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The map label for this gene is uppS2 [H]

Identifier: 50842426

GI number: 50842426

Start: 1023790

End: 1024596

Strand: Reverse

Name: uppS2 [H]

Synonym: PPA0942

Alternate gene names: 50842426

Gene position: 1024596-1023790 (Counterclockwise)

Preceding gene: 50842427

Following gene: 50842424

Centisome position: 40.02

GC content: 61.09

Gene sequence:

>807_bases
ATGGCCCGAATCACACCGCGACCCCCGAAGCGCGGCCCGCTGCCGCATCCGTCTGGAGCTCGTCCACCCGAGCTGCCACC
GGAACTCATCCCCCAACACGTCGCCATCGTCATGGACGGCAACGGACGTTGGGCCAGGCAACGCGGTCTTAGGCGCACTG
AGGGTCACGCACGTGGCGAGGATGCTCTCTTCGATGTTATCGAGGGCGCCATCGAGATGGGTATCCCCTATTTGAGCGCC
TATGCGTTTTCCACCGAAAACTGGAAGCGCTCGCCCGACGAAGTTCGGTGGCTTATGGGCTTCAATCGTGACGTCATCCA
CCGTCGTCGCGATCAACTCGACGCCATGGGAGTACGCATCCGTTGGGCTGGACGTCGTCCCAAGCTGTGGAAGTCAGTCA
TCAAGGAATTGGAATCAGCCGAGAAACAGTCGGCTGATAACACCGTCCTCACCCTCCAGTTCTGCGTCAATTACGGCGGT
CGGGCAGAGATCGTTGACGCGGTGCGTGATATTGCCCGGCTAACCGCTGAGGGCAAGATCGACCCCGACCACATCACGGA
GAAGACCTTCCGTACTCACCTTGACGAGCCCGAGGTCCCCGACGTCGACCTATTCTGGCGCTCCTCCGGGGAACAGCGCA
CATCGAATTTCCTCCTGTGGCAATCGGCCTACGCCGAAATGGTGTTCTCCGACGTTTTGTGGCCCGACGTTGACCGCCGC
GACCTCTGGGCCGCAGTGATGGAATACGCCAAGCGGGACCGGAGATTTGGTGGGGCCGTCCCCAATGAGGTCAACCCCAC
CCCATGA

Upstream 100 bases:

>100_bases
ATCATCGAGGCCTTGAACCTCGGATAACTTACCGTTGTCACCGTCACGAGGGCACCAGTCCGGCCCCACTACCGTCCTCG
ACGCCACTACGCTGTGACCC

Downstream 100 bases:

>100_bases
TCACGGCGTCATGACTCCCTATCCAAGGTTTGCCGACGGGAGCGGTTTACCGCGTTGACGACCGCCTTCAGGGAAGCCTG
GGTGATATCAGGGTCAATGC

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase 2; Di-trans,poly-cis-decaprenylcistransferase 2; Undecaprenyl diphosphate synthase 2; UDS 2 [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MARITPRPPKRGPLPHPSGARPPELPPELIPQHVAIVMDGNGRWARQRGLRRTEGHARGEDALFDVIEGAIEMGIPYLSA
YAFSTENWKRSPDEVRWLMGFNRDVIHRRRDQLDAMGVRIRWAGRRPKLWKSVIKELESAEKQSADNTVLTLQFCVNYGG
RAEIVDAVRDIARLTAEGKIDPDHITEKTFRTHLDEPEVPDVDLFWRSSGEQRTSNFLLWQSAYAEMVFSDVLWPDVDRR
DLWAAVMEYAKRDRRFGGAVPNEVNPTP

Sequences:

>Translated_268_residues
MARITPRPPKRGPLPHPSGARPPELPPELIPQHVAIVMDGNGRWARQRGLRRTEGHARGEDALFDVIEGAIEMGIPYLSA
YAFSTENWKRSPDEVRWLMGFNRDVIHRRRDQLDAMGVRIRWAGRRPKLWKSVIKELESAEKQSADNTVLTLQFCVNYGG
RAEIVDAVRDIARLTAEGKIDPDHITEKTFRTHLDEPEVPDVDLFWRSSGEQRTSNFLLWQSAYAEMVFSDVLWPDVDRR
DLWAAVMEYAKRDRRFGGAVPNEVNPTP
>Mature_267_residues
ARITPRPPKRGPLPHPSGARPPELPPELIPQHVAIVMDGNGRWARQRGLRRTEGHARGEDALFDVIEGAIEMGIPYLSAY
AFSTENWKRSPDEVRWLMGFNRDVIHRRRDQLDAMGVRIRWAGRRPKLWKSVIKELESAEKQSADNTVLTLQFCVNYGGR
AEIVDAVRDIARLTAEGKIDPDHITEKTFRTHLDEPEVPDVDLFWRSSGEQRTSNFLLWQSAYAEMVFSDVLWPDVDRRD
LWAAVMEYAKRDRRFGGAVPNEVNPTP

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=34.5291479820628, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=34.5291479820628, Blast_Score=140, Evalue=9e-34,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=42.4242424242424, Blast_Score=187, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=33.7777777777778, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=35.2112676056338, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323748, Length=231, Percent_Identity=30.3030303030303, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=36.4035087719298, Blast_Score=134, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30731; Mature: 30600

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARITPRPPKRGPLPHPSGARPPELPPELIPQHVAIVMDGNGRWARQRGLRRTEGHARGE
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEEECCCCCHHHHCCCHHCCCCCCCH
DALFDVIEGAIEMGIPYLSAYAFSTENWKRSPDEVRWLMGFNRDVIHRRRDQLDAMGVRI
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCEEE
RWAGRRPKLWKSVIKELESAEKQSADNTVLTLQFCVNYGGRAEIVDAVRDIARLTAEGKI
EECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHCCCCC
DPDHITEKTFRTHLDEPEVPDVDLFWRSSGEQRTSNFLLWQSAYAEMVFSDVLWPDVDRR
CHHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
DLWAAVMEYAKRDRRFGGAVPNEVNPTP
HHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
ARITPRPPKRGPLPHPSGARPPELPPELIPQHVAIVMDGNGRWARQRGLRRTEGHARGE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEEECCCCCHHHHCCCHHCCCCCCCH
DALFDVIEGAIEMGIPYLSAYAFSTENWKRSPDEVRWLMGFNRDVIHRRRDQLDAMGVRI
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCEEE
RWAGRRPKLWKSVIKELESAEKQSADNTVLTLQFCVNYGGRAEIVDAVRDIARLTAEGKI
EECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHCCCCC
DPDHITEKTFRTHLDEPEVPDVDLFWRSSGEQRTSNFLLWQSAYAEMVFSDVLWPDVDRR
CHHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
DLWAAVMEYAKRDRRFGGAVPNEVNPTP
HHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]