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The map label for this gene is hmuU [H]

Identifier: 50842268

GI number: 50842268

Start: 858938

End: 859996

Strand: Direct

Name: hmuU [H]

Synonym: PPA0781

Alternate gene names: 50842268

Gene position: 858938-859996 (Clockwise)

Preceding gene: 50842267

Following gene: 50842269

Centisome position: 33.55

GC content: 58.45

Gene sequence:

>1059_bases
ATGAGCGCCCTGTCACAGCCGGTTGTCCAGCGTTCTGGGATTGAGCGACGGACTCGGGTTCGCGTTATCTCCACCATCTG
CCTCGTCATCATCGTATGTGGTTTAGTGCTGTTGTCAGCGATGGTTGGTCAGTACCGCGTCGAGGCCGCCGACGTCATCA
AAATCGTTTTCGGGAGGTCGGCCACTGACGCCATGGCCGAGTCGGTGCTGTGGCAGATCCGCTTTCCGCGCATTGTTCTT
GGCCTGCTAGTGGGGGCTAGTCTTGCTGTGGCCGGAGCCGTCATGCAGGCGCTGTTTTCCAATCCGCTCGCTGAACCCGG
TGTCATTGGCGTGTCATCGGGGGCGGCTGTGGGGGCATCGATCATGATTGTGGTCGCCCCCAATTTTTTGTCCGGGTTCG
GGGTGCCGGCAGCGGCATTTGTGTCCGGACTGCTTGCGGCCAGTTCGGTCTACATTATGGCGCGGTCCGGACGACGAGCT
GAGTCGACGACCCTAGTTCTGACTGGCATCGCGGTGACGGCCGTGTGTTCGGCTATCACCTCAATATCCACTTATGTTGC
GCCGACTACCGCCCGGGACCAAATTGTCTTCTGGCAGATGGGATCCCTGAGCGGGACAACCTGGAGTCACGTGGCAACGG
TCGGGACGGTAGCCAGTGTCGGGATTGTCTGGGCCATCCTTATTGCTGGCAAGCTCGACACTCTGGCCTTGGGTGAGAGG
GCTGCAGGGCACTTGGGAGTCAACGTCAATCGGTTACGGTTGTCATCGATAGCTTTGACAGCACTGCTAACTTCGGCGGC
GGTGGCTTATGCCGGAGTTATCACATTTGTGGGGCTCATAGTGCCGCATGTTTTGAGGCTGCTCATCGGGCCAGCCAACA
AATGGCTCATCCCGTCTGCCTTGTTGGGAGGTTGTCTGTTGGTCACACTGTCCGACATCGCTGCTCGAACTGTGGTGCCC
TACGCCGATCTGCCCATTGGCATCTTTACTGCCATCGTTGGCGGTCCTACTTTCTTCATATTGTTGAGACGAGGCATGGG
TGGTGAGAAGGCCCTGTGA

Upstream 100 bases:

>100_bases
AGCAACGGGTTATTTCCATTCCTGATGGAATCTCGCTGTCTTTCGGGCCCCAAACCGGGGAGGTCCTGACCGCTGTGGCC
AAGGCTTTGTACGGAGTCAA

Downstream 100 bases:

>100_bases
TGATCCGTGCGCGGGACGTGACCTTTTGTTACGGGGAGCGAAGGATCCTCGACGGGATCAACCTCGACGTCCAAGCAGGT
GAATTCGTCGGTTTGCTGGG

Product: ABC-type transporter, permease component

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSALSQPVVQRSGIERRTRVRVISTICLVIIVCGLVLLSAMVGQYRVEAADVIKIVFGRSATDAMAESVLWQIRFPRIVL
GLLVGASLAVAGAVMQALFSNPLAEPGVIGVSSGAAVGASIMIVVAPNFLSGFGVPAAAFVSGLLAASSVYIMARSGRRA
ESTTLVLTGIAVTAVCSAITSISTYVAPTTARDQIVFWQMGSLSGTTWSHVATVGTVASVGIVWAILIAGKLDTLALGER
AAGHLGVNVNRLRLSSIALTALLTSAAVAYAGVITFVGLIVPHVLRLLIGPANKWLIPSALLGGCLLVTLSDIAARTVVP
YADLPIGIFTAIVGGPTFFILLRRGMGGEKAL

