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The map label for this gene is recQ [H]

Identifier: 50842405

GI number: 50842405

Start: 1002813

End: 1004963

Strand: Reverse

Name: recQ [H]

Synonym: PPA0921

Alternate gene names: 50842405

Gene position: 1004963-1002813 (Counterclockwise)

Preceding gene: 50842406

Following gene: 50842404

Centisome position: 39.25

GC content: 61.92

Gene sequence:

>2151_bases
ATGACGACAACTACCGACGCAATACCGAAAGTAGATGACCTACGCACCCAAGGGGTGGCAATCCTTCGTCGTCTCGTCGG
TCGCAACAATGCCGATTTCCACCCTGGACAGTGGGAGGCCATAGAGGCTCTGGTTGCCCACCACCGTCGAGCGCTCGTAG
TCCAGCGCACCGGTTGGGGAAAGTCAGCGGTTTACTTTGTCGCTACCTTGTTACAGCGTGCCATCGGCTCAGGCCCGACC
CTCATCGTCTCGCCACTTATCGCCCTCATGCGCGACCAGGTCGCTGCCGCAAAGCGAGCTGGCGTGCGCGCAGCGGCCAT
CTCATCGGCCAATGCCACCGAGTGGTCCGAAATCGCCCAACGCCTCGACGCCGACGAACTCGACGTTCTATTAGTCTCCC
CCGAGCGCCTGGTCAATCCCACATTCGCCAGTAAGCAGCTGCCCGAGCTCATAAAGCGAATGGGCATGTTGGTCATCGAC
GAAGCCCACTGCATCTCTGACTGGGGGCACGACTTTCGCCCCGATTACCGACGCATCCGTAACCTCGTCTCCGCTCTACC
GGTTACGATCCCAGTACTTGCGACAACGGCGACCGCAAACTCACGTGTGGTCCAAGATGTGGCCGAGCAGATTGCCCCCA
GCGCCGATGATGTGTTCATCCTTCGTGGGCCGTTAGCCCGGAAGTCACTGCGACTCGGCGTACTCAATCTGCCCAACCCT
TCCGAACGGCTCGGTTGGCTCGTCCAGCACCTCAGCGAACTTCCCAAGTCGGGAATTATCTACTGCCTGACTGTTTCGAC
GGCCGAGGACACCGCGCGTGCTCTAACCACGGCCGGTCACAATGTGCGGGCTTACACCGGACGCACCGATGCCGAAGCAA
GGACCGAACTCGAGGAAGCCTTGCGCAATAACCAGATCAAGGCCTTAGTGGCGACCAGTGCCCTGGGCATGGGTTTCGAC
AAACCGGACCTCGGTTTCGTCGTGCACTTGGGTGCGCCGAGCTCTCCAATCGCGTACTACCAGCAGGTAGGCCGTGCCGG
TCGCGCCACCGACCATGCCGATATCCTGTTGCTTCCGGGCCCGGAGGATCCTGACATTTGGACTTACTTCGCTACCTCCT
CTATGCCCACCCAAGAACGAGCCAATGCCGTGCTCAGAGCACTCGCAGGTGGCCAGGCGCTCTCTATCTCAGCTCTGGAG
ACGCGGGTCGACATCAGGCGTAGCCAGTTAGGGCTATTGCTTAAAGTGATGGCCGTTGATGGCTCGGTCGTGAAGGTCCG
AGATGGGTGGCAAGCCACCGGCAAGCCGTGGGTGCACGACACCGAACGGTACGAACGTATCTCCCAGGCACGTCGCGAGG
AACAGCAGGCCATGCTCGGCTACGAGCGCTCAAGAACCTGTCGCATGACCTTGCTCACCGGGCAGCTGGACGACCCCTCC
ACGACTCCTTGCGGACGCTGCGACGTCTGTGCTGGCCCGTGGTACTCAGTCGAGGTCGATCAGTCAGCCGCTGTGAGAGC
CGTCCAATCCCTCAACCGGGTGGGAGTTCCGGTGGAACCACGCGCCGCCTGGCCCGCAGGGATGGACGCCCTCCAGGTTG
CGCTCAAGGGTCGCATCAGTGCCGAGGAGATCGCTGCAGAGGGCCGCGTCATCGCCAGACTCTCCGATCTGGGTTGGGGA
GGGGCGCTGCGCGACCTACTTCGCTCCGACGCCAATGGTGTCCCTATCGACGCTGAGATCACCCCGGCGTTGGCCAAGGC
GTGCTTGCGGGTGTTGGCCGAGTGGGACTGGGAGCAGCGTCCAGCCGCGATAGTGCGGATCCCGTCGATCACTCGCCCAC
ACCTCATTGATTCCCTGGCCTCGGGAATTGCACGGGTTGGCCACCTGCAAGACCTTGGGTGGTTGGACCTGGCGGATGGG
TCCGCACGACTACAGTCATCCACGAACTCGGCTTACCGGCTCCGTGATGTCCATGATCGGTTCAGCGTCGGACCGGGGCT
GAAGTCTCGGTTATCCCATCTTGGCGGGGCATCGGTGCTGCTTATCGATGACGTCATCTCTAGCCGCTGGACGATGACGG
TCGCTGCACGGTCGTTGAGACGAGCCGGATCCGGGCCCGTTCTTCCACTAGCCCTCGCCGTCACAGCCTGA

