEECCEEEEEEHHHHCCEEEEEEEEECCCCCCCCCEEEEECCCCCCCC
IMLHSAKLGSVERFIGVLTEHYAGAFPVWLSPVQVRLVPVAEAFNDYVTGFAEVLGSRGI
EEEECCCCCHHHHHHHHHHHHHCCCCCEEECCEEEEEEEHHHHHHHHHHHHHHHHCCCCC
RVETDLSSDRFGKKIRNASKDKVPFILIAGGEDAEAGAVSFRLRDGSQVNGVVLDEAVRI
EEEECCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCEEHHHHHHH
IAAWDSRHRNDDPTAETLRGVVDD
HHHHCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA