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The map label for this gene is csbC [H]

Identifier: 50842371

GI number: 50842371

Start: 960840

End: 962198

Strand: Direct

Name: csbC [H]

Synonym: PPA0884

Alternate gene names: 50842371

Gene position: 960840-962198 (Clockwise)

Preceding gene: 50842370

Following gene: 50842372

Centisome position: 37.53

GC content: 56.73

Gene sequence:

>1359_bases
ATGTCCACCTCAACAACACCCAAACAATCAGCTCTAGACCTCATCGATTCGCGTCCCTTAACGCGCAATCAGAAGAATCT
TGTTGCCCTAGCCGTCGTCGGAAATATCTCCGAGTTCTTTGATATCTTCCTCATTGGTTTCGTCGTATCCGTCCTGACTA
AGCCATGGAATCTGACTGGCACTGAGGCGGGCGTCATTCTCGCCTGTTCCGGTCTGGGGACGGTCATTGGTGCCATCATG
TGGGGACGTCTTGCCGACAAGATCGGACGCCGCTCCTCTTTCTTCTGGTGCGTGCTCCTGTTCGTCGTGTTCACTGTAGT
ATCAGTGTTCACCCCAGATCGTGGCTGGATTATGCTCGCCATTTTGCGTATTGGCGTGGGGATCGGAGTCGGCGGACTTA
ATATCACCTCGATTCCCTACGTCCAGGAGTTCGTGCCTGCTAAGCAGCGCGGTCTTCTTGCCGGCCTGGCGTCGGTATTC
ATCCCCCTCGGTCTGTTCTTGGGGTCGTTAGCACAAAATGCACTGGGCGATAATTGGCGTGCCCTCATCGCTTTGGGCGC
CATTCCTGTTTTCCTGCTGGTGTGGATCCGTTTCGTGCCCGAATCACCACGGTTCCTACAGAGTCATGGGCGTGATAAGG
AAGCACGCGAGGCCCTAGCCTGGGCACTCGATATGCCCGCTGACGACATTGGAGATTTGCCTGCCGTTGAACACGTCCAA
GACGCTTCCTACTCACTTGTCTTTGGTAAATACCGCAAGAGTCTTCTCATCGTCAGTCTGGGATCATTCTGCTTCATTCT
GGGCTCTTTTACGATTCAGTCGTGGGGCCAGACCCTGCTCAAGACCGGCTTTGGCAAGTCTCCCGAGCAAGTCGGGACCC
TGTTCATGTTCGTTTCCCTGGCCGATCTCATCGGGCGCTTCCTATCAGCATGGCTGGCAGACCGCATTGGTCGGAGAGCC
ACCATGTTGTCGTTTGGCCTCATCGGTGCTGGCGGGACTCTCATCATCGCCCTTTCGGCCCGCCTGGGTTGGGGCTGGCA
GATCTTCTTCGTCGGTGTCCTCATTGCGATGGCCTTCGCCGACGGCGCCTTCGGCATCCTCAATGCTTTCGGCGCCGAGC
AATTCCCCAACGAAGCTCGCTCGACTGGTCTGGGACTGGGCTACGGCATCGGCGCCACCGCCAAGATCATCGGTCCGGCG
CTTATGGGACTCATGGTGGGCGGATCTGCCGTCAAGCAGAATGTCACCCTGGACGCGGTATTTCCGGCATTCATCCTGTT
CGCTGTGCTGCTAGTCATTGGCGGTATGACGTACATGTTTGCCCGCGAAACTCGTGGCACCTCGCTCGACACGATCTGA

Upstream 100 bases:

>100_bases
GGTGATCTGACTCGTGTGAGCCCTAGCGAACTCAATATTCCCCCGAATACCGACATTCTGCGCTGAACCTGATCACAGCG
CAGACAGGAGACACACTCAC

Downstream 100 bases:

>100_bases
CCAATTAGATGATCCTGATGTCGAGGGCCTGTACCTGCCTCAAAGGATTGACCGAGGCCGTGACTTGACGGGGTGGTTTA
GGGGTCCTCGACACGCCAGA

Product: sugar transporter, permease protein

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSTSTTPKQSALDLIDSRPLTRNQKNLVALAVVGNISEFFDIFLIGFVVSVLTKPWNLTGTEAGVILACSGLGTVIGAIM
WGRLADKIGRRSSFFWCVLLFVVFTVVSVFTPDRGWIMLAILRIGVGIGVGGLNITSIPYVQEFVPAKQRGLLAGLASVF
IPLGLFLGSLAQNALGDNWRALIALGAIPVFLLVWIRFVPESPRFLQSHGRDKEAREALAWALDMPADDIGDLPAVEHVQ
DASYSLVFGKYRKSLLIVSLGSFCFILGSFTIQSWGQTLLKTGFGKSPEQVGTLFMFVSLADLIGRFLSAWLADRIGRRA
TMLSFGLIGAGGTLIIALSARLGWGWQIFFVGVLIAMAFADGAFGILNAFGAEQFPNEARSTGLGLGYGIGATAKIIGPA
LMGLMVGGSAVKQNVTLDAVFPAFILFAVLLVIGGMTYMFARETRGTSLDTI

Sequences:

>Translated_452_residues
MSTSTTPKQSALDLIDSRPLTRNQKNLVALAVVGNISEFFDIFLIGFVVSVLTKPWNLTGTEAGVILACSGLGTVIGAIM
WGRLADKIGRRSSFFWCVLLFVVFTVVSVFTPDRGWIMLAILRIGVGIGVGGLNITSIPYVQEFVPAKQRGLLAGLASVF
IPLGLFLGSLAQNALGDNWRALIALGAIPVFLLVWIRFVPESPRFLQSHGRDKEAREALAWALDMPADDIGDLPAVEHVQ
DASYSLVFGKYRKSLLIVSLGSFCFILGSFTIQSWGQTLLKTGFGKSPEQVGTLFMFVSLADLIGRFLSAWLADRIGRRA
TMLSFGLIGAGGTLIIALSARLGWGWQIFFVGVLIAMAFADGAFGILNAFGAEQFPNEARSTGLGLGYGIGATAKIIGPA
LMGLMVGGSAVKQNVTLDAVFPAFILFAVLLVIGGMTYMFARETRGTSLDTI
>Mature_451_residues
STSTTPKQSALDLIDSRPLTRNQKNLVALAVVGNISEFFDIFLIGFVVSVLTKPWNLTGTEAGVILACSGLGTVIGAIMW
GRLADKIGRRSSFFWCVLLFVVFTVVSVFTPDRGWIMLAILRIGVGIGVGGLNITSIPYVQEFVPAKQRGLLAGLASVFI
PLGLFLGSLAQNALGDNWRALIALGAIPVFLLVWIRFVPESPRFLQSHGRDKEAREALAWALDMPADDIGDLPAVEHVQD
ASYSLVFGKYRKSLLIVSLGSFCFILGSFTIQSWGQTLLKTGFGKSPEQVGTLFMFVSLADLIGRFLSAWLADRIGRRAT
MLSFGLIGAGGTLIIALSARLGWGWQIFFVGVLIAMAFADGAFGILNAFGAEQFPNEARSTGLGLGYGIGATAKIIGPAL
MGLMVGGSAVKQNVTLDAVFPAFILFAVLLVIGGMTYMFARETRGTSLDTI