Upstream 100 bases:

>100_bases
TTGCCATTGCCGTTCTGACTACGGTGTTCTTCCTCCGTGCCGGAATCTCGCCACGAAACCGTCACTAGCTCCGGAAAAAA
TGACGGCACAAGGAGGAGCC

Downstream 100 bases:

>100_bases
CCCACGCCGGGTCGAGGCCGCAGGTAGGCGCCAGGCTCGATAAACAGACGTAGATTCATCGCCTAAACGCGAACGTTGCC
ACGTCGACGAGCCAATGACG

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 716; Mature: 715

Protein sequence:

>716_residues
MTTTTDAIPKVDDLRTQGVAILRRLVGRNNADFHPGQWEAIEALVAHHRRALVVQRTGWGKSAVYFVATLLQRAIGSGPT
LIVSPLIALMRDQVAAAKRAGVRAAAISSANATEWSEIAQRLDADELDVLLVSPERLVNPTFASKQLPELIKRMGMLVID
EAHCISDWGHDFRPDYRRIRNLVSALPVTIPVLATTATANSRVVQDVAEQIAPSADDVFILRGPLARKSLRLGVLNLPNP
SERLGWLVQHLSELPKSGIIYCLTVSTAEDTARALTTAGHNVRAYTGRTDAEARTELEEALRNNQIKALVATSALGMGFD
KPDLGFVVHLGAPSSPIAYYQQVGRAGRATDHADILLLPGPEDPDIWTYFATSSMPTQERANAVLRALAGGQALSISALE
TRVDIRRSQLGLLLKVMAVDGSVVKVRDGWQATGKPWVHDTERYERISQARREEQQAMLGYERSRTCRMTLLTGQLDDPS
TTPCGRCDVCAGPWYSVEVDQSAAVRAVQSLNRVGVPVEPRAAWPAGMDALQVALKGRISAEEIAAEGRVIARLSDLGWG
GALRDLLRSDANGVPIDAEITPALAKACLRVLAEWDWEQRPAAIVRIPSITRPHLIDSLASGIARVGHLQDLGWLDLADG
SARLQSSTNSAYRLRDVHDRFSVGPGLKSRLSHLGGASVLLIDDVISSRWTMTVAARSLRRAGSGPVLPLALAVTA

Sequences:

>Translated_716_residues
MTTTTDAIPKVDDLRTQGVAILRRLVGRNNADFHPGQWEAIEALVAHHRRALVVQRTGWGKSAVYFVATLLQRAIGSGPT
LIVSPLIALMRDQVAAAKRAGVRAAAISSANATEWSEIAQRLDADELDVLLVSPERLVNPTFASKQLPELIKRMGMLVID
EAHCISDWGHDFRPDYRRIRNLVSALPVTIPVLATTATANSRVVQDVAEQIAPSADDVFILRGPLARKSLRLGVLNLPNP
SERLGWLVQHLSELPKSGIIYCLTVSTAEDTARALTTAGHNVRAYTGRTDAEARTELEEALRNNQIKALVATSALGMGFD
KPDLGFVVHLGAPSSPIAYYQQVGRAGRATDHADILLLPGPEDPDIWTYFATSSMPTQERANAVLRALAGGQALSISALE
TRVDIRRSQLGLLLKVMAVDGSVVKVRDGWQATGKPWVHDTERYERISQARREEQQAMLGYERSRTCRMTLLTGQLDDPS
TTPCGRCDVCAGPWYSVEVDQSAAVRAVQSLNRVGVPVEPRAAWPAGMDALQVALKGRISAEEIAAEGRVIARLSDLGWG
GALRDLLRSDANGVPIDAEITPALAKACLRVLAEWDWEQRPAAIVRIPSITRPHLIDSLASGIARVGHLQDLGWLDLADG
SARLQSSTNSAYRLRDVHDRFSVGPGLKSRLSHLGGASVLLIDDVISSRWTMTVAARSLRRAGSGPVLPLALAVTA
>Mature_715_residues
TTTTDAIPKVDDLRTQGVAILRRLVGRNNADFHPGQWEAIEALVAHHRRALVVQRTGWGKSAVYFVATLLQRAIGSGPTL
IVSPLIALMRDQVAAAKRAGVRAAAISSANATEWSEIAQRLDADELDVLLVSPERLVNPTFASKQLPELIKRMGMLVIDE
AHCISDWGHDFRPDYRRIRNLVSALPVTIPVLATTATANSRVVQDVAEQIAPSADDVFILRGPLARKSLRLGVLNLPNPS
ERLGWLVQHLSELPKSGIIYCLTVSTAEDTARALTTAGHNVRAYTGRTDAEARTELEEALRNNQIKALVATSALGMGFDK
PDLGFVVHLGAPSSPIAYYQQVGRAGRATDHADILLLPGPEDPDIWTYFATSSMPTQERANAVLRALAGGQALSISALET
RVDIRRSQLGLLLKVMAVDGSVVKVRDGWQATGKPWVHDTERYERISQARREEQQAMLGYERSRTCRMTLLTGQLDDPST
TPCGRCDVCAGPWYSVEVDQSAAVRAVQSLNRVGVPVEPRAAWPAGMDALQVALKGRISAEEIAAEGRVIARLSDLGWGG
ALRDLLRSDANGVPIDAEITPALAKACLRVLAEWDWEQRPAAIVRIPSITRPHLIDSLASGIARVGHLQDLGWLDLADGS
ARLQSSTNSAYRLRDVHDRFSVGPGLKSRLSHLGGASVLLIDDVISSRWTMTVAARSLRRAGSGPVLPLALAVTA

Specific function: DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI14591902, Length=359, Percent_Identity=32.033426183844, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI14591904, Length=359, Percent_Identity=32.033426183844, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI4557365, Length=351, Percent_Identity=33.3333333333333, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI51242943, Length=343, Percent_Identity=34.1107871720117, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI51242947, Length=343, Percent_Identity=34.1107871720117, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI169218196, Length=372, Percent_Identity=28.7634408602151, Blast_Score=155, Evalue=2e-37,
Organism=Homo sapiens, GI110735439, Length=372, Percent_Identity=28.7634408602151, Blast_Score=155, Evalue=2e-37,
Organism=Homo sapiens, GI148612816, Length=343, Percent_Identity=34.1107871720117, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI284005309, Length=354, Percent_Identity=33.8983050847458, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI45446747, Length=333, Percent_Identity=24.3243243243243, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI45446743, Length=333, Percent_Identity=24.3243243243243, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI48994977, Length=356, Percent_Identity=35.6741573033708, Blast_Score=192, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI71987997, Length=365, Percent_Identity=33.1506849315069, Blast_Score=171, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI71987993, Length=365, Percent_Identity=33.1506849315069, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI32564293, Length=392, Percent_Identity=30.6122448979592, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25145561, Length=348, Percent_Identity=32.7586206896552, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17552866, Length=492, Percent_Identity=27.2357723577236, Blast_Score=148, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323844, Length=334, Percent_Identity=32.0359281437126, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24646066, Length=339, Percent_Identity=33.0383480825959, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24664230, Length=328, Percent_Identity=32.0121951219512, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI62472181, Length=328, Percent_Identity=32.0121951219512, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24664226, Length=330, Percent_Identity=33.030303030303, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21358123, Length=358, Percent_Identity=31.0055865921788, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24662330, Length=332, Percent_Identity=24.3975903614458, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17647335, Length=319, Percent_Identity=23.5109717868339, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 77544; Mature: 77412

