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The map label for this gene is hemN [H]

Identifier: 50842395

GI number: 50842395

Start: 992396

End: 993577

Strand: Direct

Name: hemN [H]

Synonym: PPA0911

Alternate gene names: 50842395

Gene position: 992396-993577 (Clockwise)

Preceding gene: 50842394

Following gene: 50842396

Centisome position: 38.76

GC content: 60.07

Gene sequence:

>1182_bases
ATGACGCACGCCGACAATAGCCTGCCAGAACTTCATCCAGCTGACGGGCCGTGGAGCATCTATCTCCACGTTCCCTTCTG
TGCGTCGCGGTGCGGGTACTGCGACTTCAACACCTACGTGCTGTCAGCGATGGGAGATGACGCGGTCGCGGGGTATCTCG
ACGCCGCCCACCGGGAACTCGAGCTGGCTGCCGACGCGCTGGGGGATGCACAGCCTCCGGTTTCGACGATCTTCTTTGGG
GGCGGCACTCCGACAATGCTCTCCCCAGTGCAGCTGGGGGAGCTCATCGATCACATTCGTACCCTATGGGGGATTGACCC
TGACGCCGAGGTCACCACTGAGGCCAATCCCGAAACCCTCAGCGTAGAAGTCTTAGCCGGCCTGCTGAAAGCCGGGATTA
ACCGGTTATCGATGGGAATGCAGTCCGCCGACGAGAATGTCTTGACGGTCTTAGATCGTCGCCATCGGCCAGGACGCGCC
GTCGAGATGGCACAGCTGGCGCGCCAGGTCGGATTCGATGACGTCAGCTTGGATCTCATCTTCGGCGCTCCCGGGGAGAA
CCGTGACTCGTGGCGATACAGTCTCGACGCCACGTTGACGGCTGAGCCAGACCACATTTCCGCATACTCCCTCATCGTTG
AAGAGGGAACTCGGCTGGCGGGCAGAATCCGTCGGGGAGAACTACCTATGACTGACGAGGACGATCTCGCTGACAAATAC
CTGCTTACCGAAAAGATTCTCACCGAGGCTGGGTACGTCAACTACGAGGTCTCGAACTGGGCTCGTCCTCGCAGCGGCCG
GGATCACCGATGTCGGCACAACATGGCGTACTGGTTGGGGTACGACTGGTGGGGAATTGGCCCGGGGGCTCATTCTCACG
TTGCTGGCACGCGGTGGTGGAATGTCAAACACCCTGCCACCTACCGGAACGTGCTGGATGACAGGGTGCTGCCCGTTGAC
GACTATGAGGTTCTTGGCGATGTGCAGCGTCATGAGGAGACGGTGCTTCTTCGGTTGCGTTTGGCTGATGGGTTGCCGAT
GGCGGATCTGTCCGAGGTTGAATGTATGCGGGCTACCGAGGTTGTCGAGCAGGGGCTCGGGACAATGGAGGAGGGGCGGC
TGGTACTCAACTTGTCAGGTCGAATGGTGGCTGACCGAATCATTACCGATCTCCTGGTCTAG

Upstream 100 bases:

>100_bases
AGCTATGCTGCATGGCAGATATCTTTGACAACTGCTGCGGAAGGCGTCAGGTGGCATCATGCAAAAGTGTACCCCGTACC
CCCGCATAATGAGGAGGGCC

Downstream 100 bases:

>100_bases
CCGTCTTCATCCACCAGGTCGTCAGGTCGGCCGCTAGCGCGGCTTGTCGTCATGGTCACACGTGGCAATACAGTGGCTAT
CGTGATCGATCGGTACTCTC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTHADNSLPELHPADGPWSIYLHVPFCASRCGYCDFNTYVLSAMGDDAVAGYLDAAHRELELAADALGDAQPPVSTIFFG
GGTPTMLSPVQLGELIDHIRTLWGIDPDAEVTTEANPETLSVEVLAGLLKAGINRLSMGMQSADENVLTVLDRRHRPGRA
VEMAQLARQVGFDDVSLDLIFGAPGENRDSWRYSLDATLTAEPDHISAYSLIVEEGTRLAGRIRRGELPMTDEDDLADKY
LLTEKILTEAGYVNYEVSNWARPRSGRDHRCRHNMAYWLGYDWWGIGPGAHSHVAGTRWWNVKHPATYRNVLDDRVLPVD
DYEVLGDVQRHEETVLLRLRLADGLPMADLSEVECMRATEVVEQGLGTMEEGRLVLNLSGRMVADRIITDLLV

Sequences:

>Translated_393_residues
MTHADNSLPELHPADGPWSIYLHVPFCASRCGYCDFNTYVLSAMGDDAVAGYLDAAHRELELAADALGDAQPPVSTIFFG
GGTPTMLSPVQLGELIDHIRTLWGIDPDAEVTTEANPETLSVEVLAGLLKAGINRLSMGMQSADENVLTVLDRRHRPGRA
VEMAQLARQVGFDDVSLDLIFGAPGENRDSWRYSLDATLTAEPDHISAYSLIVEEGTRLAGRIRRGELPMTDEDDLADKY
LLTEKILTEAGYVNYEVSNWARPRSGRDHRCRHNMAYWLGYDWWGIGPGAHSHVAGTRWWNVKHPATYRNVLDDRVLPVD
DYEVLGDVQRHEETVLLRLRLADGLPMADLSEVECMRATEVVEQGLGTMEEGRLVLNLSGRMVADRIITDLLV
>Mature_392_residues
THADNSLPELHPADGPWSIYLHVPFCASRCGYCDFNTYVLSAMGDDAVAGYLDAAHRELELAADALGDAQPPVSTIFFGG
GTPTMLSPVQLGELIDHIRTLWGIDPDAEVTTEANPETLSVEVLAGLLKAGINRLSMGMQSADENVLTVLDRRHRPGRAV
EMAQLARQVGFDDVSLDLIFGAPGENRDSWRYSLDATLTAEPDHISAYSLIVEEGTRLAGRIRRGELPMTDEDDLADKYL
LTEKILTEAGYVNYEVSNWARPRSGRDHRCRHNMAYWLGYDWWGIGPGAHSHVAGTRWWNVKHPATYRNVLDDRVLPVDD
YEVLGDVQRHEETVLLRLRLADGLPMADLSEVECMRATEVVEQGLGTMEEGRLVLNLSGRMVADRIITDLLV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=284, Percent_Identity=35.9154929577465, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1789325, Length=386, Percent_Identity=32.6424870466321, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI87082341, Length=308, Percent_Identity=28.8961038961039, Blast_Score=129, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43607; Mature: 43475

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHADNSLPELHPADGPWSIYLHVPFCASRCGYCDFNTYVLSAMGDDAVAGYLDAAHREL
CCCCCCCCCCCCCCCCCEEEEEECCHHHCCCCCCCCHHEEEEECCCHHHHHHHHHHHHHH
ELAADALGDAQPPVSTIFFGGGTPTMLSPVQLGELIDHIRTLWGIDPDAEVTTEANPETL
HHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEE
SVEVLAGLLKAGINRLSMGMQSADENVLTVLDRRHRPGRAVEMAQLARQVGFDDVSLDLI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEE
FGAPGENRDSWRYSLDATLTAEPDHISAYSLIVEEGTRLAGRIRRGELPMTDEDDLADKY
ECCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHH
LLTEKILTEAGYVNYEVSNWARPRSGRDHRCRHNMAYWLGYDWWGIGPGAHSHVAGTRWW
HHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHCCCEEEEECEEECCCCCCCCCCCCCEEE
NVKHPATYRNVLDDRVLPVDDYEVLGDVQRHEETVLLRLRLADGLPMADLSEVECMRATE
CCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHH
VVEQGLGTMEEGRLVLNLSGRMVADRIITDLLV
HHHHCCCCHHCCEEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure 
THADNSLPELHPADGPWSIYLHVPFCASRCGYCDFNTYVLSAMGDDAVAGYLDAAHREL
CCCCCCCCCCCCCCCCEEEEEECCHHHCCCCCCCCHHEEEEECCCHHHHHHHHHHHHHH
ELAADALGDAQPPVSTIFFGGGTPTMLSPVQLGELIDHIRTLWGIDPDAEVTTEANPETL
HHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEE
SVEVLAGLLKAGINRLSMGMQSADENVLTVLDRRHRPGRAVEMAQLARQVGFDDVSLDLI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEE
FGAPGENRDSWRYSLDATLTAEPDHISAYSLIVEEGTRLAGRIRRGELPMTDEDDLADKY
ECCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHH
LLTEKILTEAGYVNYEVSNWARPRSGRDHRCRHNMAYWLGYDWWGIGPGAHSHVAGTRWW
HHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHCCCEEEEECEEECCCCCCCCCCCCCEEE
NVKHPATYRNVLDDRVLPVDDYEVLGDVQRHEETVLLRLRLADGLPMADLSEVECMRATE
CCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHH
VVEQGLGTMEEGRLVLNLSGRMVADRIITDLLV
HHHHCCCCHHCCEEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]