Sequences:

>Translated_352_residues
MSALSQPVVQRSGIERRTRVRVISTICLVIIVCGLVLLSAMVGQYRVEAADVIKIVFGRSATDAMAESVLWQIRFPRIVL
GLLVGASLAVAGAVMQALFSNPLAEPGVIGVSSGAAVGASIMIVVAPNFLSGFGVPAAAFVSGLLAASSVYIMARSGRRA
ESTTLVLTGIAVTAVCSAITSISTYVAPTTARDQIVFWQMGSLSGTTWSHVATVGTVASVGIVWAILIAGKLDTLALGER
AAGHLGVNVNRLRLSSIALTALLTSAAVAYAGVITFVGLIVPHVLRLLIGPANKWLIPSALLGGCLLVTLSDIAARTVVP
YADLPIGIFTAIVGGPTFFILLRRGMGGEKAL
>Mature_351_residues
SALSQPVVQRSGIERRTRVRVISTICLVIIVCGLVLLSAMVGQYRVEAADVIKIVFGRSATDAMAESVLWQIRFPRIVLG
LLVGASLAVAGAVMQALFSNPLAEPGVIGVSSGAAVGASIMIVVAPNFLSGFGVPAAAFVSGLLAASSVYIMARSGRRAE
STTLVLTGIAVTAVCSAITSISTYVAPTTARDQIVFWQMGSLSGTTWSHVATVGTVASVGIVWAILIAGKLDTLALGERA
AGHLGVNVNRLRLSSIALTALLTSAAVAYAGVITFVGLIVPHVLRLLIGPANKWLIPSALLGGCLLVTLSDIAARTVVPY
ADLPIGIFTAIVGGPTFFILLRRGMGGEKAL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=283, Percent_Identity=38.5159010600707, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1790740, Length=276, Percent_Identity=34.4202898550725, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1790741, Length=301, Percent_Identity=33.2225913621262, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786805, Length=286, Percent_Identity=33.2167832167832, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786347, Length=324, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786804, Length=304, Percent_Identity=32.2368421052632, Blast_Score=103, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36245; Mature: 36113

Theoretical pI: Translated: 10.69; Mature: 10.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALSQPVVQRSGIERRTRVRVISTICLVIIVCGLVLLSAMVGQYRVEAADVIKIVFGRS
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATDAMAESVLWQIRFPRIVLGLLVGASLAVAGAVMQALFSNPLAEPGVIGVSSGAAVGAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHCCE
IMIVVAPNFLSGFGVPAAAFVSGLLAASSVYIMARSGRRAESTTLVLTGIAVTAVCSAIT
EEEEECCCHHCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEHHHHHHHHHHHHH
SISTYVAPTTARDQIVFWQMGSLSGTTWSHVATVGTVASVGIVWAILIAGKLDTLALGER
HHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
AAGHLGVNVNRLRLSSIALTALLTSAAVAYAGVITFVGLIVPHVLRLLIGPANKWLIPSA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LLGGCLLVTLSDIAARTVVPYADLPIGIFTAIVGGPTFFILLRRGMGGEKAL
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SALSQPVVQRSGIERRTRVRVISTICLVIIVCGLVLLSAMVGQYRVEAADVIKIVFGRS
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATDAMAESVLWQIRFPRIVLGLLVGASLAVAGAVMQALFSNPLAEPGVIGVSSGAAVGAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHCCE
IMIVVAPNFLSGFGVPAAAFVSGLLAASSVYIMARSGRRAESTTLVLTGIAVTAVCSAIT
EEEEECCCHHCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEHHHHHHHHHHHHH
SISTYVAPTTARDQIVFWQMGSLSGTTWSHVATVGTVASVGIVWAILIAGKLDTLALGER
HHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
AAGHLGVNVNRLRLSSIALTALLTSAAVAYAGVITFVGLIVPHVLRLLIGPANKWLIPSA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LLGGCLLVTLSDIAARTVVPYADLPIGIFTAIVGGPTFFILLRRGMGGEKAL
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]