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTTDAIPKVDDLRTQGVAILRRLVGRNNADFHPGQWEAIEALVAHHRRALVVQRTGWG
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHEEEEEECCCC
KSAVYFVATLLQRAIGSGPTLIVSPLIALMRDQVAAAKRAGVRAAAISSANATEWSEIAQ
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCHHHHHHHH
RLDADELDVLLVSPERLVNPTFASKQLPELIKRMGMLVIDEAHCISDWGHDFRPDYRRIR
HCCCCCCCEEEECCHHHCCCCHHHHHHHHHHHHCCCEEEECHHHHHHCCCCCCHHHHHHH
NLVSALPVTIPVLATTATANSRVVQDVAEQIAPSADDVFILRGPLARKSLRLGVLNLPNP
HHHHHCCCHHHHEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHEEEEECCCH
SERLGWLVQHLSELPKSGIIYCLTVSTAEDTARALTTAGHNVRAYTGRTDAEARTELEEA
HHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHH
LRNNQIKALVATSALGMGFDKPDLGFVVHLGAPSSPIAYYQQVGRAGRATDHADILLLPG
HHCCCEEEEEEHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECC
PEDPDIWTYFATSSMPTQERANAVLRALAGGQALSISALETRVDIRRSQLGLLLKVMAVD
CCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHEECC
GSVVKVRDGWQATGKPWVHDTERYERISQARREEQQAMLGYERSRTCRMTLLTGQLDDPS
CCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCC
TTPCGRCDVCAGPWYSVEVDQSAAVRAVQSLNRVGVPVEPRAAWPAGMDALQVALKGRIS
CCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCC
AEEIAAEGRVIARLSDLGWGGALRDLLRSDANGVPIDAEITPALAKACLRVLAEWDWEQR
HHHHHHCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
PAAIVRIPSITRPHLIDSLASGIARVGHLQDLGWLDLADGSARLQSSTNSAYRLRDVHDR
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHCCCCCCEEHHHHHHH
FSVGPGLKSRLSHLGGASVLLIDDVISSRWTMTVAARSLRRAGSGPVLPLALAVTA
HCCCCCHHHHHHHCCCCEEEEEEHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEECC
>Mature Secondary Structure 
TTTTDAIPKVDDLRTQGVAILRRLVGRNNADFHPGQWEAIEALVAHHRRALVVQRTGWG
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHEEEEEECCCC
KSAVYFVATLLQRAIGSGPTLIVSPLIALMRDQVAAAKRAGVRAAAISSANATEWSEIAQ
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCHHHHHHHH
RLDADELDVLLVSPERLVNPTFASKQLPELIKRMGMLVIDEAHCISDWGHDFRPDYRRIR
HCCCCCCCEEEECCHHHCCCCHHHHHHHHHHHHCCCEEEECHHHHHHCCCCCCHHHHHHH
NLVSALPVTIPVLATTATANSRVVQDVAEQIAPSADDVFILRGPLARKSLRLGVLNLPNP
HHHHHCCCHHHHEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHEEEEECCCH
SERLGWLVQHLSELPKSGIIYCLTVSTAEDTARALTTAGHNVRAYTGRTDAEARTELEEA
HHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHH
LRNNQIKALVATSALGMGFDKPDLGFVVHLGAPSSPIAYYQQVGRAGRATDHADILLLPG
HHCCCEEEEEEHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECC
PEDPDIWTYFATSSMPTQERANAVLRALAGGQALSISALETRVDIRRSQLGLLLKVMAVD
CCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHEECC
GSVVKVRDGWQATGKPWVHDTERYERISQARREEQQAMLGYERSRTCRMTLLTGQLDDPS
CCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCC
TTPCGRCDVCAGPWYSVEVDQSAAVRAVQSLNRVGVPVEPRAAWPAGMDALQVALKGRIS
CCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCC
AEEIAAEGRVIARLSDLGWGGALRDLLRSDANGVPIDAEITPALAKACLRVLAEWDWEQR
HHHHHHCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
PAAIVRIPSITRPHLIDSLASGIARVGHLQDLGWLDLADGSARLQSSTNSAYRLRDVHDR
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHCCCCCCEEHHHHHHH
FSVGPGLKSRLSHLGGASVLLIDDVISSRWTMTVAARSLRRAGSGPVLPLALAVTA
HCCCCCHHHHHHHCCCCEEEEEEHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]