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The map label for this gene is proA

Identifier: 50842321

GI number: 50842321

Start: 916534

End: 917781

Strand: Direct

Name: proA

Synonym: PPA0835

Alternate gene names: 50842321

Gene position: 916534-917781 (Clockwise)

Preceding gene: 50842320

Following gene: 50842322

Centisome position: 35.8

GC content: 60.02

Gene sequence:

>1248_bases
ATGGCCATGAGCTCGCGAGTCATCGAACAGGCCATAGCTGCCCGATCTGCCGCCACGGTGTTGCGTCGACTGCGTCGCAT
CGACAAAGACGACCTTTTGGCGGCAATGGGTATCGGGTTACGCAAAGGCGTCGACGAGATCCTTGCTGCCAACGGTGCTG
ACGTCGATCGCGGTCGCGATGCTGGGATGGACGAAGCTCTCCTCGACCGTTTGACCCTTACCCCGGAGCGGATCGAAGGG
ATGGCTGTCGGTTTGGAGGGGGTTGCTCATCTCGACGATCCCGTCGGCGAGGTGGTGCGCGGCTGGCACACTCCGCTGGG
GGTCAAGATAGAACAAGTCCGGGTGCCGATCGGTGTCATCGGGATCATTTACGAGGCTCGCCCCAATGTCACCTCTGATG
CGGCGGGTATTTGCTTGAAGTCTGGAAATGCGTGTCTGTTGCGAGGATCTTCGTCGGCCCTAGAGTCCAACCGGGCAGTG
ATTGCGGCGATGCGATCCCGGCTGCCTGAGGAGATTCGTGAGGCGGTGCAACTCGTCGAGGGCGGCCACGAGGTCACCGA
TGAACTCATGACTGCCCGAGGATACGTCGACTTGCTCATTCCGCGCGGCGGTGCCGGGCTCATCAACGCCGTCGTGACCG
GAGCCAAGGTTCCCGTCATCCAGACCGGGACCGGCAACTGCCACCTCGTCATTGACGTTAGCGCCGATGTGGAGATGGCG
GTCAATATTGCCGTCAATGCTAAAACCCAGCGTCCCAGCGTGTGCAATGCCATCGAGACGGTTTTGGTGCATCGAGGAAT
TGCGGATTCGGCAGTGCGCCCATTGGTCGACGCCATGAGCGAACGCGGAGTCACGGTACACGGTGATGAAGAGAGCATCC
GACTGGATCCGAGGATCGTTCCTGCCGCCCCTGATGAATATGACAACGAGTACTTGTCCCTGGACCTCGCGCTGCGCATT
GTGGACGATCTGGAAGAAGCGGTCGATCACATCGCCAAGCATGGTTCAGGACATTCGGAAACCATCGTCACTAAGTCGAT
GTCTTCGCAGGAGTTTTTCGCTTCAAGCGTTGATGCTGCGGCGGTGCTGGTGAATTGCTCCAGCCGATTCGTTGACGGTG
GCGAGTTCGGATTCGGTGCCGAGATCGGCATTTCTACCCAGAAGCTCCATGCGCGCGGGCCGATGGGCCTGCGGGAAATG
ACGACGACAACCTATGTCCTGCGCGGGGACGGTCAGACCCGTCCGTGA

Upstream 100 bases:

>100_bases
TGAGCCGTCGTCGAGGAACCAGAAAAGTAGCGGGTCAAGGGTGACGTCCTGACTCACGGTCTGGTTATCAGGTGAGTGAT
GCTCAGCTGACGAATACCAT

Downstream 100 bases:

>100_bases
CCGTTTAACGGTTGTCGTGGGGCGGTTGTGGGATAGGCTGAGACGTCATGAGTATCGTTCCTCTCCTGATGGAGTCGTCG
GCCCTCGTCGTCGGCATCTT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MAMSSRVIEQAIAARSAATVLRRLRRIDKDDLLAAMGIGLRKGVDEILAANGADVDRGRDAGMDEALLDRLTLTPERIEG
MAVGLEGVAHLDDPVGEVVRGWHTPLGVKIEQVRVPIGVIGIIYEARPNVTSDAAGICLKSGNACLLRGSSSALESNRAV
IAAMRSRLPEEIREAVQLVEGGHEVTDELMTARGYVDLLIPRGGAGLINAVVTGAKVPVIQTGTGNCHLVIDVSADVEMA
VNIAVNAKTQRPSVCNAIETVLVHRGIADSAVRPLVDAMSERGVTVHGDEESIRLDPRIVPAAPDEYDNEYLSLDLALRI
VDDLEEAVDHIAKHGSGHSETIVTKSMSSQEFFASSVDAAAVLVNCSSRFVDGGEFGFGAEIGISTQKLHARGPMGLREM
TTTTYVLRGDGQTRP

Sequences:

