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The map label for this gene is dcuA [H]

Identifier: 50842525

GI number: 50842525

Start: 1135240

End: 1136559

Strand: Direct

Name: dcuA [H]

Synonym: PPA1043

Alternate gene names: 50842525

Gene position: 1135240-1136559 (Clockwise)

Preceding gene: 50842524

Following gene: 50842526

Centisome position: 44.34

GC content: 59.32

Gene sequence:

>1320_bases
GTGATCTGGTTCCACCTGGCCGTGGCCATCATCTTTATCATCATCGGCTCGCGCCTCGGTGGGGTGGGCGTCGGACTCGC
GGGAGGGGCGGGATGTATCGTCCTTGTGGCCACTGGTCTTCACACGAAGGTGGCTGAGGACATCCCTTGGACGGTTATCG
GCATTATCATGACCGTCATCTGCGCCATCGCTGCCCTCCAGCTCGCGGGCGGGATGGACTATCTTGTGCATCTGGCTGAG
GTCATGCTGCGCAAGCATCCCAACCAGATCAACTACCTCGCGCCGCTGACGACCTTCCTGCTTTCCTTGCTGTGTGGTAC
TGGACATACCGCCTATTCAGTGCTGCCCGTTATCGTGGAGGTGGCTAAGGAACATAAGATCCGGCCGTCGAGGCCGCTTT
CCATAGCCGTTGTGGCATCCCAAGTCGCGGTCGCATCCTCGCCGATCTCAGCGGCGACCTTGGCCTTGGTTGGAGTTCTA
GAGCCGTTGGGAGTGGGTTACCTTGAGATCCTCGCGGTGACGATCCCTACCACCTTCATCGGATGTGCCGTCGGTGCCGT
CGTGGCATCGCGTCAGGGCAAGGATCTCATCGATGATCCGATCTATCAGGAACGCGAGGCTAAGGGACTGGTGAGCCACA
ACGCTGCTGTCGCCGACACTGGGTGGAGGCCAAAACGGACTGCCATTCCCAGCCTTGTTGCCTTCCTCGTCGCTCTTGTT
GTGGTCGTTGGTTACGCCACTGTCTCATCGGAAGAGGTCGGTGTGCTCACCAAACCGCCTATGACGTCATCGGCGGCGAT
CATGCTCATTATGCTGACGACGGCGATGATCATCTGCATGATGTCACGTGAGGACGTCAAGCAGCTCACCACCCAGACGA
CGTTCCGGGCCGGAATGTCTGCCGCGATCTGCATTCTGGGACTGGCGTGGCTGGGAAATATGTTCGTCAATAACTATATG
GATGTCCTGACCCACGCGGGGGCCTCGATCCTGCATTCGGCCCCGTGGTTCCTTTCGGTGATCCTGTACTTGGCTGCACC
ACTGATGTTCTCCCACGCTGCGACGACCGTCGCCTTCATGCCGGTGGTGGCCAAGATCGGTCTGTCTCCGATGGTGATGC
TGGCTTGCTACCCGGCTGTGGCCAACTACTACCTGCTGCCGAACTACCCCACGACGGTTGCAGCTATGGAGATGGACGAC
ACCGGATCGACGCGAGTCGGACGTATCGTCCTTAACCACCCCTTCGTCCTTCCTGGTACCGTCTCGATTGCGGTGACGGT
CCTACTGGGAGCTTTCTGGGCCCCCATTGTGCTGGGATGA

Upstream 100 bases:

>100_bases
ACAGGGGAGCTGGCATGGTGGGTCGAATACGACGATCCGGTGACGGACGCAACGACACGTGCAACGTTAACGGGGGATCG
TCGGCAAGGGGGCTGCAACG

Downstream 100 bases:

>100_bases
GGTTCGACGAGGCGCGATCGTGGTTCGTTAGGCACCGGTAGACTCAACAGCCATGAGCCACACCGACGTGCCGGCCGATC
AACGCAAACGCGTCTTCGCC

Product: anaerobic C4-dicarboxylate transporter

Products: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MIWFHLAVAIIFIIIGSRLGGVGVGLAGGAGCIVLVATGLHTKVAEDIPWTVIGIIMTVICAIAALQLAGGMDYLVHLAE
VMLRKHPNQINYLAPLTTFLLSLLCGTGHTAYSVLPVIVEVAKEHKIRPSRPLSIAVVASQVAVASSPISAATLALVGVL
EPLGVGYLEILAVTIPTTFIGCAVGAVVASRQGKDLIDDPIYQEREAKGLVSHNAAVADTGWRPKRTAIPSLVAFLVALV
VVVGYATVSSEEVGVLTKPPMTSSAAIMLIMLTTAMIICMMSREDVKQLTTQTTFRAGMSAAICILGLAWLGNMFVNNYM
DVLTHAGASILHSAPWFLSVILYLAAPLMFSHAATTVAFMPVVAKIGLSPMVMLACYPAVANYYLLPNYPTTVAAMEMDD
TGSTRVGRIVLNHPFVLPGTVSIAVTVLLGAFWAPIVLG

Sequences:

>Translated_439_residues
MIWFHLAVAIIFIIIGSRLGGVGVGLAGGAGCIVLVATGLHTKVAEDIPWTVIGIIMTVICAIAALQLAGGMDYLVHLAE
VMLRKHPNQINYLAPLTTFLLSLLCGTGHTAYSVLPVIVEVAKEHKIRPSRPLSIAVVASQVAVASSPISAATLALVGVL
EPLGVGYLEILAVTIPTTFIGCAVGAVVASRQGKDLIDDPIYQEREAKGLVSHNAAVADTGWRPKRTAIPSLVAFLVALV
VVVGYATVSSEEVGVLTKPPMTSSAAIMLIMLTTAMIICMMSREDVKQLTTQTTFRAGMSAAICILGLAWLGNMFVNNYM
DVLTHAGASILHSAPWFLSVILYLAAPLMFSHAATTVAFMPVVAKIGLSPMVMLACYPAVANYYLLPNYPTTVAAMEMDD
TGSTRVGRIVLNHPFVLPGTVSIAVTVLLGAFWAPIVLG
>Mature_439_residues
MIWFHLAVAIIFIIIGSRLGGVGVGLAGGAGCIVLVATGLHTKVAEDIPWTVIGIIMTVICAIAALQLAGGMDYLVHLAE
VMLRKHPNQINYLAPLTTFLLSLLCGTGHTAYSVLPVIVEVAKEHKIRPSRPLSIAVVASQVAVASSPISAATLALVGVL
EPLGVGYLEILAVTIPTTFIGCAVGAVVASRQGKDLIDDPIYQEREAKGLVSHNAAVADTGWRPKRTAIPSLVAFLVALV
VVVGYATVSSEEVGVLTKPPMTSSAAIMLIMLTTAMIICMMSREDVKQLTTQTTFRAGMSAAICILGLAWLGNMFVNNYM
DVLTHAGASILHSAPWFLSVILYLAAPLMFSHAATTVAFMPVVAKIGLSPMVMLACYPAVANYYLLPNYPTTVAAMEMDD
TGSTRVGRIVLNHPFVLPGTVSIAVTVLLGAFWAPIVLG

Specific function: Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane [H]

COG id: COG2704

COG function: function code R; Anaerobic C4-dicarboxylate transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dcuA/dcuB transporter (TC 2.A.13.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790580, Length=431, Percent_Identity=43.3874709976798, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1790565, Length=395, Percent_Identity=31.6455696202532, Blast_Score=212, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004668 [H]

Pfam domain/function: PF03605 DcuA_DcuB [H]

EC number: NA

Molecular weight: Translated: 46197; Mature: 46197

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIWFHLAVAIIFIIIGSRLGGVGVGLAGGAGCIVLVATGLHTKVAEDIPWTVIGIIMTVI
CHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEEECCCHHHHHHCCCHHHHHHHHHHH
CAIAALQLAGGMDYLVHLAEVMLRKHPNQINYLAPLTTFLLSLLCGTGHTAYSVLPVIVE
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VAKEHKIRPSRPLSIAVVASQVAVASSPISAATLALVGVLEPLGVGYLEILAVTIPTTFI
HHHHCCCCCCCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GCAVGAVVASRQGKDLIDDPIYQEREAKGLVSHNAAVADTGWRPKRTAIPSLVAFLVALV
HHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHH
VVVGYATVSSEEVGVLTKPPMTSSAAIMLIMLTTAMIICMMSREDVKQLTTQTTFRAGMS
HHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AAICILGLAWLGNMFVNNYMDVLTHAGASILHSAPWFLSVILYLAAPLMFSHAATTVAFM
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PVVAKIGLSPMVMLACYPAVANYYLLPNYPTTVAAMEMDDTGSTRVGRIVLNHPFVLPGT
HHHHHHCCCHHHHHHHHHHHHCEEECCCCCCEEEEEEECCCCCCEECEEEECCCEECCCH
VSIAVTVLLGAFWAPIVLG
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIWFHLAVAIIFIIIGSRLGGVGVGLAGGAGCIVLVATGLHTKVAEDIPWTVIGIIMTVI
CHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEEECCCHHHHHHCCCHHHHHHHHHHH
CAIAALQLAGGMDYLVHLAEVMLRKHPNQINYLAPLTTFLLSLLCGTGHTAYSVLPVIVE
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VAKEHKIRPSRPLSIAVVASQVAVASSPISAATLALVGVLEPLGVGYLEILAVTIPTTFI
HHHHCCCCCCCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GCAVGAVVASRQGKDLIDDPIYQEREAKGLVSHNAAVADTGWRPKRTAIPSLVAFLVALV
HHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHH
VVVGYATVSSEEVGVLTKPPMTSSAAIMLIMLTTAMIICMMSREDVKQLTTQTTFRAGMS
HHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AAICILGLAWLGNMFVNNYMDVLTHAGASILHSAPWFLSVILYLAAPLMFSHAATTVAFM
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PVVAKIGLSPMVMLACYPAVANYYLLPNYPTTVAAMEMDDTGSTRVGRIVLNHPFVLPGT
HHHHHHCCCHHHHHHHHHHHHCEEECCCCCCEEEEEEECCCCCCEECEEEECCCEECCCH
VSIAVTVLLGAFWAPIVLG
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Specific reaction: C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] = C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11004174; 14500908; 8898907 [H]