Specific function: Could serve either a nutritional or an osmotic protection function [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=445, Percent_Identity=23.5955056179775, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI24497497, Length=374, Percent_Identity=27.0053475935829, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI90669191, Length=368, Percent_Identity=27.1739130434783, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI213021148, Length=232, Percent_Identity=29.3103448275862, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI7662270, Length=191, Percent_Identity=28.2722513089005, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI166064021, Length=346, Percent_Identity=28.0346820809249, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI73695465, Length=160, Percent_Identity=30.625, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI21553331, Length=282, Percent_Identity=23.758865248227, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI4506999, Length=391, Percent_Identity=25.3196930946292, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI203098995, Length=279, Percent_Identity=26.5232974910394, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI166197673, Length=377, Percent_Identity=25.1989389920424, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI87082231, Length=475, Percent_Identity=24.4210526315789, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87082159, Length=380, Percent_Identity=29.2105263157895, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789207, Length=343, Percent_Identity=26.530612244898, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786229, Length=424, Percent_Identity=25.9433962264151, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082404, Length=432, Percent_Identity=24.0740740740741, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790463, Length=383, Percent_Identity=25.8485639686684, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788074, Length=374, Percent_Identity=25.1336898395722, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789312, Length=304, Percent_Identity=25.6578947368421, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI32564663, Length=411, Percent_Identity=23.6009732360097, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71989525, Length=355, Percent_Identity=24.7887323943662, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71989531, Length=355, Percent_Identity=24.7887323943662, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565976, Length=323, Percent_Identity=24.1486068111455, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323653, Length=288, Percent_Identity=26.7361111111111, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6322242, Length=288, Percent_Identity=25, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324417, Length=288, Percent_Identity=25, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321888, Length=293, Percent_Identity=26.962457337884, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323512, Length=519, Percent_Identity=23.6994219653179, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320766, Length=309, Percent_Identity=26.2135922330097, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6324400, Length=309, Percent_Identity=26.2135922330097, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321884, Length=289, Percent_Identity=26.643598615917, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321886, Length=178, Percent_Identity=32.0224719101124, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322247, Length=289, Percent_Identity=23.5294117647059, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320550, Length=287, Percent_Identity=26.1324041811847, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320549, Length=287, Percent_Identity=26.1324041811847, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321100, Length=287, Percent_Identity=26.1324041811847, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319956, Length=309, Percent_Identity=24.9190938511327, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322618, Length=309, Percent_Identity=24.9190938511327, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320552, Length=295, Percent_Identity=26.4406779661017, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323110, Length=291, Percent_Identity=23.3676975945017, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324469, Length=477, Percent_Identity=24.5283018867925, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320595, Length=168, Percent_Identity=27.9761904761905, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922616, Length=420, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161078612, Length=183, Percent_Identity=29.5081967213115, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644778, Length=362, Percent_Identity=24.0331491712707, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355657, Length=389, Percent_Identity=25.1928020565553, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24640198, Length=206, Percent_Identity=27.1844660194175, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24640196, Length=206, Percent_Identity=27.1844660194175, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24640200, Length=206, Percent_Identity=27.1844660194175, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR003663
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 48376; Mature: 48244

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00107 PROTEIN_KINASE_ATP ; PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSTTPKQSALDLIDSRPLTRNQKNLVALAVVGNISEFFDIFLIGFVVSVLTKPWNLTG
CCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
TEAGVILACSGLGTVIGAIMWGRLADKIGRRSSFFWCVLLFVVFTVVSVFTPDRGWIMLA
CCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ILRIGVGIGVGGLNITSIPYVQEFVPAKQRGLLAGLASVFIPLGLFLGSLAQNALGDNWR
HHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ALIALGAIPVFLLVWIRFVPESPRFLQSHGRDKEAREALAWALDMPADDIGDLPAVEHVQ
HHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHH
DASYSLVFGKYRKSLLIVSLGSFCFILGSFTIQSWGQTLLKTGFGKSPEQVGTLFMFVSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ADLIGRFLSAWLADRIGRRATMLSFGLIGAGGTLIIALSARLGWGWQIFFVGVLIAMAFA
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
DGAFGILNAFGAEQFPNEARSTGLGLGYGIGATAKIIGPALMGLMVGGSAVKQNVTLDAV
CCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCHHHH
FPAFILFAVLLVIGGMTYMFARETRGTSLDTI
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
STSTTPKQSALDLIDSRPLTRNQKNLVALAVVGNISEFFDIFLIGFVVSVLTKPWNLTG
CCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
TEAGVILACSGLGTVIGAIMWGRLADKIGRRSSFFWCVLLFVVFTVVSVFTPDRGWIMLA
CCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ILRIGVGIGVGGLNITSIPYVQEFVPAKQRGLLAGLASVFIPLGLFLGSLAQNALGDNWR
HHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ALIALGAIPVFLLVWIRFVPESPRFLQSHGRDKEAREALAWALDMPADDIGDLPAVEHVQ
HHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHH
DASYSLVFGKYRKSLLIVSLGSFCFILGSFTIQSWGQTLLKTGFGKSPEQVGTLFMFVSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ADLIGRFLSAWLADRIGRRATMLSFGLIGAGGTLIIALSARLGWGWQIFFVGVLIAMAFA
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
DGAFGILNAFGAEQFPNEARSTGLGLGYGIGATAKIIGPALMGLMVGGSAVKQNVTLDAV
CCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCHHHH
FPAFILFAVLLVIGGMTYMFARETRGTSLDTI
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 10376822 [H]