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The map label for this gene is sdhA

Identifier: 50842435

GI number: 50842435

Start: 1031676

End: 1033808

Strand: Direct

Name: sdhA

Synonym: PPA0951

Alternate gene names: 50842435

Gene position: 1031676-1033808 (Clockwise)

Preceding gene: 50842434

Following gene: 50842436

Centisome position: 40.3

GC content: 61.46

Gene sequence:

>2133_bases
ATGAATAACTGGATTGAGGCCGTCAAGAAGCCTCTCGAGATGATTACTGGGCGTCATGCGGGCGCTAGACCCGAGGAGCC
TGGCGCTGAACTAGTGAAACCCGAGCAGCTCCAGCCCAGACGGGCTGAGTCGTCGTCGGTGGCGAGACGGGCTGCCAAGG
GTCCCAAGGCTCGTGACATTCTCGGCCCGGCGCAGAAGAAGGCCGGCTACCTTGTTGGTGACGAATTGGACGGCAAGGCT
CCCGAGGGGGATCCACTCACCGCGTGGACCCGTCGTCAAAGCGAGTACAAGCTCGTCAATCCGGCGAACCGTCGCAAGAT
GAACGTCATCGTGGTGGGAACCGGCCTCTCTGGTTCCGGGGTTGCCGCAACCCTCGGCCAGCTCGGCTACCACGTCGACG
TTTTTTGCTTCCACGATTCCCCGCGTCGAGCCCACTCAGTTGCTGCCCAGGGAGGTATCAACGCTGCACGTGCCCGCAAG
GTTGACGGCGATTCCCTTAAGAGGTTCGTCAAGGACACCGTCAAGGGTGGTGACTACCGGGGCCGAGAGGCCGATGTTGT
TCGACTCGGCACCGAATCGGTACGGGTTATTGACCATATGTACGCCATCGGCGCGCCGTTCGCCCGAGAATATGGCGGTC
AGTTGGCTACTCGATCTTTCGGAGGCGTGCAGGTTTCGCGCACCTACTACACCCGCGGGGAGACCGGTCAGCAGCTCGAA
GTAGCCTGCTCCCAGGCCCTCCAGGCACAAATTGATGCCGGTTCGGTGACGATGCACAACCGCACCGAGATGCTTGACCT
CATCGTTGCTGACGGTACGGCTCAGGGCATCGTCACCCGTGACCTTCTCACCGGCGAGATCAAGGCATGGACGGCCCACG
TCGTCATCCTATGCACCGGCGGATATGGATCGGTGTACCACTGGTCCACCTTGGCCAAAGGGTCCAACGCCACCGCGACG
TGGCGTGCTCACCGTCAAGGTGCATACTTCGCCAGCCCCTGCTTCGTGCAGTTCCACCCGACCGCGCTGCCCGTCAGTTC
GCACTGGCAGTCCAAGACCACGCTCATGAGCGAGTCGTTGCGCAACGACGGCCGGATCTGGGTGCCCAAGAAAGCCGGCG
ATGATCGTCCAGCCAATGACATCCCGGAAGAGGAGCGCGACTACTATTTGGAGCGCAAGTACCCGGCCTTCGGAAACCTA
ACGCCGCGCGACGTCGCCTCCCGCAATGCTCGGACTCAGATCGAGAGCGGCCACGGAGTGGGCCCGCTTAAGAACTCGGT
GTACCTGGATTTCCGTGATGCCATTGAGCGTCTAGGAAAGAAGACGATTGCCGAGCGCTATGGCAACTTGTTCGACATGT
ATCTCGACGCCACGGGGGAGAATCCCTACGAGGTGCCCATGCGCATCGCCCCAGGAGCCCATTTTACGATGGGCGGTCTG
TGGGTTGACTACGACCAGATGAGTACCATCCCGGGTCTGTTCGTCGGTGGTGAGGCGTCAAACAACTACCACGGCGCGAA
CCGATTGGGGGCTAACTCCTTGCTGTCGGCCAGTGTCGACGGGTGGTTCACCCTGCCACTGACGGTGCCGAACTATTTGG
CTGGGTTCGTCGGAAAGCCCGTGTTACCCCTGGACGCCCCCGAGGTCAGCGCAGCCATTGAGAGGGTGCAGAAGCGCACT
GATGCCTTGCTCAACTGCGGCGGAACACACCGCCCGGAATGGTTCCACCGCAAGCTCGGCGACATCCTCTATGAGGGGTG
CGGGGTCGCCCGCGACGAGGCCGGGCTGCTCGACGCCCTTACAAAGGTGCGCGAGCTGCGTGAGGAGTTCTGGCGCGACG
TCAAGGTGGTCGGAACGGGAAACCGACTCAACCAGGAACTCGAGAAGGCCGGTCGAGTGGCCGACTTCATCGAGCTCGGC
GAGGTCATGATTCTTGACGCCCTGGACCGCCGGGAATCGGCAGGTGCACACTTCCGTAACGAGTACGCCACCGAAGCCGG
TGAAGCCAAACGTAATGACGGTGACTGGTGTGCGGTTTCGGCATGGGAGACACGTCCTGATGGCACCAAGGTGCGGCATA
GCGAACCGTTGTCGTTCTCGTTGATCGATCTGCAGGTGAGGGATTACCGATGA

Upstream 100 bases:

>100_bases
GACTGCGCGCTATTTGGACGGTGATTGGTCTCCTCATCGCGCTGGCCATTGTGGTGTGCAACGGCGCACTTCCCATGCTC
ATTCTTGCCGGGGTGATCTC

Downstream 100 bases:

>100_bases
GGGTGGAACTGGATATCTGGCGTCAGAACGGCCCTGACGCCAAAGGACATTTTGAGCACCACGTTGTCGAAGATGCCGAG
CCGGAGTGGAGCCTGCTGGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 710; Mature: 710

Protein sequence:

>710_residues
MNNWIEAVKKPLEMITGRHAGARPEEPGAELVKPEQLQPRRAESSSVARRAAKGPKARDILGPAQKKAGYLVGDELDGKA
PEGDPLTAWTRRQSEYKLVNPANRRKMNVIVVGTGLSGSGVAATLGQLGYHVDVFCFHDSPRRAHSVAAQGGINAARARK
VDGDSLKRFVKDTVKGGDYRGREADVVRLGTESVRVIDHMYAIGAPFAREYGGQLATRSFGGVQVSRTYYTRGETGQQLE
VACSQALQAQIDAGSVTMHNRTEMLDLIVADGTAQGIVTRDLLTGEIKAWTAHVVILCTGGYGSVYHWSTLAKGSNATAT
WRAHRQGAYFASPCFVQFHPTALPVSSHWQSKTTLMSESLRNDGRIWVPKKAGDDRPANDIPEEERDYYLERKYPAFGNL
TPRDVASRNARTQIESGHGVGPLKNSVYLDFRDAIERLGKKTIAERYGNLFDMYLDATGENPYEVPMRIAPGAHFTMGGL
WVDYDQMSTIPGLFVGGEASNNYHGANRLGANSLLSASVDGWFTLPLTVPNYLAGFVGKPVLPLDAPEVSAAIERVQKRT
DALLNCGGTHRPEWFHRKLGDILYEGCGVARDEAGLLDALTKVRELREEFWRDVKVVGTGNRLNQELEKAGRVADFIELG
EVMILDALDRRESAGAHFRNEYATEAGEAKRNDGDWCAVSAWETRPDGTKVRHSEPLSFSLIDLQVRDYR

Sequences:

>Translated_710_residues
MNNWIEAVKKPLEMITGRHAGARPEEPGAELVKPEQLQPRRAESSSVARRAAKGPKARDILGPAQKKAGYLVGDELDGKA
PEGDPLTAWTRRQSEYKLVNPANRRKMNVIVVGTGLSGSGVAATLGQLGYHVDVFCFHDSPRRAHSVAAQGGINAARARK
VDGDSLKRFVKDTVKGGDYRGREADVVRLGTESVRVIDHMYAIGAPFAREYGGQLATRSFGGVQVSRTYYTRGETGQQLE
VACSQALQAQIDAGSVTMHNRTEMLDLIVADGTAQGIVTRDLLTGEIKAWTAHVVILCTGGYGSVYHWSTLAKGSNATAT
WRAHRQGAYFASPCFVQFHPTALPVSSHWQSKTTLMSESLRNDGRIWVPKKAGDDRPANDIPEEERDYYLERKYPAFGNL
TPRDVASRNARTQIESGHGVGPLKNSVYLDFRDAIERLGKKTIAERYGNLFDMYLDATGENPYEVPMRIAPGAHFTMGGL
WVDYDQMSTIPGLFVGGEASNNYHGANRLGANSLLSASVDGWFTLPLTVPNYLAGFVGKPVLPLDAPEVSAAIERVQKRT
DALLNCGGTHRPEWFHRKLGDILYEGCGVARDEAGLLDALTKVRELREEFWRDVKVVGTGNRLNQELEKAGRVADFIELG
EVMILDALDRRESAGAHFRNEYATEAGEAKRNDGDWCAVSAWETRPDGTKVRHSEPLSFSLIDLQVRDYR
>Mature_710_residues
MNNWIEAVKKPLEMITGRHAGARPEEPGAELVKPEQLQPRRAESSSVARRAAKGPKARDILGPAQKKAGYLVGDELDGKA
PEGDPLTAWTRRQSEYKLVNPANRRKMNVIVVGTGLSGSGVAATLGQLGYHVDVFCFHDSPRRAHSVAAQGGINAARARK
VDGDSLKRFVKDTVKGGDYRGREADVVRLGTESVRVIDHMYAIGAPFAREYGGQLATRSFGGVQVSRTYYTRGETGQQLE
VACSQALQAQIDAGSVTMHNRTEMLDLIVADGTAQGIVTRDLLTGEIKAWTAHVVILCTGGYGSVYHWSTLAKGSNATAT
WRAHRQGAYFASPCFVQFHPTALPVSSHWQSKTTLMSESLRNDGRIWVPKKAGDDRPANDIPEEERDYYLERKYPAFGNL
TPRDVASRNARTQIESGHGVGPLKNSVYLDFRDAIERLGKKTIAERYGNLFDMYLDATGENPYEVPMRIAPGAHFTMGGL
WVDYDQMSTIPGLFVGGEASNNYHGANRLGANSLLSASVDGWFTLPLTVPNYLAGFVGKPVLPLDAPEVSAAIERVQKRT
DALLNCGGTHRPEWFHRKLGDILYEGCGVARDEAGLLDALTKVRELREEFWRDVKVVGTGNRLNQELEKAGRVADFIELG
EVMILDALDRRESAGAHFRNEYATEAGEAKRNDGDWCAVSAWETRPDGTKVRHSEPLSFSLIDLQVRDYR

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=557, Percent_Identity=27.4685816876122, Blast_Score=161, Evalue=2e-39,
Organism=Escherichia coli, GI1790597, Length=565, Percent_Identity=29.9115044247788, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1786942, Length=569, Percent_Identity=25.8347978910369, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1788928, Length=580, Percent_Identity=24.4827586206897, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17505833, Length=541, Percent_Identity=28.8354898336414, Blast_Score=176, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17550100, Length=551, Percent_Identity=28.8566243194192, Blast_Score=169, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322701, Length=559, Percent_Identity=28.4436493738819, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6322416, Length=556, Percent_Identity=26.978417266187, Blast_Score=167, Evalue=7e-42,
Organism=Drosophila melanogaster, GI17137288, Length=547, Percent_Identity=29.6160877513711, Blast_Score=189, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24655642, Length=547, Percent_Identity=29.6160877513711, Blast_Score=189, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24655647, Length=547, Percent_Identity=29.6160877513711, Blast_Score=189, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24663005, Length=598, Percent_Identity=27.0903010033445, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 78083; Mature: 78083

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNWIEAVKKPLEMITGRHAGARPEEPGAELVKPEQLQPRRAESSSVARRAAKGPKARDI
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHH
LGPAQKKAGYLVGDELDGKAPEGDPLTAWTRRQSEYKLVNPANRRKMNVIVVGTGLSGSG
CCCHHHHCCEEECCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCCEEEEEEEECCCCCCC
VAATLGQLGYHVDVFCFHDSPRRAHSVAAQGGINAARARKVDGDSLKRFVKDTVKGGDYR
HHHHHHHCCCEEEEEEEECCCHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHCCCCCC
GREADVVRLGTESVRVIDHMYAIGAPFAREYGGQLATRSFGGVQVSRTYYTRGETGQQLE
CCCCCEEEECCHHHHHHHHHHHHCCCHHHHHCCCEEECCCCCEEEEEEEEECCCCCCHHH
VACSQALQAQIDAGSVTMHNRTEMLDLIVADGTAQGIVTRDLLTGEIKAWTAHVVILCTG
HHHHHHHHHHCCCCCEEECCCHHEEEEEEECCCCCCEEEHHHHHCCCEEEEEEEEEEEEC
GYGSVYHWSTLAKGSNATATWRAHRQGAYFASPCFVQFHPTALPVSSHWQSKTTLMSESL
CCCCEEEHHHHCCCCCCCEEEEHHCCCCEEECCEEEEECCCCCCCHHCCCHHHHHHHHHH
RNDGRIWVPKKAGDDRPANDIPEEERDYYLERKYPAFGNLTPRDVASRNARTQIESGHGV
CCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCHHEECCCCCC
GPLKNSVYLDFRDAIERLGKKTIAERYGNLFDMYLDATGENPYEVPMRIAPGAHFTMGGL
CCCCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEECCCCCEEECCE
WVDYDQMSTIPGLFVGGEASNNYHGANRLGANSLLSASVDGWFTLPLTVPNYLAGFVGKP
EEEHHHHCCCCCEEECCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEEECHHHHHHHHCCC
VLPLDAPEVSAAIERVQKRTDALLNCGGTHRPEWFHRKLGDILYEGCGVARDEAGLLDAL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TKVRELREEFWRDVKVVGTGNRLNQELEKAGRVADFIELGEVMILDALDRRESAGAHFRN
HHHHHHHHHHHCCEEEEECCHHHHHHHHHHCCHHHHHHHCCEEEEHHHHHHHHCCCHHHH
EYATEAGEAKRNDGDWCAVSAWETRPDGTKVRHSEPLSFSLIDLQVRDYR
HHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEEEECCC
>Mature Secondary Structure
MNNWIEAVKKPLEMITGRHAGARPEEPGAELVKPEQLQPRRAESSSVARRAAKGPKARDI
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHH
LGPAQKKAGYLVGDELDGKAPEGDPLTAWTRRQSEYKLVNPANRRKMNVIVVGTGLSGSG
CCCHHHHCCEEECCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCCEEEEEEEECCCCCCC
VAATLGQLGYHVDVFCFHDSPRRAHSVAAQGGINAARARKVDGDSLKRFVKDTVKGGDYR
HHHHHHHCCCEEEEEEEECCCHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHCCCCCC
GREADVVRLGTESVRVIDHMYAIGAPFAREYGGQLATRSFGGVQVSRTYYTRGETGQQLE
CCCCCEEEECCHHHHHHHHHHHHCCCHHHHHCCCEEECCCCCEEEEEEEEECCCCCCHHH
VACSQALQAQIDAGSVTMHNRTEMLDLIVADGTAQGIVTRDLLTGEIKAWTAHVVILCTG
HHHHHHHHHHCCCCCEEECCCHHEEEEEEECCCCCCEEEHHHHHCCCEEEEEEEEEEEEC
GYGSVYHWSTLAKGSNATATWRAHRQGAYFASPCFVQFHPTALPVSSHWQSKTTLMSESL
CCCCEEEHHHHCCCCCCCEEEEHHCCCCEEECCEEEEECCCCCCCHHCCCHHHHHHHHHH
RNDGRIWVPKKAGDDRPANDIPEEERDYYLERKYPAFGNLTPRDVASRNARTQIESGHGV
CCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCHHEECCCCCC
GPLKNSVYLDFRDAIERLGKKTIAERYGNLFDMYLDATGENPYEVPMRIAPGAHFTMGGL
CCCCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEECCCCCEEECCE
WVDYDQMSTIPGLFVGGEASNNYHGANRLGANSLLSASVDGWFTLPLTVPNYLAGFVGKP
EEEHHHHCCCCCEEECCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEEECHHHHHHHHCCC
VLPLDAPEVSAAIERVQKRTDALLNCGGTHRPEWFHRKLGDILYEGCGVARDEAGLLDAL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TKVRELREEFWRDVKVVGTGNRLNQELEKAGRVADFIELGEVMILDALDRRESAGAHFRN
HHHHHHHHHHHCCEEEEECCHHHHHHHHHHCCHHHHHHHCCEEEEHHHHHHHHCCCHHHH
EYATEAGEAKRNDGDWCAVSAWETRPDGTKVRHSEPLSFSLIDLQVRDYR
HHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]