>Translated_415_residues
MAMSSRVIEQAIAARSAATVLRRLRRIDKDDLLAAMGIGLRKGVDEILAANGADVDRGRDAGMDEALLDRLTLTPERIEG
MAVGLEGVAHLDDPVGEVVRGWHTPLGVKIEQVRVPIGVIGIIYEARPNVTSDAAGICLKSGNACLLRGSSSALESNRAV
IAAMRSRLPEEIREAVQLVEGGHEVTDELMTARGYVDLLIPRGGAGLINAVVTGAKVPVIQTGTGNCHLVIDVSADVEMA
VNIAVNAKTQRPSVCNAIETVLVHRGIADSAVRPLVDAMSERGVTVHGDEESIRLDPRIVPAAPDEYDNEYLSLDLALRI
VDDLEEAVDHIAKHGSGHSETIVTKSMSSQEFFASSVDAAAVLVNCSSRFVDGGEFGFGAEIGISTQKLHARGPMGLREM
TTTTYVLRGDGQTRP
>Mature_414_residues
AMSSRVIEQAIAARSAATVLRRLRRIDKDDLLAAMGIGLRKGVDEILAANGADVDRGRDAGMDEALLDRLTLTPERIEGM
AVGLEGVAHLDDPVGEVVRGWHTPLGVKIEQVRVPIGVIGIIYEARPNVTSDAAGICLKSGNACLLRGSSSALESNRAVI
AAMRSRLPEEIREAVQLVEGGHEVTDELMTARGYVDLLIPRGGAGLINAVVTGAKVPVIQTGTGNCHLVIDVSADVEMAV
NIAVNAKTQRPSVCNAIETVLVHRGIADSAVRPLVDAMSERGVTVHGDEESIRLDPRIVPAAPDEYDNEYLSLDLALRIV
DDLEEAVDHIAKHGSGHSETIVTKSMSSQEFFASSVDAAAVLVNCSSRFVDGGEFGFGAEIGISTQKLHARGPMGLREMT
TTTYVLRGDGQTRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=408, Percent_Identity=36.0294117647059, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI21361368, Length=408, Percent_Identity=36.0294117647059, Blast_Score=247, Evalue=2e-65,
Organism=Escherichia coli, GI1786438, Length=413, Percent_Identity=44.0677966101695, Blast_Score=341, Evalue=6e-95,
Organism=Caenorhabditis elegans, GI17569969, Length=375, Percent_Identity=38.6666666666667, Blast_Score=260, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI17569967, Length=375, Percent_Identity=38.6666666666667, Blast_Score=260, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6324899, Length=428, Percent_Identity=34.5794392523364, Blast_Score=249, Evalue=7e-67,
Organism=Drosophila melanogaster, GI21357643, Length=369, Percent_Identity=37.1273712737127, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_PROAC (Q6A9H6)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055548.1
- ProteinModelPortal:   Q6A9H6
- SMR:   Q6A9H6
- GeneID:   2932899
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0835
- NMPDR:   fig|267747.1.peg.825
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   CLSK2763564
- BioCyc:   PACN267747:PPA0835-MONOMER
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44088; Mature: 43957

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS01223 PROA; PS00862 OX2_COVAL_FAD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMSSRVIEQAIAARSAATVLRRLRRIDKDDLLAAMGIGLRKGVDEILAANGADVDRGRD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHCHHHHHHCCCCCCCCCCC
AGMDEALLDRLTLTPERIEGMAVGLEGVAHLDDPVGEVVRGWHTPLGVKIEQVRVPIGVI
CCCCHHHHHHHCCCHHHHCCEEECCCCHHHCCCHHHHHHHHCCCCCCCEEEEEECCEEEE
GIIYEARPNVTSDAAGICLKSGNACLLRGSSSALESNRAVIAAMRSRLPEEIREAVQLVE
EEEEECCCCCCCCCCCEEEECCCEEEEECCCHHHHCCHHHHHHHHHHCHHHHHHHHHHHH
GGHEVTDELMTARGYVDLLIPRGGAGLINAVVTGAKVPVIQTGTGNCHLVIDVSADVEMA
CCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCEEE
VNIAVNAKTQRPSVCNAIETVLVHRGIADSAVRPLVDAMSERGVTVHGDEESIRLDPRIV
EEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCEEECCEEE
PAAPDEYDNEYLSLDLALRIVDDLEEAVDHIAKHGSGHSETIVTKSMSSQEFFASSVDAA
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCCHH
AVLVNCSSRFVDGGEFGFGAEIGISTQKLHARGPMGLREMTTTTYVLRGDGQTRP
EEEEECCHHCCCCCCCCCCCEECCCHHHHHCCCCCCHHHHCEEEEEEECCCCCCC
>Mature Secondary Structure 
AMSSRVIEQAIAARSAATVLRRLRRIDKDDLLAAMGIGLRKGVDEILAANGADVDRGRD
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHCHHHHHHCCCCCCCCCCC
AGMDEALLDRLTLTPERIEGMAVGLEGVAHLDDPVGEVVRGWHTPLGVKIEQVRVPIGVI
CCCCHHHHHHHCCCHHHHCCEEECCCCHHHCCCHHHHHHHHCCCCCCCEEEEEECCEEEE
GIIYEARPNVTSDAAGICLKSGNACLLRGSSSALESNRAVIAAMRSRLPEEIREAVQLVE
EEEEECCCCCCCCCCCEEEECCCEEEEECCCHHHHCCHHHHHHHHHHCHHHHHHHHHHHH
GGHEVTDELMTARGYVDLLIPRGGAGLINAVVTGAKVPVIQTGTGNCHLVIDVSADVEMA
CCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCEEE
VNIAVNAKTQRPSVCNAIETVLVHRGIADSAVRPLVDAMSERGVTVHGDEESIRLDPRIV
EEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCEEECCEEE
PAAPDEYDNEYLSLDLALRIVDDLEEAVDHIAKHGSGHSETIVTKSMSSQEFFASSVDAA
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCCHH
AVLVNCSSRFVDGGEFGFGAEIGISTQKLHARGPMGLREMTTTTYVLRGDGQTRP
EEEEECCHHCCCCCCCCCCCEECCCHHHHHCCCCCCHHHHCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA