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The map label for this gene is dacC [H]

Identifier: 50841747

GI number: 50841747

Start: 310315

End: 311745

Strand: Direct

Name: dacC [H]

Synonym: PPA0257

Alternate gene names: 50841747

Gene position: 310315-311745 (Clockwise)

Preceding gene: 50841743

Following gene: 50841748

Centisome position: 12.12

GC content: 60.87

Gene sequence:

>1431_bases
GTGCCACACTCAGATCAACCTACGTCGAAGCGAGTTATGTCGGCGCCACGACGGCGCATGCCGGGATGGGTACCCGTTAC
TGTCGGCATCGCAGTGGTCGTCATTGTTGTTGTTGCGGTTATCGTCAGTTCGCTGCGGAGCGGGTCACCTGCGCGCTGGA
CCGGAGGAGGAATCCTTCCTCATCGCCACGACAACACCGCCCAAGCGGTGCAGCCGGGACGAGGGGTTGTCGCGGCAGTG
GCACCGACGACGCCGTCGGCCAAGCCAGTCGCTGCCACGATCGCCAATCGCGTCAAGTCTGCAGGCGCAGCCCCTGGCGT
ACTGGGCGCTGACATTATGGATGCAGCGACCGGCGAGACCCTCTACCAGTCGGGTCAGAATTCCCTCCTGACTCCAGCTT
CCAATCTCAAAGTGCTTACTGCGATTGCGCTGTTGGATTGCACCGACGCCGGGCATCGTTACACGACGAAGGTTGTCGCC
AATGGGTCCGCACTGACTTTGGTCGGTGGTGGAGACCCCTACCTGCGTTCGAAGTCTTCGGCCCAGCACCCCGAGTATCC
GTCGATGGAAGAACTTGCCAAGCGTACGGCGGCGGCTCTCAAGAAGGCGGGGACGACGAAGGTCACCGTCAACTTGGACG
ACACCCTGTTTACTGGACCGGATTGGAACGGGGCCTGGCCGGTCGACAACTACTCCGACGAGGTCACTCCAATTACGTCA
TTGTGGGTCGACGAGGGAATGATCAACAACAGCCCATGGAATCGCAGTAAGACGCCAGCCGTACTTGCTACCAACGCTTT
CATCGGCTCGCTTCGTAGCGCCGGGATAACGGTAAATGGTTCGGTTTCTCGTCACAAGGCTGACAGGTCTGCCAGGGAGA
TTGCGGCGGTGCAGTCGGTCCCGGTGGAGGACCTTGTTACCCGCACCCTGGAGGAGTCAGACAACTCTGCCGCTGAGGTC
TTGAGCCGGCAGATGGCTCTTGCTAGTGGCAAGCCGGGATCCTTTGCTGGTGGTACCCAAGCCCTCGAGGAGCACCTCAA
GAACATAGGTGCCTGGCAGGACGGTGTGGTGATCCAGGACGGATCGGGATTGTCCCAGGGCAATCGGATCACCGCGTCGA
TGCTTTCGCGTGCCTGGCGCAAAGTATTGACGACCCCGAAGCTGCAGCCGGTGGCGAATGCGGTACCAGTGGGTCGGGTC
TCTGGGACCCTTCATAAACGATTTTCCGATCCGAGCACGGCAGCCGGACGCGGTGTCGTTCACGCCAAAACGGGCAGTCT
GCAAGGAGTCATCTCAATGTCGGGGTGGCTGCGTGACGCTGACGGGCGAATTTTGGTGGCTTCCTTCATCATCAATCAGA
CTGACGGCAGTGCCCGGTCGTGGCTCGACGTCGTTTACGGCAACCTGGCCGGGTGCGGCTGCACCCGCTGA

Upstream 100 bases:

>100_bases
CCTGGAATGGATTGGTGAAATCGTCGGTCACGAGGGGCCCCTCTTCTTGTATTGGACACGGTGATGATCGACACTGTATC
CGTTTGCAGGAGGGATTTTC

Downstream 100 bases:

>100_bases
TGGCACGACGGGAATTAGGGCCAGCGGCCCTGGCAGTCGCCCAGGCCGTCGAGCGGATGGTGCGAGGGGTTGATCGGTTC
GTCGTCGGGTGCTCGGGCGG

Product: putative carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 4a; PBP-4a [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MPHSDQPTSKRVMSAPRRRMPGWVPVTVGIAVVVIVVVAVIVSSLRSGSPARWTGGGILPHRHDNTAQAVQPGRGVVAAV
APTTPSAKPVAATIANRVKSAGAAPGVLGADIMDAATGETLYQSGQNSLLTPASNLKVLTAIALLDCTDAGHRYTTKVVA
NGSALTLVGGGDPYLRSKSSAQHPEYPSMEELAKRTAAALKKAGTTKVTVNLDDTLFTGPDWNGAWPVDNYSDEVTPITS
LWVDEGMINNSPWNRSKTPAVLATNAFIGSLRSAGITVNGSVSRHKADRSAREIAAVQSVPVEDLVTRTLEESDNSAAEV
LSRQMALASGKPGSFAGGTQALEEHLKNIGAWQDGVVIQDGSGLSQGNRITASMLSRAWRKVLTTPKLQPVANAVPVGRV
SGTLHKRFSDPSTAAGRGVVHAKTGSLQGVISMSGWLRDADGRILVASFIINQTDGSARSWLDVVYGNLAGCGCTR

Sequences:

>Translated_476_residues
MPHSDQPTSKRVMSAPRRRMPGWVPVTVGIAVVVIVVVAVIVSSLRSGSPARWTGGGILPHRHDNTAQAVQPGRGVVAAV
APTTPSAKPVAATIANRVKSAGAAPGVLGADIMDAATGETLYQSGQNSLLTPASNLKVLTAIALLDCTDAGHRYTTKVVA
NGSALTLVGGGDPYLRSKSSAQHPEYPSMEELAKRTAAALKKAGTTKVTVNLDDTLFTGPDWNGAWPVDNYSDEVTPITS
LWVDEGMINNSPWNRSKTPAVLATNAFIGSLRSAGITVNGSVSRHKADRSAREIAAVQSVPVEDLVTRTLEESDNSAAEV
LSRQMALASGKPGSFAGGTQALEEHLKNIGAWQDGVVIQDGSGLSQGNRITASMLSRAWRKVLTTPKLQPVANAVPVGRV
SGTLHKRFSDPSTAAGRGVVHAKTGSLQGVISMSGWLRDADGRILVASFIINQTDGSARSWLDVVYGNLAGCGCTR
>Mature_475_residues
PHSDQPTSKRVMSAPRRRMPGWVPVTVGIAVVVIVVVAVIVSSLRSGSPARWTGGGILPHRHDNTAQAVQPGRGVVAAVA
PTTPSAKPVAATIANRVKSAGAAPGVLGADIMDAATGETLYQSGQNSLLTPASNLKVLTAIALLDCTDAGHRYTTKVVAN
GSALTLVGGGDPYLRSKSSAQHPEYPSMEELAKRTAAALKKAGTTKVTVNLDDTLFTGPDWNGAWPVDNYSDEVTPITSL
WVDEGMINNSPWNRSKTPAVLATNAFIGSLRSAGITVNGSVSRHKADRSAREIAAVQSVPVEDLVTRTLEESDNSAAEVL
SRQMALASGKPGSFAGGTQALEEHLKNIGAWQDGVVIQDGSGLSQGNRITASMLSRAWRKVLTTPKLQPVANAVPVGRVS
GTLHKRFSDPSTAAGRGVVHAKTGSLQGVISMSGWLRDADGRILVASFIINQTDGSARSWLDVVYGNLAGCGCTR

Specific function: Catalyzes DD-carboxypeptidase and transpeptidation reactions [H]

COG id: COG2027

COG function: function code M; D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4)

Gene ontology:

Cell location: Secreted (Probable). Note=May be anchored in the membrane via a C-terminal amphiphatic alpha helix [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S13 family [H]

Homologues:

Organism=Escherichia coli, GI1789573, Length=177, Percent_Identity=30.5084745762712, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR000667 [H]

Pfam domain/function: PF02113 Peptidase_S13 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 49682; Mature: 49551

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHSDQPTSKRVMSAPRRRMPGWVPVTVGIAVVVIVVVAVIVSSLRSGSPARWTGGGILP
CCCCCCCHHHHHHHCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
HRHDNTAQAVQPGRGVVAAVAPTTPSAKPVAATIANRVKSAGAAPGVLGADIMDAATGET
CCCCCCHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHH
LYQSGQNSLLTPASNLKVLTAIALLDCTDAGHRYTTKVVANGSALTLVGGGDPYLRSKSS
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEECCCHHHCCCCC
AQHPEYPSMEELAKRTAAALKKAGTTKVTVNLDDTLFTGPDWNGAWPVDNYSDEVTPITS
CCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCCCCCCCCCCCCCHHHH
LWVDEGMINNSPWNRSKTPAVLATNAFIGSLRSAGITVNGSVSRHKADRSAREIAAVQSV
HHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCC
PVEDLVTRTLEESDNSAAEVLSRQMALASGKPGSFAGGTQALEEHLKNIGAWQDGVVIQD
CHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEC
GSGLSQGNRITASMLSRAWRKVLTTPKLQPVANAVPVGRVSGTLHKRFSDPSTAAGRGVV
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEE
HAKTGSLQGVISMSGWLRDADGRILVASFIINQTDGSARSWLDVVYGNLAGCGCTR
EEECCCCCEEEECCCCEECCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PHSDQPTSKRVMSAPRRRMPGWVPVTVGIAVVVIVVVAVIVSSLRSGSPARWTGGGILP
CCCCCCHHHHHHHCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
HRHDNTAQAVQPGRGVVAAVAPTTPSAKPVAATIANRVKSAGAAPGVLGADIMDAATGET
CCCCCCHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHH
LYQSGQNSLLTPASNLKVLTAIALLDCTDAGHRYTTKVVANGSALTLVGGGDPYLRSKSS
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEECCCHHHCCCCC
AQHPEYPSMEELAKRTAAALKKAGTTKVTVNLDDTLFTGPDWNGAWPVDNYSDEVTPITS
CCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCCCCCCCCCCCCCHHHH
LWVDEGMINNSPWNRSKTPAVLATNAFIGSLRSAGITVNGSVSRHKADRSAREIAAVQSV
HHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCC
PVEDLVTRTLEESDNSAAEVLSRQMALASGKPGSFAGGTQALEEHLKNIGAWQDGVVIQD
CHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEC
GSGLSQGNRITASMLSRAWRKVLTTPKLQPVANAVPVGRVSGTLHKRFSDPSTAAGRGVV
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEE
HAKTGSLQGVISMSGWLRDADGRILVASFIINQTDGSARSWLDVVYGNLAGCGCTR
EEECCCCCEEEECCCCEECCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7711903; 9384377 [H]